Detailed information for compound 1635470

Basic information

Technical information
  • TDR Targets ID: 1635470
  • Name: 2-(2-((2-(1,3-Dioxo-1H-benzo[de]isoquinolin-2 (3H)-yl)ethyl)(methyl)amino)ethyl)-1H-benzo[d e]isoquinoline-1,3(2H)-dione
  • MW: 477.511 | Formula: C29H23N3O4
  • H donors: 0 H acceptors: 4 LogP: 4.11 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCn1c(=O)c2cccc3c2c(c1=O)ccc3)CCn1c(=O)c2cccc3c2c(c1=O)ccc3
  • InChi: 1S/C29H23N3O4/c1-30(14-16-31-26(33)20-10-2-6-18-7-3-11-21(24(18)20)27(31)34)15-17-32-28(35)22-12-4-8-19-9-5-13-23(25(19)22)29(32)36/h2-13H,14-17H2,1H3
  • InChiKey: DGPSKXZEOCBESC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS-130109
  • AIDS130109

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.0024 0.0042 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0006 0.0005
Schistosoma mansoni sodium/solute symporter 0.0034 0.0111 0.0125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0221 0.0247
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0133 0.0441
Trichomonas vaginalis beta-hexosaminidase, putative 0.0135 0.0756 0.0776
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0028 0.0071 0.0026
Trichomonas vaginalis beta-hexosaminidase, putative 0.005 0.0212 0.016
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0136 0.0152
Loa Loa (eye worm) hypothetical protein 0.005 0.0212 0.0238
Echinococcus granulosus zinc finger protein 0.0019 0.0014 0.0014
Brugia malayi RNA binding protein 0.0053 0.0232 0.0259
Entamoeba histolytica fructokinase, putative 0.0028 0.0071 0.0026
Schistosoma mansoni inositol transporter 0.0034 0.0111 0.0125
Schistosoma mansoni patched 1 0.0038 0.0136 0.0152
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0082 0.0415 0.0465
Echinococcus multilocularis high affinity choline transporter 1 0.0313 0.1896 0.1895
Schistosoma mansoni serine/threonine protein kinase 0.1405 0.89 1
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0135 0.0756 0.0755
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0049 0.0202 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0008
Echinococcus multilocularis zinc finger protein 0.0019 0.0014 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0129 0.0144
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0216 0.1276 0.1434
Entamoeba histolytica protein kinase, putative 0.1405 0.89 1
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0243 0.0273
Schistosoma mansoni hypothetical protein 0.0037 0.0127 0.0142
Echinococcus multilocularis geminin 0.0149 0.0848 0.0847
Loa Loa (eye worm) doublecortin family protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0006 0.0006
Onchocerca volvulus 0.0037 0.0129 0.0987
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0034 0.0111 0.011
Trichomonas vaginalis beta-hexosaminidase, putative 0.0135 0.0756 0.0776
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0006 0.0005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.1419 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0006 0.0005
Brugia malayi beta-lactamase 0.0037 0.0129 0.0144
Brugia malayi Ribokinase 0.0028 0.0071 0.0078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0129 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0006 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0232 0.0261
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0216 0.1276 0.1433
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0006 0.0006
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0034 0.0111 0.0286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0415 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0006 0.0005
Onchocerca volvulus Ribokinase homolog 0.0028 0.0071 0.0536
Brugia malayi Sodium:solute symporter family protein 0.0034 0.0111 0.0123
Trichomonas vaginalis beta-hexosaminidase, putative 0.0135 0.0756 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0145
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0028 0.0071 0.2683
Echinococcus granulosus acetylcholinesterase 0.005 0.021 0.0235
Echinococcus multilocularis carboxylesterase 5A 0.005 0.021 0.0209
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0232 0.0261
Entamoeba histolytica ribokinase, putative 0.0028 0.0071 0.0026
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0135 0.0756 0.0848
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Schistosoma mansoni ribokinase 0.0028 0.0071 0.0079
Loa Loa (eye worm) hypothetical protein 0.0313 0.1896 0.213
Echinococcus granulosus sodium:myo inositol cotransporter 0.0034 0.0111 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0243 0.0273
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0007 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0006 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.0608 0.3792 0.426
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0129 0.0145
Trypanosoma cruzi adenosine kinase, putative 0.0248 0.1478 1
Entamoeba histolytica kinase, PfkB family 0.0028 0.0071 0.0026
Mycobacterium ulcerans lipase LipD 0.0037 0.0129 0.5159
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0047 0.1691
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0216 0.1276 0.1388
Brugia malayi Cytochrome P450 family protein 0.002 0.002 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0136 0.0074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0145
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0145
Onchocerca volvulus 0.0018 0.0006 0.0035
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0129 0.0144
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0006 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0006 0.0005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0133 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0415 0.0466
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0232 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0006 0.0005
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0028 0.0071 0.0026
Loa Loa (eye worm) carboxylesterase 0.005 0.021 0.0236
Mycobacterium ulcerans hypothetical protein 0.0025 0.0047 0.1691
