TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.503 | Formula: C19H28N2O2S
H donors: 1 H acceptors: 3 LogP: 5.23 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Sc1nc2CC(OC(c2c(n1)O)C1CCCCC1)C1CCCCC1
InChi: 1S/C19H28N2O2S/c22-18-16-14(20-19(24)21-18)11-15(12-7-3-1-4-8-12)23-17(16)13-9-5-2-6-10-13/h12-13,15,17H,1-11H2,(H2,20,21,22,24)
InChiKey: HODJWLQOPNOQNN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Pre-SET motif family protein	0.0065	0.1052	0.1135
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0483	0.0352
Schistosoma mansoni	rac gtpase activating protein	0.0017	0.0105	0.0109
Brugia malayi	acetyltransferase, GNAT family protein	0.0164	0.302	0.326
Echinococcus granulosus	raf serine:threonine protein kinase	0.0494	0.9609	0.9867
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0019	0.0135	0.2796
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0019	0.0135	0.0139
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.079	0.0822
Leishmania major	P-type H -ATPase, putative	0.0019	0.0135	0.2796
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0019	0.0135	0.1283
Loa Loa (eye worm)	calcium ATPase	0.0019	0.0135	0.0141
Brugia malayi	Protein kinase c protein 2	0.0017	0.0105	0.0113
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0019	0.0135	0.0566
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0019	0.0135	0.0139
Echinococcus multilocularis	phosphoserine phosphatase	0.0019	0.0135	0.0139
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.079	0.0822
Brugia malayi	RhoGAP domain containing protein	0.0017	0.0105	0.0113
Brugia malayi	Inositol-1	0.0036	0.0483	0.0521
Echinococcus granulosus	histone lysine methyltransferase setb	0.0065	0.1052	0.108
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0483	0.7062
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0017	0.0105	0.011
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.0019	0.0135	0.0566
Leishmania major	calcium-translocating P-type ATPase	0.0019	0.0135	0.2796
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.028	0.5345	0.559
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0017	0.0105	0.011
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2516	0.2632
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0065	0.1052	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0135	0.0141
Echinococcus multilocularis	phosphoserine phosphatase	0.0019	0.0135	0.0139
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0105	0.0113
Schistosoma mansoni	diacylglycerol kinase theta	0.0017	0.0105	0.0109
Echinococcus granulosus	protein kinase c iota type	0.0017	0.0105	0.0108
Echinococcus granulosus	cation transporting ATPase 13A3	0.0019	0.0135	0.0139
Echinococcus granulosus	N chimaerin	0.0017	0.0105	0.0108
Brugia malayi	C1-like domain containing protein	0.0017	0.0105	0.0113
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0019	0.0135	0.1283
Brugia malayi	protein kinase C3,putative	0.0017	0.0105	0.0113
Brugia malayi	diacylglycerol kinase	0.0017	0.0105	0.0113
Schistosoma mansoni	hypothetical protein	0.0017	0.0105	0.0109
Schistosoma mansoni	copper ABC transporter ATPase	0.0019	0.0135	0.014
Trypanosoma brucei	P-type H+-ATPase, putative	0.0019	0.0135	0.2796
Echinococcus multilocularis	myotubularin protein 13	0.0017	0.0105	0.0108
Schistosoma mansoni	phosphoserine phosphatase	0.0019	0.0135	0.014
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0019	0.0135	0.2796
Trypanosoma cruzi	copper-transporting ATPase, putative	0.0019	0.0135	0.2796
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0019	0.0135	0.0139
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0065	0.1052	0.108
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0019	0.0135	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0135	0.0141
Schistosoma mansoni	ATPase	0.0019	0.0135	0.014
Brugia malayi	hypothetical protein	0.0196	0.3657	0.3947
Brugia malayi	Variant SH3 domain containing protein	0.0017	0.0105	0.0113
Mycobacterium ulcerans	metal cation transporter p-type ATPase, CtpV	0.0019	0.0135	0.2796
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0494	0.9609	0.9867
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0019	0.0135	0.0566
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0019	0.0135	0.0566
Trypanosoma brucei	P-type H+-ATPase, putative	0.0019	0.0135	0.2796
Toxoplasma gondii	diacylglycerol kinase, putative	0.0017	0.0105	0.0996
Brugia malayi	hypothetical protein	0.0019	0.0135	0.0146
Schistosoma mansoni	vav2	0.0017	0.0105	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Echinococcus multilocularis	phosphoserine phosphatase	0.0019	0.0135	0.0139
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0483	0.0502
Mycobacterium ulcerans	cation transporter p-type ATPase D CtpD	0.0019	0.0135	0.2796
