Detailed information for compound 1638504

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1045.19 | Formula: C50H72N14O11
  • H donors: 13 H acceptors: 12 LogP: -2.21 Rotable bonds: 37
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)N)CCCN=C(N)N)Cc1ccc(cc1)O
  • InChi: 1S/C50H72N14O11/c1-4-5-13-34(43(68)61-37(24-31-26-55-27-57-31)48(73)64-21-10-15-39(64)46(71)62-38(49(74)75)23-29-11-7-6-8-12-29)59-45(70)36(22-30-16-18-32(65)19-17-30)60-47(72)41(28(2)3)63-44(69)35(14-9-20-56-50(53)54)58-42(67)33(51)25-40(52)66/h6-8,11-12,16-19,26-28,33-39,41,65H,4-5,9-10,13-15,20-25,51H2,1-3H3,(H2,52,66)(H,55,57)(H,58,67)(H,59,70)(H,60,72)(H,61,68)(H,62,71)(H,63,69)(H,74,75)(H4,53,54,56)/t33-,34-,35-,36-,37-,38-,39-,41-/m0/s1
  • InChiKey: PRTAIRIYLQOGOC-YEFFYANISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0155 0.021 0.021
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0413 0.0615 0.0612
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0413 0.0615 0.0828
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.005 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1349 0.2082 0.2802
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0019 0.0019
Entamoeba histolytica protein kinase, putative 0.0031 0.0016 0.0013
Plasmodium vivax vivapain-2 0.0044 0.0036 0.0542
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2147 0.3332 0.333
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0058 0.0058 0.5
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.3332 0.333
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0038 0.0038
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1211 0.1865 0.1865
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0058 0.0055
Schistosoma mansoni fkbp-rapamycin associated protein 0.1211 0.1865 0.1865
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6402 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0016 0.0016
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0036 0.0033
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1211 0.1865 0.1865
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2147 0.3332 0.333
Leishmania major hypothetical protein, conserved 0.0413 0.0615 0.0615
Onchocerca volvulus 0.0044 0.0036 0.0376
Plasmodium vivax hypothetical protein 0.0413 0.0615 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0016 0.0013
Echinococcus multilocularis cysteine protease 0.0044 0.0036 0.0036
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0936 0.1435 0.1435
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0413 0.0615 0.0828
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0413 0.0615 0.0612
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0058 0.0058 0.0058
Echinococcus multilocularis cathepsin L 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0413 0.0615 0.0615
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0413 0.0615 0.0615
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.3457 0.5385 0.5383
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0413 0.0615 0.0612
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1211 0.1865 0.1863
Schistosoma mansoni immunophilin 0.0058 0.0058 0.0058
Echinococcus multilocularis cysteine protease 0.0044 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.4761 0.7429 0.7428
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0413 0.0615 0.0615
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6402 1 1
Brugia malayi Cathepsin L-like precursor 0.0044 0.0036 0.0036
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0058 0.0058 0.0946
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.3787 0.5903 0.5902
Loa Loa (eye worm) phosphatidylinositol 3 0.0413 0.0615 0.0615
Entamoeba histolytica hypothetical protein 0.0413 0.0615 0.0612
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0413 0.0615 0.0615
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.5376 0.5375
Leishmania major phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0615
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0798 0.1218 0.1215
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0016 0.0016
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.3825 0.5962 0.5961
Brugia malayi FAT domain containing protein 0.0936 0.1435 0.1435
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0413 0.0615 0.0615
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0016 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0036 0.0036
Onchocerca volvulus Cathepsin F homolog 0.0044 0.0036 0.0376
Loa Loa (eye worm) phosphatidylinositol 3 0.2147 0.3332 0.3332
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0413 0.0615 0.0615
Brugia malayi Cathepsin L-like precursor 0.0029 0.0013 0.0013
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6402 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0413 0.0615 0.0615
Trichomonas vaginalis fk506-binding protein, putative 0.0058 0.0058 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0019 0.0017
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0413 0.0615 0.0615
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0013 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.5466 0.8533 0.8533
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0413 0.0615 0.0612
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0413 0.0615 0.0612
Brugia malayi Cathepsin L-like precursor 0.0044 0.0036 0.0036
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0413 0.0615 0.0615
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1211 0.1865 0.1865
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0029 0.0013 0.0011
Toxoplasma gondii target of rapamycin (TOR), putative 0.4761 0.7429 1
Entamoeba histolytica hypothetical protein 0.0413 0.0615 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.3457 0.5385 0.5383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0936 0.1435 0.1435
Trichomonas vaginalis PIKK family atypical protein kinase 0.5092 0.7947 0.7947
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0413 0.0615 0.0612
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0016 0.0016
Leishmania major phosphatidylinositol kinase related protein, putative 0.0413 0.0615 0.0615
