Detailed information for compound 1731205

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 501.66 | Formula: C31H39N3O3
  • H donors: 4 H acceptors: 3 LogP: 4.4 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]([C@@H](NC(=O)c1ccc(c(c1)O)CN1CCCCC1)Cc1ccccc1)CN[C@@H](c1ccccc1)C
  • InChi: 1S/C31H39N3O3/c1-23(25-13-7-3-8-14-25)32-21-30(36)28(19-24-11-5-2-6-12-24)33-31(37)26-15-16-27(29(35)20-26)22-34-17-9-4-10-18-34/h2-3,5-8,11-16,20,23,28,30,32,35-36H,4,9-10,17-19,21-22H2,1H3,(H,33,37)/t23-,28+,30-/m1/s1
  • InChiKey: CWKRHUFANRXVHK-ACHDSSIZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0748 0.1295
Schistosoma mansoni lipoxygenase 0.0114 0.2347 0.276
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0236 0.3703
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0103 0.0142
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0103 0.012
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0094 0.0147
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.058 0.0499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0094 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0177 0.0306
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0199 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0034 0.0029
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0236 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0604 0.1045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0362 0.0451
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0272 0.5777 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0094 0.01
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0362 0.5766
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0621 0.1075
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0138 0.0151
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0178 0.3722 0.3716
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0236 0.0482
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0621 0.8881
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0094 0.01
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0362 0.0451
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0685 0.181
Loa Loa (eye worm) hypothetical protein 0.0011 0.0103 0.0162
Schistosoma mansoni sugar transporter 0.0015 0.0199 0.0223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0094 0.0147
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.058 0.0988
Loa Loa (eye worm) sugar transporter 0.0015 0.0199 0.0328
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.058 0.0673
Brugia malayi beta-lactamase family protein 0.0035 0.0621 0.106
Brugia malayi follicle stimulating hormone receptor 0.0225 0.4741 0.8203
Brugia malayi MH2 domain containing protein 0.0008 0.0034 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0094 0.01
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0621 0.1302
Onchocerca volvulus 0.0015 0.0199 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Echinococcus granulosus smad 0.0008 0.0034 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0594 0.0691
Leishmania major glucose transporter, lmgt2 0.0034 0.0604 0.8627
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0103 0.011
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0268 0.3751
Entamoeba histolytica protein kinase, putative 0.0034 0.0594 0.0748
Trichomonas vaginalis hypothetical protein 0.0011 0.0103 0.0178
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.3744 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0362 0.5766
Loa Loa (eye worm) hypothetical protein 0.0069 0.1361 0.2343
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3744 0.648
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.8477 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0199 0.0344
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0468 0.0794
Brugia malayi Cam kinase protein 1 0.0034 0.0594 0.1014
Brugia malayi major facilitator superfamily protein 0.0015 0.0199 0.0328
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2377 0.4105
Schistosoma mansoni coup transcription factor 0.0011 0.0094 0.01
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0103 0.0162
Loa Loa (eye worm) helicase 0.0011 0.0103 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0116 0.0126
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0034 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0362 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0604 0.1045
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0199 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0094 0.0147
Schistosoma mansoni rab6-interacting 0.0019 0.0278 0.0317
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0094 0.0147
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0034 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0094 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0621 0.106
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0698 0.0689
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0094 0.01
Onchocerca volvulus 0.0015 0.0199 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0094 0.0147
Schistosoma mansoni hypothetical protein 0.0011 0.0103 0.011
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0103 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3744 0.648
Onchocerca volvulus 0.0035 0.0621 0.1638
Onchocerca volvulus Putative transporter 0.0015 0.0199 0.0507
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1146 0.1342
Schistosoma mansoni cpg binding protein 0.0029 0.0502 0.0582
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3744 0.648
Echinococcus granulosus chromobox protein 2 0.0011 0.0103 0.011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0362 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0685 0.1186
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0604 0.8627
Loa Loa (eye worm) hypothetical protein 0.0035 0.0621 0.106
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0604 0.8627
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0216 0.0439
Brugia malayi MH1 domain containing protein 0.0008 0.0034 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trypanosoma brucei sugar transporter, putative 0.0015 0.0199 0.2748
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0362 0.5121
