Detailed information for compound 1622607

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 680.713 | Formula: C34H36N10O6
  • H donors: 2 H acceptors: 8 LogP: 7.07 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1nc(OCCOc2nc(OC)nc(n2)Nc2ccc(c(c2)OCC=C(C)C)C#N)nc(n1)Nc1ccc(c(c1)OCC=C(C)C)C#N
  • InChi: 1S/C34H36N10O6/c1-21(2)11-13-47-27-17-25(9-7-23(27)19-35)37-29-39-31(45-5)43-33(41-29)49-15-16-50-34-42-30(40-32(44-34)46-6)38-26-10-8-24(20-36)28(18-26)48-14-12-22(3)4/h7-12,17-18H,13-16H2,1-6H3,(H,37,39,41,43)(H,38,40,42,44)
  • InChiKey: ZRBACUSQUZDMCY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin B precursor 0.0868 0.3664 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0042 0.0042
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.301 0.301
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0026 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0629 0.2636 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0207 0.0826 0.2181
Onchocerca volvulus 0.0033 0.0082 0.0118
Trypanosoma cruzi major cysteine proteinase, putative 0.0207 0.0826 0.0809
Echinococcus granulosus cathepsin L 0.0259 0.1051 0.1051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Echinococcus multilocularis importin subunit beta 1 0.003 0.0069 0.0069
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0455 0.189 0.189
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.0024 0.0042 0.0042
Echinococcus granulosus histone deacetylase 6 0.0046 0.0136 0.0136
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Brugia malayi fibroinase precursor 0.0207 0.0826 0.0826
Brugia malayi Papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Brugia malayi Histone deacetylase family protein 0.0046 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Schistosoma mansoni acetylcholine receptor subunit beta 0.021 0.0839 0.0839
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0455 0.189 0.189
Echinococcus granulosus cathepsin L 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2412 0.6551
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0455 0.189 0.189
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Echinococcus multilocularis cathepsin L 0.0207 0.0826 0.0826
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0035 0.0035
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0035 0.0035
Onchocerca volvulus 0.0629 0.2636 0.379
Giardia lamblia Cathepsin B precursor 0.0868 0.3664 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0455 0.189 0.189
Brugia malayi cathepsin F-like cysteine proteinase 0.0207 0.0826 0.0826
Onchocerca volvulus Cathepsin L homolog 0.0207 0.0826 0.1188
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0455 0.189 0.189
Echinococcus multilocularis lamin dm0 0.0027 0.0054 0.0054
Giardia lamblia Cathepsin B precursor 0.0868 0.3664 1
Schistosoma mansoni neurotransmitter gated ion channel 0.021 0.0839 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0207 0.0826 0.2181
Trypanosoma cruzi major cysteine proteinase, putative 0.0397 0.1644 0.1627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Brugia malayi hypothetical protein 0.0044 0.0128 0.0128
Echinococcus granulosus geminin 0.084 0.3544 0.3544
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.0186 0.0186
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.1051 0.1051
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0207 0.0826 0.0826
Schistosoma mansoni hypothetical protein 0.0248 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Brugia malayi cathepsin L-like precursor 0.0576 0.2412 0.2412
Onchocerca volvulus Deterin homolog 0.0537 0.2244 0.3226
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0233 0.0233
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0207 0.0826 0.3084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Brugia malayi hypothetical protein 0.0248 0.1005 0.1005
Toxoplasma gondii cathepsin CPC2 0.0207 0.0826 0.2256
Onchocerca volvulus Cell death protein 3 homolog 0.0248 0.1005 0.1445
Echinococcus granulosus cpg binding protein 0.003 0.0068 0.0068
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Leishmania major importin beta-1 subunit, putative 0.0025 0.0045 0.0041
Brugia malayi Cell death protein 3 precursor 0.0248 0.1005 0.1005
Echinococcus multilocularis smad 0.0024 0.0042 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0036 0.0036
Echinococcus multilocularis cathepsin b 0.2345 1 1
Echinococcus multilocularis calpain A 0.0056 0.0179 0.0179
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0216 0.0216
Loa Loa (eye worm) MH2 domain-containing protein 0.035 0.144 0.144
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0629 0.2636 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.1635 0.6956 0.6956
