Detailed information for compound 1721750

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 581.743 | Formula: C40H39NO3
  • H donors: 0 H acceptors: 1 LogP: 10.05 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(Cc1ccccc1)CCCCCCCOc1ccc(cc1)c1oc2c(c1C(=O)c1ccc3c(c1)cccc3)cccc2
  • InChi: 1S/C40H39NO3/c1-41(29-30-14-6-5-7-15-30)26-12-3-2-4-13-27-43-35-24-22-32(23-25-35)40-38(36-18-10-11-19-37(36)44-40)39(42)34-21-20-31-16-8-9-17-33(31)28-34/h5-11,14-25,28H,2-4,12-13,26-27,29H2,1H3
  • InChiKey: YSMXCVGNCVNXGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei epsilon tubulin 0.0081 0.0905 0.3494
Giardia lamblia Alpha-tubulin 0.0081 0.0905 0.2648
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0318 0.1247
Trypanosoma cruzi epsilon tubulin, putative 0.0081 0.0905 0.3494
Echinococcus multilocularis lamin 0.0081 0.0909 0.0909
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0035 0.0313 0.5
Schistosoma mansoni tubulin subunit alpha 0.0081 0.0905 0.3551
Echinococcus multilocularis musashi 0.0081 0.0909 0.0909
Brugia malayi nuclear receptor NHR-88 0.0021 0.0126 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0071 0.0071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.1755 0.2697
Brugia malayi beta-tubulin, identical 0.0208 0.2549 0.3919
Echinococcus multilocularis Tubulin beta 2C chain 0.0208 0.2549 0.2549
Echinococcus granulosus tubulin alpha 0.0081 0.0905 0.3551
Echinococcus granulosus tubulin alpha chain 0.0081 0.0905 0.3551
Leishmania major beta tubulin 0.0208 0.2549 1
Loa Loa (eye worm) BEN-1 protein 0.0208 0.2549 0.3919
Trypanosoma brucei beta tubulin 0.0208 0.2549 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0303
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0126 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0126 0.0194
Toxoplasma gondii beta-tubulin, putative 0.0208 0.2549 1
Loa Loa (eye worm) alpha-tubulin 0.0081 0.0905 0.1392
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0905 0.3494
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0126 0.0495
Plasmodium falciparum tubulin beta chain 0.0208 0.2549 1
Schistosoma mansoni tubulin subunit delta 0.0035 0.0313 0.1228
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Plasmodium vivax tubulin gamma chain, putative 0.0081 0.0905 0.338
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0905 0.3494
Echinococcus multilocularis tubulin alpha chain 0.0081 0.0905 0.0905
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0126 0.0495
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0459 0.1799
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0071 0.0191
Trypanosoma brucei alpha tubulin 0.0081 0.0905 0.3494
Schistosoma mansoni tubulin subunit alpha 0.0081 0.0905 0.3551
Loa Loa (eye worm) tubulin alpha-2 chain 0.0081 0.0905 0.1392
Loa Loa (eye worm) tubulin alpha 2 0.0046 0.0451 0.0693
Brugia malayi Tubulin beta-1 chain 0.0208 0.2549 0.3919
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0126 0.0126
Echinococcus granulosus tubulin beta 1 chain 0.0208 0.2549 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0126 0.0495
Echinococcus granulosus Tubulin alpha 1 chain 0.0081 0.0905 0.3551
Echinococcus multilocularis tubulin alpha chain 0.0081 0.0905 0.0905
Onchocerca volvulus 0.0081 0.0909 0.1228
Loa Loa (eye worm) hypothetical protein 0.0081 0.0905 0.1392
Loa Loa (eye worm) RecQ helicase 0.0024 0.0165 0.0254
Echinococcus granulosus bloom syndrome protein 0.0024 0.0165 0.0648
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0126 0.0194
Schistosoma mansoni hypothetical protein 0.0046 0.0459 0.1799
Echinococcus granulosus Tubulin beta 2C chain 0.0208 0.2549 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0081 0.0905 0.3494
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Echinococcus multilocularis beta tubulin 0.0208 0.2549 0.2549
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0126 0.0495
Schistosoma mansoni hypothetical protein 0.0046 0.0459 0.1799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0126 0.0194
Echinococcus granulosus tubulin subunit TubB 0.0081 0.0905 0.3551
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0126 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0126 0.0194
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Echinococcus granulosus beta tubulin 0.0208 0.2549 1
Trichomonas vaginalis tubulin, putative 0.0035 0.0313 0.1151
