Detailed information for compound 1603090

Basic information

Technical information
  • TDR Targets ID: 1603090
  • Name: [2-methoxy-5-[(E)-(naphthalene-2-carbonylhydr azinylidene)methyl]phenyl] 4-acetamidobenzene sulfonate
  • MW: 517.553 | Formula: C27H23N3O6S
  • H donors: 2 H acceptors: 4 LogP: 4.33 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1OS(=O)(=O)c1ccc(cc1)NC(=O)C)/C=N/NC(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C27H23N3O6S/c1-18(31)29-23-10-12-24(13-11-23)37(33,34)36-26-15-19(7-14-25(26)35-2)17-28-30-27(32)22-9-8-20-5-3-4-6-21(20)16-22/h3-17H,1-2H3,(H,29,31)(H,30,32)/b28-17+
  • InChiKey: ZNMWIEZYWYQUIH-OGLMXYFKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-methoxy-5-[(naphthalene-2-carbonylhydrazinylidene)methyl]phenyl] 4-acetamidobenzenesulfonate
  • [2-methoxy-5-[(E)-(naphthalene-2-carbonylhydrazono)methyl]phenyl] 4-acetamidobenzenesulfonate
  • [2-methoxy-5-[(naphthalene-2-carbonylhydrazono)methyl]phenyl] 4-acetamidobenzenesulfonate
  • 4-acetamidobenzenesulfonic acid [2-methoxy-5-[(E)-[(2-naphthyl-oxomethyl)hydrazono]methyl]phenyl] ester
  • 4-acetamidobenzenesulfonic acid [2-methoxy-5-[[(2-naphthyl-oxomethyl)hydrazono]methyl]phenyl] ester
  • 4-acetamidobenzenesulfonic acid [2-methoxy-5-[(E)-(naphthalene-2-carbonylhydrazono)methyl]phenyl] ester
  • 4-acetamidobenzenesulfonic acid [2-methoxy-5-[(naphthalene-2-carbonylhydrazono)methyl]phenyl] ester
  • [2-methoxy-5-[(E)-(naphthalen-2-ylcarbonylhydrazinylidene)methyl]phenyl] 4-acetamidobenzenesulfonate
  • [2-methoxy-5-[(naphthalen-2-ylcarbonylhydrazinylidene)methyl]phenyl] 4-acetamidobenzenesulfonate
  • AN-698/40749131
  • 2-methoxy-5-[2-(2-naphthoyl)carbohydrazonoyl]phenyl 4-(acetylamino)benzenesulfonate
  • MLS000541168
  • SMR000160961

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0053 0.0107 0.1594
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0039 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0039 0.0576
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0001
Entamoeba histolytica protein kinase rad3, putative 0.0155 0.0367 0.5461
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0173 0.0412 0.6132
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0053 0.0107 0.1594
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0327
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2464 0.2464
Brugia malayi Muscleblind-like protein 0.0164 0.0389 0.5798
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0066
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0275 0.0671 0.0671
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0053 0.0107 0.1527
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0275 0.0671 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0275 0.0671 0.1809
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0053 0.0107 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0164 0.0389 0.5798
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0053 0.0107 0.1594
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0053 0.0107 0.0107
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.9077
Brugia malayi FAT domain containing protein 0.012 0.0277 0.4129
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0064 0.0064
Leishmania major phosphatidylinositol kinase, putative 0.0053 0.0107 0.0239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0107 0.1594
Brugia malayi Pre-SET motif family protein 0.0251 0.0612 0.9118
Plasmodium falciparum glutathione reductase 0.002 0.0023 0.1943
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.000000085411 0.0000012196
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0064 0.0957
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0021 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0001
Echinococcus multilocularis serine protein kinase ATM 0.0155 0.0367 0.0367
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.1594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0327
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0341 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0039 1
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0023 0.0327
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0053 0.0107 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Entamoeba histolytica hypothetical protein 0.0053 0.0107 0.1594
Loa Loa (eye worm) hypothetical protein 0.0102 0.0232 0.3459
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0053 0.0107 0.0307
Brugia malayi MH2 domain containing protein 0.0144 0.0339 0.5056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.9077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0367 0.5461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0107 0.1594
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0023 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0053 0.0107 0.1527
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0023 0.1943
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.1527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0107 0.1594
Loa Loa (eye worm) phosphatidylinositol kinase 0.0053 0.0107 0.1594
Brugia malayi Pre-SET motif family protein 0.0036 0.0064 0.0957
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0001 0.0003
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0053 0.0107 0.0511
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0341 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0277 0.3957
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0023 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0107 0.1594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.001 0.0142
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.1594
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0022 0.1863
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0023 1
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0412 0.5877
Schistosoma mansoni coup transcription factor 0.0011 0.0001 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0275 0.0671 0.0671
Entamoeba histolytica hypothetical protein 0.0155 0.0367 0.5461
Entamoeba histolytica hypothetical protein 0.0053 0.0107 0.1594
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0001 0.0003
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0023 0.0341
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0107 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0339 0.5056
Loa Loa (eye worm) glutathione reductase 0.0057 0.0118 0.1756
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0275 0.0671 0.0671
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0118 0.1756
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2093 0.2093
Plasmodium falciparum glutathione reductase 0.0057 0.0118 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.1594
