Detailed information for compound 1571449

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.756 | Formula: C7H12ClNO7S2
  • H donors: 1 H acceptors: 6 LogP: -0.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OCC(N1Cl)(C)CS(=O)(=O)CCS(=O)(=O)O
  • InChi: 1S/C7H12ClNO7S2/c1-7(4-16-6(10)9(7)8)5-17(11,12)2-3-18(13,14)15/h2-5H2,1H3,(H,13,14,15)
  • InChiKey: PSZMYGXDCWKPCC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Matrix metalloproteinase homolog 0.0356 0.2129 0.8737
Echinococcus granulosus cpg binding protein 0.0059 0.0279 0.0556
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0242 0.0752
Echinococcus granulosus stromal cell derived factor 2 0.0101 0.0542 0.1099
Loa Loa (eye worm) malate dehydrogenase 0.0044 0.0188 0.0773
Schistosoma mansoni hypothetical protein 0.003 0.0096 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0063 0.0144
Brugia malayi hypothetical protein 0.0026 0.0074 0.0269
Loa Loa (eye worm) hypothetical protein 0.016 0.0911 0.375
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Brugia malayi Augmenter of liver regeneration 0.0035 0.0129 0.0492
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0353 0.117
Schistosoma mansoni aldo-keto reductase 0.0404 0.243 0.4993
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0041 0.0075
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0473 0.0464
Echinococcus granulosus malate dehydrogenase 0.0019 0.0028 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0139 0.0416
Echinococcus granulosus geminin 0.0172 0.0982 0.2007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0041 0.0133
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0573
Loa Loa (eye worm) hypothetical protein 0.0101 0.0542 0.2231
Onchocerca volvulus 0.0227 0.1329 0.539
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.009 0.0473 0.1616
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0117 0.0641 0.2291
Onchocerca volvulus 0.0101 0.0542 0.2096
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0374 0.1294
Onchocerca volvulus 0.0071 0.0353 0.1306
Loa Loa (eye worm) hypothetical protein 0.016 0.0911 0.375
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0096 0.0254
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0359 0.2145 0.8827
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0353 0.117
Schistosoma mansoni hypothetical protein 0.0172 0.0982 0.2007
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0063 0.0144
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0139 0.0464
Brugia malayi beta-lactamase 0.0037 0.0139 0.0537
Mycobacterium leprae Possible oxidoreductase 0.0117 0.0641 0.2251
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0404 0.243 1
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0078 0.0284
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0129 0.0419
Brugia malayi cation channel family protein 0.0101 0.0542 0.2201
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0041 0.0075
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0139 0.0481
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0119 0.011
Echinococcus multilocularis adam 0.0026 0.0074 0.0065
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0404 0.243 1
Brugia malayi jmjC domain containing protein 0.0039 0.0155 0.06
Plasmodium falciparum thioredoxin reductase 0.0038 0.0151 0.0459
Loa Loa (eye worm) hypothetical protein 0.0049 0.022 0.0905
Mycobacterium ulcerans hypothetical protein 0.0117 0.0641 0.2251
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0101 0.0542 0.2201
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0139 0.0481
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0106 0.0326
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0106 0.02
Brugia malayi Bromodomain containing protein 0.003 0.0096 0.0358
Loa Loa (eye worm) hypothetical protein 0.0074 0.0374 0.154
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0075
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0117 0.0641 0.2639
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0057
Entamoeba histolytica alcohol dehydrogenase, putative 0.0117 0.0641 0.2553
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0168 0.0159
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0106 0.0293
Giardia lamblia Aldose reductase 0.0404 0.243 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0129 0.0119
Entamoeba histolytica MIR domain protein 0.0101 0.0542 0.2141
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Loa Loa (eye worm) hypothetical protein 0.0071 0.0353 0.1454
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0374 0.1442
Loa Loa (eye worm) hypothetical protein 0.0091 0.0479 0.197
Trichomonas vaginalis aldo/keto reductase, putative 0.0404 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0353 0.1454
Brugia malayi Matrixin family protein 0.016 0.0911 0.3726
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0106 0.0097
Loa Loa (eye worm) oxidoreductase 0.0404 0.243 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0242 0.0214
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0096 0.0179
Loa Loa (eye worm) matrix metalloproteinase 0.016 0.0911 0.375
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0359 0.2145 0.2138
Trichomonas vaginalis conserved hypothetical protein 0.0277 0.1638 0.6703
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0155 0.0636
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Loa Loa (eye worm) hypothetical protein 0.0101 0.0542 0.2231
Trypanosoma brucei aldo/keto reductase, putative 0.0117 0.0641 0.2553
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Echinococcus multilocularis lactate dehydrogenase a 0.0019 0.0028 0.0019
Onchocerca volvulus Alhambra homolog 0.003 0.0096 0.0228
Echinococcus multilocularis geminin 0.0172 0.0982 0.0974
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0573
