Detailed information for compound 1611411

Basic information

Technical information
  • TDR Targets ID: 1611411
  • Name: N-[2-(6,7-dimethyl-3-oxo-2,4-dihydroquinoxali n-1-yl)-2-oxoethyl]-N-(4-ethoxyphenyl)acetami de
  • MW: 395.452 | Formula: C22H25N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)N(C(=O)C)CC(=O)N1CC(=O)Nc2c1cc(C)c(c2)C
  • InChi: 1S/C22H25N3O4/c1-5-29-18-8-6-17(7-9-18)24(16(4)26)13-22(28)25-12-21(27)23-19-10-14(2)15(3)11-20(19)25/h6-11H,5,12-13H2,1-4H3,(H,23,27)
  • InChiKey: BHOMENCYGJQALO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(6,7-dimethyl-3-oxo-2,4-dihydroquinoxalin-1-yl)-2-oxo-ethyl]-N-(4-ethoxyphenyl)acetamide
  • N-(4-ethoxyphenyl)-N-[2-keto-2-(3-keto-6,7-dimethyl-2,4-dihydroquinoxalin-1-yl)ethyl]acetamide
  • N-[2-(6,7-dimethyl-3-oxo-2,4-dihydroquinoxalin-1-yl)-2-oxo-ethyl]-N-(4-ethoxyphenyl)ethanamide
  • AIDS-140649
  • AIDS140649
  • N-(2-(6,7-Dimethyl-3-oxo-3,4-dihydro-1(2H)-quinoxalinyl)-2-oxoethyl)-N-(4-ethoxyphenyl)acetamide
  • NSC653324
  • NCI60_018630

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0258 0.0622 1
Mycobacterium leprae conserved hypothetical protein 0.0239 0.0568 0.5
Giardia lamblia GTOR 0.3557 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2127 0.5933 0.59
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0297 0.0733 0.0725
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0105 0.0185 0.0104
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0043 0.0009 0.0009
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0105 0.0185 0.0177
Schistosoma mansoni voltage-gated potassium channel 0.0168 0.0365 0.0365
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0258 0.0622 0.075
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0239 0.0568 0.9111
Trichomonas vaginalis PIKK family atypical protein kinase 0.2121 0.5917 0.5884
Leishmania major hypothetical protein, conserved 0.0328 0.0819 0.0646
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0691 0.1851 0.1851
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0258 0.0622 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.2656 0.7438 0.7417
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2841 0.7963 0.7924
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0239 0.0568 0.056
Loa Loa (eye worm) phosphatidylinositol 3 0.1231 0.3386 0.3376
Trichomonas vaginalis PIKK family atypical protein kinase 0.122 0.3356 0.3301
Schistosoma mansoni fkbp-rapamycin associated protein 0.0691 0.1851 0.1851
Entamoeba histolytica hypothetical protein 0.0691 0.1851 0.1851
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0117 0.022 0.0207
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0239 0.0568 0.9111
Trichomonas vaginalis PIKK family atypical protein kinase 0.2656 0.7438 0.7417
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0258 0.0622 0.0622
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0239 0.0568 0.0568
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0239 0.0568 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.3557 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1269 0.3495 0.3489
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0622 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.3557 1 1
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0639 0.1704 0.1704
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0042 0.0007 0.0007
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0117 0.022 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.1937 0.5393 0.5355
Entamoeba histolytica hypothetical protein 0.0239 0.0568 0.0568
Echinococcus granulosus serine/threonine protein kinase 0.0047 0.0021 0.0021
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0239 0.0568 0.0568
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0451 0.117 0.1098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0701 0.188 0.1813
Echinococcus multilocularis voltage gated potassium channel 0.0045 0.0014 0.0014
Loa Loa (eye worm) phosphatidylinositol kinase 0.0239 0.0568 0.0554
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0258 0.0622 0.0622
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1269 0.3495 0.3495
Trichomonas vaginalis PIKK family atypical protein kinase 0.2656 0.7438 0.7417
Schistosoma mansoni voltage-gated potassium channel 0.0168 0.0365 0.0365
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0424 0.1094 0.102
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0297 0.0733 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.0568 0.049
Loa Loa (eye worm) hypothetical protein 0.0691 0.1851 0.1839
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0105 0.0185 0.0185
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.053 0.1393 0.1393
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0622 0.0614
Loa Loa (eye worm) phosphatidylinositol 3 0.0239 0.0568 0.0554
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.022 0.0212
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0117 0.022 0.0212
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0117 0.022 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0956 0.2605 0.2544
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0117 0.022 0.0212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0318 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.009 0.0144 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.5401 0.5363
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0239 0.0568 0.9111
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3557 1 1
Entamoeba histolytica hypothetical protein 0.0239 0.0568 0.0568
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0117 0.022 0.0212
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0239 0.0568 0.0568
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0105 0.0185 0.0104
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0701 0.188 0.188
Trypanosoma brucei hypothetical protein, conserved 0.0117 0.022 0.014
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0592 0.1571 0.1571
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0014 0.0014
