Detailed information for compound 1714394

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 559.582 | Formula: C31H28F3N5O2
  • H donors: 1 H acceptors: 1 LogP: 6.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1CCC(CC1)/N=c/1\cc2c(cc1Nc1cccnc1)nc1c(n2c2ccc(cc2)OC(F)(F)F)cccc1
  • InChi: 1S/C31H28F3N5O2/c1-40-23-12-8-20(9-13-23)36-27-18-30-28(17-26(27)37-21-5-4-16-35-19-21)38-25-6-2-3-7-29(25)39(30)22-10-14-24(15-11-22)41-31(32,33)34/h2-7,10-11,14-20,23,37H,8-9,12-13H2,1H3/b36-27+
  • InChiKey: HCHMYXCGFDOJKR-KJFHWCLQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2284 0.3418
Loa Loa (eye worm) hypothetical protein 0.0006 0.0043 0.0115
Loa Loa (eye worm) hypothetical protein 0.0037 0.0736 0.2742
Leishmania major hypothetical protein, conserved 0.0037 0.0736 0.2866
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0736 0.1372
Brugia malayi Thioredoxin reductase 0.0037 0.0742 0.2766
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0319 0.1238
Brugia malayi MH2 domain containing protein 0.0008 0.0096 0.0316
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0648 0.0607
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0439 0.1666
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0324 0.1144
Trypanosoma brucei trypanothione reductase 0.0037 0.0742 0.2892
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.181 0.3452
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0096 0.0216
Loa Loa (eye worm) hypothetical protein 0.0037 0.0736 0.2742
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0647 0.2459
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.1135 0.448
Entamoeba histolytica protein kinase, putative 0.0033 0.0647 0.2459
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1248 0.4905
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0121 0.0412
Schistosoma mansoni cpg binding protein 0.003 0.0579 0.2245
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0198 0.0768
Loa Loa (eye worm) hypothetical protein 0.0037 0.0736 0.2742
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0053 0.0103
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0622 0.5299
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.074 0.2881
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0736 0.2866
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0319 0.118
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Echinococcus multilocularis smad 0.0008 0.0096 0.0216
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0319 0.0442
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0646 0.2501
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.074 0.1079
Echinococcus multilocularis musashi 0.0026 0.0504 0.1876
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0243 0.0873
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0736 0.1372
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.0943
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.1274 0.4942
Loa Loa (eye worm) hypothetical protein 0.0018 0.0319 0.1162
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0609 0.2353
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0504 0.1863
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0067 0.0097
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.25 1
Trichomonas vaginalis esterase, putative 0.0037 0.0736 0.2866
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0646 0.2501
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0815
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0198 0.0258
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.25 1
Schistosoma mansoni protein kinase 0.0033 0.0647 0.251
Mycobacterium ulcerans sugar transporter 0.0015 0.0243 0.0873
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0609 0.2353
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0873
Plasmodium vivax CDK-related protein kinase 6, putative 0.0449 1 1
Brugia malayi beta-lactamase 0.0037 0.0736 0.2742
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0319 0.1162
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.25 1
Schistosoma mansoni smad 0.0008 0.0096 0.0372
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0646 0.2501
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0324 0.12
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0648 0.0939
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0622 0.2309
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0243 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0319 0.118
Trypanosoma cruzi hexose transporter 0.0033 0.0646 0.2501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0103
Echinococcus granulosus smad 0.0008 0.0096 0.0216
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0767 0.2975
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0243 0.0815
Entamoeba histolytica hypothetical protein 0.0038 0.0767 0.2946
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Schistosoma mansoni glucose transport protein 0.0106 0.2284 0.8862
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0161 0.054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.202 0.7836
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0742 0.1385
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0815
Brugia malayi beta-lactamase family protein 0.0037 0.0736 0.2742
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0324 0.0282
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.25 0.943
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0622 0.2356
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0198 0.069
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0312 0.1151
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0053 0.0103
Loa Loa (eye worm) glutathione reductase 0.0037 0.0742 0.2766
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0243 0.0874
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.181 0.3452
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0324 0.12
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0198 0.069
Brugia malayi Cam kinase protein 1 0.0033 0.0647 0.2405
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0736 0.2742
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0096 0.0316
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0648 0.0607
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0198 0.0631
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2284 0.912
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.5192 1
Trypanosoma cruzi metacaspase, putative 0.0018 0.0319 0.118
Echinococcus multilocularis Smad4 0.0008 0.0096 0.0216
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0043 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Trypanosoma cruzi metacaspase, putative 0.0018 0.0319 0.118
Brugia malayi Cell death protein 3 precursor 0.0061 0.1274 0.4781
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0609 0.5185
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0609 0.2353
Plasmodium vivax sugar transporter, putative 0.0015 0.0243 0.0201
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0198 0.0156
Toxoplasma gondii sugar transporter ST2 0.0015 0.0243 0.0327
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.074 0.07
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0243 0.0874
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0043 0.0115