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0041 0.0133
Echinococcus granulosus ryanodine receptor 44f 0.0101 0.0542 0.1099
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0101 0.0542 0.1099
Brugia malayi CXXC zinc finger family protein 0.0056 0.0259 0.1032
Echinococcus granulosus adam 0.0026 0.0074 0.0134
Loa Loa (eye worm) hypothetical protein 0.0404 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0171
Schistosoma mansoni cpg binding protein 0.0056 0.0259 0.0515
Plasmodium falciparum aldo-keto reductase, putative 0.0117 0.0641 0.2291
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0583 0.3546 0.7294
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.022 0.087
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0041 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0171
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0405 0.0396
Trichomonas vaginalis aldo/keto reductase, putative 0.0404 0.243 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0041 0.0051
Brugia malayi beta-lactamase family protein 0.0037 0.0139 0.0537
Echinococcus multilocularis aldo keto reductase 0.0404 0.243 0.2423
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0449 0.2706 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0139 0.0464
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0755 0.3079
Echinococcus granulosus peregrin 0.003 0.0096 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0063 0.0144
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0106 0.0344
Mycobacterium ulcerans beta-lactamase 0.0037 0.0139 0.0367
Brugia malayi isocitrate dehydrogenase 0.0031 0.0106 0.04
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0106 0.0097
Echinococcus granulosus cytosolic malate dehydrogenase 0.0044 0.0188 0.0368
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0106 0.0097
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0151 0.0529
Loa Loa (eye worm) oxidoreductase 0.0404 0.243 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0515 0.1043
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0473 0.0957
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0044 0.0188 0.0666
Loa Loa (eye worm) hypothetical protein 0.0051 0.0228 0.0936
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0139 0.0268
Trypanosoma brucei prostaglandin f synthase 0.0404 0.243 1
Onchocerca volvulus 0.0037 0.0139 0.0409
Loa Loa (eye worm) oxidoreductase 0.0404 0.243 1
Loa Loa (eye worm) oxidoreductase 0.0021 0.0041 0.0171
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0106 0.0293
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0106 0.0097
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0026 0.0074 0.0134
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0075
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0019 0.0028 0.0019
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0295 0.0286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0518 0.2054
Echinococcus multilocularis dnaJ subfamily B 0.0794 0.4857 0.4853
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Onchocerca volvulus 0.0404 0.243 1
Brugia malayi TAR-binding protein 0.0061 0.0295 0.1179
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0295 0.0589
Entamoeba histolytica aldose reductase, putative 0.0404 0.243 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Mycobacterium tuberculosis Probable reductase 0.0088 0.0457 0.1801
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0518 0.1788
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0106 0.0293
Brugia malayi Matrixin family protein 0.016 0.0911 0.3726
Echinococcus granulosus lactate dehydrogenase a 0.0019 0.0028 0.0038
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0057
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0518 0.2054
Onchocerca volvulus Matrilysin homolog 0.0356 0.2129 0.8737
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0353 0.1355
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0041 0.0051
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.243 1
Giardia lamblia Malate dehydrogenase 0.0044 0.0188 0.0393
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0038 0.0149 0.0287
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0995
Trypanosoma cruzi aldo/keto reductase, putative 0.0117 0.0641 0.2553
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0648 0.1318
Echinococcus granulosus cytosolic malate dehydrogenase 0.0044 0.0188 0.0368
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0353 0.1355
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0063 0.0144
Schistosoma mansoni L-lactate dehydrogenase 0.0019 0.0028 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Brugia malayi glutathione reductase 0.0038 0.0151 0.0584
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0044 0.0188 0.0666
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0457 0.1801
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0129 0.0419
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0044 0.0188 0.0666
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0044 0.0188 0.0666
Schistosoma mansoni hypothetical protein 0.0172 0.0982 0.2007
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0449 0.2706 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0139 0.0367
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0041 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0755 0.1537
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0295 0.0589
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0129 0.0529
Echinococcus multilocularis lactate dehydrogenase a 0.0019 0.0028 0.0019
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0227
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0573
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0755 0.0746
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0353 0.1355