Schistosoma mansoni	protein kinase C	0.0017	0.0105	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0135	0.0141
Echinococcus granulosus	Protein kinase C brain isozyme	0.0017	0.0105	0.0108
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0105	0.0109
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0017	0.0105	0.0109
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0019	0.0135	0.1283
Chlamydia trachomatis	metal transport ATPase	0.0019	0.0135	0.5
Echinococcus multilocularis	protein kinase c iota type	0.0017	0.0105	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0196	0.3657	0.3825
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0019	0.0135	0.1283
Echinococcus granulosus	cation transporting ATPase 13A1	0.0019	0.0135	0.0139
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.079	0.0811
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0483	1
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0019	0.0135	0.0139
Onchocerca volvulus	Huntingtin homolog	0.0138	0.2516	0.2437
Brugia malayi	hypothetical protein	0.0138	0.2516	0.2716
Echinococcus granulosus	cation transporting atpase worm	0.0019	0.0135	0.0139
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0164	0.302	0.3102
Onchocerca volvulus		0.0019	0.0135	0.0031
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0105	0.0109
Mycobacterium ulcerans	cation-transporter p-type ATPase B CtpB	0.0019	0.0135	0.2796
Brugia malayi	Pre-SET motif family protein	0.0452	0.8757	0.9451
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.072	0.6844
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0483	0.0496
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0019	0.0135	0.0139
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0019	0.0135	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0135	0.0141
Schistosoma mansoni	serine/threonine protein kinase	0.0494	0.9609	1
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0105	0.0109
Mycobacterium tuberculosis	Probable cation transporter P-type ATPase D CtpD	0.0019	0.0135	0.3316
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.064	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0017	0.0105	0.0113
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.079	0.0852
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0019	0.0135	0.0139
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0483	0.459
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0159	0.2929	0.3008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0019	0.0135	0.0566
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0019	0.0135	0.2796
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0017	0.0105	0.0108
Loa Loa (eye worm)	raf kinase	0.0492	0.9561	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0135	0.0141
Mycobacterium tuberculosis	Probable metal cation transporter ATPase P-type CtpE	0.0019	0.0135	0.3316
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0019	0.0135	0.2796
Echinococcus granulosus	copper transporting ATPase 1	0.0019	0.0135	0.0139
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0019	0.0135	0.2796
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0483	0.5
Schistosoma mansoni	atpase class VI type 11c	0.0019	0.0135	0.014
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0019	0.0135	0.0566
Schistosoma mansoni	unc-13 (munc13)	0.0017	0.0105	0.0109
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB	0.0019	0.0135	0.3316
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0105	0.0109
Trypanosoma cruzi	cation-transporting ATPase, putative	0.0019	0.0135	0.2796
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0483	0.0496
Mycobacterium tuberculosis	Cation transporter P-type ATPase a CtpA	0.0019	0.0135	0.3316
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.079	0.0811
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0019	0.0135	0.3316
Plasmodium vivax	SET domain protein, putative	0.0065	0.1052	1
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0017	0.0105	0.0108
Mycobacterium ulcerans	metal cation-transporting p-type ATPase CtpC	0.0019	0.0135	0.2796
Echinococcus multilocularis	phosphoserine phosphatase	0.0019	0.0135	0.0139
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0019	0.0135	0.2796
Echinococcus multilocularis	phosphoserine phosphatase	0.0019	0.0135	0.0139
Loa Loa (eye worm)	inositol-1	0.0036	0.0483	0.0505
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0065	0.1052	0.108
Echinococcus multilocularis	cation transporting atpase worm	0.0019	0.0135	0.0139
Mycobacterium tuberculosis	Probable metal cation transporter P-type ATPase CtpV	0.0019	0.0135	0.3316
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0273	0.5196	0.5435