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0243 0.0874
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1248 0.4905
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0439 0.1704
Toxoplasma gondii exonuclease III APE 0.0018 0.0324 0.0449
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0198 0.069
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0121 0.0412
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0439 0.0398
Echinococcus multilocularis caspase 2 0.0061 0.1274 0.5009
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0319 0.1125
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0096 0.0216
Echinococcus granulosus caspase 8 0.0018 0.0319 0.1125
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0646 0.2501
Schistosoma mansoni intermediate filament proteins 0.0026 0.0504 0.1955
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0754 0.2892
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0319 0.0442
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0198 0.2738
Onchocerca volvulus 0.0028 0.0543 0.2906
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0324 0.12
Loa Loa (eye worm) hypothetical protein 0.0033 0.0647 0.2405
Loa Loa (eye worm) hypothetical protein 0.0012 0.0185 0.0655
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0319 0.118
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0736 0.2866
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.1135 0.448
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3758 0.3731
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0591 0.2232
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2651 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0736 0.1372
Schistosoma mansoni Smad4 0.0008 0.0096 0.0372
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0228 0.0816
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0815
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0243 0.0873
Giardia lamblia Hexose transporter 0.0015 0.0243 0.1834
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0096 0.0216
Trypanosoma brucei Metacaspase-4 0.0018 0.0319 0.118
Schistosoma mansoni smad1 5 8 and 0.0008 0.0096 0.0372
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2284 0.912
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0439 0.7
Schistosoma mansoni ap endonuclease 0.0018 0.0324 0.1257
Loa Loa (eye worm) hypothetical protein 0.0013 0.0196 0.0696
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0198 0.069
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1248 0.4937
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Entamoeba histolytica protein kinase, putative 0.0033 0.0647 0.2459
Onchocerca volvulus 0.0037 0.0736 0.4782
Mycobacterium tuberculosis Conserved protein 0.0037 0.0736 0.1372
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0647 0.2405
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0243 0.0815
Loa Loa (eye worm) hypothetical protein 0.0037 0.0736 0.2742
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Brugia malayi MAP kinase sur-1 0.0055 0.1135 0.4255
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0543 0.2009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0198 0.033
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0324 0.1181
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0319 0.0442
Brugia malayi MH1 domain containing protein 0.0008 0.0096 0.0316
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1135 0.448
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.0943
Trypanosoma brucei protein kinase, putative 0.0055 0.1135 0.448
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.074 0.2881
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.1135 0.4255
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0736 0.2742
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0815
Entamoeba histolytica hypothetical protein 0.0038 0.0767 0.2946
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0736 0.2866
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0439 0.1666
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Schistosoma mansoni ap endonuclease 0.0018 0.0324 0.1257
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0648 0.0607
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0736 0.2866
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0648 0.0939
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0609 0.2353
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0646 0.2501
Brugia malayi CXXC zinc finger family protein 0.0028 0.0543 0.2009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0324 0.1144
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0043 0.003
Echinococcus granulosus Smad4 0.0008 0.0096 0.0216
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Brugia malayi MH1 domain containing protein 0.0008 0.0096 0.0316
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.2022 0.3862
Schistosoma mansoni hypothetical protein 0.0042 0.0864 0.3351
Brugia malayi intermediate filament protein 0.0026 0.0504 0.1863
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0736 0.2866
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2284 0.9125
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0736 0.0696
Toxoplasma gondii thioredoxin reductase 0.0037 0.0742 0.1083
Brugia malayi hypothetical protein 0.0015 0.0243 0.0874
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0647 0.251
Brugia malayi glutathione reductase 0.0037 0.0742 0.2766
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.202 0.7608
Echinococcus multilocularis caspase 0.0018 0.0319 0.1125
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0243 0.0873
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0103 0.0342
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0609 0.0881
Brugia malayi major facilitator superfamily protein 0.0015 0.0243 0.0874
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0647 0.2459
Brugia malayi hypothetical protein 0.0038 0.0767 0.2859
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0198 0.069
Trypanosoma brucei glucose transporter 2A 0.0033 0.0646 0.2501
Loa Loa (eye worm) hypothetical protein 0.0032 0.0622 0.2309
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0198 0.069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus granulosus cpg binding protein 0.003 0.0579 0.2181
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0043 0.0115
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0622 0.2356
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0319 0.1238
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.1274 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.1135 0.4445
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0228 0.0816
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.1135 0.4445
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1248 0.2365
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0198 0.0703
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Echinococcus multilocularis caspase 8 0.0018 0.0319 0.1125
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.074 0.2881
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0243 0.0327
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0359 0.0643
Schistosoma mansoni protein kinase 0.0033 0.0647 0.251
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0609 0.0569