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0995
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0122 0.0467
Toxoplasma gondii aldose reductase, putative 0.0404 0.243 0.897
Onchocerca volvulus 0.016 0.0911 0.3641
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0041 0.0057
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0129 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0755 0.1537
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0353 0.117
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0044 0.0188 0.0666
Loa Loa (eye worm) oxidoreductase 0.0404 0.243 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.0473 0.0957
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0295 0.1213
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0117 0.0641 0.261
Onchocerca volvulus Papilin homolog 0.0029 0.0091 0.0207
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0353 0.117
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.016 0.0911 0.186
Echinococcus granulosus lactate dehydrogenase a 0.0019 0.0028 0.0038
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0129 0.0419
Mycobacterium ulcerans oxidoreductase 0.0404 0.243 0.8965
Leishmania major hypothetical protein, conserved 0.0035 0.0129 0.0419
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Loa Loa (eye worm) RNA binding protein 0.0061 0.0295 0.1213
Loa Loa (eye worm) hypothetical protein 0.0071 0.0353 0.1454
Trichomonas vaginalis mannosyltransferase 1, putative 0.0055 0.0257 0.0953
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0155 0.03
Schistosoma mansoni malate dehydrogenase 0.0019 0.0028 0.0038
Mycobacterium tuberculosis Conserved membrane protein 0.0024 0.0063 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0139 0.0464
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0129 0.0376
Schistosoma mansoni malate dehydrogenase 0.0044 0.0188 0.0368
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0353 0.117
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0106 0.0326
Mycobacterium tuberculosis Conserved protein 0.0037 0.0139 0.0481
Onchocerca volvulus 0.0037 0.0139 0.0409
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.022 0.087
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0374 0.1294
Echinococcus multilocularis stromal cell derived factor 2 0.0101 0.0542 0.0533
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0117 0.0641 0.2291
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0106 0.0326
Loa Loa (eye worm) MIR domain-containing protein 0.0101 0.0542 0.2231
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0353 0.1421
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0139 0.0464
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0359 0.2145 0.8823
Echinococcus granulosus malate dehydrogenase 0.0019 0.0028 0.0038
Echinococcus granulosus aldo keto reductase 0.0404 0.243 0.4993
Trichomonas vaginalis mannosyltransferase 1, putative 0.0277 0.1638 0.6703
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0457 0.1801
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0195 0.1129 0.4594
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0106 0.0293
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0292 0.1202
Schistosoma mansoni hypothetical protein 0.0227 0.1329 0.2722
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0139 0.013
Echinococcus multilocularis aldo keto reductase 0.0404 0.243 0.2423
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.243 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0224 0.0832
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0106 0.0326
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.243 1
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0353 0.1421
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0019 0.0028 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Onchocerca volvulus 0.0404 0.243 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0106 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0374 0.1294
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0573
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0139 0.0537
Brugia malayi Matrixin family protein 0.0388 0.2328 0.958
Leishmania major hypothetical protein, conserved 0.0037 0.0139 0.0464
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0139 0.0367
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0242 0.0799
Mycobacterium tuberculosis Conserved protein 0.0037 0.0139 0.0481
Trypanosoma brucei cytosolic malate dehydrogenase 0.0044 0.0188 0.0666
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0139 0.0481
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0117 0.0641 0.2291
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0041 0.0171
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0129 0.0376
Onchocerca volvulus 0.0056 0.0259 0.0911
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0755 0.1537
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0139 0.0268
Loa Loa (eye worm) hypothetical protein 0.0195 0.1129 0.4646
Trichomonas vaginalis esterase, putative 0.0037 0.0139 0.0464
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Trichomonas vaginalis mannosyltransferase 1, putative 0.0101 0.0542 0.2141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0019 0.001
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0038
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Echinococcus multilocularis voltage gated potassium channel subunit 0.0117 0.0641 0.0633
Echinococcus multilocularis malate dehydrogenase 0.0019 0.0028 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0277 0.1638 0.6703
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0353 0.117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0139 0.0481
Schistosoma mansoni ryanodine receptor related 0.0101 0.0542 0.1099