Loa Loa (eye worm) hypothetical protein 0.0248 0.1005 0.1005
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0207 0.0826 0.3084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0259 0.1051 0.1659
Schistosoma mansoni hypothetical protein 0.084 0.3544 0.3544
Echinococcus multilocularis musashi 0.0027 0.0054 0.0054
Onchocerca volvulus Cathepsin L homolog 0.0629 0.2636 0.379
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0455 0.189 0.189
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0455 0.189 0.189
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Onchocerca volvulus Putative nachr subunit 0.1635 0.6956 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.146 0.6204 0.6204
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0042 0.0042
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0207 0.0826 0.3084
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Schistosoma mansoni calpain C (C02 family) 0.002 0.0026 0.0026
Onchocerca volvulus 0.0027 0.0054 0.0078
Loa Loa (eye worm) acetylcholine receptor protein 0.021 0.0839 0.0839
Echinococcus multilocularis histone deacetylase 0.0046 0.0136 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.2412 0.9138
Echinococcus granulosus tar DNA binding protein 0.0065 0.0216 0.0216
Echinococcus multilocularis calpain 5 0.002 0.0026 0.0026
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Toxoplasma gondii cathepsin CPL 0.0629 0.2636 0.7196
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0164 0.0164
Trypanosoma cruzi cysteine peptidase, putative 0.0819 0.3453 0.3441
Onchocerca volvulus 0.021 0.0839 0.1206
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0207 0.0826 0.2181
Schistosoma mansoni ran 0.0022 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.146 0.6204 0.6204
Echinococcus granulosus snurportin 1 0.0323 0.1325 0.1325
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.0576 0.2412 0.2412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.1051 0.1051
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Loa Loa (eye worm) TK/ROR protein kinase 0.0019 0.0019 0.0019
Plasmodium falciparum serine repeat antigen 8 0.0207 0.0826 0.3084
Giardia lamblia Hypothetical protein 0.0207 0.0826 0.2181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.0186 0.0186
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Echinococcus multilocularis tissue type plasminogen activator 0.0019 0.0019 0.0019
Onchocerca volvulus Cathepsin F homolog 0.0629 0.2636 0.379
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1635 0.6956 0.6956
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Onchocerca volvulus 0.0629 0.2636 0.379
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Brugia malayi Kringle domain containing protein 0.0019 0.0019 0.0019
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Brugia malayi CXXC zinc finger family protein 0.0028 0.0061 0.0061
Onchocerca volvulus 0.0019 0.0019 0.0028
Loa Loa (eye worm) hypothetical protein 0.0044 0.0128 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Plasmodium falciparum serine repeat antigen 9 0.0207 0.0826 0.3084
Onchocerca volvulus 0.0245 0.099 0.1423
Onchocerca volvulus 0.0822 0.3468 0.4986
Echinococcus multilocularis cysteine protease 0.0629 0.2636 0.2636
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.0054
Loa Loa (eye worm) ACC-1 protein 0.0455 0.189 0.189
Loa Loa (eye worm) cysteine protease 0.0629 0.2636 0.2636
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0207 0.0826 0.2181
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0045 0.0025
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Onchocerca volvulus 0.0629 0.2636 0.379
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Toxoplasma gondii cathepsin CPC1 0.0207 0.0826 0.2256
Plasmodium vivax unspecified product 0.0259 0.1051 0.3941
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0216 0.0216
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2345 1 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0069 0.019
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.021 0.0839 0.0839
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0019
Echinococcus multilocularis cysteine protease 0.0629 0.2636 0.2636
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0207 0.0826 0.2181
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.168 0.168
Brugia malayi Protein kinase domain containing protein 0.0019 0.0019 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0328 0.0328
Echinococcus granulosus apoptotic protease activating factor 1 0.0248 0.1005 0.1005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0328 0.0328
Schistosoma mansoni nAChR subunit 0.021 0.0839 0.0839
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0746 0.3141 0.3141
