Detailed information for compound 1683613

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 477.539 | Formula: C23H23N7O3S
  • H donors: 2 H acceptors: 7 LogP: 2.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cn1)Nc1ncc(cc1c1nc(C)nc(n1)N)Cc1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C23H23N7O3S/c1-14-27-22(30-23(24)28-14)19-11-16(10-15-4-7-18(8-5-15)34(3,31)32)12-26-21(19)29-17-6-9-20(33-2)25-13-17/h4-9,11-13H,10H2,1-3H3,(H,26,29)(H2,24,27,28,30)
  • InChiKey: AXVUBWYMDBEDQM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Starlite/ChEMBL References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 582 aa 491 aa 25.2 %
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0723 0.5673
Plasmodium falciparum thioredoxin reductase 0.0046 0.0257 0.3162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.1244 0.1482
Loa Loa (eye worm) runx1 0.0067 0.0522 0.0702
Echinococcus granulosus L aminoadipate semialdehyde 0.0101 0.0934 0.0908
Loa Loa (eye worm) hypothetical protein 0.0181 0.1923 0.2589
Plasmodium vivax 6-phosphofructokinase, putative 0.0036 0.013 0.131
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0084 0.0723 0.1182
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0496 0.5813 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.0404
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0058
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0686 0.8156 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0257 0.0266
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0354 0.4058 0.6959
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.057 0.0543
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0279 0.3139 0.312
Echinococcus multilocularis 6 phosphofructokinase 0.0132 0.1315 0.1291
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.11
Echinococcus granulosus bloom syndrome protein 0.005 0.0307 0.0279
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0453 0.061
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.0195 0.0369
Echinococcus granulosus muscleblind protein 0.0181 0.1923 0.19
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0139 0.1409 0.2368
Loa Loa (eye worm) hypothetical protein 0.0217 0.2365 0.3183
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0326 0.0491
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0678 0.1013
Trypanosoma brucei trypanothione reductase 0.0046 0.0257 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0488 0.0771
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.1409 0.1897
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0496 0.5813 1
Brugia malayi 6-phosphofructokinase 0.0132 0.1315 0.2031
Loa Loa (eye worm) hypothetical protein 0.0536 0.6308 0.8491
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0264 0.0237
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0141 0.019
Mycobacterium ulcerans hypothetical protein 0.0126 0.1244 0.1482
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.0229 0.0201
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0678 0.0651
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0453 0.0426
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1827 0.4291
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0453 0.0453
Brugia malayi Bromodomain containing protein 0.0046 0.0264 0.0352
Schistosoma mansoni lozenge 0.0067 0.0522 0.0522
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.3931
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0036 0.013 0.131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0929 0.0903
Schistosoma mansoni DNA helicase recq5 0.0035 0.0119 0.0119
Mycobacterium ulcerans hypothetical protein 0.0126 0.1244 0.1482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.057 0.0543
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0496 0.5813 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1827 0.3092
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0244 0.0216
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0326 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0036 0.013 0.0743
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0208 0.2262 0.3542
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1179
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.2835
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0119 0.0091
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.033
Brugia malayi phosphofructokinase 0.0132 0.1315 0.2031
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0232 0.0327
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0063 0.0465 0.0731
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0043 0.0016
Leishmania major mitochondrial DNA polymerase beta 0.0366 0.4203 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0084 0.0723 0.0697
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0232 0.0327
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0122
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0161 0.1677 0.2832
Mycobacterium ulcerans 6-phosphofructokinase 0.0132 0.1315 0.157
Toxoplasma gondii thioredoxin reductase 0.0046 0.0257 0.1794
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0036 0.013 0.0222
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0686 0.8156 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Trypanosoma brucei glucosidase, putative 0.0044 0.0232 0.0458
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0474 0.5545 0.9536
Echinococcus multilocularis muscleblind protein 1 0.0181 0.1923 0.19
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0929 0.125
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0257 0.0371
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1125 0.1335
Trypanosoma brucei protein kinase, putative 0.0062 0.0453 0.099
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0678 0.153
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0453 0.0426
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0686 0.8156 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0084 0.0723 0.0697
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0929 0.0903
Brugia malayi Muscleblind-like protein 0.0181 0.1923 0.3001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0244 0.0329
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0232 0.0458
Leishmania major phosphatidylinositol 3-kinase, putative 0.0084 0.0723 0.1639
Loa Loa (eye worm) glutathione reductase 0.0046 0.0257 0.0346
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.005 0.0073
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0132 0.1315 0.3173
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0686 0.8156 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0488
Giardia lamblia GTOR 0.0072 0.0586 0.1185
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0061 0.045 0.0981
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.153
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0453 0.099
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0678 0.0678
Loa Loa (eye worm) phosphatidylinositol 3 0.0627 0.7429 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0193 0.2068 0.2498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Loa Loa (eye worm) RecQ helicase 0.005 0.0307 0.0413
Brugia malayi MAP kinase sur-1 0.0062 0.0453 0.0654
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0453 0.071
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0084 0.0723 0.1179
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0084 0.0723 0.0974
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0036 0.013 0.131
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0173 0.1825 0.2198
Echinococcus granulosus 6 phosphofructokinase 0.0132 0.1315 0.1291
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0354 0.4058 0.6959
Onchocerca volvulus 0.0536 0.6308 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Brugia malayi Thioredoxin reductase 0.0046 0.0257 0.0341
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0981 0.1158
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0929 0.0903
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0599 0.0599
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0453 0.099
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0043 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0141 0.0156