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0324 0.12
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0439 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0319 0.118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0103
Schistosoma mansoni hypothetical protein 0.0038 0.0767 0.2975
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0198 0.0156
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.1135 0.448
Brugia malayi phosphofructokinase 0.0115 0.25 0.943
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0609 0.0569
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.25 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0647 0.2405
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1135 0.4404
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0198 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0609 0.2353
Brugia malayi beta-lactamase family protein 0.0037 0.0736 0.2742
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Onchocerca volvulus 0.0042 0.0864 0.6022
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0647 0.2506
Schistosoma mansoni smad1 5 8 and 0.0008 0.0096 0.0372
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0324 0.12
Onchocerca volvulus 0.0037 0.0736 0.4782
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0198 0.5517
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0609 0.0881
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0439 0.3629
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0198 0.069
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.25 1
Echinococcus granulosus General substrate transporter 0.0091 0.195 0.7761
Trypanosoma brucei metacaspase MCA2 0.0018 0.0319 0.118
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0324 0.12
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0198 0.142
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1135 0.448
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0198 0.069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.202 0.8044
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0324 1
Trypanosoma brucei metacaspase 0.0018 0.0319 0.118
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0736 0.2821
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.25 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0609 0.2353
Schistosoma mansoni protein kinase 0.0033 0.0647 0.251
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.25 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0196 0.0624
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Loa Loa (eye worm) hypothetical protein 0.0037 0.0736 0.2742
Loa Loa (eye worm) sugar transporter 0.0015 0.0243 0.0874
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0043 0.0063
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0622 0.2356
Brugia malayi major facilitator superfamily protein 0.0015 0.0243 0.0874
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.25 0.4789
Trypanosoma cruzi metacaspase, putative 0.0018 0.0319 0.118
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0198 0.069
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0646 0.2501
Leishmania major metacaspase, putative 0.0018 0.0319 0.118
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0439 0.1666
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0647 0.2459
Brugia malayi Sugar transporter family protein 0.0015 0.0243 0.0874
Schistosoma mansoni lamin 0.0026 0.0504 0.1955
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2651 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.25 1
Echinococcus multilocularis General substrate transporter 0.0091 0.195 0.7761
Echinococcus granulosus intermediate filament protein 0.0026 0.0504 0.1876
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2284 0.912
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0374 0.1402
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2284 0.912
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0591 0.2232
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0198 0.069
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0609 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.202 0.8044
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0359 0.1343
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.074 0.2881
Loa Loa (eye worm) hypothetical protein 0.0042 0.0864 0.3227
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0324 0.0282
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0243 0.0873
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0043 0.0115
Echinococcus multilocularis cpg binding protein 0.003 0.0579 0.2181
Trypanosoma brucei metacaspase MCA3 0.0018 0.0319 0.118
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1109 0.1639
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1248 0.4937
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0873
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0243 0.0815
Entamoeba histolytica hypothetical protein 0.0038 0.0767 0.2946
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0198 0.069
Mycobacterium ulcerans hypothetical protein 0.0037 0.0736 0.2866
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Brugia malayi MH2 domain containing protein 0.0008 0.0096 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1248 0.4937
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.1135 0.448
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0319 0.118
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0105 0.0254
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0648 0.0607
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1253 0.486
Mycobacterium ulcerans lipase LipD 0.0037 0.0736 0.2866
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.1135 0.448
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0609 0.0569
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.25 0.943
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0096 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0736 0.2866
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.25 1
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0439 0.0624
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0324 0.1144
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0647 0.2459
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0736 0.1372
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0646 0.2501
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3758 0.565
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0815
Trypanosoma cruzi metacaspase, putative 0.0018 0.0319 0.118
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0243 0.0874
Echinococcus granulosus lamin 0.0026 0.0504 0.1876
Echinococcus multilocularis lamin dm0 0.0026 0.0504 0.1876
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0736 0.1372
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0646 0.2501
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.2022 0.3862
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0319 0.118
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0324 0.1144
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0198 0.0631
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0067 0.0097
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1248 0.4843
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1135 0.448
Schistosoma mansoni lamin 0.0026 0.0504 0.1955