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0042
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0164 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Giardia lamblia Hypothetical protein 0.0207 0.0826 0.2181
Entamoeba histolytica cysteine proteinase 1, putative 0.0259 0.1051 0.3905
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0328 0.0328
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Echinococcus granulosus nAChR subunit 0.0455 0.189 0.189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Loa Loa (eye worm) hypothetical protein 0.0822 0.3468 0.3468
Brugia malayi Papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Plasmodium falciparum histone deacetylase 2 0.0046 0.0136 0.0444
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0035 0.0015
Loa Loa (eye worm) hypothetical protein 0.0537 0.2244 0.2244
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Schistosoma mansoni ran 0.0022 0.0035 0.0035
Brugia malayi calpain 7 0.002 0.0026 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Echinococcus multilocularis glycine receptor subunit beta 0.0455 0.189 0.189
Schistosoma mansoni Smad4 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0629 0.2636 0.2636
Echinococcus granulosus tissue type plasminogen activator 0.0019 0.0019 0.0019
Echinococcus granulosus cathepsin l cysteine peptidase 0.0629 0.2636 0.2636
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Onchocerca volvulus 0.0822 0.3468 0.4986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Echinococcus multilocularis histone deacetylase 6 0.0046 0.0136 0.0136
Schistosoma mansoni lamin 0.0027 0.0054 0.0054
Brugia malayi RNA, U transporter 1 0.0086 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Brugia malayi cathepsin Z-like cysteine proteinase 0.0207 0.0826 0.0826
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) cathepsin B 0.0868 0.3664 0.3664
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Loa Loa (eye worm) hypothetical protein 0.0053 0.0168 0.0168
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.021 0.0839 0.0839
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.021 0.0839 0.0839
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Echinococcus granulosus glycine receptor subunit beta 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0455 0.189 0.189
Echinococcus multilocularis apoptotic protease activating factor 1 0.0248 0.1005 0.1005
Brugia malayi Papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0207 0.0826 0.2181
Schistosoma mansoni histone deacetylase 4 5 0.0046 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0613 0.2568 0.2568
Echinococcus granulosus glycine receptor subunit alpha 1 0.0455 0.189 0.189
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0207 0.0826 0.3084
Plasmodium falciparum serine repeat antigen 1 0.0207 0.0826 0.3084
Echinococcus multilocularis cathepsin L 0.0259 0.1051 0.1051
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0537 0.2244 0.2244
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.021 0.0839 0.0839
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0207 0.0826 0.3043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Echinococcus multilocularis cathepsin L cysteine protease 0.0629 0.2636 0.2636
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0168 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0207 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0052
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0108 0.0108
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0207 0.0826 0.2181
Echinococcus granulosus histone deacetylase 6 0.0046 0.0136 0.0136
Plasmodium vivax vivapain-2 0.0629 0.2636 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0145 0.0145
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0629 0.2636 0.2636
Loa Loa (eye worm) histone deacetylase 7A 0.0046 0.0136 0.0136
Trypanosoma cruzi Aph-1 protein, putative 0.0102 0.0375 0.0356
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2345 1 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Toxoplasma gondii cathepsin B 0.0868 0.3664 1
Echinococcus granulosus cysteine protease 0.0259 0.1051 0.1051
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0455 0.189 0.189
Plasmodium falciparum serine repeat antigen 6 0.0207 0.0826 0.3084
Loa Loa (eye worm) fibroinase 0.0629 0.2636 0.2636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi cruzipain precursor, putative 0.0819 0.3453 0.3441
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Echinococcus multilocularis gamma secretase subunit aph 1 0.0261 0.1057 0.1057
Leishmania major cathepsin L-like protease 0.0819 0.3453 0.5552
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0537 0.2244 0.2244