Mycobacterium ulcerans fructokinase, PfkB 0.0028 0.0071 0.2683
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0047 0.1691
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0006 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0006 0.0005
Echinococcus granulosus sodium:glucose cotransporter 0.0034 0.0111 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0129 0.0415
Echinococcus multilocularis muscleblind protein 0.04 0.2458 0.2457
Schistosoma mansoni hypothetical protein 0.0037 0.0127 0.0142
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0006 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0006 0.0005
Entamoeba histolytica hypothetical protein 0.0032 0.0093 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0032 0.0093 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0129 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0129 0.0066
Leishmania major adenosine kinase-like protein 0.0028 0.0071 0.0163
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0047 0.1691
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.005 0.021 0.0236
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0006 0.0005
Echinococcus multilocularis solute carrier family 5 0.0034 0.0111 0.011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0103 0.0552 0.062
Entamoeba histolytica hypothetical protein 0.0032 0.0093 0.0052
Loa Loa (eye worm) hypothetical protein 0.005 0.021 0.0236
Schistosoma mansoni beta-hexosaminidase B 0.0216 0.1276 0.1434
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0047 0.1691
Echinococcus multilocularis microtubule associated protein 2 0.0608 0.3792 0.3791
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Brugia malayi steroid hormone receptor 0.0018 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0037 0.0127 0.0142
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0129 0.0903
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0006 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0129 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0006 0.0004
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.0463 0.0469
Echinococcus granulosus tar DNA binding protein 0.0053 0.0232 0.0259
Brugia malayi nuclear receptor NHR-88 0.0018 0.0006 0.0005
Echinococcus multilocularis adenosine kinase 0.0248 0.1478 0.1477
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0129 0.0066
Brugia malayi beta-lactamase family protein 0.0037 0.0129 0.0144
Schistosoma mansoni hypothetical protein 0.0149 0.0848 0.0953
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0008
Onchocerca volvulus 0.0034 0.0111 0.0847
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0053 0.0228 0.0227
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.005 0.0212 0.0236
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0129 1
Echinococcus granulosus expressed conserved protein 0.0084 0.0428 0.048
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0243 0.1225
Echinococcus multilocularis ribokinase 0.0028 0.0071 0.007
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0133 0.0441
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0129 0.9718
Leishmania major ribokinase, putative 0.0028 0.0071 0.0163
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0006 0.0006
Toxoplasma gondii ABC1 family protein 0.0037 0.0129 0.0415
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0053
Schistosoma mansoni rab6-interacting 0.0017 0.0001 0.0001
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0216 0.1276 0.1388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0145
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0145
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0136 0.0151
Mycobacterium leprae Probable adenosine kinase adk 0.0028 0.0071 0.2861
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0008
Onchocerca volvulus 0.0037 0.0129 0.0987
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0103 0.0552 0.062
Onchocerca volvulus Huntingtin homolog 0.0103 0.0552 0.425
Trichomonas vaginalis AGC family protein kinase 0.1405 0.89 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0006 0.0005
Echinococcus multilocularis protein dispatched 1 0.0044 0.017 0.0169
Schistosoma mansoni hypothetical protein 0.0035 0.0116 0.0131
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0047 0.0052
Loa Loa (eye worm) hypothetical protein 0.0028 0.0071 0.0079
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0629
Brugia malayi Bromodomain containing protein 0.0035 0.0114 0.0126
Entamoeba histolytica hypothetical protein 0.0032 0.0093 0.0052
Leishmania major tagatose-6-phosphate kinase-like protein 0.0028 0.0071 0.0163
Entamoeba histolytica hypothetical protein 0.0032 0.0093 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0243 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.0463 0.0519
Brugia malayi Muscleblind-like protein 0.04 0.2458 0.276
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0006 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0006 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0129 0.5159
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0463 0.0462
Echinococcus multilocularis Niemann Pick C1 protein 0.0128 0.0709 0.0708
Brugia malayi Adenosine kinase-like 0.0248 0.1478 0.1659
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0463 0.0519
Trypanosoma brucei adenosine kinase, putative 0.0248 0.1478 1
Onchocerca volvulus 0.0028 0.0071 0.0536
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0243 1
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0006 0.0006
Leishmania major putative PfkB family sugar kinase 0.0028 0.0071 0.0163
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Schistosoma mansoni coup transcription factor 0.0018 0.0006 0.0006
Brugia malayi CHE-14 protein 0.0038 0.0136 0.0151
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0116 0.0129
Onchocerca volvulus 0.0219 0.1297 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0136 0.0134
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.1405 0.89 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.0142
