Detailed information for compound 1687619

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.422 | Formula: C22H23NO5
  • H donors: 4 H acceptors: 5 LogP: 3.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1C/C(=C\c2ccc(c(c2)O)O)/C(=O)/C(=C/c2ccc(c(c2)O)O)/C1
  • InChi: 1S/C22H23NO5/c1-2-7-23-12-16(8-14-3-5-18(24)20(26)10-14)22(28)17(13-23)9-15-4-6-19(25)21(27)11-15/h3-6,8-11,24-27H,2,7,12-13H2,1H3/b16-8+,17-9+
  • InChiKey: RAAXKWOKJWAWFX-GONBZBRSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0278 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0278 0.2465
Echinococcus granulosus CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0278 0.0129
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0327 0.8051
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0153 0.0004
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0327 0.8051
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1708 0.2454
Echinococcus granulosus importin subunit beta 1 0.0031 0.031 0.0251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1667 0.1539
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0327 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0278 0.2465
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0196 0.4818
Brugia malayi Cytochrome P450 family protein 0.0029 0.0278 0.0129
Leishmania major glucose transporter, lmgt1 0.0032 0.0327 0.3788
Loa Loa (eye worm) hypothetical protein 0.0116 0.1964 0.1841
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0307 0.0159
Schistosoma mansoni importin beta-1 0.0031 0.031 0.0162
Schistosoma mansoni protein kinase 0.0031 0.0319 0.0171
Schistosoma mansoni glucose transport protein 0.0103 0.1708 0.1581
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0327 0.0231
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1708 0.2454
Echinococcus multilocularis lysosome membrane protein 2 0.0116 0.1964 0.2858
Brugia malayi hypoxia-induced factor 1 0.0156 0.2744 0.2633
Echinococcus multilocularis importin subunit beta 1 0.0031 0.031 0.0251
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0307 0.0211
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0278 0.6834
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0307 0.9265
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0327 0.0278
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0864 0.0724
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0278 0.2465
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0278 0.0126
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1708 0.2454
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0278 0.6834
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0278 0.6834
Schistosoma mansoni hypothetical protein 0.0029 0.0278 0.0129
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0327 0.0231
Loa Loa (eye worm) hypothetical protein 0.0031 0.0319 0.0171
Brugia malayi cytochrome P450 0.0029 0.0278 0.0129
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0196 0.0099
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0153 0.0003
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0278 0.0126
Leishmania major GTP-binding protein, putative 0.0023 0.0151 0.1744
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0319 0.0223
Plasmodium vivax hexose transporter 0.0103 0.1708 0.1935
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0278 0.2465
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0278 0.6834
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0406 0.4705
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0278 0.2465
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0327 0.0179
Echinococcus granulosus GPCR family 2 0.0032 0.0327 0.0278
Schistosoma mansoni hypothetical protein 0.0032 0.0327 0.0179
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0003
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0406 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.032 0.021
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0433 0.0287
Trypanosoma brucei glucose transporter 1E 0.0032 0.0327 0.6904
Loa Loa (eye worm) hypothetical protein 0.0032 0.0327 0.0179
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0153 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0278 0.2465
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0319 0.0266
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0786 0.0645
Plasmodium falciparum protein kinase 7 0.029 0.536 0.6472
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0864 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.031 0.0198
Entamoeba histolytica protein kinase, putative 0.0031 0.0319 1
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0282 0.0206
Schistosoma mansoni hypothetical protein 0.0032 0.0327 0.0179
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.032 0.0325
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0406 0.0318
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0153 0.0003
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0406 0.4705
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0278 0.2465
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0278 0.0126
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0319 0.0266
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0278 0.6834
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.031 0.6225
Echinococcus multilocularis CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Leishmania major cytochrome p450-like protein 0.0029 0.0278 0.3216
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1708 0.2454
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.032 0.021
Trichomonas vaginalis glutaminase, putative 0.0528 1 1
Echinococcus multilocularis geminin 0.0348 0.6496 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Schistosoma mansoni glucose transport protein 0.0103 0.1708 0.1581
Echinococcus multilocularis CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0319 0.0266
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0319 0.0266
Echinococcus multilocularis CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Plasmodium falciparum hexose transporter 0.0103 0.1708 0.1935
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.294 0.3466
Schistosoma mansoni hypothetical protein 0.0348 0.6496 0.6442
Echinococcus granulosus CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0278 0.3216
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0319 0.0171
