Detailed information for compound 1587046

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 511.012 | Formula: C27H31ClN4O4
  • H donors: 1 H acceptors: 5 LogP: 4.12 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCC(=O)N1CC(O)C(CC1c1ccc(cc1)Cl)n1nnc(c1)COC(=O)c1ccccc1
  • InChi: 1S/C27H31ClN4O4/c1-2-3-5-10-26(34)31-17-25(33)24(15-23(31)19-11-13-21(28)14-12-19)32-16-22(29-30-32)18-36-27(35)20-8-6-4-7-9-20/h4,6-9,11-14,16,23-25,33H,2-3,5,10,15,17-18H2,1H3
  • InChiKey: OHOOJCQKLXWWSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0035 0.0791
Brugia malayi SH2 domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis activin receptor type 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus Niemann Pick C1 protein 0.0309 0.1693 0.3322
Brugia malayi Raf kinase 0.0009 0.0002 0.0007
Mycobacterium ulcerans hypothetical protein 0.0052 0.0243 1
Brugia malayi Patched related family protein 4 0.0013 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Brugia malayi nuclear receptor NHR-88 0.0012 0.0016 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.0905 0.0905
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0016 0.0063
Echinococcus multilocularis GPCR, family 2 0.0019 0.0057 0.0056
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0473 0.0472
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0668
Brugia malayi protein-tyrosine kinase 0.0009 0.0002 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Brugia malayi hypothetical protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0016 0.006
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0061 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.367
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.023 0.4851
Brugia malayi hypothetical protein 0.0037 0.0158 0.0627
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0243 0.0965
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0473 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0243 1
Brugia malayi Plexin repeat family protein 0.019 0.1024 0.4069
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0089 0.0454 0.0888
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0108
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.008 0.0398 0.0779
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0035 0.0546
Echinococcus granulosus activated cdc42 kinase 1 0.0009 0.0002 0.0002
Echinococcus granulosus fibroblast growth factor receptor 4 0.0009 0.0002 0.0002
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0009 0.0002 0.0001
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0035 0.0546
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Echinococcus multilocularis cpg binding protein 0.0031 0.0125 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0146 0.3062
Brugia malayi protein C24B5.3 0.0013 0.0023 0.0092
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.023 0.4851
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0146 0.3062
Echinococcus multilocularis semaphorin 5B 0.008 0.0398 0.0398
Leishmania major DNA polymerase kappa, putative 0.002 0.0061 0.2458
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0061 0.0242
Schistosoma mansoni hypothetical protein 0.005 0.0229 0.0446
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0035 0.0417
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0061 0.0116
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0157 0.6071
Onchocerca volvulus 0.008 0.0398 0.1577
Brugia malayi ecdysteroid receptor 0.0012 0.0016 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Brugia malayi Probable exocyst complex component Sec5 0.0035 0.0146 0.058
Echinococcus multilocularis protein patched 0.0093 0.0473 0.0472
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0044 0.0199 0.1686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0016 0.006
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.3951 0.7753
Onchocerca volvulus 0.019 0.1024 0.4064
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0035 0.0714
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) TK/ABL protein kinase 0.0009 0.0002 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0016 0.0063
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0163 0.1384
Echinococcus granulosus tyrosine protein kinase HCK 0.0009 0.0002 0.0002
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.0878 0.1723
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.152
Loa Loa (eye worm) SRC-1 0.0009 0.0002 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0016 0.0063
Schistosoma mansoni hypothetical protein 0.042 0.2321 0.4553
Echinococcus granulosus dna polymerase eta 0.002 0.0061 0.0119
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase csk 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Trypanosoma brucei unspecified product 0.0014 0.0026 0.152
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0061 0.367
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0009 0.0002 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0169 0.6617
Brugia malayi Patched related family protein 10 0.0013 0.0023 0.0092
Echinococcus granulosus tyrosine kinase 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0089 0.0454 0.0888
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0668
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0181 0.0721
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0061 0.367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0016 0.006
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.3213
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0016 0.0028
Schistosoma mansoni hypothetical protein 0.0111 0.0575 0.1126
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0163 0.0163
