Detailed information for compound 1600673

Basic information

Technical information
  • TDR Targets ID: 1600673
  • Name: 1-[9-[(2S)-3-[4-[di(phenyl)methyl]piperazin-1 -yl]-2-hydroxypropyl]purin-6-yl]pyrrole-2-car bonitrile
  • MW: 518.612 | Formula: C30H30N8O
  • H donors: 1 H acceptors: 5 LogP: 3.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1cccn1c1ncnc2c1ncn2C[C@H](CN1CCN(CC1)C(c1ccccc1)c1ccccc1)O
  • InChi: 1S/C30H30N8O/c31-18-25-12-7-13-38(25)30-27-29(32-21-33-30)37(22-34-27)20-26(39)19-35-14-16-36(17-15-35)28(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,21-22,26,28,39H,14-17,19-20H2/t26-/m0/s1
  • InChiKey: INZJCFBTGUJGRP-SANMLTNESA-N  

Network

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Synonyms

  • 1-[9-[(2S)-3-[4-[di(phenyl)methyl]piperazin-1-yl]-2-hydroxy-propyl]purin-6-yl]pyrrole-2-carbonitrile
  • 1-[9-[(2S)-3-[4-[di(phenyl)methyl]-1-piperazinyl]-2-hydroxypropyl]-6-purinyl]-2-pyrrolecarbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0726 0.9888
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0679 0.0802
Loa Loa (eye worm) hypothetical protein 0.051 0.6282 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0726 0.9888
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0031 0.0148 0.0266
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0679 0.9253
Schistosoma mansoni cpg binding protein 0.003 0.0142 0.0167
Toxoplasma gondii type I fatty acid synthase, putative 0.0321 0.3869 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0945 0.1115
Mycobacterium ulcerans polyketide synthase 0.0321 0.3869 0.6961
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0173 0.1974 0.3309
Onchocerca volvulus Fatty acid synthase homolog 0.055 0.6796 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1301 0.2072
Mycobacterium tuberculosis Conserved protein 0.0072 0.0679 0.0962
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0077 0.0734 1
Toxoplasma gondii acyl carrier protein ACP 0.0031 0.0148 0.0383
Plasmodium vivax SET domain protein, putative 0.003 0.0136 0.1858
Mycobacterium tuberculosis Probable thioesterase TesA 0.0254 0.3009 0.5183
Mycobacterium leprae Probable lipase LipE 0.0072 0.0679 0.0982
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0075 0.0708 0.1014
Treponema pallidum acyl carrier protein 0.0031 0.0148 0.5
Brugia malayi Phosphopantetheine attachment site family protein 0.0031 0.0148 0.0208
Plasmodium vivax acyl carrier protein, putative 0.0031 0.0148 0.2016
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2736 1
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0077 0.0734 0.0734
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0521 0.0614
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0224 0.0264
Mycobacterium ulcerans polyketide synthase Pks9 0.0199 0.2303 0.4143
Loa Loa (eye worm) beta-lactamase 0.0072 0.0679 0.1081
Loa Loa (eye worm) hypothetical protein 0.0121 0.1301 0.2072
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0321 0.3869 0.6961
Loa Loa (eye worm) hypothetical protein 0.0047 0.0353 0.0561
Schistosoma mansoni cpg binding protein 0.0029 0.0121 0.0142
Leishmania major hypothetical protein, conserved 0.0092 0.093 1
Loa Loa (eye worm) acyl carrier protein 0.0031 0.0148 0.0236
Mycobacterium ulcerans polyketide synthase MbtD 0.0094 0.0955 0.1717
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.8473 0.8473
Brugia malayi CXXC zinc finger family protein 0.0029 0.0121 0.0169
Echinococcus multilocularis AMP dependent ligase 0.0031 0.0148 0.0148
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0302 0.3626 0.6301
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0136 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0488 0.0685
Loa Loa (eye worm) hypothetical protein 0.0076 0.0726 0.1155
Schistosoma mansoni hypothetical protein 0.0341 0.4123 0.4866
Schistosoma mansoni acyl carrier protein 0.0031 0.0148 0.0175
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0121 0.0192
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0302 0.3626 0.6524
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0077 0.0734 1
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.8473 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0945 0.1115
Brugia malayi Pre-SET motif family protein 0.0205 0.2375 0.3334
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0219 0.256 0.4369
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0313 0.4269
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0945 0.1326
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0521 0.0521
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0077 0.0734 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0296 0.354 0.6146
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0077 0.0734 0.0866
Brugia malayi beta-lactamase 0.0072 0.0679 0.0953
Brugia malayi hypothetical protein 0.0076 0.0726 0.1019
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0198 0.2288 0.5913
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0136 0.0161
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0955 0.134
Mycobacterium ulcerans thioesterase TesA 0.0254 0.3009 0.5413
Onchocerca volvulus 0.0072 0.0679 0.0837
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0521 0.5597
Mycobacterium tuberculosis Conserved protein 0.0072 0.0679 0.0962
Chlamydia trachomatis acyl carrier protein 0.0031 0.0148 0.2016
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0031 0.0148 0.2016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0679 0.0802
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0136 0.0161
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0285 0.3403 0.5898
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0679 0.0679
Schistosoma mansoni hypothetical protein 0.0034 0.019 0.0224
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0679 0.0982
Mycobacterium ulcerans Type I modular polyketide synthase 0.0302 0.3626 0.6524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0945 0.0945
