Detailed information for compound 1589191

Basic information

Technical information
  • TDR Targets ID: 1589191
  • Name: [2-chloro-2-(1,2,2-trichloroethenyl)cycloprop yl]methoxymethylbenzene
  • MW: 326.046 | Formula: C13H12Cl4O
  • H donors: 0 H acceptors: 0 LogP: 4.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClC(=C(Cl)Cl)C1(Cl)CC1COCc1ccccc1
  • InChi: 1S/C13H12Cl4O/c14-11(12(15)16)13(17)6-10(13)8-18-7-9-4-2-1-3-5-9/h1-5,10H,6-8H2
  • InChiKey: WLHDJGPWRKGCGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-chloro-2-(1,2,2-trichlorovinyl)cyclopropyl]methoxymethylbenzene
  • (((2-Chloro-2-(1,2,2-trichlorovinyl)cyclopropyl)methoxy)methyl)benzene
  • AIDS-138118
  • AIDS138118
  • Benzyl (2-chloro-2-(1,2,2-trichlorovinyl)cyclopropyl)methyl ether
  • NSC644274
  • NCI60_015011

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0181 0.0181
Onchocerca volvulus 0.0027 0.0245 0.0358
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.008 0.008
Trichomonas vaginalis dullard protein, putative 0.0014 0.008 0.0117
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0181 0.2089
Loa Loa (eye worm) hypothetical protein 0.0022 0.0181 0.0301
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0046 0.0046
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0457 0.0457
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0181 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0093 0.1075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0046 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0046 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0093 0.1075
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0864 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0217 0.2636 1
Echinococcus multilocularis dna polymerase eta 0.0022 0.0181 0.0181
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.1471 0.2451
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0181 0.0181
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.007 0.0781 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.006 0.006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.0781 0.0781
Leishmania major hypothetical protein, conserved 0.0067 0.0742 0.8586
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0181 0.0685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0799
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Echinococcus granulosus cpg binding protein 0.0037 0.037 0.037
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.336 0.336
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0483 0.6001 1
Schistosoma mansoni survival motor neuron protein 0.0056 0.0604 0.0604
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0457 0.0457
Echinococcus multilocularis zinc finger protein 0.0025 0.0209 0.0209
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0252 0.0252
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0217 0.2636 1
Brugia malayi RNA binding protein 0.0124 0.1471 0.2451
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0157 0.2015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0245 0.1368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Trypanosoma brucei unspecified product 0.0015 0.0093 0.1075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1471 0.1471
Trichomonas vaginalis dullard protein, putative 0.0014 0.008 0.0117
Loa Loa (eye worm) hypothetical protein 0.009 0.1031 0.1718
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0093 0.1075
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.008 0.008
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0181 0.2089
Echinococcus multilocularis microtubule associated protein 2 0.0799 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.1031 0.1031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0262
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0157 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0245 0.1368
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0245 0.2836
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0067 0.0742 0.1085
Schistosoma mansoni zinc finger protein 0.0025 0.0209 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0046 0.0077
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0014 0.008 0.0922
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.0133
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0181 0.0685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0799
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0046 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0245 0.0409
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0046 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0046 0.0077
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0217 0.2636 0.3853
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0245 0.2836
Brugia malayi ecdysteroid receptor 0.0012 0.0046 0.0077
Brugia malayi CXXC zinc finger family protein 0.0033 0.0319 0.0531
Loa Loa (eye worm) hypothetical protein 0.0014 0.0077 0.0129
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0148 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0035 0.0035
Brugia malayi nuclear receptor NHR-88 0.0012 0.0046 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0262
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0046 0.0046
Brugia malayi PHD-finger family protein 0.0031 0.0287 0.0478
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0245 0.093
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.008 0.008
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0046 0.0046
Onchocerca volvulus 0.0217 0.2636 0.3853
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0046 0.0046
Echinococcus granulosus zinc finger protein 0.0025 0.0209 0.0209
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0051 0.0546 0.0911
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1471 0.1471
Echinococcus multilocularis neuropeptide s receptor 0.0536 0.6667 0.6667
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0046 0.0077
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0046 0.0067
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0505 0.0842
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.008 0.5065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0799
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0035
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.008 0.1021
Loa Loa (eye worm) hypothetical protein 0.0044 0.046 0.0766
Brugia malayi nuclear hormone receptor 0.0012 0.0046 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0864 0.3279