Loa Loa (eye worm) prolyl oligopeptidase 0.0171 0.0672 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2412 0.6551
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.1635 0.6956 0.6956
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0171 0.0672 0.0672
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Onchocerca volvulus 0.021 0.0839 0.1206
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0045 0.0027
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0455 0.189 0.189
Echinococcus multilocularis glycine receptor subunit beta 0.0455 0.189 0.189
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.301 0.301
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0245 0.099 0.099
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0042 0.0042
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0035 0.0015
Plasmodium vivax serine-repeat antigen (SERA) 0.0207 0.0826 0.3084
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0026 0.0026
Plasmodium falciparum cysteine proteinase falcipain 3 0.0629 0.2636 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0328 0.0328
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0819 0.3453 0.3441
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.1635 0.6956 0.6956
Echinococcus granulosus importin subunit beta 1 0.003 0.0069 0.0069
Plasmodium vivax vivapain-2 0.0629 0.2636 1
Brugia malayi Cation transporter family protein 0.0455 0.189 0.189
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0171 0.0466
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.0186 0.0507
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0948 0.0948
Entamoeba histolytica cysteine protease, putative 0.0629 0.2636 1
Echinococcus granulosus lamin dm0 0.0027 0.0054 0.0054
Schistosoma mansoni cathepsin C 0.0207 0.0826 0.0826
Toxoplasma gondii preprocathepsin c precursor, putative 0.0207 0.0826 0.2256
Brugia malayi cathepsin L-like cysteine proteinase 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0164 0.0144
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0245 0.099 0.099
Echinococcus granulosus glycine receptor subunit beta 0.0455 0.189 0.189
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.1635 0.6956 0.6956
Loa Loa (eye worm) LGC-31 protein 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Echinococcus multilocularis nAChR subunit 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Echinococcus granulosus calpain A 0.002 0.0026 0.0026
Echinococcus granulosus intermediate filament protein 0.0027 0.0054 0.0054
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0216 0.0216
Plasmodium falciparum importin beta, putative 0.003 0.0069 0.019
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.0186 0.0167
Echinococcus granulosus inhibitor of apoptosis protein 0.0537 0.2244 0.2244
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0629 0.2636 0.7169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi cysteine peptidase, putative 0.0259 0.1051 0.1033
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Echinococcus granulosus cathepsin l1 0.0629 0.2636 0.2636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0207 0.0826 0.3084
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Echinococcus granulosus cathepsin b 0.2345 1 1
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.0186 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Plasmodium vivax histone deacetylase 2, putative 0.0046 0.0136 0.0444
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Leishmania major C-8 sterol isomerase-like protein 0.146 0.6204 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0328 0.0328
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0455 0.189 0.189
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Trypanosoma brucei Aph-1 protein, putative 0.0102 0.0375 0.0565
Loa Loa (eye worm) hypothetical protein 0.0039 0.0108 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0328 0.0328
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0026 0.0026
Trypanosoma brucei histone deacetylase 3 0.0046 0.0136 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Loa Loa (eye worm) hypothetical protein 0.0576 0.2412 0.2412
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0207 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0164
Schistosoma mansoni gamma-secretase subunit aph-1 0.0261 0.1057 0.1057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0199 0.0199
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0035 0.0035
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0455 0.189 0.189
Brugia malayi MH1 domain containing protein 0.0024 0.0042 0.0042
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Onchocerca volvulus 0.0248 0.1005 0.1445
