Detailed information for compound 1729441

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.48 | Formula: C26H26O7
  • H donors: 2 H acceptors: 5 LogP: 4.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=CCc1c(O)cc(c2c1O[C@@]13[C@H]4C[C@@H](C=C1C2=O)C(=O)C3(CC=C(C)C)OC4=O)O)C
  • InChi: 1S/C26H26O7/c1-12(2)5-6-15-18(27)11-19(28)20-21(29)16-9-14-10-17-24(31)33-25(23(14)30,8-7-13(3)4)26(16,17)32-22(15)20/h5,7,9,11,14,17,27-28H,6,8,10H2,1-4H3/t14-,17+,25?,26-/m1/s1
  • InChiKey: OSDWBDHHKBVHAI-CNADFBRCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical membrane-spanning protein 0.0024 0.0283 0.0104
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0529 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0222 0.0206
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0071 0.1184 0.117
Brugia malayi hypothetical protein 0.0237 0.4342 0.5124
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0189 0.0188
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0189 0.0173
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0189 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0222 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0222 0.0246
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.4342 0.4342
Mycobacterium leprae Probable lipase LipE 0.0035 0.0504 0.0411
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0504 0.0727
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.008 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0016 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0222 0.0263
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0222 0.0206
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0504 0.0411
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0222 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0222 0.0246
Schistosoma mansoni ap endonuclease 0.0019 0.0187 0.0171
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Brugia malayi ATPase, AAA family protein 0.0027 0.0356 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Loa Loa (eye worm) vesicle-fusing ATPase 0.0313 0.5795 0.685
Mycobacterium tuberculosis Conserved protein 0.0035 0.0504 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0283 0.0205
Brugia malayi hypothetical protein 0.0121 0.2141 0.2518
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0857 0.0784
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0504 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0222 0.0246
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0283 0.0318
Brugia malayi ecdysone receptor 0.001 0.0016 0.0003
Entamoeba histolytica hypothetical protein 0.0071 0.1184 0.1074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0135 0.016
Schistosoma mansoni inositol monophosphatase 0.0037 0.0529 0.0513
Trypanosoma brucei vesicular transport protein (CDC48 homologue), putative 0.0027 0.0356 0.0295
Toxoplasma gondii ABC1 family protein 0.0035 0.0504 0.0428
Plasmodium vivax cell division cycle ATPase, putative 0.0193 0.3514 0.3655
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0016 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0222 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0222 0.0263
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0126 0.2236 0.2174
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0283 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0045
Schistosoma mansoni thyroid hormone receptor 0.002 0.0222 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0222 0.0263
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.005 0.0789 0.0932
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.164 0.2673
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.008 0.0078
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1184 0.117
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0504 0.0727
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0187 0.0114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0335
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0189 0.0003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0529 0.0478
Entamoeba histolytica ATPase, Vps4 oligomerisation domain containing protein 0.0027 0.0356 0.0182
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0977 0.1537
Brugia malayi nuclear receptor NHR-88 0.002 0.0222 0.0246
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Schistosoma mansoni nuclear hormone receptor 0.002 0.0222 0.0206
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0222 0.0206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0789 0.0932
Loa Loa (eye worm) inositol-1 0.0037 0.0529 0.0625
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0027 0.0356 0.0294
Plasmodium falciparum glutathione reductase 0.0037 0.0546 0.0496
Trypanosoma brucei katanin, putative 0.0027 0.0356 0.0295
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0977 0.1537
Schistosoma mansoni DNA polymerase eta 0.0019 0.0189 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.2505 0.2505
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0529 0.0453
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0221 0.4037 0.4763
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0283 0.0318
Echinococcus multilocularis fidgetin protein 1 0.0027 0.0356 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0222 0.0263
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0504 0.0489
Brugia malayi CXXC zinc finger family protein 0.0028 0.0373 0.0425
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0546 0.0645
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.1459 0.2362
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0529 0.0453
Brugia malayi hypothetical protein 0.001 0.0016 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0222 0.0246
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0283 0.0217
Schistosoma mansoni survival motor neuron protein 0.0048 0.0753 0.0737
