Detailed information for compound 1729503

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.816 | Formula: C19H16ClN5O
  • H donors: 3 H acceptors: 2 LogP: 2.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C[C@H](c1nc2ccc(cc2c(=O)[nH]1)c1c[nH]nc1)N
  • InChi: 1S/C19H16ClN5O/c20-14-3-1-2-11(6-14)7-16(21)18-24-17-5-4-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
  • InChiKey: RUADOXJFDNTWNZ-MRXNPFEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.1784 0.5753
Loa Loa (eye worm) hypothetical protein 0.0033 0.036 0.036
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0379 0.1131
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0026 0.0234 0.3644
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0026 0.0234 0.3644
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0135 0.5032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Plasmodium falciparum hexose transporter 0.0109 0.1784 0.2092
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0231 0.0643
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0026 0.0234 0.3644
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0381 0.0839
Leishmania major glucose transporter, lmgt1 0.0034 0.0381 0.438
Entamoeba histolytica protein kinase, putative 0.0034 0.0379 1
Entamoeba histolytica protein kinase, putative 0.0034 0.0379 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0026 0.0234 1
Leishmania major cytochrome p450-like protein 0.0026 0.0234 0.2514
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0381 0.0839
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.038 0.0412
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0461 0.0778
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0026 0.0234 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0026 0.0234 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0204 0.0409
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0381 0.438
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.038 0.0412
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0204 0.0201
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.038 0.0629
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0026 0.0234 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.036 0.1067
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0823 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0026 0.0234 0.3644
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0675 0.0641
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0026 0.0234 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0044 0.0579 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.036 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0026 0.0234 0.3644
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.038 0.0412
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0379 0.0379
Onchocerca volvulus 0.0178 0.3075 0.7396
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0135 0.5032
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0094 0.0747
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0234 0.2514
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Trypanosoma brucei cytochrome P450, putative 0.0044 0.0579 0.6899
Schistosoma mansoni hypothetical protein 0.0109 0.1784 0.5753
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0026 0.0234 0.3644
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0204 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.3075 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0204 0.2134
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0234 0.2514
Schistosoma mansoni glucose transport protein 0.0109 0.1784 0.5753
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0234 0.2514
Plasmodium falciparum protein kinase 6 0.0462 0.8394 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0026 0.0234 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0026 0.0234 0.3644
Onchocerca volvulus 0.0175 0.3029 0.7285
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0204 0.0201
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0026 0.0234 0.3644
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0379 0.1131
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0379 0.1131
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0036 0.5
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0381 0.0839
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0148 0.0273
Brugia malayi Cytochrome P450 family protein 0.0044 0.0579 0.0545
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0204 0.0169
Onchocerca volvulus 0.0235 0.4145 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.036 0.1067
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0204 0.0553
Brugia malayi Cytochrome P450 family protein 0.0026 0.0234 0.0199
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0303 0.0881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0303 0.0881
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0026 0.0234 1
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0234 0.0651
Schistosoma mansoni hypothetical protein 0.0034 0.0382 0.1139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0334 0.0982
Brugia malayi Sugar transporter family protein 0.0109 0.1784 0.1755
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0026 0.0234 1
Trypanosoma brucei glucose transporter 1E 0.0034 0.0381 0.438
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0675 0.0641
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0823 0.0942
Plasmodium falciparum protein kinase 7 0.0308 0.5506 0.6545
Schistosoma mansoni protein kinase 0.0034 0.0379 0.1131
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0026 0.0234 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.036 0.0789
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Schistosoma mansoni glucose transport protein 0.0109 0.1784 0.5753
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0379 0.0837
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0303 0.0881
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0234 0.2514
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0026 0.0234 0.3644
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.134 0.134
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Trypanosoma cruzi cytochrome P450, putative 0.0044 0.0579 0.6899
Echinococcus multilocularis General substrate transporter 0.0094 0.1498 0.4812
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0379 0.0345
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.038 0.0412
Echinococcus multilocularis rho associated protein kinase 0.0178 0.3075 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0026 0.0234 0.3644
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0283 0.0814
Plasmodium vivax SET domain protein, putative 0.003 0.0303 0.032
Plasmodium vivax hexose transporter 0.0109 0.1784 0.2092
Loa Loa (eye worm) sugar transporter 0.0015 0.0036 0.0036
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0026 0.0234 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0381 0.438
Trichomonas vaginalis set domain proteins, putative 0.0235 0.4145 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0109 0.1784 0.5753
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0381 0.0839
Brugia malayi cytochrome P450 0.0026 0.0234 0.0199
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.036 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.1784 0.4256
Schistosoma mansoni hypothetical protein 0.0026 0.0231 0.0643
Leishmania major glucose transporter, lmgt2 0.0034 0.0381 0.438
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0234 0.2514
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.038 0.0412
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0303 0.0881
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0379 0.0379
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0036 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0026 0.0234 1
Toxoplasma gondii protein kinase, putative 0.0308 0.5506 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.038 0.0412
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.036 0.0326
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0022
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0231 0.0643
Leishmania major hypothetical protein, conserved 0.0057 0.0823 1
Leishmania major glucose transporter, lmgt3 0.0034 0.0381 0.438
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0381 0.438
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0022
Loa Loa (eye worm) cytochrome P450 0.0026 0.0234 0.0234
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0379 0.1131
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.038 0.0629