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3557 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0239 0.0568 0.0554
Toxoplasma gondii FATC domain-containing protein 0.0691 0.1851 0.2417
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1231 0.3386 0.3261
Trichomonas vaginalis PIKK family atypical protein kinase 0.2308 0.6449 0.642
Trichomonas vaginalis PIKK family atypical protein kinase 0.2656 0.7438 0.7417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.1851 0.1783
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0117 0.022 0.022
Loa Loa (eye worm) phosphatidylinositol 3 0.0553 0.146 0.1448
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0105 0.0185 0.0185
Trypanosoma cruzi Protein kinase B 0.0047 0.0021 0.0012
Echinococcus multilocularis nervana 2 0.0042 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0239 0.0568 0.0568
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0258 0.0622 0.0622
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0105 0.0185 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.1937 0.5393 0.5355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0239 0.0568 0.0568
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0239 0.0568 0.056
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0258 0.0622 1
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0117 0.022 0.0212
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0239 0.0568 0.9111
Loa Loa (eye worm) hypothetical protein 0.0769 0.2073 0.2062
Trichomonas vaginalis PIKK family atypical protein kinase 0.122 0.3356 0.3301
Echinococcus granulosus voltage gated potassium channel 0.0045 0.0014 0.0014
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3557 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0258 0.0622 0.0545
Schistosoma mansoni immunophilin 0.0105 0.0185 0.0185
Leishmania major phosphatidylinositol kinase, putative 0.0239 0.0568 0.039
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0105 0.0185 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0046 0.0046
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.0082 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.5401 0.5363
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0258 0.0622 0.075
Onchocerca volvulus 0.0239 0.0568 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0046 0.0046
Giardia lamblia Hypothetical protein 0.0239 0.0568 0.056
Leishmania major phosphatidylinositol 4-kinase, putative 0.0239 0.0568 0.039
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0105 0.0185 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.2838 0.7955 0.7938
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0639 0.1704 0.1696
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0117 0.022 0.014
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0043 0.0009 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0046 0.0046
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3557 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0239 0.0568 0.0568
Schistosoma mansoni choline o-acyltransferase 0.0117 0.022 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.2387 0.6672 0.6644
Entamoeba histolytica hypothetical protein 0.0239 0.0568 0.0568
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0105 0.0185 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.3028 0.8495 0.8482
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0239 0.0568 0.0676
Schistosoma mansoni serine/threonine-protein kinase 0.0047 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.022 0.0212
Leishmania major carnitine/choline acetyltransferase, putative 0.0117 0.022 0.0036
Echinococcus multilocularis 0.0239 0.0568 0.0568
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0258 0.0622 0.0622
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0105 0.0185 0.0185
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.009 0.0144 0.0144
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0297 0.0733 0.0657
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0691 0.1851 0.1851
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0258 0.0622 0.0622
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0014 0.0014
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.053 0.1393 0.1393
Loa Loa (eye worm) hypothetical protein 0.0357 0.0903 0.089
Brugia malayi Choline O-acetyltransferase 0.0117 0.022 0.022
Schistosoma mansoni immunophilin 0.009 0.0144 0.0144
Echinococcus granulosus choline O acetyltransferase 0.0117 0.022 0.022
Trichomonas vaginalis fk506-binding protein, putative 0.0105 0.0185 0.0104
Echinococcus multilocularis Glutaredoxin protein 5 0.0042 0.0007 0.0007
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0117 0.022 0.0212
Onchocerca volvulus 0.0239 0.0568 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0105 0.0185 0.0171
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0168 0.0365 0.0365
Leishmania major phosphatidylinositol 3-kinase, putative 0.0258 0.0622 0.0445
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0691 0.1851 0.1851
Trichomonas vaginalis PIKK family atypical protein kinase 0.2838 0.7955 0.7938
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1269 0.3495 0.3495
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3557 1 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0105 0.0185 0.0104
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0258 0.0622 0.0622
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0239 0.0568 0.056
Brugia malayi p70 ribosomal S6 kinase beta 0.0064 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.5401 0.5363
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3557 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0592 0.1571 0.1571
Plasmodium vivax hypothetical protein, conserved 0.0239 0.0568 0.9111
Loa Loa (eye worm) hypothetical protein 0.1333 0.3678 0.3669
Entamoeba histolytica protein kinase, putative 0.0068 0.0082 0.0082
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0154 0.0325 0.0325
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0385 0.0983 0.0983
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0014 0.0014
