Detailed information for compound 1580631

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.201 | Formula: C14H17BrN2O2
  • H donors: 1 H acceptors: 1 LogP: 2.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCC(NCc1coc(n1)c1ccccc1Br)C
  • InChi: 1S/C14H17BrN2O2/c1-10(8-18-2)16-7-11-9-19-14(17-11)12-5-3-4-6-13(12)15/h3-6,9-10,16H,7-8H2,1-2H3
  • InChiKey: GDHJARZCIBKBKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0365 0.0812 0.18
Echinococcus granulosus dna polymerase eta 0.0012 0.0018 0.004
Trichomonas vaginalis DNA helicase recq1, putative 0.0016 0.0025 0.1033
Brugia malayi jmjC domain containing protein 0.0013 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0075
Loa Loa (eye worm) hypothetical protein 0.445 1 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0014 0.0021 0.1718
Trypanosoma cruzi hypothetical protein, conserved 0.0365 0.0812 0.18
Echinococcus granulosus dnaJ subfamily B 0.0265 0.0585 0.1309
Loa Loa (eye worm) 6-phosphofructokinase 0.0078 0.0166 0.0163
Schistosoma mansoni jumonji domain containing protein 0.0013 0.0019 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.002 0.0026
Echinococcus granulosus cpg binding protein 0.002 0.0034 0.0076
Schistosoma mansoni 6-phosphofructokinase 0.0078 0.0166 0.1634
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0018 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.0064 0.0061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0013 0.0019 0.0023
Schistosoma mansoni myelin transcription factor 1 myt1 0.0039 0.0078 0.0743
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0043 0.0086 0.0082
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0043 0.0086 0.0173
Echinococcus granulosus lysine specific demethylase 5A 0.0049 0.0101 0.0225
Schistosoma mansoni phd/f-box containing protein 0.0013 0.0019 0.0147
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0021 0.0037 0.5
Echinococcus granulosus bloom syndrome protein 0.0016 0.0025 0.0055
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0043 0.0086 0.0083
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0101 0.0975
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0039 0.0078 0.0074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.002 0.0018
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0078 0.0166 1
Loa Loa (eye worm) phosphofructokinase 0.0078 0.0166 0.0163
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.002 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0018 0.0021
Entamoeba histolytica phosphofructokinase, putative 0.0078 0.0166 1
Toxoplasma gondii phosphofructokinase PFKII 0.0021 0.0037 0.3269
Trichomonas vaginalis DNA polymerase eta, putative 0.0012 0.0018 0.0598
Onchocerca volvulus 0.0365 0.0812 1
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0018 0.0117
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0078 0.0166 0.1962
Echinococcus multilocularis hexokinase 0.0052 0.0106 0.0236
Brugia malayi Hexokinase family protein 0.0016 0.0025 0.0021
Echinococcus granulosus hexokinase type 2 0.0052 0.0106 0.0236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0003 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.002 0.0026
Echinococcus multilocularis hexokinase 0.0052 0.0106 0.0236
Echinococcus multilocularis polycomb protein SCMH1 0.0034 0.0067 0.015
Loa Loa (eye worm) hypothetical protein 0.0068 0.0143 0.0141
Schistosoma mansoni jumonji domain containing protein 0.0104 0.0223 0.2212
Echinococcus multilocularis hexokinase type 2 0.0052 0.0106 0.0236
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0078 0.0166 0.5
Loa Loa (eye worm) hexokinase 0.0032 0.0062 0.006
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0013 0.0019 0.0023
Schistosoma mansoni phosphatidylserine receptor 0.0013 0.0019 0.0147
Brugia malayi Bloom's syndrome protein homolog 0.0016 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0016
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0006 0.0004 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0101 0.0975
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0078 0.075
Leishmania major hexokinase, putative 0.0052 0.0106 0.0218
Plasmodium vivax JmjC domain containing protein 0.0013 0.0019 0.0577
Echinococcus granulosus SAM and MBT domain containing protein 0.0034 0.0067 0.015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0012 0.0018 0.0021
Schistosoma mansoni cpg binding protein 0.002 0.0034 0.0301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0064 0.0143
