Detailed information for compound 1600673

Basic information

Technical information
  • TDR Targets ID: 1600673
  • Name: 1-[9-[(2S)-3-[4-[di(phenyl)methyl]piperazin-1 -yl]-2-hydroxypropyl]purin-6-yl]pyrrole-2-car bonitrile
  • MW: 518.612 | Formula: C30H30N8O
  • H donors: 1 H acceptors: 5 LogP: 3.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1cccn1c1ncnc2c1ncn2C[C@H](CN1CCN(CC1)C(c1ccccc1)c1ccccc1)O
  • InChi: 1S/C30H30N8O/c31-18-25-12-7-13-38(25)30-27-29(32-21-33-30)37(22-34-27)20-26(39)19-35-14-16-36(17-15-35)28(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,21-22,26,28,39H,14-17,19-20H2/t26-/m0/s1
  • InChiKey: INZJCFBTGUJGRP-SANMLTNESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[9-[(2S)-3-[4-[di(phenyl)methyl]piperazin-1-yl]-2-hydroxy-propyl]purin-6-yl]pyrrole-2-carbonitrile
  • 1-[9-[(2S)-3-[4-[di(phenyl)methyl]-1-piperazinyl]-2-hydroxypropyl]-6-purinyl]-2-pyrrolecarbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0072 0.0679 0.0962
Brugia malayi Pre-SET motif family protein 0.003 0.0136 0.0191
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0576 0.7124 1
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0313 0.4269
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0031 0.0148 0.2016
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0031 0.0148 0.0266
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0679 0.0953
Mycobacterium leprae Polyketide synthase Pks13 0.0453 0.5558 1
Echinococcus multilocularis geminin 0.0341 0.4123 0.4123
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0136 0.0136
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0521 0.0614
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0302 0.3626 0.6429
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0047 0.0353 0.0371
Loa Loa (eye worm) beta-lactamase 0.0072 0.0679 0.1081
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0031 0.0148 0.0266
Toxoplasma gondii type I fatty acid synthase, putative 0.0217 0.2534 0.655
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0679 0.9253
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0077 0.0734 1
Brugia malayi hypothetical protein 0.0121 0.1301 0.1827
Chlamydia trachomatis acyl carrier protein 0.0031 0.0148 0.2016
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0256 0.0359
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0679 0.0962
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0094 0.0955 0.1461
Echinococcus granulosus AMP dependent ligase 0.0031 0.0148 0.0175
Onchocerca volvulus Huntingtin homolog 0.0121 0.1301 0.1769
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0302 0.3626 0.6301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0945 0.1115
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0488 0.0685
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0679 0.0962
Toxoplasma gondii type I fatty acid synthase 0.0047 0.0353 0.0911
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0302 0.3626 0.6301
Mycobacterium ulcerans polyketide synthase MbtD 0.0094 0.0955 0.1717
Leishmania major acyl carrier protein, putative 0.0031 0.0148 0.1591
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0031 0.0148 0.0266
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0031 0.0148 0.0236
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0077 0.0734 0.1897
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0726 0.9888
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0453 0.5558 0.9802
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0679 0.1222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0945 0.1115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0136 0.0161
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0247 0.2914 0.5012
Echinococcus granulosus microtubule associated protein 2 0.0681 0.8473 1
Schistosoma mansoni hypothetical protein 0.0034 0.019 0.0224
Echinococcus granulosus cpg binding protein 0.003 0.0142 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.093 0.1221
Mycobacterium tuberculosis Conserved protein 0.0072 0.0679 0.0962
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0173 0.1974 0.3309
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0945 0.1115
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0077 0.0734 0.0734
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0945 0.0945
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Brugia malayi CXXC zinc finger family protein 0.0029 0.0121 0.0169
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0096 0.0981 0.1508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0945 0.0945
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0679 0.0962
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0521 0.0521
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0031 0.0148 0.0266
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0075 0.0708 0.1014
Mycobacterium tuberculosis Hypothetical protein 0.0092 0.093 0.1417
Mycobacterium ulcerans hypothetical protein 0.0031 0.0148 0.0266
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0726 0.9888
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0453 0.5558 0.9802
Mycobacterium ulcerans polyketide synthase Pks13 0.0453 0.5558 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0521 0.0614
Leishmania major hypothetical protein, conserved 0.0072 0.0679 0.7301
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0031 0.0148 0.2016
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0321 0.3869 0.6877
Mycobacterium ulcerans acyl carrier protein 0.0031 0.0148 0.0266
Toxoplasma gondii ABC1 family protein 0.0072 0.0679 0.1755
Echinococcus multilocularis NADH dehydrogenase 0.0031 0.0148 0.0148
Schistosoma mansoni cpg binding protein 0.0029 0.0121 0.0142
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Brugia malayi hypothetical protein 0.0076 0.0726 0.1019
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0154 0.1728 0.4466
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0679 0.9253