Loa Loa (eye worm) RNA binding protein 0.0065 0.0216 0.0216
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.1635 0.6956 0.6956
Echinococcus multilocularis lamin 0.0027 0.0054 0.0054
Leishmania major histone deacetylase, putative 0.0046 0.0136 0.0188
Brugia malayi Importin beta-1 subunit 0.003 0.0069 0.0069
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.0186 0.0269
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0537 0.2244 0.2244
Trypanosoma cruzi histone deacetylase, putative 0.0046 0.0136 0.0116
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Loa Loa (eye worm) ctsf protein 0.0629 0.2636 0.2636
Schistosoma mansoni importin beta-1 0.003 0.0069 0.0069
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0207 0.0826 0.3084
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0948 0.0948
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Giardia lamblia Cathepsin L-like protease 0.0207 0.0826 0.2181
Brugia malayi cathepsin L precursor 0.0207 0.0826 0.0826
Echinococcus granulosus cathepsin L cysteine protease 0.0259 0.1051 0.1051
Plasmodium vivax unspecified product 0.0207 0.0826 0.3084
Plasmodium falciparum serine repeat antigen 7 0.0207 0.0826 0.3084
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Brugia malayi MH1 domain containing protein 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0136
Echinococcus multilocularis caspase 2 0.0248 0.1005 0.1005
Schistosoma mansoni cathepsin s 0.0052 0.0164 0.0164
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0259 0.1051 0.1033
Plasmodium vivax unspecified product 0.0052 0.0164 0.0551
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.021 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0164
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0164 0.0144
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0245 0.099 0.099
Onchocerca volvulus 0.0455 0.189 0.2717
Plasmodium vivax vivapain-3 0.0259 0.1051 0.3941
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0207 0.0826 0.3084
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Leishmania major GTP-binding protein, putative 0.0022 0.0035 0.0025
Entamoeba histolytica hypothetical protein 0.0025 0.0045 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0629 0.2636 0.2636
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.0839 0.0839
Schistosoma mansoni inhibitor of apoptosis protein 0.0537 0.2244 0.2244
Plasmodium vivax calpain, putative 0.002 0.0026 0.0024
Brugia malayi Histone deacetylase family protein 0.0046 0.0136 0.0136
Onchocerca volvulus 0.0048 0.0145 0.0209
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0207 0.0826 0.3084
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0245 0.099 0.099
Plasmodium falciparum cysteine proteinase falcipain 1 0.0259 0.1051 0.3941
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Plasmodium falciparum serine repeat antigen 3 0.0207 0.0826 0.3084
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0822 0.3468 0.3468
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0207 0.0826 0.2181
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0233 0.0233
Onchocerca volvulus 0.0629 0.2636 0.379
Schistosoma mansoni intermediate filament proteins 0.0027 0.0054 0.0054
Schistosoma mansoni cathepsin F (C01 family) 0.0576 0.2412 0.2412
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0207 0.0826 0.2181
Echinococcus multilocularis cathepsin b 0.2345 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0207 0.0826 0.3084
Entamoeba histolytica cysteine proteinase, putative 0.0629 0.2636 1
Schistosoma mansoni lamin 0.0027 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0868 0.3664 0.3664
Loa Loa (eye worm) hypothetical protein 0.0822 0.3468 0.3468
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0168 0.0168
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0207 0.0826 0.3084
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0108 0.0108
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0054 0.0054
Schistosoma mansoni histone deacetylase hda2 0.0046 0.0136 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0455 0.189 0.189
Schistosoma mansoni histone deacetylase 4 5 0.0046 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.1051 0.28
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Schistosoma mansoni nAChR subunit 0.021 0.0839 0.0839
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0233 0.0233
Loa Loa (eye worm) calpain 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Brugia malayi calpain family protein 1 0.0053 0.0168 0.0168
Schistosoma mansoni smad 0.0024 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0767 0.3229 0.3216
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0164
Brugia malayi TAR-binding protein 0.0065 0.0216 0.0216