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0106 0.0326
Plasmodium vivax aldehyde reductase, putative 0.0117 0.0641 0.2291
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0117 0.0641 0.1303
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0139 0.0464
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Mycobacterium leprae Conserved membrane protein 0.0055 0.0257 0.0808
Leishmania major hypothetical protein, conserved 0.0074 0.0374 0.1442
Brugia malayi hypothetical protein 0.0048 0.021 0.0831
Brugia malayi jmjC domain containing protein 0.0097 0.0515 0.2089
Brugia malayi beta-lactamase family protein 0.0037 0.0139 0.0537
Echinococcus multilocularis peregrin 0.003 0.0096 0.0087
Brugia malayi MIR domain containing protein 0.0101 0.0542 0.2201
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0295 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0374 0.1294
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0473 0.0957
Brugia malayi lactate dehydrogenase. 0.0019 0.0028 0.0077
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0119 0.0227
Mycobacterium ulcerans hydrolase 0.0195 0.1129 0.4082
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0063 0.0144
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0404 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0995
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0353 0.1355
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0041 0.0075
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0583 0.3546 0.354
Loa Loa (eye worm) hypothetical protein 0.009 0.0473 0.1947
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0041 0.0171
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0106 0.04
Onchocerca volvulus 0.0404 0.243 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0139 0.0367
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.057 0.2023
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0139 0.0481
Schistosoma mansoni hypothetical protein 0.0794 0.4857 1
Echinococcus multilocularis lactate dehydrogenase a 0.0019 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0755 0.1537
Plasmodium vivax glutathione reductase, putative 0.0038 0.0151 0.0459
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0405 0.0816
Trypanosoma brucei trypanothione reductase 0.0038 0.0151 0.0512
Leishmania major aldo-keto reductase-like protein 0.0404 0.243 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0096 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0353 0.1421
Trichomonas vaginalis conserved hypothetical protein 0.0277 0.1638 0.6703
Brugia malayi RNA binding protein 0.0061 0.0295 0.1179
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0641 0.2553
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0019 0.0021
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0449 0.2706 1
Schistosoma mansoni hypothetical protein 0.0034 0.0122 0.0233
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0044 0.0188 0.0179
Echinococcus granulosus aldo keto reductase 0.0404 0.243 0.4993
Loa Loa (eye worm) matrixin family protein 0.0356 0.2129 0.8759
Leishmania major trypanothione reductase 0.0038 0.0151 0.0512
Loa Loa (eye worm) hypothetical protein 0.016 0.0911 0.375
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.009 0.0473 0.1663
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0374 0.1442
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0259 0.1066
Trichomonas vaginalis aldo-keto reductase, putative 0.0117 0.0641 0.2553
Brugia malayi PHD-finger family protein 0.003 0.0096 0.0358
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1365 0.5574
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0277 0.1638 0.6703
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0041 0.0051
Trichomonas vaginalis aldo-keto reductase, putative 0.0117 0.0641 0.2553
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0044 0.0188 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0106 0.0325
Onchocerca volvulus 0.0117 0.0641 0.2511
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0374 0.1442
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Brugia malayi ADAM-TS Spacer 1 family protein 0.0091 0.0479 0.1939
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0353 0.1371
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0755 0.3105
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Echinococcus multilocularis aldo keto reductase 0.0404 0.243 0.2423
Echinococcus granulosus hypothetical protein 0.0404 0.243 0.4993
Loa Loa (eye worm) hypothetical protein 0.0034 0.0122 0.0504
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0449 0.2706 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0133
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0353 0.117
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0404 0.243 0.8965
Giardia lamblia Aldose reductase 0.0404 0.243 1
Echinococcus granulosus aldehyde reductase 0.0287 0.1701 0.3489
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0353 0.117
Loa Loa (eye worm) hypothetical protein 0.003 0.0096 0.0395
Trichomonas vaginalis mannosyltransferase, putative 0.0055 0.0257 0.0953
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0224 0.0832
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0044 0.0188 0.0683
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0155 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0277 0.1638 0.6703
Schistosoma mansoni malate dehydrogenase 0.0019 0.0028 0.0038
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0359 0.2145 0.4406
Echinococcus multilocularis aldo keto reductase 0.0404 0.243 0.2423
Onchocerca volvulus 0.0037 0.0139 0.0409
Plasmodium vivax hypothetical protein, conserved 0.003 0.0096 0.0254
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0155 0.03
Trypanosoma brucei aldo-keto reductase, putative 0.0404 0.243 1