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0258 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.1231 0.3386 0.3331
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0117 0.022 0.014
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0297 0.0733 0.0733
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0258 0.0622 0.0609
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0297 0.0733 0.0733
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0053 0.0038
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0424 0.1094 0.1094
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0154 0.0325 0.0311
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1269 0.3495 0.3489
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0239 0.0568 0.0568
Loa Loa (eye worm) FKBP5 protein 0.0105 0.0185 0.0171
Entamoeba histolytica hypothetical protein 0.0385 0.0983 0.0983
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0297 0.0733 0.0733
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0117 0.022 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.117 0.1098
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1269 0.3495 0.3495
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0239 0.0568 0.049
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0154 0.0325 0.0325
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1269 0.3495 0.3495
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0105 0.0185 0.5
Echinococcus granulosus serine threonine protein kinase nrc 0.0043 0.0009 0.0009
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0239 0.0568 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.2127 0.5933 0.59
Plasmodium vivax hypothetical protein 0.0239 0.0568 0.9111
Echinococcus multilocularis rac serine:threonine kinase 0.0047 0.0021 0.0021
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0045 0.0014 0.0014
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0424 0.1094 0.1086
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.5401 0.5363
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0144 0.0296 0.0216
Echinococcus granulosus serine protein kinase ATM 0.0691 0.1851 0.1851
Schistosoma mansoni choline o-acyltransferase 0.0117 0.022 0.022
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0117 0.022 0.014
Echinococcus granulosus nervana 2 0.0042 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.022 0.0212
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0021 0.0021
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0239 0.0568 0.0568
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0691 0.1851 0.1851
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0105 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.2656 0.7438 0.7417
Echinococcus granulosus Glutaredoxin protein 5 0.0042 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.2656 0.7438 0.7417
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0639 0.1704 0.1704
Brugia malayi Protein kinase domain containing protein 0.0068 0.0082 0.0082
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0278 0.0678 0.067
Loa Loa (eye worm) choline O-acetyltransferase 0.0117 0.022 0.0207
Schistosoma mansoni hypothetical protein 0.0239 0.0568 0.0568
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0592 0.1571 0.1571
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0297 0.0733 0.0733
Leishmania major phosphatidylinositol kinase related protein, putative 0.0239 0.0568 0.039
Leishmania major hypothetical protein, unknown function 0.0239 0.0568 0.039
Giardia lamblia Phosphatidylinositol 4-kinase 0.0239 0.0568 0.056
Entamoeba histolytica protein kinase, putative 0.0068 0.0082 0.0082
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0622 0.0614
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0105 0.0185 0.0104
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0239 0.0568 0.049
Trichomonas vaginalis immunophilin, putative 0.0105 0.0185 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0139 0.013
Echinococcus multilocularis nervana 2 0.0042 0.0007 0.0007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2841 0.7963 0.7946
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0239 0.0568 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.053 0.1393 0.1322
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0239 0.0568 0.056
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0258 0.0622 0.0545
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0424 0.1094 0.102
Trichomonas vaginalis PIKK family atypical protein kinase 0.2121 0.5917 0.5884
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0105 0.0185 0.0185
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0639 0.1704 0.1547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.0568 0.049
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3557 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0046 0.0046
Trypanosoma cruzi target of rapamycin kinase 3 0.2841 0.7963 0.7961
Echinococcus multilocularis fk506 binding protein 0.0105 0.0185 0.0185
Toxoplasma gondii target of rapamycin (TOR), putative 0.2656 0.7438 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0267 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0769 0.2073 0.2008
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0105 0.0185 0.2879
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0239 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0067 0.0078 0.0064
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0691 0.1851 0.1844
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0239 0.0568 0.0676
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0042 0.0007 0.0007
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0239 0.0568 0.0568
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0105 0.0185 0.0185
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1333 0.3678 0.3678
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0105 0.0185 0.0177
Leishmania major phosphatidylinositol 3-kinase, putative 0.122 0.3356 0.323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0046 0.0046
