Detailed information for compound 1620253

Basic information

Technical information
  • TDR Targets ID: 1620253
  • Name: [1,5-bis[(2-aminoacetyl)amino]-5-phosphonopen tyl]phosphonic acid
  • MW: 376.241 | Formula: C9H22N4O8P2
  • H donors: 8 H acceptors: 8 LogP: -9.78 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCC(=O)NC(P(=O)(O)O)CCCC(P(=O)(O)O)NC(=O)CN
  • InChi: 1S/C9H22N4O8P2/c10-4-6(14)12-8(22(16,17)18)2-1-3-9(23(19,20)21)13-7(15)5-11/h8-9H,1-5,10-11H2,(H,12,14)(H,13,15)(H2,16,17,18)(H2,19,20,21)
  • InChiKey: HZLIYXKJDMAPBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1,5-bis[(2-aminoacetyl)amino]-5-phosphono-pentyl]phosphonic acid
  • [1,5-bis[(2-amino-1-oxoethyl)amino]-5-phosphonopentyl]phosphonic acid
  • [1,5-bis(glycylamino)-5-phosphono-pentyl]phosphonic acid
  • [1,5-bis(2-aminoethanoylamino)-5-phosphono-pentyl]phosphonic acid
  • NSC629305
  • Phosphonic acid, [1,5-bis[(aminoacetyl)amino]-1,5-pentanediyl]bis-
  • NCI60_009510
  • AIDS-133503
  • AIDS133503

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0212 0.0715
Echinococcus multilocularis voltage dependent calcium channel 0.0075 0.0456 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0201 0.1019
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0035 0.0181 0.0213
Echinococcus multilocularis nervana 2 0.0082 0.05 0.05
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0058 0.014
Echinococcus multilocularis protein kinase c epsilon type 0.0044 0.0244 0.0244
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0058 0.0069
Mycobacterium ulcerans beta-lactamase 0.0038 0.0201 0.052
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.017 0.1106 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0201 0.1614
Trichomonas vaginalis AGC family protein kinase 0.017 0.1106 0.3971
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0192 0.0226
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0048 0.0269 0.1514
Brugia malayi serine/threonine-protein kinase 6 0.017 0.1106 0.2651
Entamoeba histolytica protein kinase, putative 0.0126 0.0805 0.7118
Echinococcus multilocularis muscleblind protein 1 0.0274 0.1825 0.1825
Trichomonas vaginalis esterase, putative 0.0038 0.0201 0.0673
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0044 0.0244 0.0244
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.017 0.1106 1
Schistosoma mansoni hypothetical protein 0.0038 0.0203 0.0238
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0058 0.034 0.1035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0135 0.0158
Echinococcus granulosus Niemann Pick C1 protein 0.0093 0.0576 0.0678
Echinococcus multilocularis Aminotransferase class III 0.0058 0.034 0.034
Brugia malayi nuclear hormone receptor 0.0017 0.0058 0.014
Loa Loa (eye worm) hypothetical protein 0.017 0.1107 0.2653
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.017 0.1106 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0058 0.014
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0075 0.0456 0.0536
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0805 0.2873
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0284 0.214
Entamoeba histolytica protein kinase , putative 0.017 0.1106 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Entamoeba histolytica hypothetical protein 0.0031 0.0152 0.0878
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0044 0.0244 0.0584
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0192 0.0226
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0192 0.046
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0201 0.0673
Echinococcus multilocularis voltage dependent calcium channel 0.0075 0.0456 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0192 0.046
Mycobacterium ulcerans L-lysine aminotransferase 0.0058 0.034 0.1035
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0284 0.1625
Schistosoma mansoni dishevelled 0.001 0.001 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0058 0.0442
Plasmodium vivax ornithine aminotransferase, putative 0.0058 0.034 0.2672
Echinococcus multilocularis protein dispatched 1 0.0045 0.0251 0.0251
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0058 0.034 0.1035
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0016 0.0039
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0126 0.0805 0.1929
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0192 0.0192
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0058 0.034 0.1035
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0201 0.0673
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0082 0.05 0.05
Schistosoma mansoni hypothetical protein 0.0061 0.0362 0.0426
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.001 0.0011
Echinococcus multilocularis ornithine aminotransferase 0.0058 0.034 0.034
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0192 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Mycobacterium ulcerans lipase LipD 0.0038 0.0201 0.052
Trypanosoma brucei protein kinase, putative 0.005 0.0284 0.1625
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0192 0.046
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0084 0.0519 0.061
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0192 0.0192
Echinococcus granulosus serine:threonine protein kinase 12 B 0.017 0.1106 0.1301
Brugia malayi nuclear receptor NHR-88 0.0037 0.0192 0.046