Echinococcus granulosus dnaJ subfamily B 0.0794 0.4857 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0353 0.117
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0295 0.1179
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0139 0.0464
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0133
Trichomonas vaginalis mannosyltransferase 1, putative 0.0055 0.0257 0.0953
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0457 0.1801
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Trichomonas vaginalis aldo-keto reductase, putative 0.0117 0.0641 0.2553
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0405 0.1666
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0449 0.2706 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0139 0.0573
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0096 0.0395
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0473 0.0464
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0096 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0139 0.0464
Trypanosoma cruzi aldo-keto reductase 0.0404 0.243 1
Echinococcus multilocularis malate dehydrogenase 0.0019 0.0028 0.0019
Schistosoma mansoni aldo-keto reductase 0.0404 0.243 0.4993
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.022 0.0905
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Mycobacterium leprae Conserved hypothetical protein 0.0287 0.1701 0.6227
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0404 0.243 1
Brugia malayi Hemopexin family protein 0.0227 0.1329 0.5451
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0041 0.0051
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0139 0.0481
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0151 0.0459
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0151 0.062
Echinococcus multilocularis ryanodine receptor 44f 0.0101 0.0542 0.0533
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0057
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0041 0.0051
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0457 0.1559
Schistosoma mansoni cpg binding protein 0.0059 0.0279 0.0556
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0041 0.0075
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0075
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0041 0.0057
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0133
Mycobacterium ulcerans malate dehydrogenase 0.0044 0.0188 0.0549
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0044 0.0188 0.0666
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0295 0.0589
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0295 0.0589
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0038 0.0149 0.0287
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0038 0.0149 0.0139
Schistosoma mansoni L-lactate dehydrogenase 0.0019 0.0028 0.0038
Toxoplasma gondii thioredoxin reductase 0.0038 0.0151 0.0459
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0009 0.0038
Trypanosoma cruzi aldo/keto reductase, putative 0.0404 0.243 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0117 0.0641 0.1303
Onchocerca volvulus 0.0404 0.243 1
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0129 0.0376
Echinococcus multilocularis aldehyde reductase 0.0287 0.1701 0.1693
Schistosoma mansoni cpg binding protein 0.0059 0.0279 0.0556
Entamoeba histolytica aldose reductase, putative 0.0404 0.243 1
Mycobacterium ulcerans hypothetical protein 0.0055 0.0257 0.0808
Loa Loa (eye worm) matrixin family protein 0.0388 0.2328 0.9581
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0151 0.0512
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Brugia malayi angiogenesis inhibito 0.0028 0.0086 0.0316
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0019 0.0079
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0135 0.0126
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0041 0.0057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0242 0.0907
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0188 0.0666
Schistosoma mansoni malate dehydrogenase 0.0044 0.0188 0.0368
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0129 0.0246
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.4138 0.4132
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0457 0.1801
Plasmodium falciparum phd finger protein, putative 0.003 0.0096 0.0254
Loa Loa (eye worm) malate dehydrogenase 0.0019 0.0028 0.0115
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.4138 0.8516
Mycobacterium leprae PROBABLE HYDROLASE 0.0195 0.1129 0.4082
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0139 0.0464
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.243 1
Entamoeba histolytica malate dehydrogenase, putative 0.0044 0.0188 0.0666
Trichomonas vaginalis mannosyltransferase 1, putative 0.0277 0.1638 0.6703
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0044 0.0188 0.0737
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0139 0.0481
Trichomonas vaginalis aldo/keto reductase, putative 0.0404 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0573
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0374
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0106 0.0437
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0139 0.0367
Echinococcus granulosus L lactate dehydrogenase B chain 0.0019 0.0028 0.0038
Echinococcus granulosus aldo keto reductase 0.0404 0.243 0.4993
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0154 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0353 0.1355
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0404 0.243 1
Echinococcus granulosus lactate dehydrogenase protein 0.0019 0.0028 0.0038
Plasmodium falciparum glutathione reductase 0.0038 0.0151 0.0459
Mycobacterium tuberculosis Conserved protein 0.0117 0.0641 0.2567