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0278 0.0129
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0327 0.0231
Schistosoma mansoni CD36-like class B scavenger receptor 0.0116 0.1964 0.1841
Echinococcus multilocularis 0.0029 0.0278 0.02
Entamoeba histolytica hypothetical protein 0.0025 0.0196 0.2677
Brugia malayi Cytochrome P450 family protein 0.0029 0.0278 0.0129
Schistosoma mansoni protein kinase 0.0031 0.0319 0.0171
Brugia malayi Sugar transporter family protein 0.0103 0.1708 0.1581
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.6146 0.6087
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0327 0.0231
Leishmania major cytochrome p450-like protein 0.0029 0.0278 0.3216
Mycobacterium leprae putative cytochrome p450 0.0029 0.0278 0.8678
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.032 0.021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1708 0.2454
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0433 0.0445
Trypanosoma brucei glucose transporter 2A 0.0032 0.0327 0.6904
Brugia malayi Importin beta-1 subunit 0.0031 0.031 0.0162
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0278 0.0244
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1667 0.1539
Echinococcus granulosus snurportin 1 0.033 0.6146 0.9449
Echinococcus multilocularis GPCR, family 2 0.0032 0.0327 0.0278
Entamoeba histolytica protein kinase, putative 0.0031 0.0319 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0278 0.2465
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0278 0.2465
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Schistosoma mansoni hypothetical protein 0.0069 0.1047 0.091
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0153 0.0056
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0319 0.0266
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0278 0.0126
Loa Loa (eye worm) sugar transporter 0.0103 0.1708 0.1581
Echinococcus multilocularis General substrate transporter 0.0088 0.1426 0.201
Schistosoma mansoni hypothetical protein 0.033 0.6146 0.6087
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0278 0.02
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 0.8199 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0406 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0153 0.3046
Leishmania major protein kinase, putative 0.0031 0.0319 0.3697
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0278 0.497
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0278 0.0129
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.032 0.021
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0278 0.0126
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0327 0.3788
Leishmania major glucose transporter, lmgt3 0.0032 0.0327 0.3788
Loa Loa (eye worm) cytochrome P450 family protein 0.0108 0.1817 0.1692
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0319 0.0266
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Loa Loa (eye worm) hypothetical protein 0.0169 0.2999 0.2892
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.294 0.5354
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0153 0.0172
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0153 0.1775
Schistosoma mansoni single-minded 0.005 0.0688 0.0546
Loa Loa (eye worm) hypothetical protein 0.0044 0.0559 0.0415
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1667 0.1539
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.2744 0.2633
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0278 0.0126
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.032 0.021
Entamoeba histolytica hypothetical protein 0.0023 0.0153 0.0159
Echinococcus granulosus CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0278 0.0126
Leishmania major glucose transporter, lmgt2 0.0032 0.0327 0.3788
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0864 0.1124
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0406 0.0318
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.1708 0.2454
Brugia malayi CD36 family protein 0.0116 0.1964 0.1841
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0406 0.0491
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Echinococcus granulosus single minded 2 0.0037 0.0433 0.0445
Schistosoma mansoni hypothetical protein 0.0348 0.6496 0.6442
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0278 0.2465
Leishmania major cytochrome p450-like protein 0.0029 0.0278 0.3216
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0278 0.2465
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0278 0.2465
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0282 0.0206
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0406 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0327 0.0278
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0151 0.3706
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0278 0.2465
Echinococcus multilocularis snurportin 1 0.033 0.6146 0.9449
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0278 0.0126
Schistosoma mansoni CD36-like class B scavenger receptor 0.0116 0.1964 0.1841
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0278 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0278 0.2465
Loa Loa (eye worm) hypothetical protein 0.0031 0.0307 0.0159
Loa Loa (eye worm) glutaminase 0.0528 1 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0307 0.0246
Schistosoma mansoni glucose transport protein 0.0103 0.1708 0.1581
Loa Loa (eye worm) hypothetical protein 0.0148 0.26 0.2487
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0307 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0864 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0559 0.0415
Leishmania major importin beta-1 subunit, putative 0.0025 0.0196 0.2267
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0864 0.1124
Brugia malayi Cytochrome P450 family protein 0.0029 0.0278 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1708 0.1625
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0307 0.0159
Toxoplasma gondii protein kinase, putative 0.029 0.536 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0278 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0278 0.2465
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0278 0.0126
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0319 0.0266
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0319 0.0266
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.031 0.0306