Brugia malayi Tubulin alpha chain 0.0035 0.0313 0.0481
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0126 0.0495
Plasmodium vivax tubulin alpha chain, putative 0.0081 0.0905 0.338
Schistosoma mansoni tubulin subunit gamma 0.0081 0.0905 0.3551
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0035 0.0313 0.1005
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0459 0.0705
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0126 0.0495
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0071 0.002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0071 0.0191
Brugia malayi hypothetical protein 0.0017 0.0077 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0126 0.0495
Echinococcus multilocularis tubulin alpha 3 chain 0.0081 0.0905 0.0905
Entamoeba histolytica tubulin alpha-1 chain 0.0081 0.0905 0.3494
Leishmania major beta tubulin 0.0208 0.2549 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0165 0.0165
Trypanosoma cruzi tubulin delta chain 0.0035 0.0313 0.1151
Leishmania major beta tubulin 0.0208 0.2549 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0071 0.0278
Giardia lamblia Gamma tubulin 0.0081 0.0905 0.2648
Echinococcus multilocularis beta tubulin 0.0208 0.2549 0.2549
Brugia malayi Tubulin beta chain 0.0035 0.0313 0.0481
Echinococcus granulosus peroxisome assembly protein 26 0.0081 0.0905 0.3551
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0126 0.0495
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0422 0.0648
Schistosoma mansoni hypothetical protein 0.0046 0.0459 0.1799
Echinococcus multilocularis tubulin alpha chain 0.0081 0.0905 0.0905
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0126 0.0126
Echinococcus multilocularis GPCR, family 2 0.0046 0.0459 0.0459
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0197 0.0509
Echinococcus multilocularis tubulin beta 1 chain 0.0208 0.2549 0.2549
Leishmania major beta tubulin 0.0208 0.2549 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.1755 0.2697
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.1155 0.1775
Echinococcus multilocularis Tubulin alpha 1 chain 0.0081 0.0905 0.0905
Loa Loa (eye worm) tubulin alpha chain 0.0081 0.0905 0.1392
Entamoeba histolytica tubulin gamma chain 0.0081 0.0905 0.3494
Echinococcus granulosus Tubulin beta 2C chain 0.0208 0.2549 1
Leishmania major beta tubulin 0.0208 0.2549 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0347 0.0533
Echinococcus multilocularis tubulin alpha chain 0.0081 0.0905 0.0905
Brugia malayi Cell division protein ftsZ 0.0035 0.0313 0.0481
Echinococcus multilocularis peroxisome assembly protein 26 0.0081 0.0905 0.0905
Echinococcus multilocularis tubulin alpha 0.0081 0.0905 0.0905
Echinococcus granulosus GPCR family 2 0.0046 0.0459 0.1799
Trichomonas vaginalis tubulin epsilon chain, putative 0.0081 0.0905 0.3494
Schistosoma mansoni tubulin subunit beta 0.0208 0.2549 1
Trypanosoma brucei alpha tubulin, putative 0.0046 0.0451 0.1696
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0071 0.0071
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0126 0.0194
Schistosoma mansoni tubulin subunit beta 0.0208 0.2549 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0459 0.0459
Echinococcus granulosus Tubulin beta 2C chain 0.0208 0.2549 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0126 0.0126
Echinococcus granulosus tubulin alpha 1C chain 0.0081 0.0905 0.3551
Echinococcus granulosus tubulin alpha chain 0.0081 0.0905 0.3551
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0126 0.0126
Loa Loa (eye worm) tubulin alpha chain 0.0081 0.0905 0.1392
Trypanosoma brucei alpha tubulin 0.0081 0.0905 0.3494
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Entamoeba histolytica tubulin alpha chain, putative 0.0081 0.0905 0.3494
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0165 0.0565
Schistosoma mansoni tubulin subunit beta 0.0208 0.2549 1
Trypanosoma brucei beta tubulin 0.0208 0.2549 1
Onchocerca volvulus 0.0081 0.0909 0.1228
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0126 0.0495
Schistosoma mansoni tubulin subunit alpha 0.0035 0.0313 0.1228
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0126 0.0194
Echinococcus multilocularis Tubulin beta 2C chain 0.0208 0.2549 0.2549
Echinococcus multilocularis tubulin subunit TubB 0.0081 0.0905 0.0905
Trichomonas vaginalis tubulin epsilon chain, putative 0.0208 0.2549 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0459 0.0705
