Detailed information for compound 173041

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.476 | Formula: C21H30N2O
  • H donors: 0 H acceptors: 1 LogP: 3.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)C1(CC1)c1ccccc1)[C@@H]1CCCC[C@@H]1N1CCCC1
  • InChi: 1S/C21H30N2O/c1-22(18-11-5-6-12-19(18)23-15-7-8-16-23)20(24)21(13-14-21)17-9-3-2-4-10-17/h2-4,9-10,18-19H,5-8,11-16H2,1H3/t18?,19-/m1/s1
  • InChiKey: MGMPZCNAKUKYJV-MUMRKEEXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.1227 0.1222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0275 0.0314 0.0314
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.052 0.0626 0.9566
Echinococcus multilocularis peregrin 0.0033 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.2117 0.2659 0.2655
Echinococcus multilocularis ecdysone induced protein 78C 0.0275 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Schistosoma mansoni nuclear receptor nhr-48 0.013 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.4683 0.5926 0.5924
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0001
Loa Loa (eye worm) FKBP5 protein 0.0178 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0145 0.0149 0.0149
Schistosoma mansoni microtubule-associated protein tau 0.0585 0.0709 0.0709
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.013 0.0129 0.0129
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.013 0.0129 0.0129
Brugia malayi nuclear receptor NHR-88 0.013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0092 0.0081 0.0081
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0025 0.0025
Brugia malayi ecdysone receptor 0.013 0.0129 0.0129
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0005 0.0005
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7884 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0542 0.0654 0.0649
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2688 0.3385 0.3319
Brugia malayi orphan nuclear receptor NR2E1 0.013 0.0129 0.0129
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0654 0.0654
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.052 0.0626 0.9566
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0154 0.016 0.016
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0006 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0145 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.1164 0.1445 0.1445
Brugia malayi conserved hypotetical protein 0.013 0.0129 0.0129
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0178 0.0191 0.0186
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.01 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5411 0.5408
Trichomonas vaginalis PIKK family atypical protein kinase 0.5876 0.7444 0.7442
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.003 0.003
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0735 0.09 0.0854
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0588 0.0712 0.0709
Leishmania major hypothetical protein, unknown function 0.052 0.0626 0.0531
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.01 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0275 0.0314 0.0314
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1164 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0654 0.056
Loa Loa (eye worm) steroid hormone receptor 0.0275 0.0314 0.0314
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0735 0.09 0.0895
Echinococcus granulosus peregrin 0.0033 0.0006 0.0006
Loa Loa (eye worm) phosphatidylinositol kinase 0.052 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.4272 0.5403 0.54
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.093 0.1148 0.1148
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2732 0.3442 0.3442
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.1889 0.1884
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0275 0.0314 0.0314
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0275 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0145 0.0149 0.0149
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.1164 0.1445 0.1441
Loa Loa (eye worm) nuclear receptor NHR-67 0.013 0.0129 0.0129
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0062 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.052 0.0626 0.0621
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0025 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0001 0.0001
Trichomonas vaginalis immunophilin, putative 0.0178 0.0191 0.0186
Trichomonas vaginalis fk506-binding protein, putative 0.0178 0.0191 0.0186
Schistosoma mansoni immunophilin 0.0178 0.0191 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.7884 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.052 0.0626 0.0621
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0565 0.0684 0.0678
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0007 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.1512 0.1889 0.1889
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.052 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0005 0.0005
Echinococcus multilocularis snurportin 1 0.0301 0.0348 0.0348
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6287 0.7967 0.7967
Brugia malayi Ets-domain containing protein 0.0062 0.0043 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.052 0.0626 0.0623
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0145 0.0149 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.01 0.01
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.0626 0.0626
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0159 0.0154
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0657 0.08 0.08
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0542 0.0654 0.0879
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0588 0.0712 0.0709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0275 0.0314 0.0314
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7884 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0178 0.0191 0.0142