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.015 0.1792 1
Schistosoma mansoni hypothetical protein 0.0018 0.0122 0.0122
Onchocerca volvulus 0.0549 0.6842 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0046 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0046 0.0077
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.0922
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1031 0.1031
Loa Loa (eye worm) TAR-binding protein 0.0124 0.1471 0.2451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0046 0.0077
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0046 0.0046
Brugia malayi TAR-binding protein 0.0124 0.1471 0.2451
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0217 0.2636 0.3853
Schistosoma mansoni hypothetical protein 0.0474 0.5886 0.5886
Schistosoma mansoni hypothetical protein 0.0014 0.0077 0.0077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0822 0.0822
Mycobacterium ulcerans hypothetical protein 0.0027 0.0245 0.093
Loa Loa (eye worm) hypothetical protein 0.0047 0.0494 0.0824
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0245 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0505 0.0505
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0181 0.0181
Schistosoma mansoni bromodomain containing protein 0.0075 0.0848 0.0848
Trypanosoma cruzi ISWI complex protein 0.0018 0.0122 0.1412
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0424 0.0424
Schistosoma mansoni microtubule-associated protein tau 0.0799 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.1031 0.1031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0799
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0157 0.0878
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.007 0.0781 0.0781
Plasmodium vivax SET domain protein, putative 0.007 0.0781 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0046 0.0077
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0046 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0046 0.0046
Echinococcus multilocularis tumor protein p63 0.0328 0.4045 0.4045
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0117
Echinococcus granulosus dna polymerase kappa 0.0022 0.0181 0.0181
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0046 0.0046
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0014 0.008 0.1021
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0181 0.2089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0014 0.008 0.0302
Brugia malayi Bromodomain containing protein 0.0044 0.0459 0.0765
Echinococcus granulosus neuropeptide s receptor 0.0536 0.6667 0.6667
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0319 0.0531
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0046 0.0046
Echinococcus granulosus tar DNA binding protein 0.0124 0.1471 0.1471
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.02 0.0334
Echinococcus granulosus tumor protein p63 0.0328 0.4045 0.4045
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0046 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0262
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0864 0.0864
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0864 0.1441
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0046 0.0067
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0252 0.0252
Brugia malayi hypothetical protein 0.0274 0.336 0.5599
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0245 0.093
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0864 0.0864
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0046 0.0046
Schistosoma mansoni cpg binding protein 0.0033 0.0319 0.0319
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0245 0.093
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0245 0.2836
Leishmania major hypothetical protein, conserved 0.0018 0.0122 0.1412
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0046 0.0046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0181 0.0264
Loa Loa (eye worm) hypothetical protein 0.0274 0.336 0.5599
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0742 0.8586
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0796 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Schistosoma mansoni hypothetical protein 0.0024 0.02 0.02
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0046 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0217 0.2636 0.3853
Brugia malayi Pre-SET motif family protein 0.007 0.0781 0.1302
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0046 0.0046
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0217 0.2636 0.4393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0046 0.0077
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0181 0.2089
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0217 0.2636 1
Loa Loa (eye worm) RNA binding protein 0.0124 0.1471 0.2451
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0046 0.0077
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0864 0.1441
Giardia lamblia DINP protein human, muc B family 0.0022 0.0181 0.0395
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1031 0.1031
Onchocerca volvulus 0.0048 0.0505 0.0738
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0087 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0046 0.0077
Trypanosoma brucei unspecified product 0.0015 0.0093 0.1075
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0148 0.0148
Onchocerca volvulus 0.007 0.0781 0.1142
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Onchocerca volvulus 0.0012 0.0046 0.0067
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.008 0.0133
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.008 0.008
Echinococcus granulosus neuropeptide receptor A26 0.0536 0.6667 0.6667
Brugia malayi steroid hormone receptor 0.0012 0.0046 0.0077
Echinococcus multilocularis 0.0014 0.008 0.008
Trichomonas vaginalis set domain proteins, putative 0.0549 0.6842 1
Brugia malayi Pre-SET motif family protein 0.0483 0.6001 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0245 0.0409
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0245 0.093
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0245 0.093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0864 1
Trypanosoma brucei unspecified product 0.0022 0.0181 0.2089
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0046 0.0046
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.1471 0.2451
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0252 0.0252
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0217 0.2636 0.4393