Toxoplasma gondii cathepsin CPL 0.0044 0.0036 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.3787 0.5903 0.5902
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.1718 0.2659 0.2657
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0016 0.0016
Onchocerca volvulus 0.0044 0.0036 0.0376
Leishmania major peptidylprolyl isomerase-like protein 0.0058 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0798 0.1218 0.1215
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0046 0.0046
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0413 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.1305 0.2012 0.2012
Entamoeba histolytica hypothetical protein 0.0413 0.0615 0.0612
Schistosoma mansoni voltage-gated potassium channel 0.0169 0.0233 0.0233
Onchocerca volvulus 0.0044 0.0036 0.0376
Toxoplasma gondii AGC kinase 0.0031 0.0016 0.0022
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Onchocerca volvulus 0.0044 0.0036 0.0376
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0044 0.0036 0.0036
Entamoeba histolytica protein kinase rad3, putative 0.1211 0.1865 0.1863
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0003 0.0003
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0413 0.0615 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Entamoeba histolytica protein kinase, putative 0.0033 0.0019 0.0017
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0016 0.0013
Brugia malayi Cathepsin L-like cysteine proteinase 0.0029 0.0013 0.0013
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0413 0.0615 0.0612
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2659 0.4135 0.4133
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0045 0.0038 0.0038
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2147 0.3332 0.3332
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0413 0.0615 0.0612
Loa Loa (eye worm) hypothetical protein 0.0413 0.0615 0.0615
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0016 0.0016
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0413 0.0615 0.0612
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.6402 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0798 0.1218 0.1215
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0413 0.0615 0.0615
Onchocerca volvulus 0.0044 0.0036 0.0376
Schistosoma mansoni immunophilin 0.0058 0.0058 0.0058
Leishmania major phosphatidylinositol 3-kinase, putative 0.2147 0.3332 0.3332
Giardia lamblia GTOR 0.6402 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0044 0.0036 0.0033
Loa Loa (eye worm) ctsf protein 0.0044 0.0036 0.0036
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Echinococcus granulosus cathepsin L 0.0022 0.0003 0.0003
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0058 0.0058 0.0058
Plasmodium falciparum cysteine proteinase falcipain 3 0.0044 0.0036 0.0585
Brugia malayi Cathepsin L-like precursor 0.0029 0.0013 0.0013
Brugia malayi Cyclic-nucleotide gated cation channel 0.0031 0.0016 0.0016
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0413 0.0615 0.0612
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0413 0.0615 0.0615
Schistosoma mansoni voltage-gated potassium channel 0.0169 0.0233 0.0233
Echinococcus granulosus cathepsin L cysteine proteinase 0.0044 0.0036 0.0036
Leishmania major fk506-binding protein 1-like protein 0.0058 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0145 0.0195 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Brugia malayi Cathepsin L-like precursor 0.0044 0.0036 0.0036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0413 0.0615 0.0615
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2147 0.3332 0.3332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.1211 0.1865 0.1865
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0413 0.0615 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0413 0.0615 0.0612
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0044 0.0036 0.0585
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.6402 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0019 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0413 0.0615 0.0828
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Brugia malayi Cathepsin L-like precursor 0.0044 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0019 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0036 0.0033
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0058 0.0055
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6402 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0016 0.0016
Onchocerca volvulus 0.0044 0.0036 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.0615 0.0612
Giardia lamblia Phosphatidylinositol 4-kinase 0.0413 0.0615 0.056
Plasmodium vivax vivapain-2 0.0044 0.0036 0.0542
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0413 0.0615 0.0612
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0413 0.0615 0.0615
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0038 0.0038
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6402 1 1
Onchocerca volvulus 0.0044 0.0036 0.0376
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.4761 0.7429 0.7428
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0013 0.0011
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0413 0.0615 0.0615
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0019 0.0017
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0413 0.0615 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0058 0.0055
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5097 0.7956 0.7955
Loa Loa (eye worm) cysteine protease 0.0044 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Echinococcus granulosus cysteine protease 0.0022 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Toxoplasma gondii FATC domain-containing protein 0.1211 0.1865 0.251
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.5376 0.5375
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.3825 0.5962 0.5961
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Entamoeba histolytica hypothetical protein 0.1211 0.1865 0.1863
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.3332 0.333
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0413 0.0615 0.0615
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0413 0.0615 0.0615