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0207 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.0839 0.0839
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0164 0.0164
Onchocerca volvulus 0.0822 0.3468 0.4986
Echinococcus multilocularis hypothetical protein 0.002 0.0026 0.0026
Trypanosoma brucei histone deacetylase, putative 0.0046 0.0136 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.1635 0.6956 0.6956
Plasmodium vivax serine-repeat antigen (SERA) 0.0207 0.0826 0.3084
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.1051 0.1051
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0455 0.189 0.189
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0455 0.189 0.189
Echinococcus granulosus nAChR subunit 0.0245 0.099 0.099
Trypanosoma cruzi C-8 sterol isomerase, putative 0.146 0.6204 0.6197
Brugia malayi hypothetical protein 0.0235 0.0948 0.0948
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0207 0.0826 0.0826
Schistosoma mansoni caspase-7 (C14 family) 0.0248 0.1005 0.1005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0207 0.0826 0.3084
Brugia malayi Cation transporter family protein 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0035 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0629 0.2636 0.2622
Schistosoma mansoni calpain (C02 family) 0.002 0.0026 0.0026
Onchocerca volvulus 0.0537 0.2244 0.3226
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0576 0.2412 0.2412
Loa Loa (eye worm) hypothetical protein 0.0537 0.2244 0.2244
Echinococcus granulosus caspase 2 0.0248 0.1005 0.1005
Giardia lamblia Cathepsin L-like protease 0.0207 0.0826 0.2181
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0261 0.1057 0.1057
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Giardia lamblia Encystation-specific protease 0.0207 0.0826 0.2181
Onchocerca volvulus 0.021 0.0839 0.1206
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Toxoplasma gondii kringle domain-containing protein 0.0019 0.0019 0.0053
Echinococcus granulosus glycine receptor subunit alpha 1 0.0455 0.189 0.189
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0233 0.0233
Echinococcus granulosus gamma secretase subunit aph 1 0.0261 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0248 0.1005 0.1005
Echinococcus granulosus Smad4 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus multilocularis snurportin 1 0.0323 0.1325 0.1325
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0207 0.0826 0.3084
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Onchocerca volvulus 0.0027 0.0054 0.0078
Echinococcus granulosus calpain 5 0.002 0.0026 0.0026
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Echinococcus granulosus calpain 0.002 0.0026 0.0026
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.0186 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Brugia malayi Cytochrome P450 family protein 0.0022 0.0036 0.0036
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.007
Schistosoma mansoni cathepsin B (C01 family) 0.0207 0.0826 0.0826
Schistosoma mansoni hypothetical protein 0.0406 0.168 0.168
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.1051 0.1051
Onchocerca volvulus 0.0207 0.0826 0.1188
Onchocerca volvulus 0.0028 0.0061 0.0088
Brugia malayi Cation transporter family protein 0.0822 0.3468 0.3468
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.0826 0.2181
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.021 0.0839 0.0839
Trypanosoma cruzi histone deacetylase, putative 0.0046 0.0136 0.0116
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0233 0.0233
Onchocerca volvulus 0.0245 0.099 0.1423
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0179 0.0179
Onchocerca volvulus 0.0576 0.2412 0.3468
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Echinococcus multilocularis nAChR subunit 0.0245 0.099 0.099
Plasmodium vivax histone deacetylase, putative 0.0046 0.0136 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0868 0.3664 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Echinococcus multilocularis histone deacetylase 6 0.0046 0.0136 0.0136
Plasmodium falciparum serine repeat antigen 4 0.0207 0.0826 0.3084
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0171 0.0672 0.0966
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0035 0.0059
Echinococcus multilocularis calpain 0.002 0.0026 0.0026
Brugia malayi prolyl oligopeptidase family protein 0.0171 0.0672 0.0672
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi histone deacetylase, putative 0.0046 0.0136 0.0116
Plasmodium falciparum serine repeat antigen 2 0.0207 0.0826 0.3084
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0868 0.3664 0.5892
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.1635 0.6956 0.6956
