TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 606.133 | Formula: C28H36ClN5O6S
H donors: 2 H acceptors: 3 LogP: 3.4 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: N=C/C(=C(\C(=O)Nc1cccc(c1)Cl)/OCC1(C)CC1)/N1CCN(CC1)S(=O)(=O)NCc1ccc(c(c1)OC)OC
InChi: 1S/C28H36ClN5O6S/c1-28(9-10-28)19-40-26(27(35)32-22-6-4-5-21(29)16-22)23(17-30)33-11-13-34(14-12-33)41(36,37)31-18-20-7-8-24(38-2)25(15-20)39-3/h4-8,15-17,30-31H,9-14,18-19H2,1-3H3,(H,32,35)/b26-23-,30-17?
InChiKey: COVONANKQIFGCD-BPDKCRNSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Candida albicans	beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to S. cerevisiae FKS3 (YMR306W) 1,3-beta glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	C terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Toxoplasma gondii	1,3-beta-glucan synthase component protein	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	C terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	N terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Neospora caninum	hypothetical protein	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	N terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0148	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0148	0.0381
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0608	0.1709
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.003	0.0014
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0118	0.0102
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0008	0.0073	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.003	0.0041
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0787	0.0787
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1028	0.1014
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0148	0.0132
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0148	0.0132
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0148	0.0132
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0148	0.0132
Schistosoma mansoni	hypothetical protein	0.0039	0.0787	0.0787
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0148	0.0381
Schistosoma mansoni	cytochrome P450	0.0008	0.0073	0.0073
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0016	0.0016
Brugia malayi	Cytochrome P450 family protein	0.0008	0.0073	0.0165
Schistosoma mansoni	zinc finger protein	0.0005	0.0016	0.0016
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.003	0.003
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0148	0.0381
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0148	0.0148
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0016	0.0016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1028	0.1028
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0148	0.0148
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0148	0.2229
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0608	0.1709
Brugia malayi	hypothetical protein	0.0006	0.003	0.0041
Schistosoma mansoni	cpg binding protein	0.0031	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0008	0.0073	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0148	0.0381
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0148	0.0381
Onchocerca volvulus		0.0011	0.0148	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0148	0.0381
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0289	0.079
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0148	0.0132
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0148	0.0381
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0787	0.0772
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0148	0.0381
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0148	0.0148
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0118	0.0102
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0787	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0026	0.003
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0118	0.0294
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0148	0.2229
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0863	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.003	0.0014
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0074	0.0059
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0863	0.5
Schistosoma mansoni	hypothetical protein	0.0008	0.0073	0.0073
Echinococcus multilocularis	cpg binding protein	0.0033	0.0648	0.0633
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0148	0.0148
Brugia malayi	nuclear hormone receptor	0.0011	0.0148	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0148	0.0132
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0016	0.0016
Echinococcus granulosus	cytochrome P450 2K1	0.0008	0.0073	0.0057
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0008	0.0073	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0148	0.0132
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0008	0.0073	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0148	0.0148
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1028	0.1028
Trypanosoma brucei	cytochrome P450, putative	0.0017	0.0289	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0148	0.0381
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0115	0.0286
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0148	0.0132
Brugia malayi	PHD-finger family protein	0.0006	0.0026	0.003
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.003	0.0041
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0148	0.0148
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.003	0.0041
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0289	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0148	0.0381
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0863	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0008	0.0073	0.5
Onchocerca volvulus		0.0031	0.0608	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0008	0.0073	0.5
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0006	0.0026	0.001
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0074	0.0059
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0951	0.1543
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0148	0.0381
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0256	0.5763	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0008	0.0073	0.5
Loa Loa (eye worm)	acetyltransferase	0.0156	0.3478	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0008	0.0073	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0148	0.0381
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0148	0.0381
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0016	0.0016
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0008	0.0073	0.5
Schistosoma mansoni	hypothetical protein	0.0441	1	1