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0031 0.0148 0.2016
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0726 0.1876
Schistosoma mansoni hypothetical protein 0.0031 0.0148 0.0175
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0521 0.0937
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0521 0.0937
Mycobacterium tuberculosis Hypothetical protein 0.0092 0.093 0.1417
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0243 0.2863 0.5018
Mycobacterium leprae Probable polyketide synthase Pks1 0.0321 0.3869 0.6877
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0945 0.1504
Brugia malayi hypothetical protein 0.0121 0.1301 0.1827
Echinococcus multilocularis NADH dehydrogenase 0.0031 0.0148 0.0148
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0679 0.0962
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0302 0.3626 0.6301
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0148 0.0208
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0679 0.9253
Onchocerca volvulus 0.0285 0.3403 0.4918
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0521 0.0614
Onchocerca volvulus 0.0072 0.0679 0.0837
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0123 0.1333 0.2147
Brugia malayi hypothetical protein 0.0037 0.0224 0.0314
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0243 0.2863 0.5151
Onchocerca volvulus Huntingtin homolog 0.0121 0.1301 0.1769
Brugia malayi Pre-SET motif family protein 0.003 0.0136 0.0191
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0302 0.3626 0.6429
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0321 0.3869 0.6877
Brugia malayi hypothetical protein 0.0049 0.0381 0.0535
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0726 0.9888
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0463 0.1196
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0148 0.0266
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0488 0.0777
Mycobacterium ulcerans polyketide synthase Pks13 0.0453 0.5558 1
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0077 0.0734 0.132
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0077 0.0734 0.1897
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0945 0.1115
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0321 0.3869 0.6741
Echinococcus granulosus cpg binding protein 0.003 0.0142 0.0167
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0521 0.1346
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0726 0.9888
Mycobacterium ulcerans polyketide synthase MbtC 0.0077 0.0734 0.132
Onchocerca volvulus 0.0031 0.0148 0.0041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.5668 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0576 0.7124 1
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Brugia malayi Methyltransferase-like protein 4 0.0092 0.093 0.1306
Loa Loa (eye worm) acyl carrier protein 0.014 0.155 0.2467
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0136 0.0161
Toxoplasma gondii ABC1 family protein 0.0072 0.0679 0.1755
Schistosoma mansoni hypothetical protein 0.0037 0.0224 0.0264
Echinococcus granulosus acyl carrier protein mitochondrial 0.0031 0.0148 0.0175
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0679 0.1081
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0199 0.2303 0.3983
Mycobacterium ulcerans Type I modular polyketide synthase 0.0302 0.3626 0.6524
Schistosoma mansoni cpg binding protein 0.003 0.0142 0.0167
Brugia malayi beta-lactamase family protein 0.0072 0.0679 0.0953
Mycobacterium ulcerans thioesterase 0.0254 0.3009 0.5413
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0679 0.0962
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.093 0.1221
Echinococcus multilocularis geminin 0.0341 0.4123 0.4123
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0154 0.1728 0.4466
Giardia lamblia Methyltransferase like 2 0.0092 0.093 0.5
Onchocerca volvulus Huntingtin homolog 0.0121 0.1301 0.1769
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0031 0.0148 0.0266
Mycobacterium ulcerans hypothetical protein 0.0031 0.0148 0.0266
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0031 0.0148 0.0208
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2375 0.3781
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0302 0.3626 0.509
Mycobacterium ulcerans fatty acid synthase Fas 0.0096 0.0981 0.1764
Mycobacterium ulcerans polyketide synthase 0.0302 0.3626 0.6524
Mycobacterium ulcerans acyl carrier protein 0.0031 0.0148 0.0266
Onchocerca volvulus 0.003 0.0136 0.0024
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0047 0.0353 0.0378
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0285 0.3403 0.5417
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0077 0.0734 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.019 0.0224
Onchocerca volvulus 0.0072 0.0679 0.0837
Toxoplasma gondii type I fatty acid synthase 0.0047 0.0353 0.0911
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0679 0.9253
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0679 0.1222
Leishmania major hypothetical protein, conserved 0.0072 0.0679 0.7301
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0077 0.0734 0.789
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.128 0.2037
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0031 0.0148 0.0266
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0521 0.0937
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0247 0.2914 0.5012
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0077 0.0734 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0302 0.3626 0.6524
Loa Loa (eye worm) hypothetical protein 0.0039 0.0256 0.0407
Mycobacterium ulcerans acyl carrier protein 0.0031 0.0148 0.0266
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0031 0.0148 0.0266
Mycobacterium tuberculosis Conserved protein 0.0072 0.0679 0.0962
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0679 0.0962
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0521 0.0614
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0077 0.0734 0.132