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0013 0.0004
Schistosoma mansoni glucose transport protein 0.011 0.2251 0.2648
Plasmodium vivax hexose transporter 0.011 0.2251 0.2244
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0362 0.5121
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0621 0.1075
Onchocerca volvulus 0.0015 0.0199 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Brugia malayi nuclear receptor NHR-88 0.0011 0.0094 0.0147
Echinococcus granulosus solute carrier family 22 0.0015 0.0199 0.0223
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0103 0.011
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0199 0.0328
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.033 0.0572
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0698 0.0689
Loa Loa (eye worm) beta-lactamase 0.0035 0.0621 0.106
Brugia malayi MH2 domain containing protein 0.0008 0.0034 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0199 0.0223
Plasmodium falciparum hexose transporter 0.011 0.2251 0.2244
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0094 0.01
Schistosoma mansoni cpg binding protein 0.0029 0.0502 0.0582
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3744 0.648
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0595 0.0886
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.058 0.9318
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0094 0.01
Brugia malayi hypothetical protein 0.0015 0.0199 0.0328
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0034 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0621 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0157 0.0256
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0094 0.01
Mycobacterium ulcerans sugar transporter 0.0015 0.0199 0.3094
Toxoplasma gondii protein kinase, putative 0.0311 0.6611 1
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0396 0.0456
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0595 0.0586
Onchocerca volvulus 0.0015 0.0199 0.0507
Brugia malayi hypothetical protein 0.0015 0.0199 0.0328
Brugia malayi hypothetical protein 0.0011 0.0103 0.0162
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0556 0.0646
Giardia lamblia DNA repair protein RAD52 0.0367 0.7825 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0199 0.0223
Schistosoma mansoni sugar transporter 0.0015 0.0199 0.0223
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0236 0.0227
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0094 0.0147
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0594 0.0691
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Brugia malayi hypothetical protein 0.0019 0.0278 0.0466
Onchocerca volvulus 0.0011 0.0103 0.0251
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0278 0.0317
Onchocerca volvulus 0.0019 0.0278 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0685 0.1186
Schistosoma mansoni chromobox protein 0.0068 0.133 0.156
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0103 0.0094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Loa Loa (eye worm) sugar transporter 0.011 0.2251 0.3887
Echinococcus granulosus Chromobox protein 3 0.0011 0.0103 0.011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Schistosoma mansoni cpg binding protein 0.0028 0.0468 0.0541
Brugia malayi Doublecortin family protein 0.0019 0.0278 0.0466
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2251 0.2648
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0594 0.0691
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0621 0.106
Schistosoma mansoni polycystin 1-related 0.0019 0.0278 0.0317
Onchocerca volvulus 0.0019 0.0278 0.0719
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0103 0.012
Schistosoma mansoni hypothetical protein 0.0021 0.031 0.0355
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0094 0.01
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0396 0.0456
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0595 0.0886
Echinococcus granulosus cpg binding protein 0.0029 0.0502 0.0582
Onchocerca volvulus 0.0015 0.0199 0.0507
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Onchocerca volvulus 0.0028 0.0468 0.1227
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0094 0.01
Schistosoma mansoni hypothetical protein 0.0343 0.7312 0.8624
Schistosoma mansoni Smad4 0.0008 0.0034 0.0029
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.2251 0.3396
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0103 0.0094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0029
Brugia malayi major facilitator superfamily protein 0.0015 0.0199 0.0328
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0698 1
Entamoeba histolytica hypothetical protein 0.0011 0.0103 0.012
Echinococcus multilocularis smad 0.0008 0.0034 0.0029
Echinococcus multilocularis Smad4 0.0008 0.0034 0.0029
Toxoplasma gondii sugar transporter ST2 0.0015 0.0199 0.0287
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0698 0.1043
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0199 0.0189
Schistosoma mansoni hypothetical protein 0.0019 0.0278 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0621 0.0612
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.2054 0.3545
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3744 0.648
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Mycobacterium ulcerans beta-lactamase 0.0035 0.0621 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Echinococcus granulosus GPCR family 2 0.0032 0.0556 0.0646
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3744 0.648
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0748 0.1977
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.024 0.0416
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0278 0.0317
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1361 0.2343
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.4707 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.2054 0.3545
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0621 0.106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0177 0.0306
Loa Loa (eye worm) hypothetical protein 0.0011 0.0103 0.0162
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0621 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0013 0.0004
Onchocerca volvulus 0.0012 0.0116 0.0286