Onchocerca volvulus 0.0048 0.0753 0.0737
Schistosoma mansoni ap endonuclease 0.0019 0.0187 0.0171
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0187 0.0183
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0222 0.0222
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0977 0.0962
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0283 0.0283
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0222 0.0246
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0187 0.0187
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0283 0.0205
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0187 0.0183
Loa Loa (eye worm) beta-lactamase 0.0035 0.0504 0.0596
Echinococcus granulosus FTZ F1 alpha 0.002 0.0222 0.0222
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0016 0.0016
Brugia malayi hypothetical protein 0.001 0.0016 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0222 0.0246
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0506 0.9477 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0504 0.0428
Mycobacterium tuberculosis Conserved protein 0.0035 0.0504 0.0727
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0024 0.0283 0.0318
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.1459 0.2362
Entamoeba histolytica hypothetical protein 0.0071 0.1184 0.1074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0135 0.0135
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0504 0.0727
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0453 0.8461 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0335
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0189 0.0118
Onchocerca volvulus 0.0035 0.0504 0.0489
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0222 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0504 0.0428
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0016 0.0019
Brugia malayi SAP1 protein 0.0027 0.0356 0.0405
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0222 0.0222
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0222 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0222 0.0246
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0222 0.0246
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0016 0.0003
Trypanosoma brucei unspecified product 0.0019 0.0189 0.0118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0335
Trypanosoma cruzi katanin, putative 0.0027 0.0356 0.0294
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0506 0.9477 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0187 0.0108
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0119
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0187 0.0183
Brugia malayi nuclear hormone receptor 0.001 0.0016 0.0003
Brugia malayi fidgetin protein 0.0027 0.0356 0.0405
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0038 0.0029
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0977 0.0955
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Loa Loa (eye worm) glutathione reductase 0.0037 0.0546 0.0645
Schistosoma mansoni cpg binding protein 0.003 0.0404 0.0388
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0283 0.0205
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0187 0.0115
Trypanosoma cruzi katanin, putative 0.0027 0.0356 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0222 0.0246
Brugia malayi Cytochrome P450 family protein 0.0023 0.0278 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0504 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Loa Loa (eye worm) hypothetical protein 0.0313 0.5795 0.685
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0504 0.0727
Brugia malayi steroid hormone receptor 0.002 0.0222 0.0246
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0789 0.0917
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0789 0.0917
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0283 0.0216
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0222 0.0222
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0278 0.0329
Trypanosoma cruzi katanin, putative 0.0027 0.0356 0.0294
Schistosoma mansoni hypothetical protein 0.0171 0.3082 0.3071
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0529 0.0478
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0283 0.0216
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0504 0.0727
Plasmodium falciparum vacuolar protein sorting-associated protein 4 0.0027 0.0356 0.0294
Loa Loa (eye worm) fidgetin protein 0.0027 0.0356 0.0421
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0045
Trichomonas vaginalis skd/vacuolar sorting, putative 0.0027 0.0356 0.0279
Loa Loa (eye worm) hypothetical protein 0.0035 0.0504 0.0596
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0038 0.0045
Brugia malayi beta-lactamase family protein 0.0035 0.0504 0.058
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0504 0.058
Mycobacterium ulcerans beta-lactamase 0.0035 0.0504 0.0727
Entamoeba histolytica hypothetical protein 0.0024 0.0283 0.0104
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0119
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.0028 0.0373 0.0358
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1184 0.1184
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0977 0.0977
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0189 0.0117
Trypanosoma cruzi katanin-like protein, putative 0.0027 0.0356 0.0294
Brugia malayi hypothetical protein 0.0011 0.0038 0.0029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0189 0.0224
Brugia malayi Nuclear hormone receptor E75 0.001 0.0016 0.0003
Echinococcus multilocularis geminin 0.0171 0.3082 0.3082
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0119
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0555 0.0555
Loa Loa (eye worm) ATPase 0.0027 0.0356 0.0421
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0221 0.4037 0.4027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0187 0.0114