Echinococcus multilocularis	protein kinase c eta type	0.0017	0.0105	0.0108
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0483	0.0352
Echinococcus granulosus	protein kinase c eta type	0.0017	0.0105	0.0108
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0017	0.0105	0.0109
Schistosoma mansoni	diacylglycerol kinase theta	0.0017	0.0105	0.0109
Onchocerca volvulus	Huntingtin homolog	0.0138	0.2516	0.2437
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0483	0.0502
Brugia malayi	Pleckstrin Homology Domain	0.0017	0.0105	0.0113
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0019	0.0135	0.0139
Brugia malayi	protein kinase C II.	0.0017	0.0105	0.0113
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.1052	0.1094
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0483	0.0352
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0019	0.0135	0.2796
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.064	1
Echinococcus granulosus	Rac GTPase activating protein 1	0.0017	0.0105	0.0108
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0017	0.0105	0.0108
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0017	0.0105	0.011
Treponema pallidum	hypothetical protein	0.0019	0.0135	0.5
Echinococcus granulosus	unc 13 munc13	0.0017	0.0105	0.0108
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0483	1
Brugia malayi	follicle stimulating hormone receptor	0.0273	0.5196	0.5608
Echinococcus granulosus	neuropeptide s receptor	0.0501	0.9739	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0483	1
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0019	0.0135	0.1283
Echinococcus multilocularis	N chimaerin	0.0017	0.0105	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Schistosoma mansoni	atypical protein kinase C	0.0017	0.0105	0.0109
Echinococcus multilocularis	unc 13 (munc13)	0.0017	0.0105	0.0108
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0483	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.079	0.0811
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0019	0.0135	0.2796
Schistosoma mansoni	cation-transporting ATPase	0.0019	0.0135	0.014
Brugia malayi	E1-E2 ATPase family protein	0.0019	0.0135	0.0146
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.0019	0.0135	0.1283
Trypanosoma cruzi	proton motive ATPase 1, putative	0.0019	0.0135	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0017	0.0105	0.0108
Toxoplasma gondii	P-type ATPase PMA1	0.0019	0.0135	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1052	0.11
Schistosoma mansoni	cation-transporting atpase worm	0.0019	0.0135	0.014
Trypanosoma brucei	copper-transporting ATPase-like protein, putative	0.0019	0.0135	0.2796
Echinococcus multilocularis	neuropeptide s receptor	0.0501	0.9739	1
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0017	0.0105	0.0108
Onchocerca volvulus		0.0065	0.1052	0.0957
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0019	0.0135	0.1283
Schistosoma mansoni	protein kinase C mu	0.0017	0.0105	0.0109
Brugia malayi	RhoGEF domain containing protein	0.0017	0.0105	0.0113
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.1052	0.1094
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0019	0.0135	0.014
Leishmania major	proton motive ATPase, putative	0.0019	0.0135	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2516	0.2632
Leishmania major	P-type H -ATPase, putative	0.0019	0.0135	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0196	0.3657	0.3825
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.064	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0407	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0483	1
Echinococcus multilocularis	phosphoserine phosphatase	0.0019	0.0135	0.0139
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0019	0.0135	0.0141
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0019	0.0135	0.0139
Toxoplasma gondii	cation-transporting atpase family protein	0.0019	0.0135	0.1283
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0019	0.0135	0.0139
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.079	0.0826
Echinococcus granulosus	Diacylglycerol kinase theta	0.0017	0.0105	0.0108
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0019	0.0135	0.2796
Brugia malayi	Raf kinase	0.0477	0.9265	1
Mycobacterium leprae	Probable metal cation-transporting P-type ATPase C CtpC	0.0019	0.0135	0.3316
Echinococcus multilocularis	neuropeptide receptor A26	0.0501	0.9739	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.079	0.0822
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0019	0.0135	0.2796
Loa Loa (eye worm)	cytochrome P450 family protein	0.0055	0.0858	0.0898
Echinococcus granulosus	neuropeptide receptor A26	0.0501	0.9739	1
Treponema pallidum	cation-transporting ATPase, P-type	0.0019	0.0135	0.5