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0169 0.2067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Plasmodium vivax perforin-like protein 3 0.0085 0.0427 0.5267
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0243 1
Schistosoma mansoni rab6-interacting 0.0152 0.0809 0.1586
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0016 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0016 0.0015
Schistosoma mansoni polycystin 1-related 0.0152 0.0809 0.1586
Onchocerca volvulus 0.0012 0.0016 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0016 0.0028
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0009 0.0002 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0261 0.1037
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Brugia malayi plexin A 0.0225 0.1221 0.485
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0289 0.1145
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Onchocerca volvulus 0.0015 0.0035 0.0134
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0016 0.0015
Plasmodium falciparum perforin-like protein 4 0.0085 0.0427 0.5267
Echinococcus granulosus plexin a4 0.0225 0.1221 0.2396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0261 0.0511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0261 0.0509
Loa Loa (eye worm) patched family protein 0.0013 0.0023 0.0089
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.023 0.5372
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0002 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0016 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Chlamydia trachomatis hypothetical protein 0.0085 0.0427 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0243 1
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0169 0.2067
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0016 0.003
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Schistosoma mansoni hypothetical protein 0.0037 0.0158 0.0306
Loa Loa (eye worm) hypothetical protein 0.008 0.0398 0.158
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0035 0.0146 0.3062
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.023 0.5372
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0061 0.1259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0289 0.1148
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0035 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus exocyst complex component 2 0.0035 0.0146 0.0285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0057 0.0225
Brugia malayi CXXC zinc finger family protein 0.003 0.0116 0.0459
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0002 0.0002
Echinococcus multilocularis protein kinase 0.0009 0.0002 0.0001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0061 0.0119
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0002 0.0004
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0216 0.1169 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0035 0.0141
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0016 0.0028
Onchocerca volvulus 0.003 0.0116 0.0453
Echinococcus granulosus raf serine:threonine protein kinase 0.0009 0.0002 0.0002
Echinococcus granulosus protein kinase 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Entamoeba histolytica tyrosin kinase, putative 0.0044 0.0199 0.1686
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0009 0.0002 0.0001
Onchocerca volvulus 0.0013 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.0455 0.2518 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0009 0.0002 0.0004
Onchocerca volvulus 0.0013 0.0023 0.0085
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0163 0.3798
Echinococcus granulosus tyrosine protein kinase Srms 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.0577
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0061 0.367
Loa Loa (eye worm) sema domain-containing protein 0.008 0.0398 0.158
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0016 0.003
Echinococcus multilocularis tyrosine protein kinase Srms 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.008 0.0398 0.158
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Brugia malayi Patched related family protein 12 0.0013 0.0023 0.0092
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0009 0.0002 0.0007
Echinococcus granulosus retinal guanylyl cyclase 2 0.0009 0.0002 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0243 1
Schistosoma mansoni lipoxygenase 0.0912 0.5095 1
Echinococcus multilocularis tyrosine protein kinase 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0016 0.003
Toxoplasma gondii perforin-like protein PLP1 0.0085 0.0427 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0061 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0668
Echinococcus multilocularis Polycystic kidney disease protein 0.0152 0.0809 0.0809
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0009 0.0002 0.0001
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0163 0.343
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0138
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0016 0.0056
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0016 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Toxoplasma gondii hypothetical protein 0.0013 0.0023 0.0502
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0152 0.0809 0.1586
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0016 0.003
Echinococcus multilocularis integrin linked protein kinase 0.0009 0.0002 0.0001
Echinococcus granulosus tyrosine protein kinase Blk 0.0009 0.0002 0.0002
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Brugia malayi hypothetical protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) patched family protein 0.0013 0.0023 0.0089
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0016 0.0028