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0021 0.0037 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0019 0.0031 0.0029
Trypanosoma brucei unspecified product 0.0009 0.0009 0.0009
Brugia malayi jmjC domain containing protein 0.0013 0.0019 0.0015
Loa Loa (eye worm) hexokinase 0.0052 0.0106 0.0103
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0365 0.0812 0.18
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0018 0.0117
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0021 0.0037 0.4408
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0138 0.0301 0.0672
Brugia malayi CXXC zinc finger family protein 0.0019 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0066
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0034 0.0067 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0365 0.0812 0.18
Leishmania major carnitine palmitoyltransferase-like protein 0.0365 0.0812 0.18
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.002 0.0743
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0079 0.7415
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0037 0.1837
Schistosoma mansoni hypothetical protein 0.0212 0.0466 0.4664
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0017 0.0133
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0043 0.0086 0.0964
Echinococcus multilocularis dna polymerase eta 0.0012 0.0018 0.004
Echinococcus multilocularis jumonji domain containing 1A 0.0013 0.0019 0.0042
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0365 0.0812 0.18
Onchocerca volvulus Alhambra homolog 0.004 0.0079 0.0614
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.0067 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Echinococcus multilocularis lysine specific demethylase 5A 0.0048 0.0098 0.022
Echinococcus granulosus hexokinase 0.0052 0.0106 0.0236
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0365 0.0812 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0014 0.002 0.075
Echinococcus multilocularis histone acetyltransferase MYST2 0.0039 0.0078 0.0174
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0043 0.0086 0.0825
Schistosoma mansoni choline o-acyltransferase 0.0365 0.0812 0.8155
Brugia malayi jmjC domain containing protein 0.0013 0.0019 0.0015
Onchocerca volvulus Hexokinase homolog 0.0032 0.0062 0.0397
Brugia malayi hexokinase 0.0052 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0365 0.0812 0.0809
Echinococcus granulosus polycomb protein SCMH1 0.0034 0.0067 0.015
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0043 0.0086 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0365 0.0812 0.18
Entamoeba histolytica deoxycytidyl transferase, putative 0.0012 0.0018 0.0598
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0064 0.0143
Echinococcus granulosus transcription factor Dp 1 0.0025 0.0045 0.0101
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0006 0.0004 0.0009
Trypanosoma brucei unspecified product 0.0012 0.0018 0.0117
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0013 0.0019 0.0133
Echinococcus granulosus hexokinase 0.0052 0.0106 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0013 0.0019 0.1467
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0018 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0175 0.0172
Echinococcus granulosus choline O acetyltransferase 0.0365 0.0812 0.1815
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0064 0.0603
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0037 0.1837
Schistosoma mansoni hexokinase 0.0052 0.0106 0.1025
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0018 0.0021
Echinococcus granulosus dna polymerase kappa 0.0012 0.0018 0.004
Trypanosoma brucei hexokinase 0.0052 0.0106 0.1211
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0365 0.0812 0.18
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0365 0.0812 0.18
Trypanosoma brucei hexokinase 0.0052 0.0106 0.1211
Echinococcus multilocularis choline O acetyltransferase 0.0365 0.0812 0.1815
Echinococcus granulosus phd:f box containing protein 0.0013 0.0019 0.0042
Echinococcus multilocularis geminin 0.011 0.0236 0.0528
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0012 0.0018 0.0598
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0037 0.1837
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0064 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0064 0.0603
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0.002 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Echinococcus multilocularis transcription factor Dp 1 0.0025 0.0045 0.0101
