Detailed information for compound 1647140

Basic information

Technical information
  • TDR Targets ID: 1647140
  • Name: N-(furan-3-ylmethylideneamino)-2-(4-methylphe nyl)quinoline-4-carboxamide
  • MW: 355.389 | Formula: C22H17N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1nc2ccccc2c(c1)C(=O)N/N=C/c1cocc1
  • InChi: 1S/C22H17N3O2/c1-15-6-8-17(9-7-15)21-12-19(18-4-2-3-5-20(18)24-21)22(26)25-23-13-16-10-11-27-14-16/h2-14H,1H3,(H,25,26)/b23-13+
  • InChiKey: DOWGGTJSETZSPF-YDZHTSKRSA-N  


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Synonyms

  • N-(3-furylmethyleneamino)-2-(4-methylphenyl)quinoline-4-carboxamide
  • N-(3-furylmethyleneamino)-2-(4-methylphenyl)-4-quinolinecarboxamide
  • N-(3-furylmethyleneamino)-2-(4-methylphenyl)cinchoninamide
  • IVK/9077645
  • AK-968/40605691

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0577 0.18 0.18
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0924 0.0924
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0109 0.0184 0.0167
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0114 0.0202 0.0202
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.029 0.0811 0.0639
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0201 0.0502 0.8218
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0393 0.1165 0.1007
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0192 0.0473 0.0294
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0094 0.0133 0.0133
Schistosoma mansoni phosphatidylinositol 4-kinase 0.022 0.0571 0.0571
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0114 0.0202 0.0202
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0577 0.18 0.18
Trichomonas vaginalis PIKK family atypical protein kinase 0.2206 0.7426 0.738
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0393 0.1165 0.115
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.022 0.0571 0.0402
Schistosoma mansoni hypothetical protein 0.0201 0.0502 0.0502
Leishmania major phosphatidylinositol 3-kinase, putative 0.1018 0.3324 0.3199
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0577 0.18 0.1646
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0201 0.0502 0.0485
Leishmania major hypothetical protein, unknown function 0.0201 0.0502 0.0323
Echinococcus granulosus serine protein kinase ATM 0.0577 0.18 0.18
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1029 0.3362 0.3237
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2951 1 1
Plasmodium vivax hypothetical protein, conserved 0.0201 0.0502 0.8218
Trichomonas vaginalis PIKK family atypical protein kinase 0.1611 0.5371 0.5288
Echinococcus multilocularis 0.0201 0.0502 0.0502
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0441 0.1333 0.1333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.0502 0.0502
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0114 0.0202 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.5379 0.5296
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0201 0.0502 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.2356 0.7945 0.7908
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0109 0.0184 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0331 0.0951 0.0789
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1237 0.4081 0.397
Loa Loa (eye worm) phosphatidylinositol 3 0.0201 0.0502 0.0502
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0587 0.1838 0.1685
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.3324 0.3204
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0459 0.1396 0.1396
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.022 0.0571 0.0402
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0261 0.071 0.0544
Schistosoma mansoni hypothetical protein 0.0205 0.0516 0.0516
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2951 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.022 0.0571 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0441 0.1333 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.3324 0.3204
Schistosoma mansoni immunophilin 0.0094 0.0133 0.0133
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2951 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.005 0.005
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0201 0.0502 0.0502
Plasmodium falciparum phosphatidylinositol 3-kinase 0.022 0.0571 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0109 0.0184 0.0167
Schistosoma mansoni immunophilin 0.0109 0.0184 0.0184
Loa Loa (eye worm) phosphatidylinositol 3 0.0201 0.0502 0.0502
Toxoplasma gondii target of rapamycin (TOR), putative 0.2206 0.7426 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.5902 0.5829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0502 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.1611 0.5371 0.5288
Entamoeba histolytica hypothetical protein 0.0201 0.0502 0.0323
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0201 0.0502 0.8218
Trichomonas vaginalis PIKK family atypical protein kinase 0.2206 0.7426 0.738
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.022 0.0571 0.0571
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.022 0.0571 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0201 0.0502 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0502 0.0332
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2951 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.022 0.0571 0.0394
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0577 0.18 0.1786
Mycobacterium leprae conserved hypothetical protein 0.0201 0.0502 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2206 0.7426 0.738
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1069 0.35 0.35
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0241 0.0641 0.0466
Loa Loa (eye worm) hypothetical protein 0.0441 0.1333 0.1333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.0502 0.0502
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0201 0.0502 0.0485