Schistosoma mansoni coup transcription factor 0.0037 0.0192 0.0226
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0044 0.0244 0.0287
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0075 0.0456 0.0536
Schistosoma mansoni cellular tumor antigen P53 0.0043 0.0232 0.0274
Leishmania major mitochondrial DNA polymerase beta 0.0218 0.1437 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0016 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0192 0.046
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0016 0.0019
Brugia malayi steroid hormone receptor 0.0037 0.0192 0.046
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0084 0.0519 0.0519
Echinococcus multilocularis nervana 2 0.0082 0.05 0.05
Brugia malayi hypothetical protein 0.0017 0.0058 0.014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0028 0.0135 0.0158
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0244 0.0829
Brugia malayi nuclear receptor RXR 0.0017 0.0058 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0244 0.0287
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0192 0.0226
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.009 0.0283
Echinococcus granulosus microtubule associated protein 2 0.1244 0.8498 1
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0016 0.0016
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0058 0.034 0.04
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0135 0.0323
Echinococcus multilocularis sodium channel protein 0.0035 0.0181 0.0181
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0244 0.0287
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0192 0.0192
Trichomonas vaginalis AGC family protein kinase 0.017 0.1106 0.3971
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0284 0.0682
Brugia malayi conserved hypotetical protein 0.0017 0.0058 0.014
Echinococcus granulosus protein kinase C gamma type 0.0044 0.0244 0.0287
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0075 0.0456 0.1092
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0201 0.0236
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0284 0.0335
Echinococcus multilocularis sterol regulatory element binding protein 0.004 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0584
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0058 0.0069
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0073 0.0174
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0016 0.0039
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0058 0.014
Brugia malayi Hr1 repeat family protein 0.0044 0.0244 0.0584
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0016 0.0016
Schistosoma mansoni serine/threonine-protein kinase 0.0084 0.0519 0.061
Schistosoma mansoni hypothetical protein 0.0038 0.0203 0.0238
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0201 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0058 0.0069
Echinococcus granulosus Glutaredoxin protein 5 0.0082 0.05 0.0588
Onchocerca volvulus 0.0043 0.0232 0.2031
Schistosoma mansoni hypothetical protein 0.0028 0.0135 0.0158
Loa Loa (eye worm) DR-78 0.0017 0.0058 0.014
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0284 0.0284
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0058 0.034 0.1035
Echinococcus granulosus GPCR family 2 0.0028 0.0135 0.0158
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0073 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0192 0.046
Mycobacterium ulcerans hypothetical protein 0.0038 0.0201 0.052
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0061 0.0061
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0058 0.014
Entamoeba histolytica protein kinase, putative 0.017 0.1106 1
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0835 0.2001
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.009 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0016 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0201 0.052
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.009 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0244 0.0829
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Schistosoma mansoni nuclear receptor 0.0017 0.0058 0.0069
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0284 0.1625
Plasmodium falciparum ornithine aminotransferase 0.0058 0.034 0.2672
Entamoeba histolytica hypothetical protein 0.0031 0.0152 0.0878
Brugia malayi serine/threonine protein kinase 6 0.017 0.1106 0.2651
Loa Loa (eye worm) TAR-binding protein 0.006 0.0349 0.0837
Leishmania major hypothetical protein, conserved 0.0038 0.0201 0.1019
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0058 0.034 0.2903
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0174
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0058 0.034 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0093 0.0576 0.1381
Toxoplasma gondii exonuclease III APE 0.0018 0.0061 0.0315
Brugia malayi nuclear receptor RXR 0.0019 0.0073 0.0174
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.009 0.1061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0332 0.1004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0192 0.046
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0332 0.039
Echinococcus multilocularis muscleblind protein 0.0274 0.1825 0.1825
Onchocerca volvulus 0.0038 0.0201 0.1743
Schistosoma mansoni hypothetical protein 0.0179 0.1172 0.1379
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0244 0.0287