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0198 0.069
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0648 0.0607
Giardia lamblia Sugar-proton symporter 0.0015 0.0243 0.1834
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.25 1
Brugia malayi Sugar transporter family protein 0.0015 0.0243 0.0874
Trichomonas vaginalis helicase, putative 0.0006 0.0053 0.0103
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.2022 0.8065
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0324 0.2574
Brugia malayi 6-phosphofructokinase 0.0115 0.25 0.943
Plasmodium falciparum metacaspase 1 0.0018 0.0319 0.0278
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0622 0.2412
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0647 0.2459
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0319 0.1125
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0043 0.0063
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0243 0.0874
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0198 0.5517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0243 0.0815
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.1135 0.448
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0439 0.1666
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0754 0.2892
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0319 0.0278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0736 0.2855
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.0943
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0609 0.2353
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2284 0.912
Schistosoma mansoni glucose transporter 0.0015 0.0243 0.0943
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0647 0.2405
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0609 1
Treponema pallidum NADH oxidase 0.0013 0.0198 0.0631
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0324 0.12
Loa Loa (eye worm) Smad1 0.0008 0.0096 0.0316
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.1135 0.1678
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0067 0.0097
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2284 0.912
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1248 0.1849
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0439 0.1704
Plasmodium falciparum glutathione reductase 0.0037 0.0742 0.0703
Brugia malayi 6-phosphofructokinase 0.0115 0.25 0.943
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0609 0.2305
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0815
Brugia malayi hypothetical protein 0.0015 0.0243 0.0874
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0043 0.0166
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0647 0.2459
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0439 0.1613
Mycobacterium ulcerans beta-lactamase 0.0037 0.0736 0.2866
Leishmania major glucose transporter, lmgt3 0.0033 0.0646 0.2501
Trypanosoma brucei sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2284 0.912
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0243 0.0943
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0198 0.0156
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0243 0.0201
Toxoplasma gondii protein kinase, putative 0.0299 0.663 1
Plasmodium vivax metacaspase 1, putative 0.0018 0.0319 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0043 0.0063
Brugia malayi hypothetical protein 0.0015 0.0243 0.0874
Plasmodium falciparum thioredoxin reductase 0.0013 0.0198 0.0156
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0504 0.1863
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0815
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0198 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0103
Loa Loa (eye worm) hypothetical protein 0.0032 0.0622 0.2309
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0736 0.2866
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0243 0.0873
Entamoeba histolytica hypothetical protein 0.0038 0.0767 0.2946
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0161 0.048
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0043 0.0063
Plasmodium falciparum proline--tRNA ligase 0.0037 0.074 0.07
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0043 0.0063
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.0943
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0319 0.1238
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.25 1
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0742 0.0703
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0622 0.2412
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.181 0.7207
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.25 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0198 0.069
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0736 0.2866
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.25 0.9701
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0161 0.2084
Plasmodium falciparum thioredoxin reductase 0.0037 0.0742 0.0703
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0504 0.1863
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0622 0.2309
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.1135 0.4445
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0736 0.2866
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0243 0.0873
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0096 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0736 0.2866
Trypanosoma brucei glucose transporter, putative 0.0033 0.0646 0.2501
Onchocerca volvulus 0.0037 0.0736 0.4782
Loa Loa (eye worm) hypothetical protein 0.0026 0.0488 0.1803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.202 0.8044
Leishmania major protein kinase, putative 0.0033 0.0647 0.2506
Schistosoma mansoni cpg binding protein 0.0028 0.0543 0.2105
Echinococcus granulosus caspase 0.0018 0.0319 0.1125
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.25 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1274 0.4781
Toxoplasma gondii sugar transporter ST1 0.0015 0.0243 0.0327
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0736 0.1372
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0105 0.0351
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0647 0.2459
Toxoplasma gondii sugar transporter ST3 0.0015 0.0243 0.0327
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.1135 0.448
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0609 0.0569
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0243 0.7125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0736 0.2742
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0319 0.118
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0043 0.0115
Trypanosoma brucei glucose transporter 1E 0.0033 0.0646 0.2501
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0646 0.2501
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0873
Onchocerca volvulus 0.0026 0.0504 0.2531
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0043 0.0063
Loa Loa (eye worm) hypothetical protein 0.0026 0.0493 0.1822
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0067 0.0258
Brugia malayi Smad1 0.0008 0.0096 0.0316
Plasmodium falciparum glutathione reductase 0.0013 0.0198 0.0156
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0646 0.2501
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.202 0.7608