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0053 0.0107 0.1527
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0021 0.0314
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0053 0.0107 0.0511
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0275 0.0671 0.1929
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0001 0.0003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0118 0.3064
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0039 0.0576
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0001 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0021 0.0314
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0327
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0001 0.0011
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0039 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0173 0.0412 0.6132
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0039 0.0576
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0001 0.0003
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0155 0.0367 0.5461
Loa Loa (eye worm) hypothetical protein 0.0182 0.0437 0.6508
Schistosoma mansoni fkbp-rapamycin associated protein 0.0155 0.0367 0.1752
Leishmania major phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.0239
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0304 0.885
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0039 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0053 0.0107 0.0307
Brugia malayi steroid hormone receptor 0.0011 0.0001 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0039 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.001 0.0142
Giardia lamblia GTOR 0.0275 0.0671 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0023 0.0023
Leishmania major phosphatidylinositol kinase related protein, putative 0.0053 0.0107 0.0239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0039 0.0603
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0039 0.0576
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.000000085411 0.0000012196
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0039 0.1134
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0023 0.0341
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0011
Onchocerca volvulus 0.0053 0.0107 0.1527
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0107 0.1594
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0155 0.0367 0.1053
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0023 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0011
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0118 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0107 0.1594
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0039 0.0049
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0275 0.0671 0.3207
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.000000085411 0.000000085411
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0011
Toxoplasma gondii thioredoxin reductase 0.0057 0.0118 0.1756
Onchocerca volvulus 0.0036 0.0064 0.0918
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0053 0.0107 0.0107
Leishmania major hypothetical protein, conserved 0.1431 0.3614 1
Onchocerca volvulus 0.0026 0.0039 0.0552
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0053 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1238
Mycobacterium leprae conserved hypothetical protein 0.0053 0.0107 0.3137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0107 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0039 0.0049
Onchocerca volvulus 0.0286 0.07 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0022 0.5677
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0023 0.0341
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0039 0.0049
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0155 0.0367 0.5461
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0001
Leishmania major phosphatidylinositol 3-kinase, putative 0.0275 0.0671 0.1809
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0023 0.0327
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0053 0.0107 0.1527
Echinococcus granulosus replication factor c subunit 1 0.0011 0.000000085411 0.000000085411
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0053 0.0107 0.1527
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0053 0.0107 0.1594
Echinococcus multilocularis muscleblind protein 0.0164 0.0389 0.0389
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0023 0.0066
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0576
Echinococcus multilocularis Zinc finger, PHD finger 0.0053 0.0107 0.0107
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0001 0.0011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0023 0.0341
Onchocerca volvulus 0.0011 0.0001 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0039 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0053 0.0107 0.9077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0021 0.0021
Toxoplasma gondii FATC domain-containing protein 0.0155 0.0367 0.5461
Giardia lamblia Hypothetical protein 0.0053 0.0107 0.1594
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0053 0.0107 0.0307
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0053 0.0107 0.1527
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0275 0.0671 0.1929
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0053 0.0107 0.0511
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0155 0.0367 0.1752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0011
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0083 0.0397
Schistosoma mansoni hypothetical protein 0.0043 0.0083 0.0397
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0023 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.000000085411 0.00000040814
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0021 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0107 0.1594
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0304 0.885
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0021 0.179
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0053 0.0107 0.0107
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.000000085411 0.0000012726
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.012 0.0277 0.0277
Brugia malayi hypothetical protein 0.0043 0.0083 0.1238
Entamoeba histolytica hypothetical protein 0.0053 0.0107 0.1594
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0023 0.1943
Trichomonas vaginalis set domain proteins, putative 0.0286 0.07 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.9077
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0021 0.0061
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0021 0.0314