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0025
Trypanosoma cruzi target of rapamycin kinase 3 0.6287 0.7967 0.7957
Schistosoma mansoni hypothetical protein 0.0301 0.0348 0.0348
Schistosoma mansoni fkbp-rapamycin associated protein 0.1512 0.1889 0.1889
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.01 0.0095
Echinococcus multilocularis GPCR, family 2 0.0029 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor HR96 0.013 0.0129 0.0129
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0164 0.0173 0.0173
Brugia malayi hypothetical protein 0.013 0.0129 0.0129
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0145 0.0149 0.0149
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0626 0.0626
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0542 0.0654 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0275 0.0314 0.0314
Brugia malayi RNA binding protein 0.0062 0.0043 0.0043
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0178 0.0191 0.0188
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.0101 0.0101
Brugia malayi Ets-domain containing protein 0.0062 0.0043 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0735 0.09 0.0897
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.052 0.0626 0.0841
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0275 0.0314 0.0314
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.093 0.1148 0.1148
Leishmania major phosphatidylinositol 3-kinase, putative 0.2675 0.337 0.3303
Trichomonas vaginalis PIKK family atypical protein kinase 0.052 0.0626 0.0621
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.01 0.005
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.052 0.0626 0.0626
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1512 0.1889 0.1889
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.052 0.0626 0.0626
Echinococcus multilocularis nuclear receptor nhr 48 0.013 0.0129 0.0129
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7884 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0275 0.0314 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0275 0.0314 0.0314
Echinococcus multilocularis Zinc finger, PHD finger 0.0542 0.0654 0.0654
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.052 0.0626 0.0841
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0542 0.0654 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.337 0.3366
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0015 0.0015
Loa Loa (eye worm) fli-1 protein 0.0189 0.0204 0.0204
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0215 0.0238 0.0235
Echinococcus multilocularis FTZ F1 alpha 0.0275 0.0314 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.01 0.0095
Echinococcus multilocularis 0.052 0.0626 0.0626
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0178 0.0191 0.2921
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0178 0.0191 0.0191
Schistosoma mansoni nuclear hormone receptor 0.013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Brugia malayi ecdysteroid receptor 0.0275 0.0314 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.5117 0.6478 0.6476
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.052 0.0626 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.337 0.3366
Brugia malayi steroid hormone receptor 0.0275 0.0314 0.0314
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0015 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0145 0.0149 0.0149
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7884 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.2688 0.3385 0.3382
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0043
Brugia malayi photoreceptor-specific nuclear receptor 0.0275 0.0314 0.0314
Schistosoma mansoni thyroid hormone receptor 0.0275 0.0314 0.0314
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.372 0.47 0.47
Brugia malayi nuclear hormone receptor 0.0275 0.0314 0.0314
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.01 0.01
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0275 0.0314 0.0314
Schistosoma mansoni thyroid hormone receptor 0.0275 0.0314 0.0314
Schistosoma mansoni hypothetical protein 0.052 0.0626 0.0626
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1512 0.1889 0.1889
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5411 0.5408
Entamoeba histolytica protein kinase rad3, putative 0.1512 0.1889 0.1886
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0626 0.0626
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0005 0.0005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0159 0.0154
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0588 0.0712 0.0707
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0626 0.0626
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0542 0.0654 0.0651
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0005 0.0005
Plasmodium falciparum phosphatidylinositol 4-kinase 0.052 0.0626 0.9566
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0542 0.0654 0.0654
Echinococcus granulosus snurportin 1 0.0301 0.0348 0.0348
Toxoplasma gondii FATC domain-containing protein 0.1512 0.1889 0.2537
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1512 0.1889 0.1889
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0542 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0145 0.0149 0.0149
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6287 0.7967 0.7947
Entamoeba histolytica protein kinase, putative 0.0033 0.0007 0.0003
Entamoeba histolytica protein kinase, putative 0.0031 0.0004 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.0275 0.0314 0.0314
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0626 0.0626
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0145 0.0149 0.0149
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2732 0.3442 0.3409
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0588 0.0712 0.0665
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0588 0.0712 0.0707