Brugia malayi Hexokinase family protein 0.0052 0.0106 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.002 0.0045
Entamoeba histolytica phosphofructokinase, putative 0.0078 0.0166 1
Onchocerca volvulus 0.0052 0.0106 0.095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0029 0.0255
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0077
Schistosoma mansoni DNA polymerase eta 0.0012 0.0018 0.0138
Toxoplasma gondii PHD-finger domain-containing protein 0.0013 0.0019 0.1467
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Toxoplasma gondii histone lysine methyltransferase SET1 0.0035 0.0069 0.6381
Loa Loa (eye worm) hypothetical protein 0.0034 0.0067 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0037 0.1837
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0365 0.0812 0.0809
Giardia lamblia DINP protein human, muc B family 0.0012 0.0018 0.1816
Echinococcus multilocularis SAM and MBT domain containing protein 0.0034 0.0067 0.015
Onchocerca volvulus 0.0052 0.0106 0.095
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0138 0.0301 0.0672
Plasmodium vivax hexokinase, putative 0.0052 0.0106 1
Trypanosoma brucei unspecified product 0.0009 0.0009 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0078 0.0166 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0034 0.0067 0.0635
Brugia malayi PHD-finger family protein 0.0014 0.0021 0.0017
Schistosoma mansoni hypothetical protein 0.011 0.0236 0.2346
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0021 0.0037 0.3269
Schistosoma mansoni hypothetical protein 0.0265 0.0585 0.5868
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0037 0.1837
Echinococcus multilocularis peregrin 0.004 0.0079 0.0177
Echinococcus multilocularis bloom syndrome protein 0.0016 0.0025 0.0055
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0078 0.0166 0.0353
Schistosoma mansoni cpg binding protein 0.0019 0.0031 0.0277
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.0879
Echinococcus multilocularis PHD finger protein rhinoceros 0.004 0.0079 0.0177
Trypanosoma cruzi hexokinase, putative 0.0052 0.0106 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0009 0.0009
Echinococcus multilocularis lysine specific demethylase 6a 0.0013 0.0019 0.0042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0019
Loa Loa (eye worm) hexokinase type II 0.0052 0.0106 0.0103
Brugia malayi mbt repeat family protein 0.0034 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0001
Brugia malayi PHD-finger family protein 0.004 0.0079 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0078 0.0166 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0021 0.0037 0.3269
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0365 0.0812 0.0808
Echinococcus granulosus peregrin 0.004 0.0079 0.0177
Schistosoma mansoni choline o-acyltransferase 0.0365 0.0812 0.8155
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0032 0.0028
Loa Loa (eye worm) choline O-acetyltransferase 0.0365 0.0812 0.0809
Mycobacterium ulcerans 6-phosphofructokinase 0.0078 0.0166 1
Leishmania major DNA polymerase eta, putative 0.0012 0.0018 0.0021
Schistosoma mansoni protein phosphatase 2C 0.0013 0.0019 0.0147
Echinococcus granulosus geminin 0.011 0.0236 0.0528
Echinococcus multilocularis dnaJ subfamily B 0.0265 0.0585 0.1309
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.0067 0.0635
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0013 0.0019 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0365 0.0812 0.18
Loa Loa (eye worm) MBCTL1 0.0039 0.0078 0.0075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0024
Brugia malayi phosphofructokinase 0.0078 0.0166 0.0162
Schistosoma mansoni hypothetical protein 0.011 0.0236 0.2346
Brugia malayi 6-phosphofructokinase 0.0078 0.0166 0.0162
Entamoeba histolytica phosphofructokinase, putative 0.0078 0.0166 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0101 0.0098
Brugia malayi Bromodomain containing protein 0.004 0.0079 0.0075
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.002 0.075
Schistosoma mansoni ap endonuclease 0.0014 0.002 0.0162
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.1993 0.4472 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0018 0.0021
Leishmania major hypothetical protein, conserved 0.0013 0.0019 0.0023
Plasmodium falciparum JmjC domain-containing protein, putative 0.0013 0.0019 0.1431
Trypanosoma brucei hypothetical protein, conserved 0.0365 0.0812 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0019 0.0016