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0019	0.0135	0.0139
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.079	0.0811
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0019	0.0135	0.014
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0019	0.0135	0.0566
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0019	0.0135	0.0146
Loa Loa (eye worm)	acetyltransferase	0.0164	0.302	0.3159
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.072	0.638
Trichomonas vaginalis	set domain proteins, putative	0.0514	1	1
Toxoplasma gondii	P-type ATPase4, putative	0.0019	0.0135	0.1283
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0017	0.0105	0.011
Echinococcus multilocularis	protein kinase c epsilon type	0.0017	0.0105	0.0108
Mycobacterium ulcerans	metal cation transporter ATPase p-type CtpE	0.0019	0.0135	0.2796
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.0019	0.0135	0.0146
Brugia malayi	E1-E2 ATPase family protein	0.0019	0.0135	0.0146
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0019	0.0135	0.2796
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.072	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0017	0.0105	0.0108
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0019	0.0135	0.0139
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.0019	0.0135	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0019	0.0135	0.0141
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0019	0.0135	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0019	0.0135	0.2796
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.072	0.0593
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0105	0.0109
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.072	0.6844
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0019	0.0135	0.2796
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0017	0.0105	0.0108
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0407	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Mycobacterium ulcerans	cation transporter p-type ATPase a CtpA	0.0019	0.0135	0.2796
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0062	0.1004	0.1031
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0017	0.0105	0.0108
Echinococcus granulosus	protein kinase c epsilon type	0.0017	0.0105	0.0108
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.072	0.0739
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0019	0.0135	0.3316
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.1052	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Brugia malayi	Ras association domain family 1 isoform A	0.0017	0.0105	0.0113
Trypanosoma brucei	cation-transporting ATPase, putative	0.0019	0.0135	0.2796
Schistosoma mansoni	ATPase	0.0019	0.0135	0.014
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0019	0.0135	0.2796
Brugia malayi	Cytochrome P450 family protein	0.0055	0.0858	0.0926
Brugia malayi	RhoGAP domain containing protein	0.0017	0.0105	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0105	0.011
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0065	0.1052	1
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0019	0.0135	0.2796
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0452	0.8757	0.9159
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0017	0.0105	0.011
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0164	0.302	0.3143
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0019	0.0135	0.0566
Schistosoma mansoni	protein kinase C mu	0.0017	0.0105	0.0109
Loa Loa (eye worm)	E1-E2 ATPase	0.0019	0.0135	0.0141
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0017	0.0105	0.011
Echinococcus granulosus	myotubularin protein 13	0.0017	0.0105	0.0108
Schistosoma mansoni	type V p-type atpase isoform	0.0019	0.0135	0.014
Brugia malayi	Na,K-ATPase alpha subunit	0.0019	0.0135	0.0146
Schistosoma mansoni	eyes absent homolog	0.0196	0.3657	0.3806
Leishmania major	copper-transporting ATPase-like protein, putative	0.0019	0.0135	0.2796
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0017	0.0105	0.0108
Schistosoma mansoni	unc-13 (munc13)	0.0017	0.0105	0.0109
Schistosoma mansoni	cation-transporting atpase worm	0.0019	0.0135	0.014
Brugia malayi	diacylglycerol kinase	0.0017	0.0105	0.0113
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0017	0.0105	0.011
Echinococcus multilocularis	copper transporting ATPase 1	0.0019	0.0135	0.0139
Trypanosoma cruzi	phospholipid-transporting ATPase-like protein, putative	0.0019	0.0135	0.2796
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0019	0.0135	0.0566
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0019	0.0135	0.0139

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2135991

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1709091