Detailed information for compound 1683613

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 477.539 | Formula: C23H23N7O3S
  • H donors: 2 H acceptors: 7 LogP: 2.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cn1)Nc1ncc(cc1c1nc(C)nc(n1)N)Cc1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C23H23N7O3S/c1-14-27-22(30-23(24)28-14)19-11-16(10-15-4-7-18(8-5-15)34(3,31)32)12-26-21(19)29-17-6-9-20(33-2)25-13-17/h4-9,11-13H,10H2,1-3H3,(H,26,29)(H2,24,27,28,30)
  • InChiKey: AXVUBWYMDBEDQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 582 aa 491 aa 25.2 %
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0279 0.3139 0.312
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0084 0.0723 0.1179
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0244 0.0216
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0584 0.0557
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0244 0.0321
Trypanosoma brucei protein kinase, putative 0.0062 0.0453 0.099
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0599 0.0572
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0453 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0351 0.0534
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.0404
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0704 0.8383 0.8378
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0043 0.0015
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0173 0.1825 0.2198
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0378 0.435 0.7466
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0599 0.0806
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0089 0.0089
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0419 0.4859 0.8348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Schistosoma mansoni alpha glucosidase 0.0044 0.0232 0.0232
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0161 0.1677 0.2832
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0084 0.0723 0.0723
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.0141 0.0113
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0281
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0257 0.0266
Schistosoma mansoni alpha-glucosidase 0.017 0.1787 0.1787
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0268 0.3324
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0244 0.0488
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0264 0.0237
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0453 0.0426
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0349
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0929 0.0903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0349
Plasmodium vivax 6-phosphofructokinase, putative 0.0036 0.013 0.131
Entamoeba histolytica hypothetical protein 0.0028 0.0043 0.0003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0036 0.013 0.131
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0981 0.1158
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0158 0.0203
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0453 0.071
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0139 0.1409 0.2368
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0678 0.1103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0119 0.0161
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0704 0.8383 0.8383
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0061 0.045 0.0981
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0232 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Trypanosoma cruzi target of rapamycin kinase 3 0.0061 0.045 0.0705
Echinococcus multilocularis muscleblind protein 1 0.0181 0.1923 0.19
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0084 0.0723 0.1182
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0119 0.0161
Echinococcus multilocularis 6 phosphofructokinase 0.0132 0.1315 0.1291
Leishmania major mitochondrial DNA polymerase beta 0.0366 0.4203 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0084 0.0723 0.0974
Brugia malayi Thioredoxin reductase 0.0046 0.0257 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Mycobacterium ulcerans hypothetical protein 0.0126 0.1244 0.1482
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0678 0.0651
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.1409 0.1897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0126 0.1244 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0748 0.1007
Toxoplasma gondii target of rapamycin (TOR), putative 0.0059 0.0414 0.3104
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.1244 0.1482
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0244 0.0352
Loa Loa (eye worm) hypothetical protein 0.0279 0.3139 0.4226
Schistosoma mansoni 6-phosphofructokinase 0.0132 0.1315 0.1315
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0244 0.0216
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1827 0.4291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.153
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0126 0.1244 0.1482
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1827 0.4291
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0496 0.5813 0.9209
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0929 0.0929
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0199
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0453 0.0426
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0453 0.3424
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0244 0.0349
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.1677 0.2608
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1179
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0173 0.1825 0.2198
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0232 0.0327
Loa Loa (eye worm) hypothetical protein 0.0101 0.0934 0.1257
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0061 0.045 0.0981
Loa Loa (eye worm) hypothetical protein 0.0181 0.1923 0.2589
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0232 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Treponema pallidum licC protein (licC) 0.0126 0.1244 0.2994
Loa Loa (eye worm) hypothetical protein 0.0217 0.2365 0.3183
Brugia malayi 6-phosphofructokinase 0.0132 0.1315 0.2031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0599 0.0599
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0981 0.1158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Echinococcus multilocularis Protein lozenge 0.0067 0.0522 0.0495
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0929 0.0903
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0496 0.5813 1
Toxoplasma gondii 6-phosphofructokinase 0.0036 0.013 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Loa Loa (eye worm) phosphatidylinositol 3 0.0072 0.0586 0.0789
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0072 0.0586 0.0559
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0161 0.1677 0.1677
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0119 0.1148
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0678 0.0912
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0072 0.0586 0.1309
Trypanosoma brucei glucosidase, putative 0.0044 0.0232 0.0458
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0072 0.0586 0.1309
Echinococcus granulosus muscleblind protein 0.0181 0.1923 0.19
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0232 0.0327
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0981 0.1158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Brugia malayi hypothetical protein 0.0536 0.6308 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0651
Schistosoma mansoni 6-phosphofructokinase 0.0132 0.1315 0.1315
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1179
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0651
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0072 0.0586 0.0941
Entamoeba histolytica hypothetical protein 0.0419 0.4859 0.8348
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0244 0.0349
Toxoplasma gondii hypothetical protein 0.0059 0.0419 0.3146
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0084 0.0723 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0036 0.013 0.0151
Schistosoma mansoni memapsin-2 (A01 family) 0.0377 0.434 0.434
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0704 0.8383 0.8378
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0072 0.0586 0.0586
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0043 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0058 0.0137