Trichomonas vaginalis AAA ATPase, putative 0.0027 0.0356 0.0279
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0529 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Brugia malayi nuclear hormone receptor 0.002 0.0222 0.0246
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0187 0.0114
Loa Loa (eye worm) hypothetical protein 0.0121 0.2141 0.2531
Brugia malayi tailless protein 0.001 0.0016 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0187 0.2384
Trypanosoma brucei katanin, putative 0.0027 0.0356 0.0295
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.1459 0.8468
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0187 0.0108
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0016 0.0003
Brugia malayi vps4b-prov protein 0.0027 0.0356 0.0405
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0555 0.0555
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.1459 0.2362
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0222 0.0206
Toxoplasma gondii katanin-like family protein 0.0027 0.0356 0.0279
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.4342 0.4342
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0486 0.0575
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0187 0.0187
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0283 0.0205
Brugia malayi nuclear receptor RXR 0.0011 0.0038 0.0029
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0189 0.0188
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0189 0.0118
Echinococcus multilocularis GPCR, family 2 0.0016 0.0135 0.0135
Giardia lamblia AAA family ATPase 0.0319 0.5918 1
Trypanosoma cruzi Valosin-containing protein, putative 0.0506 0.9477 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0222 0.0206
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0283 0.0318
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0189 0.0207
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0189 0.0173
Brugia malayi hypothetical protein 0.0011 0.0038 0.0029
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0221 0.4037 0.4037
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0529 0.0368
Giardia lamblia Topoisomerase II 0.0027 0.0356 0.0474
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0189 0.0207
Entamoeba histolytica hypothetical protein 0.0071 0.1184 0.1074
Brugia malayi nuclear receptor NHR-67 0.001 0.0016 0.0003
Plasmodium falciparum thioredoxin reductase 0.0037 0.0546 0.0496
Plasmodium vivax sphingomyelin synthase 1, putative 0.0024 0.0283 0.0216
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0135 0.0143
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0222 0.0222
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Entamoeba histolytica hypothetical protein 0.0024 0.0283 0.0104
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0283 0.0318
Trichomonas vaginalis hypothetical protein 0.0024 0.0283 0.0205
Schistosoma mansoni coup transcription factor 0.002 0.0222 0.0206
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0189 0.0188
Mycobacterium tuberculosis Probable reductase 0.0085 0.1459 0.2362
Trypanosoma brucei metalloprotease, putative 0.0027 0.0356 0.0295
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0283 0.0283
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0504 0.0428
Echinococcus granulosus dna polymerase eta 0.0019 0.0189 0.0189
Trichomonas vaginalis skd/vacuolar sorting, putative 0.0027 0.0356 0.0279
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0506 0.9477 0.9476
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0319 0.5917 0.5885
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.164 0.2673
Brugia malayi hypothetical protein 0.0071 0.1184 0.1385
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0016 0.0016
Onchocerca volvulus Huntingtin homolog 0.0121 0.2141 0.2128
Loa Loa (eye worm) vps4b-prov protein 0.0027 0.0356 0.0421
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0504 0.0727
Mycobacterium ulcerans ATPase 0.0319 0.5918 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0504 0.0596
Leishmania major DNA polymerase kappa, putative 0.0019 0.0189 0.0117
Entamoeba histolytica hypothetical protein 0.0024 0.0283 0.0104
Trypanosoma brucei inositol phosphorylceramide synthase 0.0024 0.0283 0.0217
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0189 0.0118
Mycobacterium tuberculosis Conserved protein 0.0035 0.0504 0.0727
Mycobacterium ulcerans lipase LipD 0.0035 0.0504 0.0727
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0504 0.0596
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.164 0.2673
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0187 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.2505 0.2961
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0283 0.0216
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0016 0.0016
Trypanosoma brucei vacuolar protein sorting-associated protein 4, putative 0.0027 0.0356 0.0295
Leishmania major trypanothione reductase 0.0037 0.0546 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.2505 0.2493
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0189 0.0189
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.008 0.0001
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0529 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.1459 0.2362
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0529 0.0453
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Echinococcus granulosus dna polymerase kappa 0.0019 0.0189 0.0189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0135 0.0135
Echinococcus multilocularis katanin p60 ATPase containing subunit A1 0.0027 0.0356 0.0356
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0126 0.2236 0.2174
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0373 0.0441
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0189 0.0117