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0094 0.01
Schistosoma mansoni loxhd1 0.0019 0.0278 0.0317
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0396 0.6319
Brugia malayi MH2 domain containing protein 0.0116 0.2377 0.4105
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0396 0.6319
Schistosoma mansoni glucose transporter 0.0015 0.0199 0.0223
Schistosoma mansoni hypothetical protein 0.0397 0.8477 1
Echinococcus multilocularis geminin 0.0343 0.7312 0.8624
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2251 0.2648
Schistosoma mansoni glucose transport protein 0.011 0.2251 0.2648
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.2251 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) hypothetical protein 0.0017 0.0236 0.0393
Trypanosoma cruzi hexose transporter 0.0034 0.0604 0.8627
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0199 0.0403
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0103 0.011
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Schistosoma mansoni chromobox protein 0.0068 0.133 0.156
Entamoeba histolytica protein kinase, putative 0.0034 0.0594 0.0748
Onchocerca volvulus 0.003 0.0508 0.1334
Trichomonas vaginalis chromobox protein, putative 0.0068 0.133 0.2303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0094 0.0147
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.058 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0094 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0621 0.1302
Brugia malayi Protein cec-1. 0.0011 0.0103 0.0162
Schistosoma mansoni hypothetical protein 0.0032 0.0556 0.0646
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0594 0.1014
Schistosoma mansoni lipoxygenase 0.008 0.1599 0.1878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0094 0.0147
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0094 0.01
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0604 0.1045
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Onchocerca volvulus 0.0011 0.0103 0.0251
Echinococcus granulosus Smad4 0.0008 0.0034 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0362 0.5766
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0621 0.0722
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0595 0.0586
Brugia malayi nuclear hormone receptor 0.0011 0.0094 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0094 0.0147
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0103 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0445 0.0755
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0556 0.0646
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Schistosoma mansoni rab6-interacting 0.0019 0.0278 0.0317
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0278 0.0317
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0396 0.5612
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0396 0.5612
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.2054 0.3545
Brugia malayi hypothetical protein 0.0019 0.0278 0.0466
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0595 0.0586
Brugia malayi beta-lactamase family protein 0.0035 0.0621 0.106
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0396 0.0585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0094 0.0147
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0094 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0094 0.0147
Loa Loa (eye worm) hypothetical protein 0.0033 0.058 0.0988
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0595 0.0586
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0138 0.0222
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0595 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0094 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0278 0.0466
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0094 0.01
Trypanosoma brucei glucose transporter 1E 0.0034 0.0604 0.8627
Trichomonas vaginalis chromobox protein, putative 0.0068 0.133 0.2303
Onchocerca volvulus 0.0015 0.0199 0.0507
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.5777 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0508 0.0864
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.024 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0445 0.0771
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.2347 0.276
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0604 0.8627
Schistosoma mansoni hypothetical protein 0.0069 0.1361 0.1596
Trichomonas vaginalis esterase, putative 0.0035 0.0621 0.1075
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0621 0.8881
Loa Loa (eye worm) hypothetical protein 0.0017 0.0236 0.0393
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0278 0.0466
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0199 0.2748
Mycobacterium tuberculosis Conserved protein 0.0035 0.0621 0.1302
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0094 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0094 0.0147
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0178 0.3722 0.5624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0362 0.0751
Brugia malayi steroid hormone receptor 0.0011 0.0094 0.0147
Schistosoma mansoni protein kinase 0.0034 0.0594 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0199 0.0344
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2251 0.2648
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0556 0.0646
Schistosoma mansoni glucose transport protein 0.011 0.2251 0.2648
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0396 0.5612
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0094 0.01
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0094 0.01
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0604 0.1045
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0362 0.5766
Loa Loa (eye worm) Smad1 0.0008 0.0034 0.0043
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Loa Loa (eye worm) hypothetical protein 0.0017 0.0236 0.0393
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0396 0.6319
Schistosoma mansoni hypothetical protein 0.0032 0.0556 0.0646
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.133 0.229
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Brugia malayi Sugar transporter family protein 0.011 0.2251 0.3887