Schistosoma mansoni coup transcription factor 0.0012 0.0046 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0245 1
Trypanosoma brucei ISWI complex protein 0.0018 0.0122 0.1412
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0796 0.0796
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0181 0.2089
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0181 0.0301
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0217 0.2636 0.3853
Trypanosoma cruzi ISWI complex protein 0.0018 0.0122 0.1412
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0864 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0046 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0046 0.0077
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.336 0.336
Schistosoma mansoni cpg binding protein 0.0037 0.037 0.037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0046 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1471 0.1471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0046 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0046 0.0077
Schistosoma mansoni DNA polymerase eta 0.0022 0.0181 0.0181
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0181 0.0181
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0046 0.0046
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0157 0.0597
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0245 0.093
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0046 0.0077
Leishmania major DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0067 0.074 0.074
Echinococcus multilocularis neuropeptide receptor A26 0.0536 0.6667 0.6667
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0217 0.2636 0.3853
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.008 0.1021
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0046 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.5886 0.5886
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Schistosoma mansoni zinc finger protein 0.0018 0.0122 0.0122
Loa Loa (eye worm) histone methyltransferase 0.0013 0.006 0.0101
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0181 0.0685
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0864 0.0864
Echinococcus multilocularis cpg binding protein 0.0037 0.037 0.037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0864 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0181 0.0181
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0035 0.0035
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0181 0.1008
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0046 0.0046
Echinococcus granulosus dna polymerase eta 0.0022 0.0181 0.0181
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0181 0.1008
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0217 0.2636 0.3853
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0046 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0424 0.0424
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0148 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0245 0.093
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0742 0.8586
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0217 0.2636 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0245 0.093
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.0245 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1471 0.1471
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0781 0.0781
Schistosoma mansoni cpg binding protein 0.0037 0.037 0.037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0761 0.9746
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0067 0.0742 0.8586
Loa Loa (eye worm) hypothetical protein 0.0082 0.0933 0.1555
Echinococcus granulosus dnaJ subfamily B 0.0474 0.5886 0.5886
Echinococcus multilocularis tar DNA binding protein 0.0124 0.1471 0.1471
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0245 0.093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0046 0.0077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0046 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0181 0.0301
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0046 0.0077
Schistosoma mansoni hypothetical protein 0.0056 0.0604 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0046 0.0077
Brugia malayi Bromodomain containing protein 0.0089 0.102 0.17
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0245 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0046 0.0077
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0157 0.0261
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0245 0.0409
Trichomonas vaginalis dullard protein, putative 0.0014 0.008 0.0117
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0046 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0046 0.0046
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0604 0.1007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1471 0.1471
Onchocerca volvulus 0.0056 0.0604 0.0883
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0117
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0046 0.0046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0046 0.0046
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0181 0.0264
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0262
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0181 0.2089
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0157 1
Onchocerca volvulus 0.0033 0.0319 0.0465
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0046 0.0067
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.006 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0181 0.2089
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0148 0.0148
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0046 0.0046
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0067 0.0742 0.1085
Leishmania major DNA polymerase eta, putative 0.0022 0.0181 0.2089
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0245 0.093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0245 0.0409
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0046 0.0077
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0035 0.0035

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.814 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.806 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.598 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.588 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.405 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.287 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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