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0011
Treponema pallidum NADH oxidase 0.002 0.0023 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0107 0.1594
Schistosoma mansoni hypothetical protein 0.0053 0.0107 0.0511
Plasmodium falciparum thioredoxin reductase 0.002 0.0023 0.1943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0001 0.001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0021 0.0021
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0173 0.0412 0.6132
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0053 0.0107 0.1594
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0367 0.1053
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0022 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0023 0.0066
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0118 0.0118
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0275 0.0671 0.1809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0066
Leishmania major trypanothione reductase 0.0057 0.0118 0.0269
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.1594
Loa Loa (eye worm) phosphatidylinositol 3 0.0275 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0021 0.0314
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0275 0.0671 1
Echinococcus multilocularis 0.0053 0.0107 0.0107
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0023 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0107 0.1594
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0275 0.0671 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0304 0.885
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1238
Brugia malayi Thioredoxin reductase 0.0057 0.0118 0.1756
Plasmodium vivax SET domain protein, putative 0.0036 0.0064 0.5454
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0275 0.0671 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0275 0.0671 0.1929
Entamoeba histolytica hypothetical protein 0.0053 0.0107 0.1594
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0275 0.0671 0.3207
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0275 0.0671 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0022 0.1863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0107 0.9077
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0232 0.3315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0001 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0021 0.0021
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.012 0.0277 0.0277
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0039 0.0576
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0021 0.0314
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0304 0.885
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0039 0.1134
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3941 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0053 0.0107 0.1527
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0053 0.0107 0.9077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0001 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0083 0.0083
Plasmodium falciparum thioredoxin reductase 0.0057 0.0118 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0275 0.0671 0.1929
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0023 0.0341
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0021 0.0021
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0107 0.0107
Leishmania major hypothetical protein, unknown function 0.0053 0.0107 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0064 0.0307
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0023 0.5921
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Onchocerca volvulus 0.0053 0.0107 0.1527
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0064 0.0307
Leishmania major phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.0239
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0339 0.5056
Trypanosoma brucei trypanothione reductase 0.0057 0.0118 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0107 0.1527
Echinococcus granulosus muscleblind protein 0.0164 0.0389 0.0389
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0053 0.0107 0.1527
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0275 0.0671 0.0671
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0367 0.5461
Mycobacterium ulcerans hypothetical protein 0.0026 0.0039 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0053 0.0107 0.1594
Loa Loa (eye worm) hypothetical protein 0.0164 0.0389 0.5798
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0064 0.0064
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0275 0.0671 0.1809
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0102 0.0232 0.0667
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0275 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0412 0.5877
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.1594
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.1594
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2093 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0053 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0232 0.3315
Plasmodium vivax glutathione reductase, putative 0.0057 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0021 0.179
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0275 0.0671 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Brugia malayi glutathione reductase 0.0057 0.0118 0.1756
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0304 0.885
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1238
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0053 0.0107 0.0239
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0021 0.0061
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0064 0.0307
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0053 0.0107 0.0511
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0001 0.0003
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0021 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.1378 0.348 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0001 0.0001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0107 0.1594
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0275 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0277 0.4129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0064 0.0307
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2093 0.2093
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.000000085411 0.0000012726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0039 0.0576
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0053 0.0107 0.9077
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0107 0.2727
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0053 0.0107 0.1527