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0034 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.3953 0.6841
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2251 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.058 0.0988
Echinococcus granulosus dnaJ subfamily B 0.0397 0.8477 1
Brugia malayi Heterochromatin protein 1 0.0068 0.133 0.229
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0199 0.3094
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0094 0.0227
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0594 0.0691
Loa Loa (eye worm) hypothetical protein 0.0011 0.0103 0.0162
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0621 0.1302
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0396 0.0456
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0094 0.01
Echinococcus multilocularis chromobox protein 1 0.0068 0.133 0.156
Loa Loa (eye worm) hypothetical protein 0.0023 0.0362 0.0612
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0138 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0199 0.0344
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0362 0.5766
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0216 0.0439
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0103 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0103 0.0094
Brugia malayi MH1 domain containing protein 0.0008 0.0034 0.0043
Echinococcus granulosus Chromo domain 0.0011 0.0103 0.011
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2377 0.4105
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2251 0.2648
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0094 0.0227
Onchocerca volvulus 0.0015 0.0199 0.0507
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0621 0.1075
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0396 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3744 0.648
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.005 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0199 0.0344
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0103 0.0178
Schistosoma mansoni protein kinase 0.0034 0.0594 0.0691
Trypanosoma brucei glucose transporter, putative 0.0034 0.0604 0.8627
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0316 0.0652
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Echinococcus multilocularis solute carrier family 22 0.0015 0.0199 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Toxoplasma gondii sugar transporter ST1 0.0015 0.0199 0.0287
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0094 0.01
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0103 0.0178
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0594 0.0691
Loa Loa (eye worm) hypothetical protein 0.0019 0.0278 0.0466
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0594 0.0691
Brugia malayi Sugar transporter family protein 0.0015 0.0199 0.0328
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0621 0.0722
Schistosoma mansoni hypothetical protein 0.0343 0.7312 0.8624
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0103 0.012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0604 0.8627
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0595 0.0586
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0316 0.0652
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0367 0.7825 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0698 1
Onchocerca volvulus 0.0015 0.0199 0.0507
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0034 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0216 0.0439
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1009 0.1514
Loa Loa (eye worm) hypothetical protein 0.0017 0.0236 0.0393
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0167 0.0288
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0621 0.1302
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0103 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Echinococcus multilocularis chromobox protein 1 0.0068 0.133 0.156
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0236 0.4285
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0094 0.01
Toxoplasma gondii sugar transporter ST3 0.0015 0.0199 0.0287
Echinococcus multilocularis chromobox protein 2 0.0011 0.0103 0.011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0094 0.01
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0094 0.01
Brugia malayi chromobox protein homolog 3 0.0038 0.0685 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Schistosoma mansoni protein kinase 0.0034 0.0594 0.0691
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0362 0.5766
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.058 0.0673
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0698 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0013 0.0004
Echinococcus granulosus solute carrier family 22 0.0015 0.0199 0.0223
Onchocerca volvulus 0.0015 0.0199 0.0507
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0103 0.0178
Onchocerca volvulus 0.0015 0.0199 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0604 0.1045
Schistosoma mansoni chromobox protein 0.0011 0.0103 0.011
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0595 0.0886
Brugia malayi Smad1 0.0008 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0362 0.0612
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.058 0.0673
Schistosoma mansoni smad 0.0008 0.0034 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0278 0.0317
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0556 0.0948
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0199 0.0344
Mycobacterium ulcerans hypothetical protein 0.0035 0.0621 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.005 0.007
Trypanosoma brucei glucose transporter 2A 0.0034 0.0604 0.8627
Schistosoma mansoni hypothetical protein 0.011 0.2251 0.2648
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Schistosoma mansoni sugar transporter 0.0015 0.0199 0.0223
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0621 0.1302
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0604 0.8627
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0604 0.8627
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0103 0.0178
Echinococcus granulosus General substrate transporter 0.0095 0.1916 0.2251
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0556 0.0948