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0224 0.0264
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0044 0.0313 0.4269
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0453 0.5558 0.9802
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0453 0.5558 0.9802
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0302 0.3626 0.6429
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0077 0.0734 0.0866
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0296 0.354 0.6146
Schistosoma mansoni methyltransferase-related 0.0092 0.093 0.1098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0679 0.0802
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0047 0.0353 0.0371
Brugia malayi beta-lactamase family protein 0.0072 0.0679 0.0953
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0136 0.0161
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.128 0.2037
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0679 0.0962
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0102 0.1063 0.1657
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0679 0.0962
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0256 0.0359
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0115 0.0135
Schistosoma mansoni hypothetical protein 0.0039 0.0256 0.0302
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0077 0.0734 0.103
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0199 0.2303 0.4143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0136 0.0161
Echinococcus multilocularis cpg binding protein 0.003 0.0142 0.0142
Mycobacterium ulcerans hypothetical protein 0.0072 0.0679 0.1222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0945 0.0945
Echinococcus granulosus geminin 0.0341 0.4123 0.4866
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0679 0.1222
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0077 0.0734 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0136 0.0352
Toxoplasma gondii type I fatty acid synthase, putative 0.0217 0.2534 0.655
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0224 0.0224
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0031 0.0148 0.0041
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0031 0.0148 0.0236
Loa Loa (eye worm) hypothetical protein 0.0047 0.0353 0.0561
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0726 0.9888
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0031 0.0148 0.2016
Mycobacterium ulcerans beta-lactamase 0.0072 0.0679 0.1222
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0521 0.0675
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0321 0.3869 0.6961
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0321 0.3869 0.6877
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0679 0.0953
Echinococcus granulosus NADH dehydrogenase 0.0031 0.0148 0.0175
Schistosoma mansoni hypothetical protein 0.0341 0.4123 0.4866
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0945 0.1115
Mycobacterium tuberculosis Conserved protein 0.0092 0.093 0.1417
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Onchocerca volvulus 0.0233 0.2736 0.3919
Loa Loa (eye worm) hypothetical protein 0.003 0.0136 0.0217
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0321 0.3869 0.6741
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0546 0.0644
Onchocerca volvulus 0.0531 0.6553 0.9636
Leishmania major acyl carrier protein, putative 0.0031 0.0148 0.1591
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0136 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0726 0.9888
Loa Loa (eye worm) hypothetical protein 0.0168 0.1908 0.3038
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0679 0.0962
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0077 0.0734 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0488 0.0685
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0047 0.0353 0.0371
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Echinococcus granulosus AMP dependent ligase 0.0031 0.0148 0.0175
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0031 0.0148 0.0266
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0679 0.0962
Brugia malayi MH2 domain containing protein 0.0119 0.128 0.1796
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0094 0.0955 0.1461
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0047 0.0353 0.0371
Mycobacterium ulcerans lipase LipD 0.0072 0.0679 0.1222
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0077 0.0734 0.1168
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0031 0.0148 0.0266
Mycobacterium leprae Polyketide synthase Pks13 0.0453 0.5558 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0254 0.3009 0.5288
Echinococcus granulosus microtubule associated protein 2 0.0681 0.8473 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0488 0.0777
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0321 0.3869 0.6741
Plasmodium falciparum acyl carrier protein 0.0031 0.0148 0.2016
Loa Loa (eye worm) hypothetical protein 0.0072 0.0679 0.1081
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0679 0.9253
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.019 0.019
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0302 0.3626 0.6301
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0096 0.0981 0.1508
Entamoeba histolytica hypothetical protein 0.0037 0.0224 1
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0031 0.0148 0.0148
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0096 0.0981 0.1539
Loa Loa (eye worm) fatty acid synthase 0.0301 0.3608 0.5743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0945 0.1115
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0243 0.2863 0.5151
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0047 0.0353 0.0371
Brugia malayi AMP-binding enzyme family protein 0.0285 0.3403 0.4777
Leishmania major hypothetical protein, conserved 0.0076 0.0726 0.7801

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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