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0515 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0106 0.0325
Toxoplasma gondii ABC1 family protein 0.0037 0.0139 0.0416
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.243 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0457 0.1801
Brugia malayi Matrixin family protein 0.016 0.0911 0.3726
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0044 0.0188 0.0549
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0101 0.0542 0.1099
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0096 0.0254
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0449 0.2706 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0063 0.0144
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0518 0.2054
Brugia malayi ADAMTS-like protease 0.0028 0.0086 0.0316
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0041 0.0057
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0041 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0755 0.0746
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0139 0.0268
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0306
Echinococcus multilocularis cpg binding protein 0.0059 0.0279 0.027
Echinococcus granulosus tar DNA binding protein 0.0061 0.0295 0.0589
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Leishmania major prostaglandin f synthase, putative 0.0404 0.243 1
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0391 0.0787
Brugia malayi hypothetical protein 0.0074 0.0374 0.1508
Toxoplasma gondii aldo-keto reductase 0.0117 0.0641 0.2291
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0108 0.0584 0.2328
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0041 0.0032
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0117 0.0641 0.2553
Trichomonas vaginalis mannosyltransferase 1, putative 0.0055 0.0257 0.0953
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Entamoeba histolytica alcohol dehydrogenase, putative 0.0117 0.0641 0.2553
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0353 0.1371
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0359 0.2145 0.4406
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0041 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0224 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0277 0.1638 0.6703
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0995
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0195 0.1129 0.4626
Onchocerca volvulus 0.0404 0.243 1
Trichomonas vaginalis mannosyltransferase 1, putative 0.0055 0.0257 0.0953
Entamoeba histolytica aldose reductase, putative 0.0404 0.243 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0295 0.1213
Leishmania major cytosolic malate dehydrogenase 0.0044 0.0188 0.0666
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0449 0.2706 0.5
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0044 0.0188 0.0179
Onchocerca volvulus 0.0404 0.243 1
Mycobacterium ulcerans hypothetical protein 0.0071 0.0353 0.117
Trichomonas vaginalis mannosyltransferase 1, putative 0.0277 0.1638 0.6703
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0257 0.0953
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0755 0.1537
Loa Loa (eye worm) oxidoreductase 0.0404 0.243 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0139 0.0367
Schistosoma mansoni potassium channel beta 0.0117 0.0641 0.1303
Schistosoma mansoni pol-related 0.0404 0.243 0.4993
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Trichomonas vaginalis conserved hypothetical protein 0.0277 0.1638 0.6703
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0224 0.0832
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0154 0.0145
Loa Loa (eye worm) hypothetical protein 0.0101 0.0542 0.2231
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.243 0.2423
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.243 0.4993
Onchocerca volvulus Matrilysin homolog 0.016 0.0911 0.3641
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0117 0.0641 0.2553
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0041 0.0057
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0129 0.0376
Echinococcus multilocularis lactate dehydrogenase protein 0.0019 0.0028 0.0019
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0168 0.0328
Mycobacterium ulcerans lipase LipD 0.0037 0.0139 0.0367
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0057
Brugia malayi NADH-dependent xylose reductase 0.0117 0.0641 0.261
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0041 0.0075
Brugia malayi Thioredoxin reductase 0.0038 0.0151 0.0584
Plasmodium falciparum aldehyde reductase, putative 0.0117 0.0641 0.2291
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0242 0.0799
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0133
Echinococcus granulosus microtubule associated protein 2 0.0678 0.4138 0.8516
Loa Loa (eye worm) beta-lactamase 0.0037 0.0139 0.0573
Mycobacterium tuberculosis Probable oxidoreductase 0.0404 0.243 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0353 0.1355
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0041 0.0057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0106 0.0097
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0405 0.1634
Mycobacterium tuberculosis Conserved protein 0.0037 0.0139 0.0481
Loa Loa (eye worm) glutathione reductase 0.0038 0.0151 0.062
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0128 0.0418
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0058 0.0101
Brugia malayi Matrixin family protein 0.016 0.0911 0.3726
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0449 0.2706 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0041 0.0075
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0041 0.0066

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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