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0047 0.0353 0.0371
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0047 0.0353 0.0378
Loa Loa (eye worm) fatty acid synthase 0.0301 0.3608 0.5743
Onchocerca volvulus 0.0072 0.0679 0.0837
Mycobacterium leprae Probable lipase LipE 0.0072 0.0679 0.0982
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0285 0.3403 0.5417
Onchocerca volvulus 0.0285 0.3403 0.4918
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0679 0.9253
Schistosoma mansoni hypothetical protein 0.0341 0.4123 0.4866
Mycobacterium ulcerans acyl carrier protein 0.0031 0.0148 0.0266
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0679 0.0962
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0521 0.0937
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.019 0.019
Mycobacterium ulcerans Type I modular polyketide synthase 0.0302 0.3626 0.6524
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0302 0.3626 0.509
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.5668 1
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0726 0.1876
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0136 0.0161
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0321 0.3869 0.6877
Schistosoma mansoni hypothetical protein 0.0039 0.0256 0.0302
Plasmodium vivax SET domain protein, putative 0.003 0.0136 0.1858
Schistosoma mansoni hypothetical protein 0.0341 0.4123 0.4866
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0077 0.0734 0.789
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0321 0.3869 0.6961
Schistosoma mansoni methyltransferase-related 0.0092 0.093 0.1098
Echinococcus multilocularis cpg binding protein 0.003 0.0142 0.0142
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0224 0.0264
Echinococcus granulosus geminin 0.0341 0.4123 0.4866
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0488 0.0685
Mycobacterium ulcerans beta-lactamase 0.0072 0.0679 0.1222
Brugia malayi hypothetical protein 0.0037 0.0224 0.0314
Leishmania major hypothetical protein, conserved 0.0076 0.0726 0.7801
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0679 0.0679
Loa Loa (eye worm) acyl carrier protein 0.014 0.155 0.2467
Mycobacterium tuberculosis Conserved protein 0.0092 0.093 0.1417
Mycobacterium tuberculosis Probable thioesterase TesA 0.0254 0.3009 0.5183
Schistosoma mansoni cpg binding protein 0.003 0.0142 0.0167
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0199 0.2303 0.3983
Plasmodium vivax acyl carrier protein, putative 0.0031 0.0148 0.2016
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0321 0.3869 0.6741
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0302 0.3626 0.6301
Treponema pallidum acyl carrier protein 0.0031 0.0148 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0945 0.1504
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0224 0.0224
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0679 0.1222
Loa Loa (eye worm) hypothetical protein 0.051 0.6282 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0321 0.3869 0.6961
Mycobacterium ulcerans thioesterase 0.0254 0.3009 0.5413
Loa Loa (eye worm) acyl carrier protein 0.0031 0.0148 0.0236
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0285 0.3403 0.5898
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0521 0.0937
Onchocerca volvulus 0.0031 0.0148 0.0041
Brugia malayi Phosphopantetheine attachment site family protein 0.0031 0.0148 0.0208
Mycobacterium ulcerans polyketide synthase 0.0302 0.3626 0.6524
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.019 0.0224
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0679 0.0962
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0136 0.0161
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0679 0.1081
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Mycobacterium ulcerans polyketide synthase 0.0321 0.3869 0.6961
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2375 0.3781
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0521 0.0614
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0321 0.3869 0.6741
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.8473 0.8473
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0077 0.0734 1
Schistosoma mansoni acyl carrier protein 0.0031 0.0148 0.0175
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0031 0.0148 0.2016
Onchocerca volvulus 0.0072 0.0679 0.0837
Onchocerca volvulus Fatty acid synthase homolog 0.055 0.6796 1
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0679 0.0962
Mycobacterium ulcerans Type I modular polyketide synthase 0.0302 0.3626 0.6524
Loa Loa (eye worm) hypothetical protein 0.0076 0.0726 0.1155
Onchocerca volvulus 0.003 0.0136 0.0024
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0031 0.0148 0.0148
Onchocerca volvulus 0.0531 0.6553 0.9636
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0121 0.0192
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0243 0.2863 0.5151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0136 0.0161
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0102 0.1063 0.1657
Toxoplasma gondii acyl carrier protein ACP 0.0031 0.0148 0.0383
Echinococcus multilocularis AMP dependent ligase 0.0031 0.0148 0.0148
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0031 0.0148 0.0041
Mycobacterium ulcerans lipase LipD 0.0072 0.0679 0.1222
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.8473 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.128 0.2037
Mycobacterium leprae Probable polyketide synthase Pks1 0.0321 0.3869 0.6877
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0521 0.0937
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0679 0.9253
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0243 0.2863 0.5151
Schistosoma mansoni hypothetical protein 0.0031 0.0148 0.0175
Mycobacterium ulcerans polyketide synthase Pks9 0.0199 0.2303 0.4143
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0077 0.0734 1