Trypanosoma cruzi beta tubulin, putative 0.0208 0.2549 1
Brugia malayi Tubulin gamma chain 0.0081 0.0905 0.1392
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Echinococcus granulosus alpha tubulin 0.0081 0.0905 0.3551
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0905 0.3494
Entamoeba histolytica tubulin family protein 0.0208 0.2549 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0071 0.0071
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0126 0.0495
Loa Loa (eye worm) hypothetical protein 0.0147 0.1755 0.2697
Echinococcus granulosus tubulin gamma 1 chain 0.0081 0.0905 0.3551
Echinococcus granulosus tubulin alpha 3 chain 0.0081 0.0905 0.3551
Loa Loa (eye worm) hypothetical protein 0.0038 0.0347 0.0533
Toxoplasma gondii beta-1 tubulin, putative 0.0208 0.2549 1
Trichomonas vaginalis tubulin, putative 0.0208 0.2549 1
Trypanosoma cruzi zeta tubulin, putative 0.0035 0.0313 0.1151
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0071 0.0071
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0101 0.0395
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0197 0.0691
Schistosoma mansoni tubulin subunit epsilon 0.0081 0.0905 0.3551
Brugia malayi Tubulin alpha-2 chain 0.0081 0.0905 0.1392
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0313 0.1151
Trichomonas vaginalis tubulin alpha chain, putative 0.0208 0.2549 1
Loa Loa (eye worm) BEN-1 protein 0.0208 0.2549 0.3919
Entamoeba histolytica hypothetical protein 0.0036 0.0318 0.1169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Loa Loa (eye worm) hypothetical protein 0.008 0.089 0.1369
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0041
Echinococcus multilocularis tubulin alpha 1C chain 0.0081 0.0905 0.0905
Leishmania major beta tubulin 0.0208 0.2549 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Trichomonas vaginalis tubulin gamma chain, putative 0.0081 0.0905 0.3494
Onchocerca volvulus 0.0149 0.1787 0.2604
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0165 0.0254
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0046 0.0451 0.1696
Leishmania major beta tubulin 0.0208 0.2549 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0126 0.0194
Trypanosoma brucei tubulin gamma chain 0.0081 0.0905 0.3494
Trichomonas vaginalis tubulin beta chain, putative 0.0046 0.0451 0.1696
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Trypanosoma brucei zeta tubulin 0.0035 0.0313 0.1151
Brugia malayi Tubulin beta chain 0.0046 0.0451 0.0693
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0126 0.0194
Schistosoma mansoni hypothetical protein 0.01 0.1155 0.453
Trypanosoma brucei epsilon tubulin 0.0081 0.0905 0.3494
Trichomonas vaginalis tubulin, putative 0.0046 0.0451 0.1696
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0197 0.0691
Leishmania major beta tubulin 0.0208 0.2549 1
Brugia malayi steroid hormone receptor 0.0021 0.0126 0.0194
Echinococcus granulosus tubulin alpha 1C chain 0.0081 0.0905 0.3551
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0197 0.0538
Echinococcus granulosus tubulin alpha chain 0.0081 0.0905 0.3551
Leishmania major beta tubulin 0.0208 0.2549 1
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Schistosoma mansoni lamin 0.0081 0.0909 0.3568
Onchocerca volvulus 0.0046 0.0451 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0126 0.0194
Loa Loa (eye worm) hypothetical protein 0.0039 0.0366 0.0562
Leishmania major beta tubulin 0.0208 0.2549 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0126 0.0495
Echinococcus granulosus tubulin alpha 3 chain 0.0081 0.0905 0.3551
Loa Loa (eye worm) tubulin beta chain 0.0035 0.0313 0.0481
Trypanosoma brucei zeta tubulin, putative 0.0035 0.0313 0.1151
Echinococcus granulosus tubulin beta 4A class IVa 0.0208 0.2549 1
Brugia malayi Tubulin alpha-2 chain 0.0081 0.0905 0.1392
Brugia malayi tubulin alpha chain - mouse 0.0081 0.0905 0.1392
Echinococcus multilocularis Tubulin beta 2C chain 0.0208 0.2549 0.2549
Echinococcus granulosus Tubulin alpha 1 chain 0.0081 0.0905 0.3551
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0071 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0459 0.0459
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0459 0.0705
Plasmodium falciparum alpha tubulin 1 0.0081 0.0905 0.3367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0313 0.0481
Schistosoma mansoni lamin 0.0081 0.0909 0.3568