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0278 0.2465
Plasmodium falciparum protein kinase 6 0.0436 0.8199 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0327 0.0278
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0307 0.0159
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0864 0.0722
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.032 0.0325
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0278 0.2465
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0278 0.0126
Brugia malayi hypothetical protein 0.0148 0.26 0.2487
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0278 0.0126
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0151 0.3706
Schistosoma mansoni cd36 antigen 0.0044 0.0559 0.0415
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.032 0.021
Echinococcus granulosus CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0327 0.6904
Brugia malayi hypothetical protein 0.0044 0.0559 0.0415
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0278 0.0126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0688 0.0546
Brugia malayi PAS domain containing protein 0.005 0.0688 0.0546
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.032 0.021
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0153 0.3772
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0153 0.5
Loa Loa (eye worm) hypothetical protein 0.0044 0.0559 0.0415
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0327 0.6904
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0327 0.8051
Loa Loa (eye worm) hypothetical protein 0.0101 0.1667 0.1539
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0278 0.0126
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0319 0.6597
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.032 0.0325
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0319 0.0171
Brugia malayi Cytochrome P450 family protein 0.0108 0.1817 0.1692
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0153 0.0105
Schistosoma mansoni hypothetical protein 0.0103 0.1708 0.1581
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1708 0.2454
Brugia malayi Cam kinase protein 1 0.0031 0.0319 0.0171
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.032 0.021
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0153 0.0003
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0307 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0327 0.0231
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0278 0.2465
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0327 0.0179
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0319 0.0171
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0278 0.0126
Brugia malayi RNA, U transporter 1 0.0088 0.1422 0.1291
Loa Loa (eye worm) hypothetical protein 0.0116 0.1964 0.1841
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0153 0.0003
Loa Loa (eye worm) glutaminase 2 0.0528 1 1
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0433 0.0284
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0307 0.0159
Echinococcus granulosus geminin 0.0348 0.6496 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0307 0.0246
Plasmodium falciparum importin beta, putative 0.0031 0.031 0.0198
Onchocerca volvulus 0.0148 0.26 1
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0046 0.113
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0278 0.0126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0327 0.0231
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0319 0.0171
Trichomonas vaginalis ran, putative 0.0023 0.0151 0.0053
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0278 0.0126
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0327 0.6904
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.294 0.3466
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0278 0.2465
Loa Loa (eye worm) hypothetical protein 0.0069 0.1047 0.091
Loa Loa (eye worm) hypothetical protein 0.0031 0.0307 0.0159
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0278 0.497
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0327 0.0179
Loa Loa (eye worm) cytochrome P450 0.0029 0.0278 0.0129
Schistosoma mansoni protein kinase 0.0031 0.0319 0.0171
Loa Loa (eye worm) hypothetical protein 0.0116 0.1964 0.1841
Mycobacterium ulcerans glutaminase 0.0528 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0864 0.0722
Schistosoma mansoni hypothetical protein 0.0032 0.0327 0.0179
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0196 0.0099
Brugia malayi hypothetical protein 0.0169 0.2999 0.2892
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.0278 0.8678
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1047 0.091
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0196 0.0099
Loa Loa (eye worm) hypothetical protein 0.0025 0.0194 0.0044
Echinococcus granulosus General substrate transporter 0.0088 0.1426 0.201
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.031 0.6225
Schistosoma mansoni hypothetical protein 0.0032 0.0327 0.0179
Schistosoma mansoni cytochrome P450 0.0029 0.0278 0.0129
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0864 0.0724
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0116 0.1964 0.7065
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1708 0.2454
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0278 0.0126
Schistosoma mansoni glutaminase 0.0528 1 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.032 0.021
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0278 0.0126
Loa Loa (eye worm) hypothetical protein 0.0031 0.031 0.0162
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0278 0.2465
Echinococcus granulosus lysosome membrane protein 2 0.0116 0.1964 0.2858
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0153 0.0004
Brugia malayi hypothetical protein 0.0044 0.0559 0.0415
Trypanosoma cruzi hexose transporter 0.0032 0.0327 0.8051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0327 0.0278
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0153 0.0003
Trypanosoma brucei glucose transporter, putative 0.0032 0.0327 0.6904
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0116 0.1964 0.1841
Echinococcus granulosus CD36 class B scavenger receptor 0.0116 0.1964 0.2858
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.1708 0.2989

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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