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0218 0.1437 1
Schistosoma mansoni hypothetical protein 0.0126 0.0802 0.0944
Echinococcus multilocularis serine:threonine protein kinase 38 0.0044 0.0244 0.0244
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0078 0.0477 0.0561
Brugia malayi beta-lactamase family protein 0.0038 0.0201 0.0482
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0044 0.0244 0.0244
Schistosoma mansoni amyloid beta A4 protein related 0.005 0.028 0.0329
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0073 0.0085
Entamoeba histolytica protein kinase domain containing protein 0.017 0.1106 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.009 0.0589
Schistosoma mansoni serine/threonine-protein kinase 0.0084 0.0519 0.061
Brugia malayi beta-lactamase family protein 0.0038 0.0201 0.0482
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0192 0.0226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0482
Brugia malayi hypothetical protein 0.0115 0.0732 0.1754
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0061 0.0145
Brugia malayi nuclear receptor NHR-67 0.0017 0.0058 0.014
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0332 0.039
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.041 0.276 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0192 0.046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0192 0.046
Echinococcus multilocularis amyloid beta A4 protein 0.005 0.028 0.028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0135 0.0323
Brugia malayi CHE-14 protein 0.004 0.0212 0.0509
Loa Loa (eye worm) hypothetical protein 0.0115 0.0732 0.1754
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.001 0.001
Echinococcus granulosus calcium activated potassium channel 0.001 0.001 0.0012
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.017 0.1106 0.1106
Mycobacterium tuberculosis Probable aminotransferase 0.041 0.276 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0126 0.0802 0.1923
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0058 0.034 0.1035
Brugia malayi Protein kinase domain containing protein 0.0044 0.0244 0.0584
Echinococcus granulosus muscleblind protein 0.0274 0.1825 0.2147
Brugia malayi DIX domain containing protein 0.001 0.001 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0835 0.2001
Loa Loa (eye worm) AUR protein kinase 0.017 0.1106 0.2651
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0192 0.0192
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0016 0.0019
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0016 0.0019
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0084 0.0519 0.438
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0058 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0284 0.0977
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0201 0.1342
Schistosoma mansoni ap endonuclease 0.0018 0.0061 0.0071
Brugia malayi hypothetical protein 0.0048 0.0266 0.0638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0192 0.046
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0073 0.0174
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0332 0.1004
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0805 0.2873
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0044 0.0244 0.0584
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0201 0.0673
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0061 0.0071
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0058 0.034 0.0815
Trypanosoma brucei aurora B kinase 0.017 0.1106 0.7595
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0201 0.052
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.009 0.011
Brugia malayi MAP kinase sur-1 0.005 0.0284 0.0682
Plasmodium vivax serine/threonine protein kinase 6, putative 0.017 0.1106 1
Echinococcus granulosus geminin 0.0179 0.1172 0.1379
Schistosoma mansoni dishevelled 0.001 0.001 0.0011
Entamoeba histolytica protein kinase, putative 0.0126 0.0805 0.7118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0192 0.046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0192 0.046
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0061 0.0145
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0044 0.0244 0.0584
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0189
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0058 0.0069
Onchocerca volvulus 0.0038 0.0201 0.1743
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0058 0.014
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0519 0.438
Echinococcus granulosus ornithine aminotransferase 0.0058 0.034 0.04
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0075 0.0456 0.1092
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0332 0.2826
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.001 0.0023
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0016 0.0019
Echinococcus granulosus survival motor neuron protein 1 0.0615 0.4172 0.4909
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.0152 0.0179
Echinococcus granulosus protein kinase c iota type 0.0044 0.0244 0.0287
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0332 0.0332
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0058 0.034 0.1035
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.041 0.276 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0174