Trypanosoma cruzi adenosine kinase, putative 0.0248 0.1478 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0006 0.0005
Echinococcus granulosus carboxylesterase 5A 0.005 0.021 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0006 0.0006
Mycobacterium tuberculosis Adenosine kinase 0.0028 0.0071 0.0491
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Leishmania major tagatose-6-phosphate kinase-like protein 0.0028 0.0071 0.0163
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0034 0.0111 0.011
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.1405 0.89 0.89
Mycobacterium leprae Probable lipase LipE 0.0037 0.0129 1
Schistosoma mansoni hypothetical protein 0.0149 0.0848 0.0953
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0136 0.0151
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.1405 0.89 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0243 0.1369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Entamoeba histolytica acetyltransferase, GNAT family 0.0033 0.0101 0.0061
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0216 0.1276 0.1275
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0129 0.0903
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0006 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0415 0.0465
Brugia malayi Carboxylesterase family protein 0.005 0.021 0.0235
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0133 0.007
Toxoplasma gondii kinase, pfkB family protein 0.0248 0.1478 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0145
Loa Loa (eye worm) hypothetical protein 0.04 0.2458 0.2761
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0006 0.0005
Echinococcus granulosus Niemann Pick C1 protein 0.0128 0.0709 0.0795
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0415 0.0466
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0124 0.0686 0.077
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0082 0.0415 0.0466
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0006 0.0005
Giardia lamblia Histone acetyltransferase GCN5 0.0033 0.0101 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0129 0.0903
Schistosoma mansoni adenosine kinase 0.0248 0.1478 0.1661
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0133 0.0148
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0129 0.0903
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0034 0.0111 0.0123
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0232 0.0231
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0125
Echinococcus multilocularis acetylcholinesterase 0.005 0.021 0.0209
Loa Loa (eye worm) hypothetical protein 0.005 0.021 0.0236
Brugia malayi acetyltransferase, GNAT family protein 0.0124 0.0686 0.0769
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0028 0.0071 0.007
Trichomonas vaginalis esterase, putative 0.0037 0.0129 0.0066
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0082 0.0081
Mycobacterium tuberculosis Ribokinase RbsK 0.0028 0.0071 0.0491
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0129 0.5159
Schistosoma mansoni lipoxygenase 0.0017 0.0001 0.0001
Onchocerca volvulus 0.0025 0.0047 0.0356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0415 0.0465
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0232 0.0261
Onchocerca volvulus Putative pyridoxal kinase 0.0028 0.0071 0.0536
Trichomonas vaginalis AGC family protein kinase 0.1405 0.89 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0221 0.0247
Brugia malayi GH02984p 0.0313 0.1896 0.2129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0415 0.0466
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0082 0.0091
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0243 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0053
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0232 0.0261
Echinococcus granulosus adenosine kinase 0.0248 0.1478 0.1659
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0047 0.0326
Echinococcus granulosus high affinity choline transporter 1 0.0313 0.1896 0.2129
Echinococcus multilocularis muscleblind protein 1 0.04 0.2458 0.2457
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0049 0.0202 0.0201
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0216 0.1276 0.1388
Mycobacterium ulcerans beta-lactamase 0.0037 0.0129 0.5159
Loa Loa (eye worm) hypothetical protein 0.0089 0.0463 0.052
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0006 0.0035
Loa Loa (eye worm) hypothetical protein 0.0047 0.0191 0.0215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0006 0.0006
Brugia malayi Carboxylesterase family protein 0.005 0.021 0.0235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0116 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0006 0.0005
Schistosoma mansoni rab6-interacting 0.0017 0.0001 0.0001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.001 0.0009
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.001 0.001
Plasmodium falciparum histone acetyltransferase GCN5 0.0033 0.0101 1
Schistosoma mansoni inositol transporter 0.0034 0.0111 0.0125
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0129 0.0903
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0093 0.0103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0006 0.0006
Loa Loa (eye worm) acetyltransferase 0.0124 0.0686 0.077
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0133 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0006 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0221 0.0248
Brugia malayi phosphoinositide-dependent protein kinase I 0.1405 0.89 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi TAR-binding protein 0.0053 0.0232 0.0259
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0135 0.0756 0.0776
Echinococcus granulosus histone acetyltransferase KAT2B 0.0119 0.0651 0.073
Brugia malayi Protein kinase domain containing protein 0.1405 0.89 1
Schistosoma mansoni polycystin 1-related 0.0017 0.0001 0.0001
Loa Loa (eye worm) RNA binding protein 0.0053 0.0232 0.0261
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0129 0.0128
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0232 0.0259
