Detailed information for compound 1660118

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 310.307 | Formula: C16H14N4O3
  • H donors: 2 H acceptors: 3 LogP: 3.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1nc[nH]c1/N=N/c1c(O)ccc2c1cccc2
  • InChi: 1S/C16H14N4O3/c1-2-23-16(22)14-15(18-9-17-14)20-19-13-11-6-4-3-5-10(11)7-8-12(13)21/h3-9,21H,2H2,1H3,(H,17,18)/b20-19+
  • InChiKey: QFGQXFPLOJFEDK-FMQUCBEESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia DINP protein human, muc B family 0.0023 0.0085 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0168
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0159 1
Schistosoma mansoni hypothetical protein 0.0205 0.1966 0.2284
Schistosoma mansoni hypothetical protein 0.0058 0.0447 0.0488
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0065 0.2037
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.014 0.2855
Brugia malayi AMP-binding enzyme family protein 0.0029 0.014 0.0302
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0079 0.0597
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0294 1
Brugia malayi tumor suppressor. 0.0388 0.3871 1
Echinococcus granulosus lamin 0.0033 0.0181 0.0206
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0041 0.0044
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0041 0.017
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0079 0.3197
Mycobacterium tuberculosis Conserved protein 0.0043 0.0294 0.0943
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0079 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0184 0.0475
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0362
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0362
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0126 0.0107
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0126 0.0119
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0591 0.0585
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.014 0.3277
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0294 0.0307
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0159 0.4656
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0294 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0294 0.7025
Schistosoma mansoni hypothetical protein 0.0033 0.0184 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Onchocerca volvulus 0.0043 0.0294 0.5014
Loa Loa (eye worm) beta-lactamase 0.0043 0.0294 0.076
Loa Loa (eye worm) hypothetical protein 0.0052 0.0377 0.0975
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0065 0.0089
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0064 0.0166
Loa Loa (eye worm) hypothetical protein 0.0043 0.0294 0.076
Mycobacterium ulcerans hypothetical protein 0.0029 0.014 0.3277
Echinococcus granulosus zinc finger protein 0.0024 0.0088 0.0097
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0184 0.0416
Brugia malayi hypothetical protein 0.002 0.0047 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0294 0.0339
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0294 1
Entamoeba histolytica hypothetical protein 0.0043 0.0294 1
Echinococcus granulosus geminin 0.0205 0.1966 0.2311
Schistosoma mansoni hypothetical protein 0.0043 0.0294 0.0306
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0404 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0016
Schistosoma mansoni lamin 0.0033 0.0181 0.0173
Trichomonas vaginalis esterase, putative 0.0043 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.013 0.1189 0.307
Echinococcus granulosus hypothetical protein 0.0033 0.0184 0.021
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0404 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0294 0.076
Mycobacterium tuberculosis Conserved protein 0.0043 0.0294 0.0943
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0085 0.0219
Echinococcus granulosus protein quaking 0.0033 0.0184 0.021
Echinococcus granulosus lamin dm0 0.0033 0.0181 0.0206
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0035
Schistosoma mansoni hypothetical protein 0.0033 0.0184 0.0176
Mycobacterium leprae Probable lipase LipE 0.0043 0.0294 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0085 0.0158
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0035
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.014 0.2855
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0085 0.1904
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0065 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0102 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0294 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0085 0.1904
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0362
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0085 0.0866
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0057 0.006
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0057 0.006
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0294 0.0943
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0085 0.0729 0.1883
Brugia malayi Bromodomain containing protein 0.0091 0.0783 0.1971
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0294 0.0288
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.014 0.3277
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0159 0.3362
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0294 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0079 0.119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0053 0.0044
Echinococcus granulosus muscleblind protein 0.018 0.1714 0.2014
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.014 0.2853
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0085 0.1357
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0085 0.1357
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0294 0.0943
Trypanosoma brucei ISWI complex protein 0.0018 0.0035 0.0632
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.014 0.3277
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0035
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0085 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.014 0.0369
Loa Loa (eye worm) hypothetical protein 0.0043 0.0294 0.076
Echinococcus granulosus dna polymerase kappa 0.0023 0.0085 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0029 0.014 0.0302
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0046 0.0324 0.0836
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0159 0.4656
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0591 0.069
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.014 0.3277
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0041 0.0791
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0293 0.0338
Leishmania major hypothetical protein, conserved 0.0043 0.0294 0.7025
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0447 0.11
Entamoeba histolytica hypothetical protein 0.0043 0.0294 1
Echinococcus multilocularis protein quaking 0.0033 0.0184 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0029 0.014 0.0302
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0181 0.0467
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2724 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0159 0.041
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2805 0.33
Leishmania major DNA polymerase kappa, putative 0.0023 0.0085 0.1357
Loa Loa (eye worm) tumor suppressor 0.0388 0.3871 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0085 0.1357
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.014 0.2853
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0085 0.0163
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0041 0.0791
Leishmania major DNA polymerase eta, putative 0.0054 0.0404 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0053 0.0044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0294 0.076
Loa Loa (eye worm) hypothetical protein 0.018 0.1714 0.4428
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0294 0.0943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0294 0.0288
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0237 0.5484
Brugia malayi intermediate filament protein 0.0033 0.0181 0.0408
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.1195 0.3044
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0085 0.0286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0085 0.1357
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0159 0.3362