Treponema pallidum hexokinase (hxk) 0.0052 0.0106 0.5864
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.002 0.1582
Loa Loa (eye worm) RecQ helicase 0.0016 0.0025 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0009 0.0009
Brugia malayi Hexokinase family protein 0.0032 0.0062 0.0058
Toxoplasma gondii hexokinase 0.0052 0.0106 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0012 0.0018 0.0138
Onchocerca volvulus 0.0365 0.0812 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0064 0.0143
Loa Loa (eye worm) hexokinase 0.0016 0.0025 0.0023
Brugia malayi Choline O-acetyltransferase 0.0365 0.0812 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1993 0.4472 1
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0365 0.0812 0.1815
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0365 0.0812 0.0808
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0365 0.0812 0.0809
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0039 0.0078 0.0174
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.002 0.0026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0003 0.0006
Echinococcus multilocularis jumonji domain containing protein 0.0056 0.0114 0.0256
Onchocerca volvulus 0.0365 0.0812 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1993 0.4472 1
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0365 0.0812 0.1815
Trypanosoma cruzi hypothetical protein, conserved 0.0365 0.0812 0.18
Brugia malayi mbt repeat family protein 0.0034 0.0067 0.0063
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0021 0.0047
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.002 0.0045
Trypanosoma cruzi hexokinase, putative 0.0052 0.0106 0.0218
Echinococcus granulosus microtubule associated protein 2 0.0447 0.0994 0.2224
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0004 0.00000000064711
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0043 0.0086 0.0192
Brugia malayi jmjC domain containing protein 0.0013 0.0019 0.0015
Trypanosoma brucei DNA polymerase eta, putative 0.0012 0.0018 0.0117
Plasmodium vivax 6-phosphofructokinase, putative 0.0021 0.0037 0.2598
Schistosoma mansoni 6-phosphofructokinase 0.0078 0.0166 0.1634
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0013 0.0019 0.1431
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.1993 0.4472 1
Echinococcus multilocularis microtubule associated protein 2 0.0447 0.0994 0.2224
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0014 0.002 0.2134
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.1993 0.4472 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0015
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0012 0.0018 0.0015
Trichomonas vaginalis DNA helicase recq, putative 0.0016 0.0025 0.1033
Echinococcus granulosus hexokinase 0.0052 0.0106 0.0236
Loa Loa (eye worm) mbt repeat family protein 0.0034 0.0067 0.0064
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0043 0.0086 0.0173
Echinococcus multilocularis JmjC domain containing protein 4 0.0013 0.0019 0.0042
Echinococcus granulosus lysine specific demethylase 6a 0.0013 0.0019 0.0042
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0013 0.0019 0.1431
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0021 0.0037 0.1837
Brugia malayi AF-10 protein 0.0013 0.0019 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0037 0.1837
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0021 0.0893
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.002 0.0016
Schistosoma mansoni terminal deoxycytidyl transferase 0.0012 0.0018 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Onchocerca volvulus 0.0034 0.0067 0.0455
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.002 0.0162
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0365 0.0812 1
Schistosoma mansoni hypothetical protein 0.0013 0.0019 0.015
Echinococcus granulosus 6 phosphofructokinase 0.0078 0.0166 0.0371
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0019 0.0016
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0039 0.0078 0.0174
Loa Loa (eye worm) hexokinase 0.0052 0.0106 0.0103
Onchocerca volvulus 0.0365 0.0812 1
Trichomonas vaginalis phosphofructokinase, putative 0.0078 0.0166 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0131 0.0283 0.0634
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0078 0.0166 1
Echinococcus multilocularis cpg binding protein 0.002 0.0034 0.0076
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0079 0.0077
Echinococcus granulosus histone acetyltransferase MYST2 0.0039 0.0078 0.0174