Brugia malayi conserved hypotetical protein 0.001 0.0016 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0135 0.0143
Brugia malayi beta-lactamase family protein 0.0035 0.0504 0.058
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0027 0.0356 0.0294
Brugia malayi ecdysteroid receptor 0.002 0.0222 0.0246
Giardia lamblia SKD1 protein 0.0027 0.0356 0.0474
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Echinococcus granulosus geminin 0.0171 0.3082 0.3082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0504 0.0596
Loa Loa (eye worm) VCP protein 0.0221 0.4037 0.4772
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0222 0.0206
Trichomonas vaginalis esterase, putative 0.0035 0.0504 0.0428
Trypanosoma cruzi katanin, putative 0.0027 0.0356 0.0294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0024 0.0283 0.0104
Echinococcus granulosus GPCR family 2 0.0016 0.0135 0.0135
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0189 0.0117
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0546 0.0798
Brugia malayi Thioredoxin reductase 0.0037 0.0546 0.0629
Trichomonas vaginalis AAA ATPase, putative 0.0027 0.0356 0.0279
Giardia lamblia SKD1 protein 0.0027 0.0356 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0222 0.0246
Trypanosoma brucei Valosin-containing protein 0.0506 0.9477 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0222 0.0206
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.164 1
Onchocerca volvulus 0.0028 0.0373 0.0358
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0977 0.0977
Leishmania major katanin, putative,serine peptidase, Clan SJ, family S16, putative 0.0027 0.0356 0.0294
Onchocerca volvulus 0.0035 0.0504 0.0489
Echinococcus granulosus dnaJ subfamily B 0.0404 0.7533 0.7533
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0222 0.0206
Trypanosoma brucei trypanothione reductase 0.0037 0.0546 0.0497
Echinococcus granulosus cpg binding protein 0.003 0.0404 0.0404
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0189 0.0111
Trypanosoma cruzi katanin-like protein, putative 0.0027 0.0356 0.0294
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.008 0.0063
Giardia lamblia DINP protein human, muc B family 0.0019 0.0189 0.0188
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0187 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0504 0.0596
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0016 0.0003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0187 0.0114
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0222 0.0246
Trypanosoma brucei katanin, putative 0.0027 0.0356 0.0295
Mycobacterium tuberculosis Putative conserved ATPase 0.0319 0.5918 1
Brugia malayi valosin containing protein 0.0313 0.5795 0.6844
Schistosoma mansoni cpg binding protein 0.003 0.0404 0.0388
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0977 0.0904
Echinococcus multilocularis dna polymerase eta 0.0019 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0237 0.4342 0.5132
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.7533 0.7533
Onchocerca volvulus 0.002 0.0222 0.0206
Echinococcus granulosus katanin p60 ATPase containing subunit A1 0.0027 0.0356 0.0356
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0504 0.0428
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0283 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0504 0.0727
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Leishmania major hypothetical protein, conserved 0.0035 0.0504 0.0452
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0038 0.0022
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0546 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0504 0.0452
Brugia malayi nuclear receptor RXR 0.001 0.0016 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.2505 0.2493
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.098 0.0965
Mycobacterium ulcerans hypothetical protein 0.0035 0.0504 0.0727
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0456 0.0644
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0038 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0135 0.0135
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0506 0.9477 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Schistosoma mansoni skd/vacuolar sorting 0.0027 0.0356 0.034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Echinococcus granulosus vacuolar protein sorting associated protein 4A 0.0027 0.0356 0.0356
Giardia lamblia Katanin 0.0027 0.0356 0.0474
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0189 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0016 0.0016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0222 0.0222
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0038 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0222 0.0246
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0486 0.0559
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.2505 0.2505
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0222 0.0206
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0529 0.0769
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0283 0.0216
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Brugia malayi vesicle-fusing ATPase 0.0313 0.5795 0.6844
Onchocerca volvulus 0.0035 0.0504 0.0489
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0222 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0504 0.0452
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0504 0.0504
Brugia malayi Inositol-1 0.0037 0.0529 0.0609
Trypanosoma brucei katanin, putative 0.0027 0.0356 0.0295
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.008 0.008
Brugia malayi glutathione reductase 0.0037 0.0546 0.0629
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0283 0.0205
Schistosoma mansoni inositol monophosphatase 0.0037 0.0529 0.0513
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0506 0.9477 1
Trypanosoma cruzi katanin, putative 0.0027 0.0356 0.0294