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0132 0.1315 0.2205
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0366 0.4203 0.7211
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0101 0.0934 0.1422
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0279 0.3139 0.312
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1639
Plasmodium falciparum glutathione reductase 0.0046 0.0257 0.3162
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0232 0.0458
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0173 0.1825 0.2198
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.005 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0141 0.0156
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0244 0.0216
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1125 0.1335
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.013
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0233 0.0461
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0122
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0257 0.3162
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.0229 0.0201
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0084 0.0723 0.1086
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0263 0.0235
Brugia malayi glutathione reductase 0.0046 0.0257 0.0341
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0161 0.1677 0.2832
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0232 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0313 0.0467
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0132 0.1315 0.3173
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0208 0.2262 0.3542
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0981 0.1158
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.057 0.0543
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2125 0.2861
Loa Loa (eye worm) 6-phosphofructokinase 0.0132 0.1315 0.1771
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0072 0.0586 0.0944
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0723 0.5673
Brugia malayi Muscleblind-like protein 0.0181 0.1923 0.3001
Entamoeba histolytica protein kinase rad3, putative 0.0028 0.0043 0.0003
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0929 0.0903
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0101 0.0934 0.0934
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0072 0.0586 0.0941
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0232 0.0327
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0084 0.0723 0.1182
Mycobacterium tuberculosis Conserved hypothetical protein 0.0193 0.2068 0.2498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.11
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0122
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0036 0.013 0.0028
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0036 0.013 0.0222
Brugia malayi Bromodomain containing protein 0.0091 0.0812 0.1227
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0366 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0072 0.0586 0.1309
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0132 0.1315 0.157
Schistosoma mansoni bromodomain containing protein 0.0077 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.01 0.0929 0.125
Loa Loa (eye worm) hypothetical protein 0.0046 0.0265 0.0357
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0496 0.5813 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0453 0.071
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0496 0.5813 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.0141 0.0113
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.024
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0036 0.013 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0119 0.0091
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0029 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Echinococcus granulosus 6 phosphofructokinase 0.0132 0.1315 0.1291
Loa Loa (eye worm) RecQ helicase 0.005 0.0307 0.0413
Loa Loa (eye worm) hypothetical protein 0.0536 0.6308 0.8491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0488 0.0771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Mycobacterium tuberculosis Probable reductase 0.0104 0.0981 0.1158
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Schistosoma mansoni microtubule-associated protein tau 0.0835 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0488
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0132 0.1315 0.157
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0043 0.0043
Echinococcus multilocularis muscleblind protein 0.0181 0.1923 0.19
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0084 0.0723 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0028 0.0043 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0279 0.3139 0.4942
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0453 0.0453
Giardia lamblia Fructose-bisphosphate aldolase 0.0354 0.4058 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0119 0.0091
Leishmania major trypanothione reductase 0.0046 0.0257 0.0518
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2125 0.3324
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0084 0.0723 0.1179
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Leishmania major phosphatidylinositol 3-kinase, putative 0.0084 0.0723 0.1639
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.2835
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0496 0.5813 1
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0232 0.0301
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0981 0.1158
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0453 0.0426
Brugia malayi 6-phosphofructokinase 0.0132 0.1315 0.2031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0354 0.4058 0.6959
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0099 0.0913 0.2016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0141 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0326 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0686 0.8156 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0929 0.0903
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.057 0.0543
Onchocerca volvulus 0.0536 0.6308 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1827 0.3092
Giardia lamblia GTOR 0.0072 0.0586 0.1185
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0072 0.0586 0.0559
Loa Loa (eye worm) 6-phosphofructokinase 0.0132 0.1315 0.1771
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0084 0.0723 0.0697
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0453 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0313 0.0467
Schistosoma mansoni alpha-glucosidase 0.017 0.1787 0.1787
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0084 0.0723 0.0723
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0723 0.5673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Loa Loa (eye worm) runx1 0.0067 0.0522 0.0702
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0981 0.1158
Loa Loa (eye worm) phosphatidylinositol 3 0.0627 0.7429 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0141 0.019
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0063 0.0465 0.0731
Loa Loa (eye worm) hypothetical protein 0.0052 0.0329 0.0443
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0084 0.0723 0.0697
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.2186 0.3716
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0366 0.4203 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0584 0.0557
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0232 0.0327
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0141 0.024
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0678 0.0651
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0119 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0028 0.0043 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0028 0.0043 0.0015
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0043 0.0005
Echinococcus multilocularis Zinc finger, PHD finger 0.0084 0.0723 0.0697
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0158 0.0199
Schistosoma mansoni DNA helicase recq5 0.0035 0.0119 0.0119
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0354 0.4058 0.6959
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0244 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0092
Loa Loa (eye worm) phosphofructokinase 0.0132 0.1315 0.1771