Echinococcus multilocularis	dnaJ subfamily B	0.0441	1	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0951	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1028	0.1014
Brugia malayi	Bromodomain containing protein	0.0006	0.0026	0.003
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0148	0.0148
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.003	0.003
Loa Loa (eye worm)	CYP4Cod1	0.0017	0.0289	0.079
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0148	0.0132
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0148	0.0148
Echinococcus granulosus	zinc finger protein	0.0006	0.0026	0.001
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0148	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0148	0.0132
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0148	0.0148
Schistosoma mansoni	cpg binding protein	0.0033	0.0648	0.0648
Echinococcus granulosus	cpg binding protein	0.0033	0.0648	0.0633
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0008	0.0073	0.5
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0008	0.0073	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1403	0.1403
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0148	0.0132
Brugia malayi	cytochrome P450	0.0008	0.0073	0.0165
Mycobacterium leprae	putative cytochrome p450	0.0008	0.0073	0.5
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0951	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.1028	0.2923
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0008	0.0073	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0115	0.0285
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0148	0.0381
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0951	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1028	0.1014
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0148	0.0132
Brugia malayi	Cytochrome P450 family protein	0.0008	0.0073	0.0165
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0148	0.0381
Leishmania major	cytochrome p450-like protein	0.0017	0.0289	1
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0289	0.079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1028	0.1014
Echinococcus multilocularis		0.0008	0.0073	0.0057
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0008	0.0073	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0148	0.0381
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0008	0.0073	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0148	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0148	0.0148
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0148	0.0381
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.003	0.0041
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0148	0.2229
Brugia malayi	hypothetical protein	0.0006	0.003	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0006	0.003	0.0041
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1028	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0026	0.003
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0016	0.0016
Brugia malayi	nuclear receptor RXR	0.0006	0.003	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0951	0.1543
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0289	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0008	0.0073	0.0165
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0006	0.003	0.0041
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0148	0.0381
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0074	0.0059
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0148	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0148	0.0381
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0148	0.0381
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0156	0.3478	0.3467
Schistosoma mansoni	nuclear receptor	0.0005	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0039	0.0787	0.2227
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0008	0.0073	0.5
Brugia malayi	steroid hormone receptor	0.0011	0.0148	0.0381
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0148	0.0381
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0017	0.0289	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0148	0.0381
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0289	0.079
Schistosoma mansoni	nuclear receptor	0.0005	0.0016	0.0016
Echinococcus multilocularis	zinc finger protein	0.0006	0.0026	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0148	0.0381
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0148	0.0132
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0148	0.0132
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0008	0.0073	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0148	0.0381
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0006	0.0026	0.001
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0074	0.0059
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0289	0.079
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.1028	0.2923
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0148	0.0148
Loa Loa (eye worm)	cytochrome P450	0.0008	0.0073	0.0165
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0006	0.003	0.0041
Brugia malayi	ecdysteroid receptor	0.0011	0.0148	0.0381
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.133	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0006	0.003	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0148	0.0381
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0152	0.3377	0.3367
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0008	0.0073	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0156	0.3478	1
Mycobacterium leprae	Conserved hypothetical protein	0.0008	0.0073	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0008	0.0073	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0008	0.0073	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0148	0.0132
Schistosoma mansoni	zinc finger protein	0.0006	0.0026	0.0026
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0156	0.3478	0.3478
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0148	0.0148
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0951	0.0936
Schistosoma mansoni	cpg binding protein	0.0033	0.0648	0.0648
Schistosoma mansoni	coup transcription factor	0.0011	0.0148	0.0148
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0008	0.0073	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.18 ug ml-1	Inhibition of glucan synthase in Candida albicans BWP17 membrane	ChEMBL.	22687744
MIC100 (functional)	= 0.26 ug ml-1	Antifungal activity against Candida albicans C693 by broth dilution method	ChEMBL.	22687744

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2046735

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1694848