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0604 0.1045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0013 0.0004
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0595 0.0586
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.3953 0.6841
Entamoeba histolytica hypothetical protein 0.0011 0.0103 0.012
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0362 0.5766
Echinococcus granulosus solute carrier family 22 0.0015 0.0199 0.0223
Schistosoma mansoni hypothetical protein 0.0032 0.0556 0.0646
Plasmodium falciparum protein kinase 7 0.0311 0.6611 0.6608
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0199 0.0223
Loa Loa (eye worm) hypothetical protein 0.0034 0.0594 0.1014
Plasmodium vivax CDK-related protein kinase 6, putative 0.0467 1 1
Brugia malayi SET domain containing protein 0.0012 0.0116 0.0185
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0103 0.0142
Schistosoma mansoni sugar transporter 0.0015 0.0199 0.0223
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0621 0.8881
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0216 0.0439
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.005 0.0048
Echinococcus multilocularis cpg binding protein 0.0029 0.0502 0.0582
Echinococcus multilocularis solute carrier family 22 0.0015 0.0199 0.0223
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0396 0.0456
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0199 0.2748
Brugia malayi CXXC zinc finger family protein 0.0028 0.0468 0.0794
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0199 0.0344
Leishmania major hypothetical protein, conserved 0.0035 0.0621 0.8881
Echinococcus granulosus solute carrier family 22 0.0015 0.0199 0.0223
Echinococcus multilocularis GPCR, family 2 0.0032 0.0556 0.0646
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) hypothetical protein 0.0033 0.058 0.0988
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0278 0.0317
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0604 0.1045
Onchocerca volvulus 0.0015 0.0199 0.0507
Leishmania major glucose transporter, lmgt1 0.0034 0.0604 0.8627
Loa Loa (eye worm) hypothetical protein 0.0011 0.0103 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.5777 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0278 0.0269
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0094 0.01
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0103 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0556 0.0646
Echinococcus granulosus chromobox protein 1 0.0068 0.133 0.156
Onchocerca volvulus 0.0023 0.0362 0.0945
Echinococcus multilocularis solute carrier family 22 0.0015 0.0199 0.0223
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.5777 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0362 0.5121
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.4741 0.8203
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0048 0.0066
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0199 0.0328
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.024 0.0416
Plasmodium vivax sugar transporter, putative 0.0015 0.0199 0.0189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0621 0.0722
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0103 0.011
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0621 0.1302
Loa Loa (eye worm) hypothetical protein 0.0023 0.0362 0.0612
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0094 0.01
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0199 0.0223
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0594 0.1014
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0396 1
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0094 0.01
Toxoplasma gondii ABC1 family protein 0.0035 0.0621 0.0927
Loa Loa (eye worm) hypothetical protein 0.0011 0.0103 0.0162
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0621 0.106
Echinococcus multilocularis Chromo domain 0.0011 0.0103 0.011
Mycobacterium leprae Probable lipase LipE 0.0035 0.0621 1
Echinococcus granulosus chromobox protein 1 0.0068 0.133 0.156
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0094 0.01
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0116 0.1741
Leishmania major glucose transporter, lmgt3 0.0034 0.0604 0.8627
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0362 0.0612
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.024 0.0416
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.058 0.0673
Brugia malayi ecdysteroid receptor 0.0011 0.0094 0.0147
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0199 0.3094
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0199 0.0223
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0698 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0103 0.0162
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0094 0.01
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.5777 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0445 0.0771
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0103 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Plasmodium falciparum mitogen-activated protein kinase 2 0.0178 0.3722 0.3716
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0549 0.0637
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0362 0.0751
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0103 0.0094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0396 0.067
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0029
Onchocerca volvulus 0.0015 0.0199 0.0507
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0604 0.8627
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.2347 0.276
Loa Loa (eye worm) hypothetical protein 0.0101 0.2054 0.3545
Echinococcus multilocularis RUN 0.0019 0.0278 0.0317
Echinococcus granulosus geminin 0.0343 0.7312 0.8624
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.5777 1
Onchocerca volvulus 0.0015 0.0199 0.0507
Echinococcus granulosus RUN 0.0019 0.0278 0.0317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.024 0.0416
Leishmania major hypothetical protein, conserved 0.0015 0.0199 0.2748
Onchocerca volvulus 0.0015 0.0199 0.0507
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.024 0.0416
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0595 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0103 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.024 0.0416