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0035 0.2083
Echinococcus granulosus activated cdc42 kinase 1 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0766 0.4272 0.8384
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0016 0.0056
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0009 0.0002 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0163 1
Echinococcus multilocularis plexin a4 0.0225 0.1221 0.1221
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0009 0.0002 0.0002
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0035 0.2083
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.0577
Schistosoma mansoni hypothetical protein 0.0089 0.0454 0.0888
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0163 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0473 0.1876
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0009 0.0002 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0243 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0035 0.0141
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis c src tyrosine kinase 0.0009 0.0002 0.0001
Plasmodium falciparum perforin-like protein 1 0.0085 0.0427 0.5267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0163 0.343
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0668
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1235
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0035 0.0417
Echinococcus granulosus tyrosine protein kinase Lyn 0.0009 0.0002 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0016 0.0028
Entamoeba histolytica hypothetical protein 0.0037 0.0158 0.1336
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0002 0.0002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0035 0.2083
Brugia malayi hypothetical protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0009 0.0002 0.0004
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus insulin receptor 0.0009 0.0002 0.0002
Leishmania major DNA polymerase eta, putative 0.002 0.0061 0.2458
Echinococcus granulosus tyrosine protein kinase pr2 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0289 0.1145
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0009 0.0002 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.008 0.0398 0.158
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0243 1
Echinococcus multilocularis transcription factor collier 0.0035 0.0146 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0157 0.6071
Echinococcus granulosus c src tyrosine kinase 0.0009 0.0002 0.0002
Echinococcus multilocularis heat shock protein 70 0.0009 0.0002 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0016 0.0015
Echinococcus granulosus Polycystic kidney disease protein 0.0152 0.0809 0.1588
Brugia malayi Guanylyl cyclase protein 23 0.0009 0.0002 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0057 0.0225
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0009 0.0002 0.0007
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0061 0.1259
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0035 0.0141
Echinococcus granulosus transcription factor collier 0.0035 0.0146 0.0285
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0009 0.0002 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.0152 0.0809 0.1588
Onchocerca volvulus 0.0015 0.0035 0.0134
Echinococcus multilocularis transfer RNA-Thr 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0016 0.0063
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0009 0.0002 0.0002
Onchocerca volvulus 0.0015 0.0035 0.0134
Schistosoma mansoni hypothetical protein 0.0035 0.0146 0.0283
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0216 0.1169 0.4643
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Echinococcus multilocularis raf serine:threonine protein kinase 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.008 0.0398 0.158
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.0056
Echinococcus granulosus cpg binding protein 0.0031 0.0125 0.0244
Echinococcus multilocularis Niemann Pick C1 protein 0.0216 0.1169 0.1169
Brugia malayi IPT/TIG domain containing protein 0.0035 0.0146 0.058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Brugia malayi Furin-like cysteine rich region family protein 0.0009 0.0002 0.0007
Echinococcus granulosus tyrosine protein kinase Src64B 0.0009 0.0002 0.0002
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0243 1
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0009 0.0002 0.0001
Brugia malayi hypothetical protein 0.0243 0.132 0.5245
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0035 0.0714
Toxoplasma gondii patched family protein 0.0013 0.0023 0.0502
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0009 0.0002 0.0001
Echinococcus granulosus epidermal growth factor receptor 0.0009 0.0002 0.0002
Echinococcus granulosus retinal guanylyl cyclase 2 0.0009 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0016 0.0063
Echinococcus granulosus tyrosine protein kinase Src42A 0.0009 0.0002 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0152 0.0809 0.0809
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0163 0.343
Echinococcus granulosus RUN 0.0152 0.0809 0.1588
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0035 0.2083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0035 0.0546
Echinococcus multilocularis lipoxygenase domain containing protein 0.0152 0.0809 0.0809
Echinococcus multilocularis insulin receptor 0.0009 0.0002 0.0001
Onchocerca volvulus 0.0013 0.0023 0.0085
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.0905 0.3595
Onchocerca volvulus 0.0052 0.0243 0.0959
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0016 0.006
Plasmodium vivax perforin-like protein 5 0.0085 0.0427 0.5267