Echinococcus granulosus nuclear receptor nhr 48 0.013 0.0129 0.0129
Brugia malayi Calcitonin receptor-like protein seb-1 0.0092 0.0081 0.0081
Brugia malayi Nuclear hormone receptor E75 0.013 0.0129 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0275 0.0314 0.0314
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0623 0.0757 0.0664
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2732 0.3442 0.3442
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0542 0.0654 0.0649
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2732 0.3442 0.3442
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2675 0.337 0.337
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0025 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7959 0.7958
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0025 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0001 0.0001
Echinococcus granulosus tar DNA binding protein 0.0062 0.0043 0.0043
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0542 0.0654 0.0654
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0025 0.0025
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0654 0.0607
Loa Loa (eye worm) nuclear hormone receptor 0.013 0.0129 0.0129
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0043 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.5876 0.7444 0.7442
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.052 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.5876 0.7444 0.7442
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0275 0.0314 0.0314
Leishmania major phosphatidylinositol kinase related protein, putative 0.052 0.0626 0.0531
Mycobacterium tuberculosis Conserved hypothetical protein 0.052 0.0626 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.013 0.0129 0.0129
Echinococcus granulosus ecdysone induced protein 78C 0.0275 0.0314 0.0314
Brugia malayi nuclear hormone receptor 0.013 0.0129 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.1684 0.2107 0.2103
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0015 0.0015
Schistosoma mansoni kinase 0.0054 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0275 0.0314 0.0314
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.052 0.0626 0.9566
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0178 0.0191 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0275 0.0314 0.0314
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.052 0.0626 0.0579
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0092 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0029 0.0001 0.0001
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7884 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0005
Schistosoma mansoni coup transcription factor 0.0275 0.0314 0.0314
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0178 0.0191 0.0191
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1684 0.2107 0.2831
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1164 0.1445 0.1445
Schistosoma mansoni hypothetical protein 0.0033 0.0006 0.0006
Giardia lamblia Hypothetical protein 0.052 0.0626 0.0621
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0735 0.09 0.0895
Brugia malayi PHD-finger family protein 0.0033 0.0006 0.0006
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1524 0.1904 0.1901
Trichomonas vaginalis PIKK family atypical protein kinase 0.5876 0.7444 0.7442
Trichomonas vaginalis PIKK family atypical protein kinase 0.5289 0.6696 0.6695
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.052 0.0626 0.0579
Loa Loa (eye worm) hypothetical protein 0.0445 0.053 0.053
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.01 0.01
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1512 0.1889 0.1889
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0164 0.0173 0.0173
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0178 0.0191 0.0185
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0542 0.0654 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.1889 0.1884
Echinococcus multilocularis geminin 0.0311 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0657 0.08 0.08
Onchocerca volvulus Bile acid receptor homolog 0.0275 0.0314 0.497
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.062 0.0754 0.0748
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.01 0.1516
Mycobacterium leprae conserved hypothetical protein 0.052 0.0626 0.5
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0178 0.0191 0.0191
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0031 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7959 0.7958
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0178 0.0191 0.0191
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0001 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0005 0.0005
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0178 0.0191 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0275 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Giardia lamblia Kinase, PLK 0.0107 0.01 0.0094
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0666 0.0811 0.0807
Schistosoma mansoni hypothetical protein 0.1164 0.1445 0.1445
Onchocerca volvulus 0.013 0.0129 0.1988
Echinococcus granulosus nuclear receptor 2DBD gamma 0.013 0.0129 0.0129
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0178 0.0191 0.0191
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.01 0.0095
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.0003 0.0003
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0005 0.0005
Echinococcus granulosus GA binding protein alpha chain 0.0062 0.0043 0.0043
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0005 0.0005
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.052 0.0626 0.0579
Loa Loa (eye worm) hypothetical protein 0.1597 0.1997 0.1997
Loa Loa (eye worm) phosphatidylinositol 3 0.0885 0.1091 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0275 0.0314 0.0314
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0015 0.0015