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0016 0.0019
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0058 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0192 0.046
Brugia malayi Muscleblind-like protein 0.0274 0.1825 0.4374
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0016 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0073 0.0174
Echinococcus multilocularis Niemann Pick C1 protein 0.0093 0.0576 0.0576
Schistosoma mansoni tar DNA-binding protein 0.006 0.0349 0.0411
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1106 0.1301
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0201 0.052
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0073 0.0085
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.017 0.1107 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0192 0.046
Loa Loa (eye worm) hypothetical protein 0.0061 0.0362 0.0867
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0805 0.2873
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0218 0.1437 1
Echinococcus granulosus protein kinase c epsilon type 0.0044 0.0244 0.0287
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0058 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0244 0.0287
Brugia malayi hypothetical protein 0.0615 0.4172 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.009 0.0589
Onchocerca volvulus 0.0038 0.0201 0.1743
Trichomonas vaginalis AGC family protein kinase 0.017 0.1106 0.3971
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0075 0.0456 0.0536
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0805 0.2873
Mycobacterium ulcerans hypothetical protein 0.041 0.276 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1612 0.575
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0011 0.0016 0.0039
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.009 0.011
Mycobacterium tuberculosis Conserved protein 0.0038 0.0201 0.052
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0061 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0201 0.1019
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0058 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0201 0.052
Loa Loa (eye worm) AUR protein kinase 0.017 0.1106 0.2651
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.009 0.011
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.009 1
Echinococcus granulosus voltage dependent calcium channel 0.002 0.0079 0.0093
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0058 0.034 0.0935
Echinococcus granulosus nervana 2 0.0082 0.05 0.0588
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0192 0.0226
Echinococcus multilocularis tumor protein p63 0.0292 0.1944 0.1944
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.009 0.0557 0.1336
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0349 0.0837
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.041 0.276 1
Schistosoma mansoni hypothetical protein 0.0031 0.0152 0.0179
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0079 0.0483
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0244 0.0829
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0192 0.046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0031 0.015 0.0646
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0075 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0482
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0201 0.052
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0192 0.0226
Mycobacterium tuberculosis Conserved protein 0.0038 0.0201 0.052
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0016 0.0016
Brugia malayi p70 ribosomal S6 kinase beta 0.0126 0.0805 0.1929
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0016 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0058 0.0442
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Schistosoma mansoni hypothetical protein 0.0038 0.0203 0.0238
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0016 0.0019
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0058 0.014
Schistosoma mansoni serine/threonine kinase 0.0044 0.0244 0.0287
Schistosoma mansoni tar DNA-binding protein 0.006 0.0349 0.0411
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0016 0.0019
Schistosoma mansoni survival motor neuron protein 0.0126 0.0802 0.0944
Loa Loa (eye worm) RNA binding protein 0.006 0.0349 0.0837
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0332 0.1969
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0103 0.0648 0.4267
Onchocerca volvulus Huntingtin homolog 0.0115 0.0732 0.6584
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0192 0.0226
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0084 0.0519 0.3327
Mycobacterium tuberculosis Conserved hypothetical protein 0.0115 0.0728 0.2472
Brugia malayi protein kinase C II. 0.0044 0.0244 0.0584
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0174
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0011 0.0016 0.0039
Brugia malayi beta-lactamase 0.0038 0.0201 0.0482
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0284 0.0335
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0058 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0192 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0244 0.0287
Loa Loa (eye worm) hypothetical protein 0.0078 0.0477 0.1144
Echinococcus multilocularis rac serine:threonine kinase 0.0084 0.0519 0.0519