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1235
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0163 0.0319
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0116 0.0457
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0243 1
Brugia malayi CHE-14 protein 0.0093 0.0473 0.1878
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0016 0.003
Loa Loa (eye worm) TK/EGFR protein kinase 0.0009 0.0002 0.0004
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0035 0.2083
Entamoeba histolytica hypothetical protein 0.0037 0.0158 0.1336
Schistosoma mansoni inositol monophosphatase 0.0038 0.0163 0.0317
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Schistosoma mansoni survival motor neuron protein 0.005 0.0229 0.0446
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0035 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0016 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0016 0.003
Schistosoma mansoni hypothetical protein 0.0035 0.0146 0.0283
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0002 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0243 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0016 0.0063
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0061 0.1235
Loa Loa (eye worm) doublecortin family protein 0.0152 0.0809 0.3213
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0016 0.0063
Plasmodium vivax perforin-like protein 1 0.0085 0.0427 0.5267
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0035 0.0791
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0261 0.0509
Echinococcus granulosus retinal guanylyl cyclase 2 0.0009 0.0002 0.0002
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0009 0.0002 0.0002
Brugia malayi bone morphogenetic protein type 1 receptor 0.0009 0.0002 0.0007
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0016 0.0015
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0035 0.0066
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0035 0.0546
Echinococcus multilocularis exocyst complex component 2 0.0035 0.0146 0.0145
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Echinococcus multilocularis protein KINase family member (kin 25) 0.0009 0.0002 0.0001
Echinococcus granulosus protein tyrosine kinase 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0243 0.132 0.5243
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0243 0.0965
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1235
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0035 0.0546
Brugia malayi integrin-linked kinase 0.0009 0.0002 0.0007
Brugia malayi hypothetical protein 0.0455 0.2518 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/ACK protein kinase 0.0009 0.0002 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0309 0.1693 0.1693
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0016 0.006
Schistosoma mansoni inositol monophosphatase 0.0038 0.0163 0.0317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0261 0.026
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.367
Plasmodium falciparum LCCL domain-containing protein 0.0152 0.0809 1
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0009 0.0002 0.0002
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0243 0.2066
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0158 0.0306
Onchocerca volvulus 0.0013 0.0023 0.0085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0016 0.003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0158 0.0157
Trypanosoma brucei unspecified product 0.0014 0.0026 0.152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0016 0.0015
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0009 0.0002 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0061 0.367
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0061 0.1714
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.024
Loa Loa (eye worm) patched family protein 0.0013 0.0023 0.0089
Plasmodium vivax perforin-like protein 4 0.0085 0.0427 0.5267
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus macrophage expressed protein 0.0766 0.4272 0.8384
Brugia malayi hypothetical protein 0.008 0.0398 0.1582
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) sema domain-containing protein 0.008 0.0398 0.158
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0009 0.0002 0.0002
Loa Loa (eye worm) serine/threonine protein kinase 0.0009 0.0002 0.0004
Brugia malayi Niemann-Pick C1 protein precursor 0.0216 0.1169 0.4645
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.0577
Echinococcus multilocularis protein kinase 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0009 0.0002 0.0004
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Onchocerca volvulus 0.0013 0.0023 0.0085
Echinococcus multilocularis dna polymerase eta 0.002 0.0061 0.006
Loa Loa (eye worm) oxidoreductase 0.0015 0.0035 0.0138
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0016 0.0015
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0035 0.1395
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0009 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0035 0.0141
Brugia malayi Inositol-1 0.0038 0.0163 0.0649
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0009 0.0002 0.0001
Echinococcus granulosus tyrosine protein kinase csk 0.0009 0.0002 0.0002
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Brugia malayi Sema domain containing protein 0.008 0.0398 0.1582
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) TK/ROR protein kinase 0.0009 0.0002 0.0004
Echinococcus granulosus microtubule associated protein 2 0.0709 0.3951 0.7753
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0016 0.0028
Echinococcus multilocularis tyrosine protein kinase Abl 0.0009 0.0002 0.0001