Brugia malayi jmjC domain containing protein 0.0049 0.0101 0.0097
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0012 0.0018 0.004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0006 0.0004 0.0001
Leishmania major hexokinase, putative 0.0052 0.0106 0.0218
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0021 0.0037 0.3269
Entamoeba histolytica hexokinase 2 0.0052 0.0106 0.6174
Toxoplasma gondii exonuclease III APE 0.0014 0.002 0.1582
Leishmania major ATP-dependent phosphofructokinase 0.0078 0.0166 0.0353
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0012 0.0018 0.004
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0021 0.0047
Echinococcus granulosus jumonji domain containing protein 0.0056 0.0114 0.0256
Echinococcus multilocularis hexokinase 0.0052 0.0106 0.0236
Echinococcus multilocularis 6 phosphofructokinase 0.0078 0.0166 0.0371
Brugia malayi ImpB/MucB/SamB family protein 0.0012 0.0018 0.0014
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0043 0.0086 0.0173
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0006 0.0004 0.0009
Plasmodium vivax 6-phosphofructokinase, putative 0.0021 0.0037 0.2598
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.004 0.0079 0.076
Trichomonas vaginalis phosphofructokinase, putative 0.0078 0.0166 1
Leishmania major DNA polymerase kappa, putative 0.0012 0.0018 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0018 0.0117
Schistosoma mansoni ap endonuclease 0.0014 0.002 0.0162
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0013 0.0019 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0064 0.0603
Toxoplasma gondii 6-phosphofructokinase 0.0021 0.0037 0.3269
Giardia lamblia PHD finger protein 15 0.004 0.0079 1
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.076
Onchocerca volvulus 0.0032 0.0062 0.0397
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.002 0.075
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0043 0.0086 0.4914
Loa Loa (eye worm) hypothetical protein 0.0078 0.0166 0.0163
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0365 0.0812 1
Echinococcus multilocularis dna polymerase kappa 0.0012 0.0018 0.004
Trypanosoma brucei hexokinase, putative 0.0052 0.0106 0.1211
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0021 0.0037 0.1175
Plasmodium falciparum phd finger protein, putative 0.004 0.0079 0.7415
Leishmania major carnitine/choline acetyltransferase, putative 0.0365 0.0812 0.18
Echinococcus granulosus JmjC domain containing protein 4 0.0013 0.0019 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Echinococcus granulosus PHD finger protein rhinoceros 0.004 0.0079 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0018 0.0117
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.002 0.0162
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0131 0.0283 0.0634
Loa Loa (eye worm) 6-phosphofructokinase 0.0078 0.0166 0.0163
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0079 0.7415
Echinococcus multilocularis phd:f box containing protein 0.0013 0.0019 0.0042
Entamoeba histolytica hexokinase 1 0.0052 0.0106 0.6174
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.002 0.1603
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0365 0.0812 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.0064 0.006
Brugia malayi jmjC domain containing protein 0.0131 0.0283 0.028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0024
Brugia malayi hexokinase type II 0.0016 0.0026 0.0022
Schistosoma mansoni cpg binding protein 0.002 0.0034 0.0301
Schistosoma mansoni microtubule-associated protein tau 0.0447 0.0994 1
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0365 0.0812 0.18
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0021 0.0037 0.1837
Plasmodium falciparum hexokinase 0.0052 0.0106 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0079 0.7157
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0006 0.0004 0.0009
Onchocerca volvulus 0.0052 0.0106 0.095
Brugia malayi 6-phosphofructokinase 0.0078 0.0166 0.0162
Brugia malayi ImpB/MucB/SamB family protein 0.0012 0.0018 0.0014
Echinococcus granulosus jumonji domain containing 1A 0.0013 0.0019 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0009 0.0009
Brugia malayi Choline O-acetyltransferase 0.0365 0.0812 0.0808
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0013 0.0019 0.0147

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 12 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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