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.036 0.8888
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.038 0.0629
Loa Loa (eye worm) hypothetical protein 0.0034 0.0379 0.0379
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0379 0.1131
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0026 0.0234 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0026 0.0234 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0026 0.0234 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0204 0.0553
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.036 0.1067
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0334 0.0982
Trypanosoma brucei glucose transporter 2A 0.0034 0.0381 0.438
Loa Loa (eye worm) hypothetical protein 0.003 0.0303 0.0303
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0204 0.2134
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0379 0.1131
Loa Loa (eye worm) sugar transporter 0.0109 0.1784 0.1784
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0022
Brugia malayi hypothetical protein 0.0057 0.0823 0.079
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0026 0.0234 0.3644
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0461 0.0509
Echinococcus granulosus GPCR family 2 0.0016 0.0042 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0303 0.049
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0234 0.0362
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0026 0.0234 0.3644
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0381 0.438
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0379 0.4367
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Echinococcus granulosus General substrate transporter 0.0094 0.1498 0.4812
Schistosoma mansoni hypothetical protein 0.0026 0.0234 0.0651
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0204 0.2134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0026 0.0234 1
Echinococcus multilocularis 0.0026 0.0234 0.0651
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0823 0.0942
Leishmania major protein kinase, putative 0.0034 0.0379 0.4367
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0579 0.0579
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0026 0.0234 0.3644
Brugia malayi hypothetical protein 0.0037 0.0443 0.0409
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.038 0.0412
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0245 0.0245
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0026 0.0234 0.3644
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0204 0.3094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0379 0.1131
Brugia malayi Pre-SET motif family protein 0.003 0.0303 0.0269
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Leishmania major cytochrome p450-like protein 0.0026 0.0234 0.2514
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0675 0.0675
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0026 0.0234 0.3644
Leishmania major cytochrome p450-like protein 0.0044 0.0579 0.6899
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0381 0.438
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0823 0.144
Toxoplasma gondii facilitative glucose transporter GT1 0.0109 0.1784 0.3197
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Schistosoma mansoni cytochrome P450 0.0026 0.0234 0.0651
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0204 0.0307
Brugia malayi Cytochrome P450 family protein 0.0044 0.0579 0.0545
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0026 0.0234 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0042 0.0007
Loa Loa (eye worm) CYP4Cod1 0.0044 0.0579 0.0579
Echinococcus multilocularis GPCR, family 2 0.0016 0.0042 0.0022
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.038 0.0412
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0022
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0026 0.0234 0.3644
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0026 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0823 1
Brugia malayi Pre-SET motif family protein 0.0207 0.3612 0.3589
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.038 0.0412
Loa Loa (eye worm) hypothetical protein 0.0049 0.0675 0.0675
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0303 0.0881
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.1784 0.5753
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.1784 0.5753
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0026 0.0234 0.3644
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0204 0.0204
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0381 0.438
Brugia malayi Cam kinase protein 1 0.0034 0.0379 0.0345
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.036 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0026 0.0234 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0204 0.0553
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.1784 0.5753
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0234 0.4377
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0381 0.0839
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.1784 0.5753
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0461 0.5403
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0379 0.1131
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0381 0.0839
Schistosoma mansoni protein kinase 0.0034 0.0379 0.1131
Trypanosoma brucei glucose transporter, putative 0.0034 0.0381 0.438
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0381 0.438
Schistosoma mansoni glucose transport protein 0.0109 0.1784 0.5753
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0461 0.5403
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.3075 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.1784 0.5753
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0461 0.5403
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0823 1
Brugia malayi Cytochrome P450 family protein 0.0085 0.134 0.1309
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0022
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0026 0.0234 0.3644
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0823 0.0823
Plasmodium vivax CDK-related protein kinase 6, putative 0.0462 0.8394 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.3612 0.3612
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0823 0.0942
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0579 0.0579
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0026 0.0234 0.3644
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0026 0.0234 1
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0461 0.0509
Plasmodium falciparum mitogen-activated protein kinase 2 0.0176 0.3045 0.36
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0381 0.0839
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0042 0.0007
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.1784 0.5753
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.036 0.1067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0204 0.5182
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0026 0.0234 0.3644
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0036
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0026 0.0234 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0461 0.5403
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0204 0.5
Trypanosoma cruzi hexose transporter 0.0034 0.0381 0.438
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0176 0.3045 0.36
Loa Loa (eye worm) hypothetical protein 0.0033 0.036 0.036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0042 0.0042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0303 0.0881
Trypanosoma cruzi cytochrome P450, putative 0.0044 0.0579 0.6899
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0379 0.1131
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0461 0.5403
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0176 0.3045 0.5501
Loa Loa (eye worm) hypothetical protein 0.0034 0.0382 0.0382
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0204 0.3046
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0204 0.3094
Onchocerca volvulus 0.003 0.0303 0.0652
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0382 0.0348
Schistosoma mansoni protein kinase 0.0034 0.0379 0.1131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0303 0.0881
Mycobacterium leprae putative cytochrome p450 0.0026 0.0234 0.4377

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13 nM Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins by TR-FRET assay ChEMBL. 23416002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.