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0192 0.166
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0201 0.1019
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.001 0.0011
Echinococcus granulosus sterol regulatory element binding protein 0.004 0.0212 0.025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0201 0.052
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0044 0.0244 0.0244
Loa Loa (eye worm) AGC/NDR protein kinase 0.0044 0.0244 0.0584
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0648 0.4267
Onchocerca volvulus 0.0037 0.0192 0.166
Onchocerca volvulus 0.0078 0.0477 0.4261
Entamoeba histolytica hypothetical protein 0.0022 0.009 0.0283
Loa Loa (eye worm) calcium channel 0.0075 0.0456 0.1092
Entamoeba histolytica hypothetical protein 0.0031 0.0152 0.0878
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0058 0.0069
Schistosoma mansoni atypical protein kinase C 0.0044 0.0244 0.0287
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.004 0.0212 0.0509
Brugia malayi Protein kinase domain containing protein 0.0044 0.0244 0.0584
Entamoeba histolytica protein kinase, putative 0.0044 0.0244 0.1752
Echinococcus multilocularis Glutaredoxin protein 5 0.0082 0.05 0.05
Schistosoma mansoni hypothetical protein 0.0028 0.0135 0.0158
Loa Loa (eye worm) hypothetical protein 0.0093 0.0576 0.1381
Brugia malayi serine/threonine kinase 12 0.017 0.1106 0.2651
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0323
Echinococcus granulosus voltage dependent calcium channel 0.0075 0.0456 0.0536
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0244 0.0287
Schistosoma mansoni protein kinase 0.017 0.1106 0.1301
Brugia malayi ecdysteroid receptor 0.0037 0.0192 0.046
Echinococcus granulosus Protein patched homolog 1 0.004 0.0212 0.025
Echinococcus granulosus nervana 2 0.0082 0.05 0.0588
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0016 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0192 0.0192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0192 0.0192
Onchocerca volvulus 0.0017 0.0058 0.0442
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0016 0.0019
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0016 0.0016
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0058 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0192 0.046
Brugia malayi N-terminal motif family protein 0.017 0.1107 0.2653
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0284 0.2387
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0058 0.034 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0192 0.0226
Loa Loa (eye worm) hypothetical protein 0.0274 0.1825 0.4374
Echinococcus granulosus Niemann Pick C1 protein 0.0132 0.085 0.1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0031 0.015 0.0646
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0805 0.2873
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0192 0.046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0135 0.0135
Mycobacterium leprae Probable lipase LipE 0.0038 0.0201 0.0414
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0192 0.046
Entamoeba histolytica protein kinase, putative 0.0126 0.0805 0.7118
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0482
Trypanosoma brucei rac serine-threonine kinase, putative 0.0126 0.0805 0.5406
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0044 0.0244 0.0584
Giardia lamblia Aurora kinase 0.017 0.1106 1
Schistosoma mansoni patched 1 0.004 0.0212 0.025
Echinococcus multilocularis GPCR, family 2 0.0028 0.0135 0.0135
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0094 0.0586 0.069
Schistosoma mansoni tar DNA-binding protein 0.006 0.0349 0.0411
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0482
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0044 0.0244 0.0287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0192 0.0226
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0192 0.166
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0058 0.0069
Echinococcus multilocularis ornithine aminotransferase 0.0058 0.034 0.034
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.041 0.276 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0044 0.0244 0.0584
Brugia malayi latrophilin 2 splice variant baaae 0.0061 0.0362 0.0867
Echinococcus granulosus serine threonine protein kinase nrc 0.0084 0.0519 0.061
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0084 0.0519 0.3327
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0075 0.0456 0.0536
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0016 0.0019
Schistosoma mansoni hypothetical protein 0.0038 0.0203 0.0238
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0075 0.0456 0.0456
Schistosoma mansoni tar DNA-binding protein 0.006 0.0349 0.0411
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0332 0.1004
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0061 0.0162
Schistosoma mansoni tar DNA-binding protein 0.006 0.0349 0.0411
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0031 0.015 0.0646
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0016 0.0019
Echinococcus multilocularis protein kinase c iota type 0.0044 0.0244 0.0244
Toxoplasma gondii aurora kinase 0.017 0.1106 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0093 0.0576 0.4932
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0044 0.0244 0.0287
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0079 0.0189