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0393 0.1165 0.115
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0577 0.18 0.18
Loa Loa (eye worm) hypothetical protein 0.006 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0376 0.1108 0.0948
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0201 0.0502 0.0502
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0184 0.0184
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0184 0.0008
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0094 0.0133 0.0133
Schistosoma mansoni immunophilin 0.0109 0.0184 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.2951 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.2358 0.7953 0.7949
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0642 0.2026 0.2201
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2026 0.1883
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0114 0.0202 0.0202
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2951 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0201 0.0502 0.0323
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0567 0.1767 0.1767
Loa Loa (eye worm) phosphatidylinositol 3 0.0201 0.0502 0.0502
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0376 0.1108 0.1092
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0201 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0587 0.1838 0.1692
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0201 0.0502 0.0323
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0184 0.0184
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.022 0.0571 0.0554
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0768 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0924 0.0924
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2951 1 1
Giardia lamblia GTOR 0.2951 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2206 0.7426 0.738
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0201 0.0502 0.0502
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0201 0.0502 0.0485
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0184 0.0008
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2358 0.7953 0.7915
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0567 0.1767 0.1767
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0201 0.0502 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.2206 0.7426 0.738
Trichomonas vaginalis PIKK family atypical protein kinase 0.198 0.6646 0.6586
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0201 0.0502 0.0323
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.0238 0.0238
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0577 0.18 0.1786
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0577 0.18 0.18
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0201 0.0502 0.8218
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0201 0.0502 0.8218
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0261 0.071 0.0536
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0577 0.18 0.18
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0017 0.0017
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0393 0.1165 0.1007
Trichomonas vaginalis PIKK family atypical protein kinase 0.2356 0.7945 0.7908
Loa Loa (eye worm) phosphatidylinositol 3 0.0201 0.0502 0.0502
Plasmodium vivax hypothetical protein 0.0201 0.0502 0.8218
Loa Loa (eye worm) FKBP5 protein 0.0109 0.0184 0.0184
Echinococcus multilocularis serine protein kinase ATM 0.0577 0.18 0.18
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0201 0.0502 0.0502
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.1165 0.0999
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.5379 0.5296
Echinococcus multilocularis Zinc finger, PHD finger 0.022 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.2206 0.7426 0.738
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0109 0.0184 0.0184
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0109 0.0184 0.0167
Entamoeba histolytica hypothetical protein 0.0352 0.1026 0.0857
Giardia lamblia Phosphatidylinositol 4-kinase 0.0201 0.0502 0.0323
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2951 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0261 0.071 0.071
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.0238 0.0238
Trichomonas vaginalis fk506-binding protein, putative 0.0109 0.0184 0.0008
Leishmania major phosphatidylinositol kinase related protein, putative 0.0201 0.0502 0.0323
Onchocerca volvulus 0.0201 0.0502 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1763 0.5898 0.5824
Trichomonas vaginalis PIKK family atypical protein kinase 0.1611 0.5371 0.5288
Entamoeba histolytica hypothetical protein 0.0201 0.0502 0.0323
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0352 0.1026 0.0857
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0393 0.1165 0.1007
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0109 0.0184 0.0184
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.022 0.0571 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.5902 0.5829
Loa Loa (eye worm) phosphatidylinositol 3 0.0527 0.1628 0.1628
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.022 0.0571 0.0554
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0441 0.1333 0.1333
Loa Loa (eye worm) hypothetical protein 0.0376 0.1108 0.1108
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2358 0.7953 0.7915
Echinococcus multilocularis fk506 binding protein 0.0109 0.0184 0.0184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0323 0.0924 0.0924
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0174 0.0411 0.0411
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0282 0.0785 0.0612
Loa Loa (eye worm) hypothetical protein 0.0201 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0642 0.2026 0.2026
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0109 0.0184 0.0184
Giardia lamblia Hypothetical protein 0.0201 0.0502 0.0323
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2951 1 1