Echinococcus multilocularis L aminoadipate semialdehyde 0.0101 0.0934 0.0908
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0244 0.0216
Loa Loa (eye worm) hypothetical protein 0.0045 0.0244 0.0329
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0307 0.0421
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1125 0.1335
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0119 0.0091
Schistosoma mansoni DNA helicase recq1 0.0035 0.0119 0.0119
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0244 0.0244
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0326 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0084 0.0723 0.1179
Mycobacterium ulcerans hypothetical protein 0.0126 0.1244 0.1482
Loa Loa (eye worm) glutathione reductase 0.0046 0.0257 0.0346
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.0141 0.0141
Brugia malayi Bromodomain containing protein 0.0046 0.0264 0.0352
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0043 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1125 0.1335
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0599 0.0599
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0453 0.0426
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0678 0.1013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.1244 0.1482
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0929 0.125
Schistosoma mansoni jumonji domain containing protein 0.0071 0.057 0.057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0453 0.099
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0453 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Treponema pallidum fructose-bisphosphate aldolase 0.0354 0.4058 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0232 0.0312
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0036 0.013 0.0155
Plasmodium vivax 6-phosphofructokinase, putative 0.0036 0.013 0.131
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.017
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.3931
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.1677 0.2832
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0072 0.0586 0.0867
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0232 0.0204
Echinococcus granulosus bloom syndrome protein 0.005 0.0307 0.0279
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.057 0.0543
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0072 0.0586 0.0944
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0496 0.5813 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1125 0.1335
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.024
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0257 0.0346
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0084 0.0723 0.0697
Schistosoma mansoni apoptosis regulator bax 0.01 0.0929 0.0929
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.1586
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0678 0.0678
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0161 0.1677 0.2832
Echinococcus multilocularis microtubule associated protein 2 0.0835 1 1
Schistosoma mansoni lozenge 0.0067 0.0522 0.0522
Onchocerca volvulus 0.0114 0.1099 0.0308
Leishmania major ATP-dependent phosphofructokinase 0.0132 0.1315 0.3062
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0678 0.153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0307 0.0457
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0281
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0058 0.0251
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0244 0.0349
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.0229 0.0201
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0036 0.013 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus granulosus L aminoadipate semialdehyde 0.0101 0.0934 0.0908
Brugia malayi MAP kinase sur-1 0.0062 0.0453 0.0654
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.11
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0058
Brugia malayi jmjC domain containing protein 0.0074 0.0599 0.0887
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0453 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0036 0.013 1
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0307 0.0457
Brugia malayi jmjC domain containing protein 0.0071 0.057 0.0842
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0058 0.0025
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0686 0.8156 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.017
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0244 0.0216
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0326 0.0685
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0326 0.0491
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.033
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0366 0.4203 0.7211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0686 0.8156 1
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0072 0.0586 0.1309
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0453 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Mycobacterium ulcerans hypothetical protein 0.0193 0.2068 0.2498
Loa Loa (eye worm) hypothetical protein 0.0536 0.6308 0.8491
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.0195 0.0369
Trypanosoma brucei trypanothione reductase 0.0046 0.0257 0.0518
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Brugia malayi PHD-finger family protein 0.003 0.0064 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Toxoplasma gondii thioredoxin reductase 0.0046 0.0257 0.1794
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1639
Plasmodium falciparum thioredoxin reductase 0.0046 0.0257 0.3162
Plasmodium vivax glutathione reductase, putative 0.0046 0.0257 0.3162
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0028 0.0043 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0257 0.0371
Toxoplasma gondii phosphofructokinase PFKII 0.0036 0.013 0.0743
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0496 0.5813 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0036 0.013 0.131
Brugia malayi phosphofructokinase 0.0132 0.1315 0.2031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Echinococcus multilocularis bloom syndrome protein 0.005 0.0307 0.0279
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0686 0.8156 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0132 0.1315 0.157
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0244 0.0244
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0132 0.1315 0.3062
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.033
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.03 0.3397 0.8322
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0263 0.0235
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0264 0.0237
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0929 0.1414
Loa Loa (eye worm) hypothetical protein 0.0181 0.1923 0.2589
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0378 0.435 0.7466
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0453 0.061
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0244 0.0317
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0474 0.5545 0.9536

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assay ChEMBL. 22548365
IC50 (binding) > 10000 nM BindingDB_Patents: In Vitro Inhibition Assay. The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vitro setting. Active mTOR phosphorylates eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) on residue threonine 46. This phosphorylation event can be detected with a phospho-specific terbium (Tb) labeled Ab, in turn bringing the Tb label in close proximity to the GFP tagged 4E-BP1 and allowing for time-resolved fluorescence resonance energy transfer (TR-FRET), which correlates 4E-BP1 phosphorylation levels with mTOR kinase activity. ChEMBL. No reference
Ki (binding) = 1 nM Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365
Ki (binding) = 2 nM Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365
Ki (binding) = 2 nM BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein. ChEMBL. No reference
Ki (binding) = 2 nM BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein. ChEMBL. No reference
Ki (binding) = 3 nM Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365
Ki (binding) = 7 nM Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay ChEMBL. 22548365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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