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0044 0.0244 0.0244
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0075 0.0456 0.0536
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0284 0.1625
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0135 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0192 0.046
Loa Loa (eye worm) hypothetical protein 0.0615 0.4172 1
Echinococcus multilocularis microtubule associated protein 2 0.1244 0.8498 0.8498
Brugia malayi TAR-binding protein 0.006 0.0349 0.0837
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0284 0.1625
Leishmania major protein kinase, putative 0.017 0.1106 0.7595
Loa Loa (eye worm) pigment dispersing factor receptor c 0.009 0.0557 0.1336
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0016 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0192 0.0226
Onchocerca volvulus 0.0126 0.0802 0.7226
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.001 0.0023
Brugia malayi nuclear receptor NHR-88 0.0017 0.0058 0.014
Echinococcus granulosus L aminoadipate semialdehyde 0.0078 0.0477 0.0561
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0016 0.0039
Loa Loa (eye worm) AUR protein kinase 0.017 0.1106 0.2651
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0075 0.0456 0.0456
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0192 0.0226
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0192 0.046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0016 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0192 0.0192
Brugia malayi Calcitonin receptor-like protein seb-1 0.009 0.0557 0.1336
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0201 0.0673
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0482
Loa Loa (eye worm) hypothetical protein 0.0115 0.0732 0.1754
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0192 0.0226
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0192 0.0226
Schistosoma mansoni nuclear receptor 0.0017 0.0058 0.0069
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0284 0.1625
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0201 0.0673
Loa Loa (eye worm) hypothetical protein 0.0274 0.1825 0.4374
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0082 0.05 0.0588
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0016 0.0019
Brugia malayi nuclear hormone receptor 0.0037 0.0192 0.046
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0201 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0192 0.046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.0152 0.0152
Brugia malayi hypothetical protein 0.0031 0.0152 0.0366
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0284 0.0977
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0192 0.0226
Echinococcus granulosus amyloid beta A4 protein 0.005 0.028 0.0329
Echinococcus multilocularis protein patched 0.004 0.0212 0.0212
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0058 0.034 0.1035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0058 0.0058
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0519 0.438
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0196 0.0981
Echinococcus granulosus Aminotransferase class III 0.0058 0.034 0.04
Brugia malayi RNA binding protein 0.006 0.0349 0.0837
Echinococcus granulosus expressed conserved protein 0.0087 0.0538 0.0633
Schistosoma mansoni voltage-gated cation channel 0.0075 0.0456 0.0536
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0192 0.0226
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.009 0.0557 0.1336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0135 0.0158
Echinococcus granulosus serine/threonine protein kinase 0.0084 0.0519 0.061
Echinococcus multilocularis survival motor neuron protein 1 0.0615 0.4172 0.4172
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0284 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0244 0.0287
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0192 0.046
Echinococcus granulosus tumor protein p63 0.0292 0.1944 0.2288
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0073 0.0073
Schistosoma mansoni ap endonuclease 0.0018 0.0061 0.0071
Brugia malayi tailless protein 0.0017 0.0058 0.014
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0078 0.0477 0.1144
Loa Loa (eye worm) AGC/AKT protein kinase 0.0126 0.0805 0.1929
Echinococcus granulosus Protein kinase C brain isozyme 0.0044 0.0244 0.0287
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0048 0.0266 0.0638
Trypanosoma cruzi Protein kinase B 0.0084 0.0519 0.3327
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0192 0.166
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0084 0.0519 0.438
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0201 0.052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0284 0.1625
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0192 0.0226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0058 0.0058
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0218 0.1437 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0284 0.1625
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0192 0.046
Brugia malayi MH2 domain containing protein 0.013 0.0835 0.2001
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0284 0.0977
Mycobacterium ulcerans acetylornithine aminotransferase 0.0058 0.034 0.1035