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Treponema pallidum licC protein (licC) 0.0126 0.1244 0.2994
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0119 0.0091
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0584 0.0557
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0307 0.0457
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1827 0.4291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0263 0.0235
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0036 0.013 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0244 0.0216
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0366 0.4203 0.7211
Brugia malayi jmjC domain containing protein 0.0074 0.0599 0.0887
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0453 0.0847
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0313 0.0467
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0453 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0981 0.1158
Plasmodium falciparum glutathione reductase 0.0046 0.0257 0.3162
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0981 0.1158
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0651
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0161 0.1677 0.2832
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0453 0.3424
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0132 0.1315 0.3062
Trypanosoma cruzi target of rapamycin kinase 3 0.0061 0.045 0.0705
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.024
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.03 0.3397 0.8322
Schistosoma mansoni alpha-glucosidase 0.017 0.1787 0.1787
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Loa Loa (eye worm) 6-phosphofructokinase 0.0132 0.1315 0.1771
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0161 0.1677 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Echinococcus multilocularis muscleblind protein 0.0181 0.1923 0.19
Echinococcus multilocularis Protein lozenge 0.0067 0.0522 0.0495
Loa Loa (eye worm) phosphofructokinase 0.0132 0.1315 0.1771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2125 0.2861
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0072 0.0586 0.0559
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0326 0.0685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Echinococcus multilocularis L aminoadipate semialdehyde 0.0101 0.0934 0.0908
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0028 0.0043 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0496 0.5813 0.9209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0099 0.0913 0.2016
Loa Loa (eye worm) hypothetical protein 0.0086 0.0748 0.1007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0453 0.071
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0122
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2125 0.3324
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0161 0.1677 0.2832
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.033
Schistosoma mansoni jumonji domain containing protein 0.0071 0.057 0.057
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0366 0.4203 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0244 0.0349
Schistosoma mansoni bromodomain containing protein 0.0077 0.0637 0.0637
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0678 0.0912
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0061 0.045 0.0981
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0257 0.3162
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0119 0.0161
Schistosoma mansoni microtubule-associated protein tau 0.0835 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.1677 0.2608
Echinococcus multilocularis microtubule associated protein 2 0.0835 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0453 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Schistosoma mansoni apoptosis regulator bax 0.01 0.0929 0.0929
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0232 0.0327
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0084 0.0723 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0084 0.0723 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0268 0.3324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0043 0.0015
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.013
Leishmania major trypanothione reductase 0.0046 0.0257 0.0518
Brugia malayi Bromodomain containing protein 0.0091 0.0812 0.1227
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0101 0.0934 0.1422
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0126 0.1244 0.1482
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.2186 0.3716
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0307 0.0421
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0981 0.1158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0378 0.435 0.7466
Loa Loa (eye worm) hypothetical protein 0.0536 0.6308 0.8491
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Plasmodium vivax 6-phosphofructokinase, putative 0.0036 0.013 0.131
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0077
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0453 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.0141 0.0113
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0084 0.0723 0.0697
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0244 0.0352
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0119 0.1148
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0089 0.0089
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0419 0.4859 0.8348
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0232 0.0327
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0036 0.013 0.0151
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0281
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0084 0.0723 0.0723
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0036 0.013 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0036 0.013 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0929 0.0903
Loa Loa (eye worm) hypothetical protein 0.0035 0.0119 0.0161
Brugia malayi jmjC domain containing protein 0.0071 0.057 0.0842
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0173 0.1825 0.2198
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0043 0.0043
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0141 0.024
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0232 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Loa Loa (eye worm) 6-phosphofructokinase 0.0132 0.1315 0.1771
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0028 0.0043 0.0015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1125 0.1335
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0084 0.0723 0.1179
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0233 0.0461
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0084 0.0723 0.0723
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0678 0.1103
Brugia malayi glutathione reductase 0.0046 0.0257 0.0341
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0307 0.0457
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0072 0.0586 0.0944
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0072 0.0586 0.1309
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0599 0.0572
Entamoeba histolytica protein kinase rad3, putative 0.0028 0.0043 0.0003
Toxoplasma gondii phosphofructokinase PFKII 0.0036 0.013 0.0743
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0244 0.0349
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0678 0.0651
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0651
Loa Loa (eye worm) hypothetical protein 0.0101 0.0934 0.1257
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.1677 0.2832
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1125 0.1335
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0281
Brugia malayi hypothetical protein 0.0536 0.6308 1
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.01 0.0929 0.125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0232 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0349
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0072 0.0586 0.0559
Entamoeba histolytica hypothetical protein 0.0028 0.0043 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.1244 0.1482
Schistosoma mansoni fkbp-rapamycin associated protein 0.0028 0.0043 0.0043
Schistosoma mansoni alpha-glucosidase 0.017 0.1787 0.1787