Schistosoma mansoni bromodomain containing protein 0.0056 0.0247 0.0278
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0091 0.0472 0.053
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.1405 0.89 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0006 0.0004
Onchocerca volvulus Hexosaminidase D homolog 0.005 0.0212 0.1624
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0129 0.0415
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0093 0.0105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Schistosoma mansoni loxhd1 0.0017 0.0001 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0053 0.0228 0.0255
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.005 0.0212 0.0236
Schistosoma mansoni high-affinity choline transporter 0.0313 0.1896 0.213
Echinococcus granulosus sodium:glucose cotransporter 2 0.0034 0.0111 0.0123
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0006 0.0004
Schistosoma mansoni zinc finger protein 0.0019 0.0014 0.0015
Echinococcus granulosus acetylcholinesterase 0.005 0.021 0.0235
Brugia malayi hypothetical protein 0.0103 0.0552 0.0619
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0047 0.1691
Schistosoma mansoni beta-hexosaminidase B 0.0216 0.1276 0.1434
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0028 0.0071 0.0078
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0047 0.1691
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0477
Schistosoma mansoni hypothetical protein 0.0037 0.0127 0.0142
Brugia malayi nuclear hormone receptor 0.0018 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0059 0.0268 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0006 0.0005
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.001 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0129 0.0415
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0037 0.0129 0.0571
Brugia malayi hypothetical protein 0.0028 0.0071 0.0078
Echinococcus granulosus geminin 0.0149 0.0848 0.0951
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0047 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0243 0.0242
Trichomonas vaginalis AGC family protein kinase 0.1405 0.89 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0129 0.5159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0006 0.0004
Echinococcus granulosus muscleblind protein 0.04 0.2458 0.276
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0047 0.1691
Trypanosoma brucei adenosine kinase, putative 0.0248 0.1478 1
Onchocerca volvulus Huntingtin homolog 0.0103 0.0552 0.425
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0034 0.0111 0.011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0006 0.0005
Echinococcus granulosus microtubule associated protein 2 0.0608 0.3792 0.4259
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0006 0.0006
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0006 0.0035
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0006 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0006 0.0006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0045
Mycobacterium tuberculosis Conserved protein 0.0037 0.0129 0.0903
Loa Loa (eye worm) acetylcholinesterase 1 0.005 0.021 0.0236
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0071 0.0079
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0124 0.0686 0.0685
Brugia malayi ecdysteroid receptor 0.0018 0.0006 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0129 0.0903
Loa Loa (eye worm) hypothetical protein 0.0248 0.1478 0.1661
Echinococcus multilocularis expressed conserved protein 0.0084 0.0428 0.0427
Brugia malayi Bromodomain containing protein 0.0066 0.031 0.0347
Echinococcus multilocularis acetylcholinesterase 0.005 0.021 0.0209
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0232 0.0261
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0216 0.1276 0.1388
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.002 0.0023
Schistosoma mansoni lipoxygenase 0.0049 0.0202 0.0227
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0107
Mycobacterium tuberculosis Conserved protein 0.0037 0.0129 0.0903
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0243 1
Echinococcus granulosus solute carrier family 5 0.0034 0.0111 0.0123
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0006 0.0006
Brugia malayi hypothetical protein 0.0032 0.0093 0.0103
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0006 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0129 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0415 0.0413
Echinococcus granulosus ribokinase 0.0028 0.0071 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0006 0.0006
Schistosoma mansoni adenosine kinase 0.0248 0.1478 0.1661
Leishmania major adenosine kinase, putative 0.0248 0.1478 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0243 0.1708
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.04 0.2458 0.2761
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0129 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0232 0.0261
Loa Loa (eye worm) beta-lactamase 0.0037 0.0129 0.0145
Loa Loa (eye worm) hypothetical protein 0.0052 0.0221 0.0248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0136 0.0152
Echinococcus granulosus beta hexosaminidase subunit beta 0.0216 0.1276 0.1433
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.005 0.0212 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0006 0.0005
Mycobacterium tuberculosis Conserved protein 0.0037 0.0129 0.0903
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0129 0.0903
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0047 0.0052
Brugia malayi beta-lactamase family protein 0.0037 0.0129 0.0144
Echinococcus multilocularis protein patched 0.0038 0.0136 0.0134
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0028 0.0071 0.0491
Onchocerca volvulus 0.0037 0.0129 0.0987
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0047 0.0326
Leishmania major adenosine kinase-like protein 0.0028 0.0071 0.0163

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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