Loa Loa (eye worm) patched family protein 0.0013 0.0023 0.0089
Plasmodium vivax perforin-like protein 2 0.0085 0.0427 0.5267
Loa Loa (eye worm) TK/EPH protein kinase 0.0009 0.0002 0.0004
Echinococcus multilocularis epidermal growth factor receptor 0.0009 0.0002 0.0001
Echinococcus multilocularis epidermal growth factor receptor 0.0009 0.0002 0.0001
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.132 0.132
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0035 0.0141
Brugia malayi hypothetical protein 0.0152 0.0809 0.3215
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0035 0.0146 0.3062
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0002 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0035 0.0791
Echinococcus multilocularis ephrin type A receptor 4 A 0.0009 0.0002 0.0001
Echinococcus granulosus lipoxygenase domain containing protein 0.0152 0.0809 0.1588
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0718
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0163 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0288 0.6731
Brugia malayi protein C24B5.3 0.0013 0.0023 0.0092
Onchocerca volvulus 0.0455 0.2518 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0035 0.0546
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0035 0.1395
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0668
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Toxoplasma gondii patched family protein 0.0013 0.0023 0.0502
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0912 0.5095 1
Brugia malayi Myosin head containing protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.0052 0.0243 0.0963
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0061 0.1714
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0016 0.0063
Echinococcus multilocularis protein dispatched 1 0.0106 0.0547 0.0546
Onchocerca volvulus 0.0013 0.0023 0.0085
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0035 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0016 0.0063
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0009 0.0002 0.0004
Brugia malayi hypothetical protein 0.0013 0.0023 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0146 0.3062
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus granulosus semaphorin 5B 0.008 0.0398 0.0781
Echinococcus granulosus kinase suppressor of Ras 1 0.0009 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.023 0.2829
Loa Loa (eye worm) hypothetical protein 0.0111 0.0575 0.2282
Toxoplasma gondii patched family protein 0.0013 0.0023 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0146 0.3062
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Schistosoma mansoni plexin 0.019 0.1024 0.2008
Schistosoma mansoni niemann-pick C1 (NPC1) 0.022 0.1188 0.2329
Echinococcus multilocularis natriuretic peptide receptor 1 0.0009 0.0002 0.0001
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0009 0.0002 0.0002
Echinococcus granulosus ephrin type A receptor 4 A 0.0009 0.0002 0.0002
Brugia malayi hypothetical protein 0.0013 0.0023 0.0092
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0061 0.2458
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0157 0.6071
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0141 0.5349
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0016 0.0015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0002 0.0007
Echinococcus granulosus expressed conserved protein 0.0203 0.1095 0.2149
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0146 0.3062
Loa Loa (eye worm) plexin A 0.0225 0.1221 0.4849
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0108
Brugia malayi Tyrosine-protein kinase abl-1 0.0009 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0035 0.0546
Toxoplasma gondii MAC/Perforin domain-containing protein 0.0085 0.0427 1
Plasmodium falciparum perforin-like protein 3 0.0085 0.0427 0.5267
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0009 0.0002 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0061 0.1235
Schistosoma mansoni plexin 0.0111 0.0575 0.1126
Echinococcus granulosus tyrosine protein kinase ABL1 0.0009 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase HCK 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0016 0.0028
Trypanosoma brucei unspecified product 0.002 0.0061 0.367
Schistosoma mansoni loxhd1 0.0152 0.0809 0.1586
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0243 0.2066
Echinococcus multilocularis tyrosine kinase 0.0009 0.0002 0.0001
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0207 0.2539
Brugia malayi C-terminal src kinase protein 1 0.0009 0.0002 0.0007
Onchocerca volvulus 0.0013 0.0023 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0016 0.003
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Brugia malayi steroid hormone receptor 0.0012 0.0016 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0261 0.026
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0052 0.0243 0.0963
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0009 0.0002 0.0001
Echinococcus granulosus tyrosine protein kinase shark 0.0009 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0157 0.6071
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0035 0.0138
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.023 0.0451
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus granulosus Niemann Pick C1 protein 0.0216 0.1169 0.2294
Loa Loa (eye worm) TK/ALK protein kinase 0.0009 0.0002 0.0004
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0016 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0016 0.0028
Schistosoma mansoni cpg binding protein 0.0031 0.0125 0.0242
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0222
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0243 1