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0072 0.0586 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Brugia malayi PHD-finger family protein 0.003 0.0064 0.0033
Plasmodium vivax glutathione reductase, putative 0.0046 0.0257 0.3162
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0279 0.3139 0.312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0244 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0366 0.0559
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0244 0.0349
Echinococcus multilocularis bloom syndrome protein 0.005 0.0307 0.0279
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0326 0.0491
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0072 0.0586 0.0941
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.0141 0.0113
Toxoplasma gondii target of rapamycin (TOR), putative 0.0059 0.0414 0.3104
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0072 0.0586 0.1309
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0028 0.0043 0.0003
Giardia lamblia Fructose-bisphosphate aldolase 0.0354 0.4058 1
Toxoplasma gondii hypothetical protein 0.0059 0.0419 0.3146
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0244 0.0216
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.0141 0.0141
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.0229 0.0201
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0158 0.0199
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0029 0.0029
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.024
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0704 0.8383 0.8383
Schistosoma mansoni 6-phosphofructokinase 0.0132 0.1315 0.1315
Schistosoma mansoni alpha glucosidase 0.0044 0.0232 0.0232
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0232 0.0327
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0084 0.0723 0.1182
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0058 0.0137
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0496 0.5813 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0072 0.0586 0.0586
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0244 0.0244
Onchocerca volvulus 0.0114 0.1099 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0072 0.0586 0.1309
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0072 0.0586 0.0867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1639
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0199
Toxoplasma gondii 6-phosphofructokinase 0.0036 0.013 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0173 0.1825 0.2198
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0366 0.4203 0.7211
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0132 0.1315 0.2205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0232 0.0204
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.017
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0058 0.0025
Mycobacterium ulcerans hypothetical protein 0.0193 0.2068 0.2498
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0453 0.0426
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.11
Loa Loa (eye worm) hypothetical protein 0.0046 0.0265 0.0357
Mycobacterium tuberculosis Probable reductase 0.0104 0.0981 0.1158
Schistosoma mansoni memapsin-2 (A01 family) 0.0377 0.434 0.434
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0072 0.0586 0.0941
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0244 0.0216
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0036 0.013 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0058 0.0251
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0257 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0119 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Treponema pallidum fructose-bisphosphate aldolase 0.0354 0.4058 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0232 0.0327
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0141 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0723 0.5673
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0101 0.0934 0.0934
Loa Loa (eye worm) phosphatidylinositol 3 0.0072 0.0586 0.0789
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0119 0.0091
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0158 0.0203
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0349
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0072 0.0586 0.0944
Loa Loa (eye worm) hypothetical protein 0.0181 0.1923 0.2589
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0599 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0279 0.3139 0.4942
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0232 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0132 0.1315 0.157
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0244 0.0216
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0981 0.1158
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.1586
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1639
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0132 0.1315 0.157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0351 0.0534
Leishmania major ATP-dependent phosphofructokinase 0.0132 0.1315 0.3062
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0264 0.0237
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0126 0.1244 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0084 0.0723 0.1179
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0244 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0313 0.0467
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0084 0.0723 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0084 0.0723 0.1086
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0981 0.1158
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0453 0.099
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0496 0.5813 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.057 0.0543
Entamoeba histolytica hypothetical protein 0.0419 0.4859 0.8348
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0263 0.0235
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0929 0.1414
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0584 0.0557
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0704 0.8383 0.8378
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0244 0.0216
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.0052 0.0329 0.0443
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0704 0.8383 0.8378
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0043 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0244 0.0244
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0496 0.5813 1
Schistosoma mansoni DNA helicase recq1 0.0035 0.0119 0.0119
Brugia malayi 6-phosphofructokinase 0.0132 0.1315 0.2031
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0599 0.0806
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1125 0.1335
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0244 0.0317
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0378 0.435 0.7466
Loa Loa (eye worm) hypothetical protein 0.0279 0.3139 0.4226
Schistosoma mansoni 6-phosphofructokinase 0.0132 0.1315 0.1315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assay ChEMBL. 22548365
IC50 (binding) > 10000 nM BindingDB_Patents: In Vitro Inhibition Assay. The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vitro setting. Active mTOR phosphorylates eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) on residue threonine 46. This phosphorylation event can be detected with a phospho-specific terbium (Tb) labeled Ab, in turn bringing the Tb label in close proximity to the GFP tagged 4E-BP1 and allowing for time-resolved fluorescence resonance energy transfer (TR-FRET), which correlates 4E-BP1 phosphorylation levels with mTOR kinase activity. ChEMBL. No reference
Ki (binding) = 1 nM Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365
Ki (binding) = 2 nM Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365
Ki (binding) = 2 nM BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein. ChEMBL. No reference
Ki (binding) = 2 nM BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein. ChEMBL. No reference
Ki (binding) = 3 nM Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365
Ki (binding) = 7 nM Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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