Brugia malayi hypothetical protein 0.0182 0.0439 0.0439
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0109 0.0184 0.0184
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1069 0.35 0.3488
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.5902 0.5829
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.3324 0.3204
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1069 0.35 0.3488
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0261 0.071 0.071
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0577 0.18 0.1646
Trichomonas vaginalis PIKK family atypical protein kinase 0.2951 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0261 0.071 0.0544
Loa Loa (eye worm) phosphatidylinositol 3 0.2951 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1018 0.3324 0.3199
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0109 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0205 0.0516 0.0516
Entamoeba histolytica protein kinase rad3, putative 0.0577 0.18 0.1646
Trichomonas vaginalis PIKK family atypical protein kinase 0.2356 0.7945 0.7908
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0201 0.0502 0.0502
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1069 0.35 0.35
Loa Loa (eye worm) hypothetical protein 0.0577 0.18 0.18
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.022 0.0571 0.0571
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1069 0.35 0.35
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.0502 0.0502
Leishmania major hypothetical protein, conserved 0.0292 0.0819 0.0646
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0109 0.0184 0.5
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0459 0.1396 0.1396
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1069 0.35 0.35
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.2549 0.2415
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.022 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.1763 0.5898 0.5824
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0201 0.0502 0.0502
Trichomonas vaginalis immunophilin, putative 0.0109 0.0184 0.0008
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.022 0.0571 0.0394
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0201 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0099 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0182 0.0439 0.0439
Loa Loa (eye worm) phosphatidylinositol 3 0.006 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1915 0.6421 0.6357
Loa Loa (eye worm) hypothetical protein 0.0593 0.1856 0.1856
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.1165 0.1165
Brugia malayi FAT domain containing protein 0.0441 0.1333 0.1333
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0201 0.0502 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.3324 0.3204
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0331 0.0951 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.1029 0.3362 0.3243
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0261 0.071 0.0544
Loa Loa (eye worm) hypothetical protein 0.0094 0.0133 0.0133
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2951 1 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0577 0.18 0.18
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2951 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0261 0.071 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.2951 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.022 0.0571 0.0394
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1029 0.3362 0.3237
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.022 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.251 0.8476 0.8449
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0201 0.0502 0.0485
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0109 0.0184 0.0167
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.022 0.0571 0.0571
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.022 0.0571 0.0099
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1388 0.4604 0.4503
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.022 0.0571 0.0099
Echinococcus multilocularis geminin 0.0205 0.0516 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.2356 0.7945 0.7908
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0126 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.1108 0.0948
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0201 0.0502 0.0332
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0924 0.0924
Loa Loa (eye worm) phosphatidylinositol kinase 0.0201 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.18 0.1653
Echinococcus granulosus geminin 0.0205 0.0516 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.18 0.1653
Trichomonas vaginalis PIKK family atypical protein kinase 0.2206 0.7426 0.738
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.5379 0.5296
Schistosoma mansoni hypothetical protein 0.0441 0.1333 0.1333
Leishmania major phosphatidylinositol 3-kinase, putative 0.022 0.0571 0.0394
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2951 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0261 0.071 0.0694
Onchocerca volvulus 0.0201 0.0502 1
Loa Loa (eye worm) phosphatidylinositol 3 0.1029 0.3362 0.3362
Toxoplasma gondii FATC domain-containing protein 0.0577 0.18 0.1875
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0201 0.0502 0.8218
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.5379 0.5296
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0567 0.1767 0.1767
Trichomonas vaginalis PIKK family atypical protein kinase 0.2356 0.7945 0.7908
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0261 0.071 0.0536
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.022 0.0571 0.0394
Entamoeba histolytica hypothetical protein 0.0201 0.0502 0.0323

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.7755 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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