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0753 0.0874
Plasmodium vivax glutathione reductase, putative 0.0037 0.0546 0.0496
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0283 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0977 0.1537
Echinococcus granulosus fidgetin protein 1 0.0027 0.0356 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0222 0.0246
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0529 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0222 0.0263
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0038 0.0038
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0189 0.0117
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0189 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0977 0.1537
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0546 0.0496
Toxoplasma gondii exonuclease III APE 0.0019 0.0187 0.0108
Brugia malayi beta-lactamase 0.0035 0.0504 0.058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.2505 0.2505
Loa Loa (eye worm) hypothetical protein 0.0035 0.0504 0.0596
Trypanosoma cruzi vesicular transport protein (CDC48 homologue), putative 0.0027 0.0356 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0189 0.0118
Loa Loa (eye worm) DR-78 0.001 0.0016 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0222 0.0246
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0189 0.0111
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0187 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0222 0.0263
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1184 0.1184
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0504 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.2505 0.2493
Schistosoma mansoni hypothetical protein 0.0171 0.3082 0.3071
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0027 0.0356 0.034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.008 0.0001
Toxoplasma gondii cell division protein CDC48AP 0.0319 0.5918 0.5885
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0189 0.0188
Trypanosoma cruzi vacuolar protein sorting-associated protein 4, putative 0.0027 0.0356 0.0294
Trichomonas vaginalis spastin, putative 0.0027 0.0356 0.0279
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.008 0.008
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0024 0.0283 0.0217
Echinococcus multilocularis cpg binding protein 0.003 0.0404 0.0404
Schistosoma mansoni hypothetical protein 0.0404 0.7533 0.7529
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.008 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0121 0.2141 0.2531
Schistosoma mansoni hypothetical protein 0.0034 0.0486 0.047
Leishmania major vacuolar protein sorting-associated protein 4 0.0027 0.0356 0.0294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0222 0.0222
Trypanosoma cruzi vacuolar transport protein 4A, putative 0.0027 0.0356 0.0294
Schistosoma mansoni hypothetical protein 0.0048 0.0753 0.0737
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.2505 0.2505
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0504 0.0453
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.2505 0.2949
Loa Loa (eye worm) hypothetical protein 0.0035 0.0504 0.0596
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0119
Entamoeba histolytica hypothetical protein 0.0024 0.0283 0.0104
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0189 0.0189
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Entamoeba histolytica hypothetical protein 0.0071 0.1184 0.1074
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0529 0.0453
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0504 0.0452
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0453 0.8461 1
Trypanosoma cruzi metalloprotease, putative 0.0027 0.0356 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0222 0.0246
Entamoeba histolytica cdc48-like protein, putative 0.0506 0.9477 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.1459 0.2362
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0024 0.0283 0.0216
Echinococcus multilocularis vacuolar protein sorting associated protein 4A 0.0027 0.0356 0.0356
Brugia malayi Nuclear hormone receptor E75 0.001 0.0016 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0222 0.0222
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0222 0.0222
Entamoeba histolytica vacuolar sorting protein-associating protein 4A (VPS4), putative 0.0027 0.0356 0.0182
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0222 0.0263
Toxoplasma gondii thioredoxin reductase 0.0037 0.0546 0.047
Onchocerca volvulus Huntingtin homolog 0.0121 0.2141 0.2128
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.4124 0.6928
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Leishmania major DNA polymerase eta, putative 0.0019 0.0189 0.0117
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0529 0.0478
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0222 0.0222
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0222 0.0206
Brugia malayi nuclear receptor NHR-88 0.001 0.0016 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0504 0.0727
Plasmodium vivax sphingomyelin synthase 2, putative 0.0024 0.0283 0.0216
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0189 0.0189
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.008 0.0001
Toxoplasma gondii hypothetical protein 0.0024 0.0283 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0222 0.0263
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0222 0.0263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0135 0.016
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0977 0.0962

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Cytotoxicity against human U251 cells assessed as cell viability after 24 hrs by MTT assay ChEMBL. 23167526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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