Echinococcus multilocularis General substrate transporter 0.0095 0.1916 0.2251
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.5777 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0103 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0556 0.0948
Mycobacterium ulcerans lipase LipD 0.0035 0.0621 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0362 0.5766
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0594 0.1014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0094 0.01
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0199 0.0328
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0272 0.5777 1
Onchocerca volvulus 0.0035 0.0621 0.1638
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0199 0.0223
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0396 0.0387
Brugia malayi Sugar transporter family protein 0.0015 0.0199 0.0328
Entamoeba histolytica hypothetical protein 0.0104 0.2128 0.2711
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0199 0.0328
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0094 0.01
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0698 1
Onchocerca volvulus 0.0011 0.0094 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0094 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0621 0.106
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0621 0.1075
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0199 0.0287
Entamoeba histolytica hypothetical protein 0.0011 0.0103 0.012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0685 0.1172
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0103 0.0094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0621 0.1075
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0621 0.1302
Onchocerca volvulus 0.0015 0.0199 0.0507
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0103 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0236 0.0393
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) hypothetical protein 0.0035 0.0621 0.106
Mycobacterium tuberculosis Conserved protein 0.0035 0.0621 0.1302
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2251 0.3897
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.024 0.0416
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0103 0.0094
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0199 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0094 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0094 0.0147
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0094 0.01
Loa Loa (eye worm) hypothetical protein 0.0015 0.0199 0.0328
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0094 0.0227
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0199 0.2748
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0199 0.2748
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0594 0.8491
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0549 0.0637
Onchocerca volvulus 0.0035 0.0621 0.1638
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0594 0.1029
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0621 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0316 0.5005
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0094 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0103 0.0178
Schistosoma mansoni hypothetical protein 0.0032 0.0556 0.0646
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0103 0.011
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0748 0.1295
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0138 0.0151
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0362 0.0451
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0094 0.01
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Brugia malayi hypothetical protein 0.0015 0.0199 0.0328
Schistosoma mansoni chromobox protein 0.0011 0.0103 0.011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0621 0.0722
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0595 0.0586
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.2128 0.2711
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0594 0.0691
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0396 0.0387
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0362 0.5766
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0199 0.3094
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0396 0.0686
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0556 0.0948
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0116 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0094 0.01
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0199 0.2748
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0199 0.0344
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.058 0.1003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0278 0.0317
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0362 0.5766
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0094 0.0147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0094 0.0147
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0034 0.0029
Entamoeba histolytica hypothetical protein 0.0025 0.0396 0.0495
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0396 0.0259
Mycobacterium tuberculosis Conserved protein 0.0035 0.0621 0.1302
Brugia malayi CHD4 protein 0.0013 0.0138 0.0222
Onchocerca volvulus 0.0015 0.0199 0.0507
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0594 0.0691
Brugia malayi beta-lactamase 0.0035 0.0621 0.106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0594 0.0691
Leishmania major protein kinase, putative 0.0034 0.0594 0.8491
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0278 0.0269
Loa Loa (eye worm) hypothetical protein 0.0035 0.0621 0.106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2251 0.2648
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2251 0.2648
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0094 0.0147

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.9 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 50 % serum ChEMBL. 23260352

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 23260352

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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