Onchocerca volvulus 0.0455 0.189 0.2717
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0207 0.0826 0.2181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0045 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0629 0.2636 0.2636
Onchocerca volvulus Cathepsin L homolog 0.0629 0.2636 0.379
Echinococcus multilocularis Smad4 0.0024 0.0042 0.0042
Brugia malayi gamma-secretase subunit aph-1 0.0261 0.1057 0.1057
Brugia malayi Smad1 0.0024 0.0042 0.0042
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.021 0.0839 0.0839
Brugia malayi calpain family protein 1 0.0053 0.0168 0.0168
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0054 0.0054
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0455 0.189 0.189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Brugia malayi Papain family cysteine protease containing protein 0.0629 0.2636 0.2636
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0537 0.2244 0.2244
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Echinococcus multilocularis cathepsin L cysteine protease 0.0629 0.2636 0.2636
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0822 0.3468 0.3468
Toxoplasma gondii histone deacetylase HDAC1 0.0046 0.0136 0.037
Echinococcus granulosus smad 0.0024 0.0042 0.0042
Leishmania major cathepsin L-like protease 0.0819 0.3453 0.5552
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0629 0.2636 0.2636
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0035 0.0059
Schistosoma mansoni hypothetical protein 0.0323 0.1325 0.1325
Loa Loa (eye worm) ACC-1 protein 0.0455 0.189 0.189
Schistosoma mansoni hypothetical protein 0.084 0.3544 0.3544
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Echinococcus granulosus microtubule associated protein 2 0.0716 0.301 0.301
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0171 0.0672 0.0672
Entamoeba histolytica cysteine proteinase 2 0.0259 0.1051 0.3905
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0216 0.0216
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0186 0.0186
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Leishmania major cysteine peptidase A (CPA) 0.0629 0.2636 0.4231
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Echinococcus granulosus calpain A 0.0056 0.0179 0.0179
Schistosoma mansoni cathepsin S (C01 family) 0.0207 0.0826 0.0826
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0455 0.189 0.189
Entamoeba histolytica hypothetical protein 0.0207 0.0826 0.3043
Schistosoma mansoni neurotransmitter gated ion channel 0.0245 0.099 0.099
Trypanosoma brucei cysteine peptidase C (CPC) 0.0868 0.3664 0.5888
Brugia malayi intermediate filament protein 0.0027 0.0054 0.0054
Plasmodium falciparum serine repeat antigen 5 0.0207 0.0826 0.3084
Onchocerca volvulus 0.0629 0.2636 0.379
Echinococcus multilocularis histone deacetylase 7 0.0046 0.0136 0.0136
Brugia malayi MH2 domain containing protein 0.0024 0.0042 0.0042
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.1635 0.6956 0.6956
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0042 0.0042
Schistosoma mansoni cpg binding protein 0.0028 0.0061 0.0061
Onchocerca volvulus 0.0629 0.2636 0.379
Brugia malayi Cathepsin L-like precursor 0.0052 0.0164 0.0164
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0629 0.2636 0.2636
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.1325 0.1325
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0245 0.099 0.099
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0455 0.189 0.189
Brugia malayi Cathepsin L-like precursor 0.0576 0.2412 0.2412
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0054 0.0054
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0207 0.0826 0.3043
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0045 0.0027
Schistosoma mansoni hypothetical protein 0.0537 0.2244 0.2244
Loa Loa (eye worm) Smad1 0.0024 0.0042 0.0042
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.0186 0.0167
Brugia malayi excitatory GABA receptor EXP-1A 0.0455 0.189 0.189
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0069 0.0189
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0171 0.0672 0.0672
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0047 0.0142 0.0142
Echinococcus granulosus cathepsin b 0.2345 1 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0245 0.099 0.099
Leishmania major histone deacetylase, putative 0.0046 0.0136 0.0188
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2345 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.1051 0.28
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Echinococcus multilocularis geminin 0.084 0.3544 0.3544
Brugia malayi cathepsin Z-like cysteine proteinase 0.0207 0.0826 0.0826
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0179 0.0179