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0726 0.9888
Giardia lamblia Methyltransferase like 2 0.0092 0.093 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0302 0.3626 0.6429
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0726 0.9888
Toxoplasma gondii type I fatty acid synthase, putative 0.0321 0.3869 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0115 0.0135
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0488 0.0777
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0148 0.0266
Onchocerca volvulus 0.0072 0.0679 0.0837
Onchocerca volvulus Huntingtin homolog 0.0121 0.1301 0.1769
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0077 0.0734 0.103
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0955 0.134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0463 0.1196
Mycobacterium ulcerans hypothetical protein 0.0072 0.0679 0.1222
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0096 0.0981 0.1539
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0254 0.3009 0.5288
Mycobacterium ulcerans fatty acid synthase Fas 0.0096 0.0981 0.1764
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0077 0.0734 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0296 0.354 0.6146
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0123 0.1333 0.2147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0945 0.1115
Brugia malayi Methyltransferase-like protein 4 0.0092 0.093 0.1306
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0679 0.0982
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2736 1
Leishmania major hypothetical protein, conserved 0.0092 0.093 1
Mycobacterium ulcerans polyketide synthase MbtC 0.0077 0.0734 0.132
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0679 0.0962
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0077 0.0734 1
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0726 0.9888
Brugia malayi beta-lactamase family protein 0.0072 0.0679 0.0953
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0679 0.0802
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0219 0.256 0.4369
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0077 0.0734 0.132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0148 0.0208
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0077 0.0734 1
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0031 0.0148 0.0208
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0044 0.0313 0.4269
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0726 0.9888
Brugia malayi Pre-SET motif family protein 0.0205 0.2375 0.3334
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0679 0.0802
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0224 0.0264
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0136 0.0136
Echinococcus granulosus NADH dehydrogenase 0.0031 0.0148 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0945 0.1326
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0243 0.2863 0.5018
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0302 0.3626 0.6524
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0136 0.0352
Plasmodium falciparum acyl carrier protein 0.0031 0.0148 0.2016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0199 0.2303 0.4143
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0256 0.0407
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0077 0.0734 0.0866
Brugia malayi MH2 domain containing protein 0.0119 0.128 0.1796
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0521 0.1346
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0077 0.0734 0.0866
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0546 0.0644
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0521 0.5597
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0679 0.0802
Mycobacterium tuberculosis Conserved protein 0.0072 0.0679 0.0962
Loa Loa (eye worm) hypothetical protein 0.0047 0.0353 0.0561
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0077 0.0734 1
Onchocerca volvulus 0.0233 0.2736 0.3919
Mycobacterium ulcerans thioesterase TesA 0.0254 0.3009 0.5413
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0031 0.0148 0.0266
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0047 0.0353 0.0371
Brugia malayi hypothetical protein 0.0049 0.0381 0.0535
Brugia malayi beta-lactamase 0.0072 0.0679 0.0953
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0077 0.0734 0.1168
Brugia malayi AMP-binding enzyme family protein 0.0285 0.3403 0.4777
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0198 0.2288 0.5913
Loa Loa (eye worm) hypothetical protein 0.0168 0.1908 0.3038
Loa Loa (eye worm) hypothetical protein 0.003 0.0136 0.0217
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0031 0.0148 0.0266
Brugia malayi beta-lactamase family protein 0.0072 0.0679 0.0953
Loa Loa (eye worm) hypothetical protein 0.0121 0.1301 0.2072
Schistosoma mansoni cpg binding protein 0.003 0.0142 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0136 0.0161
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.128 0.2037
Loa Loa (eye worm) hypothetical protein 0.0121 0.1301 0.2072
Echinococcus granulosus acyl carrier protein mitochondrial 0.0031 0.0148 0.0175
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0321 0.3869 0.6741
Loa Loa (eye worm) hypothetical protein 0.0047 0.0353 0.0561
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0077 0.0734 0.132
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0296 0.354 0.6146
Loa Loa (eye worm) hypothetical protein 0.0057 0.0488 0.0777
Mycobacterium ulcerans Type I modular polyketide synthase 0.0302 0.3626 0.6524
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0047 0.0353 0.0371
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0945 0.1115
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0521 0.0675
Schistosoma mansoni hypothetical protein 0.0037 0.0224 0.0264

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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