Schistosoma mansoni zinc finger protein 0.0024 0.0088 0.0063
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.1189 0.307
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0079 0.1489
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0024 0.0062
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0294 0.0306
Schistosoma mansoni DNA polymerase eta 0.0054 0.0404 0.0437
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0294 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0447 0.0488
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8487 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0079 0.0086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0294 0.0943
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0079 0.119
Brugia malayi beta-lactamase 0.0043 0.0294 0.0702
Schistosoma mansoni ap endonuclease 0.0023 0.0079 0.0052
Schistosoma mansoni ap endonuclease 0.0023 0.0079 0.0052
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0085 0.0286
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0294 0.0943
Mycobacterium ulcerans hypothetical protein 0.0043 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0467
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.014 0.3277
Onchocerca volvulus 0.0043 0.0294 0.5014
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0294 0.7025
Echinococcus multilocularis musashi 0.0033 0.0181 0.0175
Onchocerca volvulus 0.0058 0.0447 1
Schistosoma mansoni hypothetical protein 0.0205 0.1966 0.2284
Loa Loa (eye worm) hypothetical protein 0.0049 0.0353 0.0913
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0079 0.119
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0293 0.0287
Brugia malayi beta-lactamase family protein 0.0043 0.0294 0.0702
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0057 0.0051
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2805 0.2801
Echinococcus multilocularis zinc finger protein 0.0024 0.0088 0.0082
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0085 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Echinococcus multilocularis geminin 0.0205 0.1966 0.1961
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0065 0.0948
Mycobacterium tuberculosis Conserved protein 0.0043 0.0294 0.0943
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0041 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0294 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8487 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0294 0.076
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0085 0.1904
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0085 0.0079
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0451
Onchocerca volvulus 0.0033 0.0181 0.1329
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.014 0.2855
Mycobacterium ulcerans lipase LipD 0.0043 0.0294 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0041 0.017
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0085 0.0866
Entamoeba histolytica hypothetical protein 0.0043 0.0294 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0294 0.0307
Schistosoma mansoni lamin 0.0033 0.0181 0.0173
Echinococcus multilocularis lamin dm0 0.0033 0.0181 0.0175
Echinococcus multilocularis muscleblind protein 0.018 0.1714 0.1709
Brugia malayi hypothetical protein 0.0043 0.0294 0.0701
Brugia malayi Bromodomain containing protein 0.0046 0.0323 0.0777
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0041 0.017
Loa Loa (eye worm) hypothetical protein 0.018 0.1714 0.4428
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0159 0.3781
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0294 0.0943
Loa Loa (eye worm) hypothetical protein 0.0054 0.0404 0.1043
Brugia malayi PHD-finger family protein 0.003 0.0155 0.0341
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0168
Onchocerca volvulus 0.0043 0.0294 0.5014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0057 0.0026
Toxoplasma gondii exonuclease III APE 0.0023 0.0079 0.1489
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0294 0.0943
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.014 0.3277
Echinococcus multilocularis transcription factor eb 0.013 0.1195 0.119
Mycobacterium ulcerans beta-lactamase 0.0043 0.0294 1
Schistosoma mansoni hypothetical protein 0.0025 0.0102 0.0079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0053 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0085 0.1357
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.014 0.3277
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0168
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0079 0.1747
Echinococcus multilocularis lamin 0.0033 0.0181 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0057 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Brugia malayi hypothetical protein 0.0033 0.0184 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Echinococcus multilocularis dna polymerase eta 0.0054 0.0404 0.0398
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0079 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0057 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0079 0.0073
Leishmania major DNA polymerase eta, putative 0.0038 0.0237 0.5484
Echinococcus multilocularis muscleblind protein 1 0.018 0.1714 0.1709
Echinococcus granulosus dna polymerase eta 0.0054 0.0404 0.0469
Leishmania major hypothetical protein, conserved 0.003 0.0159 0.3362
Trypanosoma brucei unspecified product 0.0023 0.0085 0.1904
Brugia malayi beta-lactamase family protein 0.0043 0.0294 0.0702
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0079 0.014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0294 0.0702
Brugia malayi Muscleblind-like protein 0.018 0.1714 0.4393
Brugia malayi hypothetical protein 0.0286 0.2805 0.7229
Loa Loa (eye worm) hypothetical protein 0.0043 0.0294 0.076
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0294 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0126 0.0141
Echinococcus granulosus intermediate filament protein 0.0033 0.0181 0.0206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0053 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0294 0.7213
Echinococcus granulosus transcription factor eb 0.013 0.1195 0.1402
Brugia malayi isocitrate dehydrogenase 0.0019 0.0041 0.0044
Schistosoma mansoni intermediate filament proteins 0.0033 0.0181 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0057 0.0026
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.014 0.0369
Brugia malayi hypothetical protein 0.003 0.0159 0.035
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0041 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0085 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Toxoplasma gondii ABC1 family protein 0.0043 0.0294 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0079 0.0142
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.014 0.2853
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8487 0.8486
Entamoeba histolytica hypothetical protein 0.0043 0.0294 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0181 0.0408
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0181 0.0467
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0294 0.034
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0085 0.0093
Loa Loa (eye worm) hypothetical protein 0.0286 0.2805 0.7246
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0404 0.0987
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0085 0.0286
Loa Loa (eye worm) hypothetical protein 0.0043 0.0294 0.076
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0041 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0041 0.0035
Schistosoma mansoni bromodomain containing protein 0.0076 0.0636 0.0711
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0159 1
Onchocerca volvulus 0.0033 0.0181 0.1329
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0079 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0085 0.1904
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0085 0.0163
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0237 0.7753

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.9 Displacement of [3H]ZM241385 from human AA2AR expressed in HEK293T cells after 2 hrs by liquid scintillation counter ChEMBL. 22563707

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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