Echinococcus multilocularis macrophage expressed protein 0.0766 0.4272 0.4272
Schistosoma mansoni coup transcription factor 0.0012 0.0016 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0169 0.6421
Entamoeba histolytica hypothetical protein 0.0037 0.0158 0.1336
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.152
Echinococcus multilocularis Protein lozenge 0.0057 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0041 0.0181 0.0353
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0061 0.0242
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0163 0.6697
Brugia malayi hypothetical protein 0.0009 0.0002 0.0007
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Onchocerca volvulus 0.0152 0.0809 0.321
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0016 0.006
Echinococcus multilocularis tyrosine protein kinase pr2 0.0009 0.0002 0.0001
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0035 0.0146 0.3062
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus granulosus activin receptor type 0.0009 0.0002 0.0002
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0207 0.1756
Loa Loa (eye worm) TK/Met protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) inositol-1 0.0038 0.0163 0.0646
Echinococcus granulosus GPCR family 2 0.0019 0.0057 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0016 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0261 0.0509
Echinococcus granulosus dna polymerase kappa 0.002 0.0061 0.0119
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0141 0.5081
Loa Loa (eye worm) protein kinase domain-containing protein 0.0009 0.0002 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0243 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0016 0.0028
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0009 0.0002 0.0001
Brugia malayi Sema domain containing protein 0.008 0.0398 0.1582
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0016 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0243 0.0965
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0243 0.2066
Brugia malayi Patched protein homolog 1 0.0013 0.0023 0.0092
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0473 0.0927
Loa Loa (eye worm) hypothetical protein 0.008 0.0398 0.158
Onchocerca volvulus Protein patched homolog 0.0013 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Schistosoma mansoni fibrocystin l 0.0035 0.0146 0.0283
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0035 0.0146 0.3062
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0009 0.0002 0.0001
Schistosoma mansoni cpg binding protein 0.003 0.0116 0.0224
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0016 0.0063
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0009 0.0002 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0035 0.0546
Echinococcus multilocularis expressed conserved protein 0.0203 0.1095 0.1095
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Echinococcus granulosus dnaJ subfamily B 0.042 0.2321 0.4554
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.132 0.259
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0009 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0031 0.0125 0.0242
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.008 0.0398 0.0779
Echinococcus granulosus integrin linked protein kinase 0.0009 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0455 0.2518 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0009 0.0002 0.0001
Echinococcus multilocularis tyrosine protein kinase shark 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0261 0.1034
Schistosoma mansoni hypothetical protein 0.0089 0.0454 0.0888
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0243 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0261 0.0511
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Brugia malayi hypothetical protein 0.0009 0.0002 0.0007
Brugia malayi Receptor family ligand binding region containing protein 0.0009 0.0002 0.0007
Plasmodium falciparum lipid/sterol:H+ symporter 0.0013 0.0023 0.0265
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Onchocerca volvulus Protein patched homolog 0.0013 0.0023 0.0085
Schistosoma mansoni DNA polymerase eta 0.002 0.0061 0.0116
Loa Loa (eye worm) acetyltransferase 0.0169 0.0905 0.3593
Brugia malayi Doublecortin family protein 0.0152 0.0809 0.3215
Schistosoma mansoni semaphorin 5-related 0.008 0.0398 0.0779
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0289 0.1148
Echinococcus granulosus tyrosine protein kinase csk 0.0009 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0146 0.3062
Brugia malayi SH2 domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0035 0.0138
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0016 0.0056
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2321 0.2321
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.3213
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0009 0.0002 0.0002
Brugia malayi SRC-1 0.0009 0.0002 0.0007
Plasmodium falciparum perforin-like protein 2 0.0085 0.0427 0.5267
Loa Loa (eye worm) TK/DDR protein kinase 0.0009 0.0002 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0114 0.0591 0.2344
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Onchocerca volvulus 0.005 0.0229 0.0903
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0009 0.0002 0.0004
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0061 0.0508
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0057 0.0222
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0035 0.0146 0.3062
Schistosoma mansoni rab6-interacting 0.0152 0.0809 0.1586
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0473 0.0927
Brugia malayi hypothetical protein 0.0152 0.0809 0.3215