Echinococcus multilocularis Zinc finger, PHD finger 0.0413 0.0615 0.0615
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6402 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0044 0.0036 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0036 0.0033
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0413 0.0615 1
Loa Loa (eye worm) hypothetical protein 0.0798 0.1218 0.1218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1211 0.1865 0.1863
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0044 0.0036 0.0033
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0058 0.0055
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0058 0.0058 0.0058
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5097 0.7956 0.7956
Echinococcus granulosus cathepsin l1 0.0029 0.0013 0.0013
Loa Loa (eye worm) fibroinase 0.0044 0.0036 0.0036
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0016 0.0016
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0413 0.0615 0.0615
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0058 0.0058 0.0905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Leishmania major hypothetical protein, unknown function 0.0413 0.0615 0.0615
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6402 1 1
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Plasmodium falciparum cysteine proteinase falcipain 1 0.0022 0.0003 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.3825 0.5962 0.5961
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0036 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.3332 0.333
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0155 0.021 0.021
Trypanosoma brucei rac serine-threonine kinase, putative 0.0033 0.0019 0.0017
Brugia malayi cathepsin L-like precursor 0.0029 0.0013 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0413 0.0615 0.0615
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6402 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0413 0.0615 0.0615
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.5092 0.7947 0.7947
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2147 0.3332 0.3332
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0038 0.0038
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0413 0.0615 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.3332 0.333
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0058 0.0055
Leishmania major cysteine peptidase A (CPA) 0.0044 0.0036 0.0036
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2147 0.3332 0.333
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0006 0.0006
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0413 0.0615 0.0828
Echinococcus granulosus serine protein kinase ATM 0.1211 0.1865 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.5092 0.7947 0.7947
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0413 0.0615 0.0828
Echinococcus multilocularis serine protein kinase ATM 0.1211 0.1865 0.1865
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0413 0.0615 0.0612
Loa Loa (eye worm) hypothetical protein 0.0044 0.0036 0.0036
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0058 0.0055
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0413 0.0615 0.0615
Mycobacterium tuberculosis Conserved hypothetical protein 0.0413 0.0615 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0155 0.021 0.021
Plasmodium vivax hypothetical protein, conserved 0.0413 0.0615 1
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Schistosoma mansoni cathepsin F (C01 family) 0.0044 0.0036 0.0036
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0044 0.0036 0.0036
Giardia lamblia Hypothetical protein 0.0413 0.0615 0.056
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0036 0.0033
Trypanosoma cruzi target of rapamycin kinase 3 0.5097 0.7956 0.7955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0019 0.0017
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.5092 0.7947 0.7947
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0003 0.0003
Onchocerca volvulus 0.0413 0.0615 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3027 0.4712 0.4711
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0038 0.0038
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0612
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0058 0.0058 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0413 0.0615 0.0612
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1211 0.1865 0.1865
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0413 0.0615 0.0612
Mycobacterium leprae conserved hypothetical protein 0.0413 0.0615 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6402 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0413 0.0615 0.0615
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0413 0.0615 0.0615
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1211 0.1865 0.1863
Echinococcus multilocularis cathepsin L cysteine protease 0.0044 0.0036 0.0036
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0413 0.0615 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.3332 0.333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.3457 0.5385 0.5383
Loa Loa (eye worm) phosphatidylinositol 3 0.0413 0.0615 0.0615
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0413 0.0615 0.0615
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0031 0.0016 0.0016
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0413 0.0615 0.0612
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0058 0.0058 0.0055
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0413 0.0615 0.0615
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0413 0.0615 0.0615
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0155 0.021 0.021
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0044 0.0036 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.4156 0.648 0.6479
Leishmania major cathepsin L-like protease 0.0044 0.0036 0.0036
Brugia malayi Cathepsin L-like precursor 0.0044 0.0036 0.0036
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2147 0.3332 0.3332
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0058 0.0058 0.0058
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2147 0.3332 0.333