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0043 0.0063
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0609 0.0881
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0742 0.2892
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0873
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0609 0.2305
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0742 0.2766
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.202 0.7836
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0243 0.0418
Leishmania major glucose transporter, lmgt1 0.0033 0.0646 0.2501
Schistosoma mansoni hypothetical protein 0.0106 0.2284 0.8862
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.25 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0103
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0319 0.118
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1248 0.4843
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0647 0.2459
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0648 0.0607
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0439 0.1666
Plasmodium vivax glutathione reductase, putative 0.0037 0.0742 0.0703
Toxoplasma gondii ABC1 family protein 0.0037 0.0736 0.1073
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0815
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.181 0.3452
Brugia malayi hypothetical protein 0.0042 0.0864 0.3227
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0648 0.0607
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.074 0.2881
Schistosoma mansoni glucose transport protein 0.0106 0.2284 0.8862
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0646 0.2501
Entamoeba histolytica hypothetical protein 0.0024 0.0439 0.1613
Loa Loa (eye worm) sugar transporter 0.0106 0.2284 0.861
Schistosoma mansoni smad1 5 8 and 0.0008 0.0096 0.0372
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0439 0.1666
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0767 0.2946
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0767 0.2946
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Onchocerca volvulus 0.0026 0.0504 0.2531
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.1863
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Loa Loa (eye worm) phosphofructokinase 0.0115 0.25 0.943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.202 0.7836
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0096 0.0216
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0243 0.0873
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0864 0.3341
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1135 0.448
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0198 0.069
Plasmodium falciparum metacaspase-like protein 0.0018 0.0319 0.0278
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.1135 1
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0043 0.0063
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0359 0.0643
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1248 0.4937
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0105 0.0254
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.25 0.9701
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0439 0.1666
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.181 0.3452
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0648 0.0607
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0736 0.2821
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0319 0.118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.25 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0243 0.0418
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0648 0.0939
Loa Loa (eye worm) beta-lactamase 0.0037 0.0736 0.2742
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0622 0.2404
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0864 0.3341
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2284 0.912
Mycobacterium tuberculosis Conserved protein 0.0037 0.0736 0.1372
Echinococcus multilocularis lamin 0.0026 0.0504 0.1876
Schistosoma mansoni cpg binding protein 0.003 0.0579 0.2245
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0043 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0185 0.0655
Echinococcus granulosus lamin dm0 0.0026 0.0504 0.1876
Loa Loa (eye worm) hypothetical protein 0.0024 0.0439 0.1618
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0319 0.118
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0043 0.0115
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0324 0.1181
Plasmodium vivax hexose transporter 0.0106 0.2284 0.2251
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0043 0.0024
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3758 0.3731
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0647 0.2506
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0103
Leishmania major glucose transporter, lmgt2 0.0033 0.0646 0.2501
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0736 0.2855
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0646 0.2501
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0243 0.0873
Echinococcus granulosus caspase 2 0.0061 0.1274 0.5009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0198 0.069
Leishmania major hypothetical protein, conserved 0.0015 0.0243 0.0873
Mycobacterium tuberculosis Probable reductase 0.0084 0.181 0.3452
Mycobacterium tuberculosis Conserved protein 0.0037 0.0736 0.1372
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0736 0.2866
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.181 0.3452
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0646 0.2501
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0736 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0873
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0243 0.0873
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0202 0.0717
Mycobacterium leprae Probable lipase LipE 0.0037 0.0736 0.2866
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0439 0.1613
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0196 0.0624
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.1135 0.4445
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.202 0.8044
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0067 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0874
Plasmodium falciparum hexose transporter 0.0106 0.2284 0.2251
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.2022 0.3862
Schistosoma mansoni glucose transport protein 0.0106 0.2284 0.8862
Plasmodium falciparum protein kinase 7 0.0299 0.663 0.6616
Brugia malayi MH2 domain containing protein 0.0122 0.2651 1
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0439 0.1618
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0646 0.2501
Brugia malayi Sugar transporter family protein 0.0106 0.2284 0.861
Leishmania major trypanothione reductase 0.0037 0.0742 0.2892
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0648 0.0607
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0324 0.0575
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0622 0.2404

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.03 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate Alamar blue assay ChEMBL. 22931472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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