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0053 0.0107 0.0511
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0023 0.0341
Loa Loa (eye worm) hypothetical protein 0.0036 0.0064 0.0957
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0275 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0107 0.1594
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0053 0.0107 0.0107
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0001 0.0001
Plasmodium vivax hypothetical protein 0.0053 0.0107 0.9077
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0039 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0061 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0001 0.0011
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0023 0.1943
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0107 0.1594
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0107 0.1594
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0066
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0053 0.0107 0.1594
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0053 0.0107 0.1594
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0001 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0304 0.8915
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0053 0.0107 0.0307
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0022 0.9588
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0001 0.0001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0023 0.0341
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0001 0.0001
Brugia malayi isocitrate dehydrogenase 0.0019 0.0021 0.0314
Echinococcus granulosus serine protein kinase ATM 0.0155 0.0367 0.0367
Brugia malayi hypothetical protein 0.0182 0.0437 0.6508
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0107 0.1527
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0023 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0053 0.0107 0.1527
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0053 0.0107 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0107 0.1527
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0023 0.0341
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0275 0.0671 1
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0023 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Loa Loa (eye worm) hypothetical protein 0.0155 0.0367 0.5461
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0118 0.0339
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0155 0.0367 0.0367
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0023 0.5921
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0005
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0389 0.0389
Brugia malayi ecdysteroid receptor 0.0011 0.0001 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.1594
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0011
Schistosoma mansoni hypothetical protein 0.012 0.0277 0.1324
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0053 0.0107 0.0307
Mycobacterium tuberculosis Probable reductase 0.013 0.0304 0.885
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.0307
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0021 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0107 0.1594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Brugia malayi nuclear hormone receptor 0.0011 0.0001 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0011
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0053 0.0107 0.1594
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0327
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0053 0.0107 0.0307
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.000000085411 0.0000012196
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0023 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0021 0.0314
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0275 0.0671 0.1929
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0155 0.0367 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0107 0.1594
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0612 0.9118
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0039 0.0603
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0023 0.5921
Onchocerca volvulus 0.0182 0.0437 0.6237
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0053 0.0107 0.1527
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0341 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0053 0.0107 0.0107
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0107 0.1594
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0001
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0275 0.0671 0.1809
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0327
Toxoplasma gondii target of rapamycin (TOR), putative 0.0275 0.0671 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0053 0.0107 0.1594
Brugia malayi nuclear receptor NHR-88 0.0011 0.0001 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0083 0.0083
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0053 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0367 0.5234
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0023 0.1943
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0053 0.0107 0.9077
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0053 0.0107 0.0511
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0341 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0576
Loa Loa (eye worm) hypothetical protein 0.0053 0.0107 0.1594
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0118 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0023 0.0066
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0053 0.0107 0.1594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0107 0.0107
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0107 0.1594
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.0671 0.9583
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0053 0.0107 0.1527

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 49.75 um PUBCHEM_BIOASSAY: Cytotoxicity counterscreen assay for inhibitors of Wee1 degradation. (Class of assay: confirmatory) [Related pubchem assays: 1410, 1321 ] ChEMBL. No reference
EC50 (functional) > 49.75 um PUBCHEM_BIOASSAY: Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation. (Class of assay: confirmatory) [Related pubchem assays: 1410, 1321 ] ChEMBL. No reference
EC50 (functional) > 49.75 um PUBCHEM_BIOASSAY: Dose Response Cell-based Assay for Inhibitors of Wee1 Degradation. (Class of assay: confirmatory) [Related pubchem assays: 1410, 1321 ] ChEMBL. No reference
Potency (functional) 0.1259 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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