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0413 0.0615 0.0615
Loa Loa (eye worm) phosphatidylinositol 3 0.6402 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0044 0.0036 0.0036
Echinococcus multilocularis voltage gated potassium channel 0.0045 0.0038 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.6402 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0036 0.0033
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0031 0.0016 0.0016
Echinococcus granulosus cathepsin L cysteine protease 0.0022 0.0003 0.0003
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0413 0.0615 0.056
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0016 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0019 0.0017
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0058 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1211 0.1865 0.1863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0013 0.0011
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0936 0.1435 0.1435
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0016 0.0016
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0003 0.0003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0044 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0413 0.0615 0.0612
Loa Loa (eye worm) hypothetical protein 0.0045 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0413 0.0615 0.0615
Schistosoma mansoni immunophilin 0.005 0.0046 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0036 0.0376
Trichomonas vaginalis immunophilin, putative 0.0058 0.0058 0.0055
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.1211 0.1865 0.1863
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0612
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0016 0.0016
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0058 0.0058 0.0055
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0612
Loa Loa (eye worm) FKBP5 protein 0.0058 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.4761 0.7429 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.1211 0.1865 0.1863
Echinococcus multilocularis 0.0413 0.0615 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Entamoeba histolytica hypothetical protein 0.0413 0.0615 0.0612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.1211 0.1865 0.1863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2147 0.3332 0.3332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0413 0.0615 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.3451 0.5376 0.5375
Loa Loa (eye worm) hypothetical protein 0.0135 0.0178 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.5092 0.7947 0.7947
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0413 0.0615 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.3457 0.5385 0.5383
Echinococcus multilocularis cathepsin L cysteine protease 0.0044 0.0036 0.0036
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0413 0.0615 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0413 0.0615 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0936 0.1435 0.1432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0036 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.1349 0.2082 0.208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1211 0.1865 0.1865
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0612
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0413 0.0615 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0413 0.0615 0.0615
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0019 0.0017
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0058 0.0055
Entamoeba histolytica cysteine protease, putative 0.0044 0.0036 0.0033
Brugia malayi Protein kinase domain containing protein 0.0033 0.0019 0.0019
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6402 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0016 0.0016
Leishmania major phosphatidylinositol kinase, putative 0.0413 0.0615 0.0615
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0031 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0936 0.1435 0.1435
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0145 0.0195 0.0192
Entamoeba histolytica protein kinase, putative 0.0033 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.4761 0.7429 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.4294 0.6697 0.6696
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0413 0.0615 1
Echinococcus granulosus cathepsin l1 0.0044 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0413 0.0615 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.4761 0.7429 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.4761 0.7429 0.7428
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0413 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0016
Brugia malayi Cathepsin L-like precursor 0.0044 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.0615 0.0612
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0413 0.0615 0.0612
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0413 0.0615 1
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0036 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.4761 0.7429 0.7428
Onchocerca volvulus 0.0413 0.0615 1
Echinococcus granulosus voltage gated potassium channel 0.0045 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0036 0.0033
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0413 0.0615 0.0615
Leishmania major phosphatidylinositol 4-kinase, putative 0.0413 0.0615 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0036 0.0033
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0413 0.0615 0.0612
Echinococcus multilocularis fk506 binding protein 0.0058 0.0058 0.0058
Loa Loa (eye worm) phosphatidylinositol kinase 0.0413 0.0615 0.0615
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0013 0.0013
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0058 0.0055
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0031 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.1349 0.2082 0.2082
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6402 1 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0031 0.0016 0.0016

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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