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0239 0.0568 0.9111
Trichomonas vaginalis PIKK family atypical protein kinase 0.2127 0.5933 0.59
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0691 0.1851 0.1844
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0691 0.1851 0.1851
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0357 0.0903 0.0903
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0489 0.1276 0.1276
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1488 0.4118 0.407
Loa Loa (eye worm) phosphatidylinositol 3 0.3557 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0046 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0056 0.0046 0.0031
Entamoeba histolytica protein kinase 2, putative 0.0043 0.0009 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0056 0.0046 0.0046
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0239 0.0568 0.056
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0365 0.0924 0.0849
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1231 0.3386 0.3331
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.122 0.3356 0.3301
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3557 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0424 0.1094 0.1094
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0117 0.022 0.0212
Loa Loa (eye worm) phosphatidylinositol 3 0.0239 0.0568 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.122 0.3356 0.3301
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0622 0.0445
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0424 0.1094 0.102
Trichomonas vaginalis PIKK family atypical protein kinase 0.3557 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0489 0.1276 0.1276
Trichomonas vaginalis PIKK family atypical protein kinase 0.2838 0.7955 0.7938
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0154 0.0325 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0046 0.0046
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0064 0.007 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0357 0.0903 0.0903
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0769 0.2073 0.2719
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0105 0.0185 0.0177
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1675 0.465 0.4606
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0105 0.0185 0.5
Loa Loa (eye worm) hypothetical protein 0.0239 0.0568 0.0554
Echinococcus multilocularis serine protein kinase ATM 0.0691 0.1851 0.1851
Loa Loa (eye worm) hypothetical protein 0.0451 0.117 0.1158
Loa Loa (eye worm) hypothetical protein 0.0717 0.1925 0.1913
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3557 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0047 0.0021 0.0021
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0357 0.0903 0.0903
Loa Loa (eye worm) phosphatidylinositol 3 0.0239 0.0568 0.0554
Echinococcus multilocularis choline O acetyltransferase 0.0117 0.022 0.022
Brugia malayi FAT domain containing protein 0.053 0.1393 0.1393
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0297 0.0733 0.0657
Mycobacterium tuberculosis Conserved hypothetical protein 0.0239 0.0568 0.5
Schistosoma mansoni immunophilin 0.0105 0.0185 0.0185
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0117 0.022 0.014
Brugia malayi Choline O-acetyltransferase 0.0117 0.022 0.022
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0239 0.0568 0.0676
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.009 0.0144 0.0144
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0691 0.1851 0.1783
Schistosoma mansoni hypothetical protein 0.053 0.1393 0.1393
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0117 0.022 0.022
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3557 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0424 0.1094 0.1086
Leishmania major carnitine palmitoyltransferase-like protein 0.0117 0.022 0.0036
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0451 0.117 0.1163
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0144 0.0296 0.0216
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0297 0.0733 0.0657
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0365 0.0924 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.122 0.3356 0.3301
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0047 0.0021 0.0012
Echinococcus granulosus nervana 2 0.0042 0.0007 0.0007
Echinococcus multilocularis Zinc finger, PHD finger 0.0258 0.0622 0.0622
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0185 0.0413 0.0413
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0326 0.0813 0.0805
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0058 0.0053 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.022 0.0212
Entamoeba histolytica protein kinase, putative 0.0064 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.022 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.2838 0.7955 0.7938
Entamoeba histolytica protein kinase rad3, putative 0.0691 0.1851 0.1851
Loa Loa (eye worm) hypothetical protein 0.0117 0.022 0.0207
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0639 0.1704 0.1696
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0014 0.0014
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0105 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.053 0.1393 0.138
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0105 0.0185 0.2879
Trichomonas vaginalis PIKK family atypical protein kinase 0.2838 0.7955 0.7938
Trichomonas vaginalis PIKK family atypical protein kinase 0.2656 0.7438 0.7417
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3557 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0258 0.0622 0.0622
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0239 0.0568 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.1937 0.5393 0.5355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.1851 0.1783

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.121 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.08 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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