Brugia malayi Pax transcription factor protein 2 0.0515 0.6505 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0126 0.0126
Echinococcus multilocularis Tubulin alpha 1 chain 0.0081 0.0905 0.0905
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0318 0.1247
Echinococcus multilocularis Tubulin beta 2C chain 0.0208 0.2549 0.2549
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.001 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Echinococcus multilocularis tubulin epsilon chain 0.0081 0.0905 0.0905
Entamoeba histolytica hypothetical protein 0.0036 0.0318 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0126 0.0194
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0459 0.1799
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0126 0.0495
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0126 0.0495
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0071 0.0278
Schistosoma mansoni tubulin subunit beta 0.0035 0.0313 0.1228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0318 0.0318
Trypanosoma cruzi zeta tubulin, putative 0.0035 0.0313 0.1151
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0081 0.0905 0.3494
Schistosoma mansoni intermediate filament proteins 0.0081 0.0909 0.3568
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0126 0.0495
Echinococcus granulosus tubulin alpha chain 0.0081 0.0905 0.3551
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0197 0.0509
Loa Loa (eye worm) hypothetical protein 0.0046 0.0459 0.0705
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0126 0.0495
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0071 0.0109
Echinococcus multilocularis hypothetical protein 0.0081 0.0905 0.0905
Toxoplasma gondii alpha tubulin TUBA1 0.0081 0.0905 0.3387
Trypanosoma cruzi epsilon tubulin, putative 0.0081 0.0905 0.3494
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0126 0.0194
Loa Loa (eye worm) alpha-tubulin 0.0081 0.0905 0.1392
Schistosoma mansoni hypothetical protein 0.0046 0.0459 0.1799
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0905 0.3494
Echinococcus granulosus Tubulin beta 2C chain 0.0208 0.2549 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0126 0.0495
Mycobacterium leprae cell division protein FtsZ 0.0035 0.0313 0.5
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Schistosoma mansoni coup transcription factor 0.0021 0.0126 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0126 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0126 0.0194
Echinococcus granulosus tubulin epsilon chain 0.0081 0.0905 0.3551
Entamoeba histolytica hypothetical protein 0.0036 0.0318 0.1169
Echinococcus granulosus Tubulin alpha 1 chain 0.0081 0.0905 0.3551
Treponema pallidum cell division protein FtsZ 0.0035 0.0313 0.5
Echinococcus multilocularis tubulin subunit beta 0.0208 0.2549 0.2549
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0071 0.0191
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0366 0.1435
Entamoeba histolytica tubulin family protein 0.0208 0.2549 1
Trypanosoma brucei beta tubulin 0.0081 0.0905 0.3494
Leishmania major beta tubulin 0.0208 0.2549 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.1755 0.2697
Echinococcus multilocularis tubulin delta chain 0.0035 0.0313 0.0313
Giardia lamblia Beta tubulin 0.0208 0.2549 1
Leishmania major epsilon tubulin, putative 0.0081 0.0905 0.3494
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0905 0.3494
Brugia malayi tubulin alpha-2 chain 0.0081 0.0905 0.1392
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0126 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0126 0.0194
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Trichomonas vaginalis tubulin beta chain, putative 0.0208 0.2549 1
Echinococcus granulosus beta tubulin 0.0208 0.2549 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0126 0.0194
Toxoplasma gondii beta tubulin 0.0208 0.2549 1
Echinococcus granulosus lamin 0.0081 0.0909 0.3568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0126 0.0194
Schistosoma mansoni alpha tubulin 0.0081 0.0905 0.3551
Trichomonas vaginalis tubulin gamma chain, putative 0.0208 0.2549 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0046 0.0451 0.1696
Brugia malayi hypothetical protein 0.0149 0.1787 0.2747
Loa Loa (eye worm) tubulin beta-4 chain 0.0208 0.2549 0.3919
Loa Loa (eye worm) tubulin gamma chain 0.0081 0.0905 0.1392