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0192 0.046
Echinococcus multilocularis tar DNA binding protein 0.006 0.0349 0.0349
Echinococcus granulosus tar DNA binding protein 0.006 0.0349 0.0411
Echinococcus multilocularis calcium activated potassium channel 0.001 0.001 0.001
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0058 0.034 0.0935
Plasmodium falciparum serine/threonine protein kinase, putative 0.017 0.1106 1
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0058 0.034 0.1035
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0058 0.0058
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0042 0.0225 0.0761
Brugia malayi hypothetical protein 0.0019 0.0073 0.0174
Mycobacterium tuberculosis Conserved protein 0.0038 0.0201 0.052
Echinococcus granulosus NDR protein kinase 0.0044 0.0244 0.0287
Echinococcus multilocularis serine threonine protein kinase 0.0044 0.0244 0.0244
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.0152 0.0179
Echinococcus multilocularis geminin 0.0179 0.1172 0.1172
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0192 0.0226
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.009 0.0283
Giardia lamblia Kinase, AGC PKA 0.0084 0.0519 0.438
Entamoeba histolytica protein kinase, putative 0.017 0.1106 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Brugia malayi Protein kinase domain containing protein 0.0126 0.0805 0.1929
Echinococcus granulosus aurora kinase A 0.017 0.1106 0.1301
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0201 0.052
Trichomonas vaginalis AGC family protein kinase 0.017 0.1106 0.3971
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0284 0.0284
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0058 0.0069
Echinococcus multilocularis L aminoadipate semialdehyde 0.0078 0.0477 0.0477
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0201 0.0236
Loa Loa (eye worm) hypothetical protein 0.0049 0.0274 0.0657
Schistosoma mansoni hypothetical protein 0.0028 0.0135 0.0158
Schistosoma mansoni hypothetical protein 0.0179 0.1172 0.1379
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0332 0.039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0135 0.0135
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0016 0.0019
Onchocerca volvulus 0.0017 0.0058 0.0442
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0058 0.014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0192 0.0226
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0058 0.034 0.0935
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0284 0.0977
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0557
Brugia malayi hypothetical protein 0.0017 0.0058 0.014
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0648 0.4267
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0044 0.0244 0.0584
Loa Loa (eye worm) X11 protein 0.005 0.028 0.067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0192 0.046
Brugia malayi ecdysone receptor 0.0017 0.0058 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0332 0.1004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0349 0.0837
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0031 0.015 0.0646
Trypanosoma cruzi aurora B kinase, putative 0.017 0.1106 0.7595
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0201 0.0236
Echinococcus multilocularis aurora kinase A 0.017 0.1106 0.1106
Toxoplasma gondii AGC kinase 0.0126 0.0805 0.7208
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0048 0.0269 0.1514
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0174
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0201 0.0414
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0201 0.0482
Schistosoma mansoni zinc finger protein 0.0017 0.0058 0.0069
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0192 0.0226
Brugia malayi hypothetical protein 0.0019 0.0073 0.0174
Echinococcus granulosus serine:threonine protein kinase N2 0.0044 0.0244 0.0287
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0016 0.0039
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0201 0.052
Loa Loa (eye worm) hypothetical protein 0.004 0.0212 0.0509
Entamoeba histolytica hypothetical protein 0.0031 0.0152 0.0878
Mycobacterium ulcerans hypothetical protein 0.0115 0.0728 0.2472
Entamoeba histolytica protein kinase 2, putative 0.0084 0.0519 0.438
Loa Loa (eye worm) beta-lactamase 0.0038 0.0201 0.0482
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0244 0.0829
Echinococcus multilocularis Niemann Pick C1 protein 0.0132 0.085 0.085
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0192 0.0226
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0058 0.014
Toxoplasma gondii hypothetical protein 0.0035 0.0181 0.1425
Schistosoma mansoni microtubule-associated protein tau 0.1244 0.8498 1
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0016 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0805 0.2873
Onchocerca volvulus Huntingtin homolog 0.0115 0.0732 0.6584
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0805 0.2873
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.046
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0244 0.0244
Echinococcus multilocularis expressed conserved protein 0.0087 0.0538 0.0538
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0075 0.0456 0.0456

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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