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0666 0.0811 0.0807
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0275 0.0314 0.0314
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.0348 0.0348
Onchocerca volvulus 0.013 0.0129 0.1988
Brugia malayi Steroid receptor seven-up type 2 0.0275 0.0314 0.0314
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0178 0.0191 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.013 0.0129 0.0129
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1512 0.1889 0.1848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0275 0.0314 0.0314
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0275 0.0314 0.0314
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0007 0.0001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0542 0.0654 0.0879
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0735 0.09 0.09
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0178 0.0191 0.0142
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0626 0.0626
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0542 0.0654 0.0651
Schistosoma mansoni nuclear hormone receptor 0.013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0053 0.0032 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0007 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.672 0.8519 0.8518
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0022 0.0022
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0542 0.0654 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0275 0.0314 0.0314
Brugia malayi hypothetical protein 0.0145 0.0149 0.0149
Onchocerca volvulus 0.052 0.0626 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.013 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7959 0.7958
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0542 0.0654 0.0654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1512 0.1889 0.1889
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.093 0.1148 0.1148
Trichomonas vaginalis PIKK family atypical protein kinase 0.5876 0.7444 0.7442
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5411 0.5408
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1512 0.1889 0.1889
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.081 0.0995 0.0995
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0164 0.0173 0.0173
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7884 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.052 0.0626 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0275 0.0314 0.0314
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0178 0.0191 0.0185
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.052 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0063 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0275 0.0314 0.0314
Brugia malayi nuclear receptor NHR-67 0.013 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.4712 0.5962 0.596
Echinococcus multilocularis Nuclear hormone receptor HR96 0.013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0992 0.1227 0.1227
Schistosoma mansoni immunophilin 0.0154 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0007 0.0001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0588 0.0712 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.4683 0.5926 0.5924
Entamoeba histolytica hypothetical protein 0.052 0.0626 0.0623
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0275 0.0314 0.0314
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0005 0.0005
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0005 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0275 0.0314 0.0314
Entamoeba histolytica hypothetical protein 0.069 0.0842 0.0839
Echinococcus multilocularis thyroid hormone receptor alpha 0.0275 0.0314 0.0314
Schistosoma mansoni nuclear receptor 0.013 0.0129 0.0129
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.337 0.3366
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0275 0.0314 0.0314
Onchocerca volvulus 0.0275 0.0314 0.497
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0043 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.0626 0.0626
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.053 0.053
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0612 0.0743 0.074
Leishmania major fk506-binding protein 1-like protein 0.0178 0.0191 0.0092
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Brugia malayi Bromodomain containing protein 0.0033 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.1684 0.2107 0.2107
Entamoeba histolytica hypothetical protein 0.052 0.0626 0.0623
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0275 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0227 0.0253 0.0253
Giardia lamblia GTOR 0.7884 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.013 0.0129 0.1988
Schistosoma mansoni hypothetical protein 0.0029 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.1512 0.1889 0.1886
Schistosoma mansoni hypothetical protein 0.0029 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2732 0.3442 0.3409
Echinococcus multilocularis serine protein kinase ATM 0.1512 0.1889 0.1889
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0043
Echinococcus granulosus microtubule associated protein 2 0.0585 0.0709 0.0709
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2732 0.3442 0.3442
Trichomonas vaginalis PIKK family atypical protein kinase 0.4712 0.5962 0.596
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.4272 0.5403 0.54
Echinococcus multilocularis fk506 binding protein 0.0178 0.0191 0.0191
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0004 0.0004
Onchocerca volvulus Protein ultraspiracle homolog 0.0275 0.0314 0.497
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0178 0.0191 0.0191
Brugia malayi nuclear receptor RXR 0.013 0.0129 0.0129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.003 0.003
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0007 0.0001