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0126 0.0495
Mycobacterium tuberculosis Cell division protein FtsZ 0.0035 0.0313 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0081 0.0905 0.0905
Leishmania major hypothetical protein, conserved 0.0026 0.0197 0.0691
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0071 0.003
Brugia malayi hypothetical protein 0.0026 0.0197 0.0303
Giardia lamblia Beta tubulin 0.0208 0.2549 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0197 0.0528
Plasmodium vivax tubulin beta chain, putative 0.0208 0.2549 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0071 0.0191
Giardia lamblia Alpha-tubulin 0.0081 0.0905 0.2648
Brugia malayi isocitrate dehydrogenase 0.0016 0.0071 0.0109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0126 0.0495
Trypanosoma brucei epsilon tubulin 0.0081 0.0905 0.3494
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0071 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0126 0.0495
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0165 0.0565
Echinococcus granulosus tubulin delta chain 0.0035 0.0313 0.1228
Loa Loa (eye worm) tubulin beta-1 chain 0.0208 0.2549 0.3919
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0126 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0126 0.0194
Brugia malayi intermediate filament protein 0.0081 0.0909 0.1398
Trichomonas vaginalis tubulin gamma chain, putative 0.0035 0.0313 0.1151
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0126 0.0194
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Loa Loa (eye worm) beta-tubulin 0.0208 0.2549 0.3919
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0126 0.0126
Echinococcus multilocularis Tubulin beta 2C chain 0.0208 0.2549 0.2549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0126 0.0126
Echinococcus multilocularis tubulin alpha chain 0.0081 0.0905 0.0905
Schistosoma mansoni tubulin subunit beta 0.0208 0.2549 1
Leishmania major delta tubulin, putative 0.0035 0.0313 0.1151
Brugia malayi Tubulin alpha chain 0.0081 0.0905 0.1392
Trypanosoma brucei tubulin delta chain 0.0035 0.0313 0.1151
Echinococcus granulosus intermediate filament protein 0.0081 0.0909 0.3568
Brugia malayi nuclear hormone receptor 0.0021 0.0126 0.0194
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0905 0.3494
Trypanosoma cruzi tubulin gamma chain 0.0081 0.0905 0.3494
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0909 0.1398
Mycobacterium ulcerans cell division protein FtsZ 0.0035 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0119 0.1401 0.2154
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0071 0.0191
Onchocerca volvulus 0.0515 0.6505 1
Leishmania major beta tubulin 0.0208 0.2549 1
Trypanosoma brucei alpha tubulin 0.0081 0.0905 0.3494
Schistosoma mansoni tubulin subunit beta 0.0208 0.2549 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0081 0.0905 0.0905
Trichomonas vaginalis tubulin epsilon chain, putative 0.0208 0.2549 1
Brugia malayi ecdysteroid receptor 0.0021 0.0126 0.0194
Leishmania major zeta tubulin, putative 0.0035 0.0313 0.1151
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0035 0.0313 0.1151
Entamoeba histolytica hypothetical protein 0.0036 0.0318 0.1169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0194
Loa Loa (eye worm) hypothetical protein 0.0149 0.1787 0.2747
Schistosoma mansoni hypothetical protein 0.0036 0.0318 0.1247
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0909 0.1398
Loa Loa (eye worm) pax transcription factor protein 2 0.0515 0.6505 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0081 0.0905 0.0905
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0909 0.1398
Leishmania major gamma-tubulin 0.0081 0.0905 0.3494
Trichomonas vaginalis tubulin alpha chain, putative 0.0046 0.0451 0.1696
Leishmania major beta tubulin 0.0208 0.2549 1
Plasmodium falciparum alpha tubulin 2 0.0081 0.0905 0.3367
Loa Loa (eye worm) hypothetical protein 0.0046 0.0451 0.0693
Trypanosoma cruzi tubulin delta chain 0.0035 0.0313 0.1151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0126 0.0194
Plasmodium vivax tubulin epsilon chain, putative 0.0081 0.0905 0.338
Plasmodium falciparum tubulin epsilon chain, putative 0.0081 0.0905 0.3367
Trypanosoma brucei beta tubulin 0.0208 0.2549 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0081 0.0905 0.3387
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0126 0.0495