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis tyrosine protein kinase Blk 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.008 0.0398 0.158
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0016 0.0063
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0009 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0035 0.0146 0.1235
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0009 0.0002 0.0007
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis RUN 0.0152 0.0809 0.0809
Brugia malayi DNA-binding protein LAG-1 0.0035 0.0146 0.058
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0163 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0035 0.0546
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0061 0.006
Echinococcus granulosus tyrosine protein kinase 0.0009 0.0002 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0243 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0016 0.0063
Brugia malayi ephrin receptor 1 precursor 0.0009 0.0002 0.0007
Toxoplasma gondii patched family protein 0.0013 0.0023 0.0502
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Brugia malayi Tyrosine-protein kinase PR2 0.0009 0.0002 0.0007
Entamoeba histolytica hypothetical protein 0.0037 0.0158 0.1336
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0002 0.0001
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0061 0.367
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0243 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Schistosoma mansoni lozenge 0.0057 0.0271 0.0529
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) TK/CSK protein kinase 0.0009 0.0002 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0302 0.059
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0009 0.0002 0.0002
Echinococcus multilocularis protein tyrosine kinase 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0093 0.0473 0.1876
Echinococcus granulosus tyrosine kinase 0.0009 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0035 0.0141
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0035 0.1395
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0061 0.024
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.006
Loa Loa (eye worm) TK/FAK protein kinase 0.0009 0.0002 0.0004
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Entamoeba histolytica cell surface protease gp63, putative 0.0035 0.0146 0.1235
Loa Loa (eye worm) hypothetical protein 0.019 0.1024 0.4067
Echinococcus granulosus semaphorin 1A 0.008 0.0398 0.0781
Plasmodium falciparum perforin-like protein 5 0.0085 0.0427 0.5267
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0146 0.3062
Echinococcus multilocularis hypothetical protein 0.008 0.0398 0.0398
Plasmodium vivax multidomain scavenger receptor, putative 0.0152 0.0809 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0243 0.0963
Loa Loa (eye worm) TK/RYK protein kinase 0.0009 0.0002 0.0004
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0035 0.2083
Loa Loa (eye worm) runx1 0.0057 0.0271 0.1075
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.0905 0.1773
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0912 0.5095 0.5095
Echinococcus granulosus tyrosine kinase 0.0009 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.367
Brugia malayi nuclear hormone receptor 0.0012 0.0016 0.0063
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.011
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0207 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0016 0.003
Schistosoma mansoni lipoxygenase 0.0637 0.3547 0.696
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0229 0.0909
Loa Loa (eye worm) patched family protein 0.0013 0.0023 0.0089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.367
Echinococcus multilocularis kinase suppressor of Ras 1 0.0009 0.0002 0.0001
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0035 0.0546
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus granulosus receptor type guanylyl cyclase 0.0009 0.0002 0.0002
Echinococcus multilocularis activated cdc42 kinase 1 0.0009 0.0002 0.0001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0163 0.6162
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0138
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0002 0.0001
Plasmodium vivax patched family protein, putative 0.0013 0.0023 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0016 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Brugia malayi Patched family protein 0.0013 0.0023 0.0092
Schistosoma mansoni patched 1 0.0093 0.0473 0.0925
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Echinococcus granulosus natriuretic peptide receptor 1 0.0009 0.0002 0.0002
Giardia lamblia DINP protein human, muc B family 0.002 0.0061 0.2891
Loa Loa (eye worm) TK protein kinase 0.0009 0.0002 0.0004
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0002 0.0004
Echinococcus multilocularis tyrosine kinase 0.0009 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0009 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0089
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0009 0.0002 0.0001
Echinococcus multilocularis FL cytokine receptor 0.0009 0.0002 0.0001
Brugia malayi hypothetical protein 0.008 0.0398 0.1582
Brugia malayi Protein kinase domain containing protein 0.0009 0.0002 0.0007
Onchocerca volvulus 0.0152 0.0809 0.321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0158 0.0308
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.367
Echinococcus granulosus epidermal growth factor receptor 0.0009 0.0002 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.3951 0.395
Onchocerca volvulus 0.0015 0.0035 0.0134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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