Echinococcus granulosus serine protein kinase ATM 0.1512 0.1889 0.1889
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0154 0.016 0.016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0992 0.1227 0.1182
Brugia malayi TAR-binding protein 0.0062 0.0043 0.0043
Schistosoma mansoni retinoic acid receptor RXR 0.0275 0.0314 0.0314
Schistosoma mansoni hypothetical protein 0.0063 0.0044 0.0044
Brugia malayi RNA, U transporter 1 0.008 0.0066 0.0066
Schistosoma mansoni gabp alpha 0.0062 0.0043 0.0043
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7884 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0025 0.0025
Loa Loa (eye worm) DR-78 0.013 0.0129 0.0129
Echinococcus granulosus geminin 0.0311 0.036 0.036
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0145 0.0149 0.0149
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0178 0.0191 0.0186
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0006
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0073 0.0073
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.052 0.0626 0.0841
Toxoplasma gondii AGC kinase 0.0031 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0275 0.0314 0.0314
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0275 0.0314 0.0314
Echinococcus granulosus thyroid hormone receptor alpha 0.013 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.5876 0.7444 0.7442
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0007 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0178 0.0191 0.0142
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.053 0.0482
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.003 0.003
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0005 0.0005
Trypanosoma brucei polo-like protein kinase 0.0107 0.01 0.01
Brugia malayi Nuclear hormone receptor E75 0.013 0.0129 0.0129
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0275 0.0314 0.0314
Schistosoma mansoni hypothetical protein 0.0311 0.036 0.036
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0145 0.0149 0.0149
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.052 0.0626 0.0626
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7884 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0063 0.0044 0.0044
Schistosoma mansoni phosphatidylinositol 4-kinase 0.052 0.0626 0.0626
Brugia malayi Nuclear hormone receptor-like 1 0.0275 0.0314 0.0314
Brugia malayi nuclear hormone receptor family member odr-7 0.013 0.0129 0.0129
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0149 0.0149
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0178 0.0191 0.0191
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0178 0.0191 0.2921
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0022 0.0022
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.013 0.0129 0.0129
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0588 0.0712 0.0707
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.01 0.0095
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0043 0.0043
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3287 0.4148 0.4148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0275 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0178 0.0191 0.5
Brugia malayi tailless protein 0.013 0.0129 0.0129
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0992 0.1227 0.1222
Trichomonas vaginalis PIKK family atypical protein kinase 0.7884 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 0.337 0.3366
Echinococcus multilocularis microtubule associated protein 2 0.0585 0.0709 0.0709
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0195 0.0213 0.0213
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0542 0.0654 0.0607
Plasmodium vivax hypothetical protein, conserved 0.052 0.0626 0.9566
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0005 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0275 0.0314 0.497
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0092 0.0081 0.0081
Loa Loa (eye worm) RNA binding protein 0.0062 0.0043 0.0043
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0178 0.0191 0.0191
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0542 0.0654 0.0654
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.013 0.0129 0.0129
Plasmodium vivax hypothetical protein 0.052 0.0626 0.9566
Echinococcus granulosus Nuclear hormone receptor HR96 0.013 0.0129 0.0129
Brugia malayi hypothetical protein 0.013 0.0129 0.0129
Brugia malayi nuclear receptor NHR-88 0.0275 0.0314 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0031 0.0026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0588 0.0712 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.01 0.0095
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7884 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0542 0.0654 0.0654
Schistosoma mansoni zinc finger protein 0.013 0.0129 0.0129
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0007 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7959 0.7958
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0657 0.08 0.08
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0275 0.0314 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0142 0.0145 0.0145
Echinococcus multilocularis GA binding protein alpha chain 0.0062 0.0043 0.0043
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2688 0.3385 0.3385
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0006 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0275 0.0314 0.0314
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0588 0.0712 0.0712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.0626 0.0626
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0005 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.01 0.0095
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7884 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0003 0.0003
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0005 0.0005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.069 0.0842 0.0839