Echinococcus granulosus tubulin subunit beta 0.0208 0.2549 1
Brugia malayi hypothetical protein 0.0036 0.0318 0.0489
Loa Loa (eye worm) tubulin beta chain 0.0208 0.2549 0.3919
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0208 0.2549 0.2549
Trypanosoma brucei alpha tubulin 0.0081 0.0905 0.3494
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0035 0.0313 0.1151
Loa Loa (eye worm) tubulin beta-2A chain 0.0208 0.2549 0.3919
Leishmania major beta tubulin 0.0208 0.2549 1
Toxoplasma gondii alpha-tubulin I, putative 0.0081 0.0905 0.3387
Plasmodium falciparum tubulin gamma chain 0.0081 0.0905 0.3367
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0071 0.0109
Leishmania major beta tubulin 0.0208 0.2549 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1155 0.1775
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0035 0.0313 0.1005
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0046 0.0451 0.1696
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0197 0.0691
Trichomonas vaginalis tubulin, putative 0.0046 0.0451 0.1696
Brugia malayi alpha-tubulin 0.0081 0.0905 0.1392
Schistosoma mansoni tubulin subunit alpha 0.0081 0.0905 0.3551
Plasmodium falciparum tubulin delta chain, putative 0.0035 0.0313 0.0978
Leishmania major beta tubulin 0.0208 0.2549 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0035 0.0313 0.0481
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0422 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0126 0.0194
Plasmodium vivax delta tubulin, putative 0.0035 0.0313 0.0996
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0128 0.023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0366 0.0366
Trypanosoma cruzi alpha tubulin, putative 0.0081 0.0905 0.3494
Echinococcus multilocularis lamin dm0 0.0081 0.0909 0.0909
Schistosoma mansoni alpha tubulin 0.0081 0.0905 0.3551
Echinococcus multilocularis tubulin alpha 3 chain 0.0081 0.0905 0.0905
Echinococcus granulosus Tubulin beta 2C chain 0.0208 0.2549 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0905 0.3494
Echinococcus granulosus lamin dm0 0.0081 0.0909 0.3568
Loa Loa (eye worm) tubulin alpha 2 0.0046 0.0451 0.0693
Trichomonas vaginalis tubulin alpha chain, putative 0.0046 0.0451 0.1696
Leishmania major beta tubulin 0.0208 0.2549 1
Schistosoma mansoni tubulin subunit beta 0.0208 0.2549 1
Plasmodium vivax tubulin alpha chain, putative 0.0081 0.0905 0.338
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0126 0.0495
Trichomonas vaginalis tubulin epsilon chain, putative 0.0035 0.0313 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0126 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0313 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0126 0.0194
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Trypanosoma brucei beta tubulin 0.0208 0.2549 1
Leishmania major beta tubulin 0.0208 0.2549 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.001 0.001
Schistosoma mansoni alpha tubulin 0.0081 0.0905 0.3551
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0046 0.0451 0.0693
Trichomonas vaginalis tubulin gamma chain, putative 0.0081 0.0905 0.3494
Leishmania major alpha tubulin 0.0081 0.0905 0.3494
Loa Loa (eye worm) hypothetical protein 0.0081 0.0909 0.1398
Giardia lamblia Beta tubulin 0.0208 0.2549 1
Echinococcus granulosus tubulin alpha chain 0.0081 0.0905 0.3551

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 6.87 % Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells at 10 uM after 90 mins ChEMBL. 23164658
Activity (binding) = 35.06 % Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells at 10 uM after 90 mins ChEMBL. 23164658
EC50 (binding) > 10 uM Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 mins ChEMBL. 23164658
EC50 (binding) > 10 uM Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 mins ChEMBL. 23164658
IC50 (binding) Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior to substrate addition by Ellman's method ChEMBL. 23164658
IC50 (binding) = 89.1 uM Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior to substrate addition by Ellman's method ChEMBL. 23164658
Ki (binding) > 10 uM Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 mins ChEMBL. 23164658
Ki (binding) > 10 uM Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 mins ChEMBL. 23164658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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