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0235 0.0948 0.0948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0259 0.1051 0.1659
Echinococcus granulosus dnaJ subfamily B 0.0406 0.168 0.168
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0035 0.0095
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Loa Loa (eye worm) hypothetical protein 0.0576 0.2412 0.2412
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Onchocerca volvulus 0.0455 0.189 0.2717
Echinococcus granulosus cathepsin L cysteine proteinase 0.0629 0.2636 0.2636
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.0839 0.0839
Echinococcus granulosus glycine receptor subunit alpha 1 0.0455 0.189 0.189
Schistosoma mansoni acetylcholine receptor-related 0.021 0.0839 0.0839
Trypanosoma cruzi Aph-1 protein, putative 0.0102 0.0375 0.0356
Trypanosoma cruzi cysteine proteinase, putative 0.0259 0.1051 0.1033
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Onchocerca volvulus 0.0629 0.2636 0.379
Trypanosoma cruzi cysteine protease, putative 0.0259 0.1051 0.1033
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Brugia malayi MH2 domain containing protein 0.035 0.144 0.144
Brugia malayi RNA binding protein 0.0065 0.0216 0.0216
Trypanosoma brucei C-8 sterol isomerase, putative 0.146 0.6204 1
Trypanosoma cruzi cysteine proteinase, putative 0.0259 0.1051 0.1033
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0207 0.0826 0.0826
Echinococcus multilocularis inhibitor of apoptosis protein 0.0537 0.2244 0.2244
Plasmodium falciparum histone deacetylase, putative 0.0046 0.0136 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0179 0.0179
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0868 0.3664 0.3651
Brugia malayi Cathepsin L-like cysteine proteinase 0.0576 0.2412 0.2412
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.0186 0.0186
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.001
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.021 0.0839 0.0839
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2345 1 1
Entamoeba histolytica hypothetical protein 0.0245 0.099 0.3672
Echinococcus granulosus histone deacetylase 0.0046 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trypanosoma brucei histone deacetylase 4 0.0046 0.0136 0.0178
Loa Loa (eye worm) histone deacetylase 0.0046 0.0136 0.0136
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0455 0.189 0.189
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.021 0.0839 0.0839
Loa Loa (eye worm) transcription factor SMAD2 0.035 0.144 0.144
Leishmania major cathepsin L-like protease 0.0819 0.3453 0.5552
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0819 0.3453 0.3441
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.001
Schistosoma mansoni neurotransmitter gated ion channel 0.021 0.0839 0.0839
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0207 0.0826 0.3084
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Echinococcus granulosus cathepsin l1 0.0576 0.2412 0.2412
Echinococcus multilocularis histone deacetylase 6 0.0046 0.0136 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Schistosoma mansoni survival motor neuron protein 0.0048 0.0145 0.0145
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0061 0.0061
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0233 0.0233
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2345 1 1
Echinococcus granulosus calpain 7 C02 family 0.002 0.0026 0.0026
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0455 0.189 0.189
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0455 0.189 0.189
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0455 0.189 0.189
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0537 0.2244 0.2244
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Echinococcus granulosus histone deacetylase 7 0.0046 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0455 0.189 0.189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.021 0.0839 0.0839
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0629 0.2636 1
Echinococcus granulosus lamin 0.0027 0.0054 0.0054
Echinococcus granulosus histone deacetylase 6 0.0046 0.0136 0.0136
Echinococcus multilocularis cpg binding protein 0.003 0.0068 0.0068
Loa Loa (eye worm) GABA receptor subunit 0.0245 0.099 0.099
Plasmodium vivax vivapain-1 0.0259 0.1051 0.3941
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.2345 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0629 0.2636 0.2636

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 42 uM Cytotoxicity against human MT2 cells by MTT assay ChEMBL. 22269110

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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