Entamoeba histolytica hypothetical protein 0.052 0.0626 0.0623
Giardia lamblia Phosphatidylinositol 4-kinase 0.052 0.0626 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.628 0.7959 0.7958
Schistosoma mansoni nuclear hormone receptor 0.0275 0.0314 0.0314
Schistosoma mansoni immunophilin 0.0178 0.0191 0.0191
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.053 0.0435
Entamoeba histolytica protein kinase, putative 0.0033 0.0007 0.0003
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.01 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0192 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.4712 0.5962 0.596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.003 0.003
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0006 0.0008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7884 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0145 0.0149 0.0149
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.0101 0.0101
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0657 0.08 0.08
Schistosoma mansoni ets-related 0.0189 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.01 0.01
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.052 0.0626 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.7884 1 1
Brugia malayi Fli-1 protein 0.0189 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0275 0.0314 0.0314
Plasmodium falciparum phd finger protein, putative 0.0033 0.0006 0.009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0275 0.0314 0.0314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0275 0.0314 0.0314
Schistosoma mansoni nuclear receptor 0.013 0.0129 0.0129
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Leishmania major phosphatidylinositol 3-kinase, putative 0.0542 0.0654 0.056
Leishmania major phosphatidylinositol kinase, putative 0.052 0.0626 0.0531
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0275 0.0314 0.0314
Trypanosoma brucei rac serine-threonine kinase, putative 0.0033 0.0007 0.0007
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0164 0.0173 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.003 0.003
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0033 0.0007 0.0007
Toxoplasma gondii target of rapamycin (TOR), putative 0.5876 0.7444 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.013 0.0129 0.0129
Loa Loa (eye worm) phosphatidylinositol 3 0.7884 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0735 0.09 0.0895
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.01 0.005
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0735 0.09 0.0854
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0275 0.0314 0.0314
Brugia malayi hypothetical protein 0.0031 0.0003 0.0003
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0154 0.016 0.016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0275 0.0314 0.0314
Brugia malayi nuclear receptor RXR 0.0145 0.0149 0.0149
Onchocerca volvulus 0.013 0.0129 0.1985
Leishmania major phosphatidylinositol 4-kinase, putative 0.052 0.0626 0.0531
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.005 0.005
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.052 0.0626 0.0626
Brugia malayi FAT domain containing protein 0.1164 0.1445 0.1445
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.013 0.0129 0.1988
Brugia malayi hypothetical protein 0.0145 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0078 0.0063 0.0063
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.052 0.0626 0.9566
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.003 0.003
Brugia malayi jmjC domain containing protein 0.004 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.5876 0.7444 0.7442
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.081 0.0995 0.0995
Brugia malayi jmjC domain containing protein 0.0108 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.013 0.0129 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0095 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.4272 0.5403 0.54
Trichomonas vaginalis PIKK family atypical protein kinase 0.4279 0.5411 0.5408
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0192 0.0192
Onchocerca volvulus 0.052 0.0626 1
Schistosoma mansoni hypothetical protein 0.0311 0.036 0.036
Leishmania major peptidylprolyl isomerase-like protein 0.0178 0.0191 0.0092
Echinococcus granulosus GPCR family 2 0.0029 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.2688 0.3385 0.3385
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1512 0.1889 0.1848
Loa Loa (eye worm) phosphatidylinositol 3 0.052 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0056 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Loa Loa (eye worm) nuclear receptor nhr-7B 0.013 0.0129 0.0129
Brugia malayi hypothetical protein 0.013 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.1524 0.1904 0.19
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0275 0.0314 0.0314
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0043 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0275 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0275 0.0314 0.0314
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0178 0.0191 0.0188
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.005 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0275 0.0314 0.0314

Activities

Activity type Activity value Assay description Source Reference
Control (binding) = 86.35 % Binding affinity against opioid receptor kappa 1 using [3H]U-69,593 as a radioligand ChEMBL. 2172538
Control (binding) = 106.81 % Binding affinity against opioid receptor kappa 1 using with [3H]-bremazocine as radioligand ChEMBL. 2172538
IC50 (binding) = 6058 nM Binding affinity for sigma opioid receptor using [3H]-(+)-3-PPP as radioligand ChEMBL. 2172538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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