Detailed information for compound 173440

Basic information

Technical information
  • TDR Targets ID: 173440
  • Name: 2-(4-methoxyphenyl)-6-morpholin-4-ylthiopyran -4-one
  • MW: 303.376 | Formula: C16H17NO3S
  • H donors: 0 H acceptors: 1 LogP: 2.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cc(=O)cc(s1)N1CCOCC1
  • InChi: 1S/C16H17NO3S/c1-19-14-4-2-12(3-5-14)15-10-13(18)11-16(21-15)17-6-8-20-9-7-17/h2-5,10-11H,6-9H2,1H3
  • InChiKey: XQTRMYUJFYVIMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-6-morpholino-thiopyran-4-one
  • 2-(4-methoxyphenyl)-6-morpholino-4-thiopyranone
  • 2-(4-methoxyphenyl)-6-morpholin-4-yl-thiopyran-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0313 0.285 0.3487
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Leishmania major hypothetical protein, conserved 0.0313 0.285 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0119 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Loa Loa (eye worm) beta-lactamase 0.0035 0.0243 0.0298
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0022 0.0018
Onchocerca volvulus 0.0157 0.139 0.1637
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.0294
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0063 0.012
Trichomonas vaginalis esterase, putative 0.0035 0.0243 0.0294
Toxoplasma gondii ran binding protein 0.0313 0.285 0.3466
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0119 1
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Mycobacterium ulcerans lipase LipD 0.0035 0.0243 1
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0016 0.0063 0.0074
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.6226 0.7623
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0243 0.0943
Brugia malayi RING zinc finger protein 0.0016 0.0063 0.0074
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0243 0.5
Plasmodium vivax trophozoite exported protein 1, putative 0.0016 0.0063 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1006 0.1232
Trichomonas vaginalis ankyrin, putative 0.0016 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0157 0.139 0.1702
Echinococcus multilocularis serine protein kinase ATM 0.0012 0.003 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.0055
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0243 0.0758
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0016 0.0063 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Onchocerca volvulus 0.0313 0.285 0.3438
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Loa Loa (eye worm) hypothetical protein 0.0029 0.0187 0.0229
Loa Loa (eye worm) brahma associated protein 0.088 0.8167 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Giardia lamblia Kinase, NEK 0.0016 0.0063 0.0000020628
Onchocerca volvulus 0.0313 0.285 0.3438
Echinococcus granulosus zinc finger protein Ran binding 0.0313 0.285 0.2847
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0243 1
Onchocerca volvulus 0.0035 0.0243 0.0222
Brugia malayi brahma associated protein 60 kDa 0.088 0.8167 1
Trypanosoma brucei predicted zinc finger protein 0.0016 0.0063 0.012
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis ankyrin, putative 0.0016 0.0063 0.0074
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0119 0.0317
Echinococcus granulosus serine protein kinase ATM 0.0012 0.003 0.0026
Onchocerca volvulus 0.0035 0.0243 0.0222
Echinococcus multilocularis ring finger protein 113a 0.0016 0.0063 0.006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0187 0.0194
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0022 0.0023
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0016 0.0063 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Plasmodium vivax hypothetical protein, conserved 0.088 0.8167 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Toxoplasma gondii hypothetical protein 0.0016 0.0063 0.0042
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0313 0.285 0.3466
Trypanosoma brucei DNA repair protein, putative 0.0016 0.0063 0.012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0262 0.0316
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0063 0.0074
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0059 0.0103
Toxoplasma gondii RING zinc finger protein 0.0016 0.0063 0.0042
Mycobacterium tuberculosis Conserved protein 0.0035 0.0243 0.0943
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0187 0.0225
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.088 0.8167 1
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0016 0.0063 0.0074
Brugia malayi hypothetical protein 0.0016 0.0063 0.0074
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Schistosoma mansoni rnf5 0.0016 0.0063 0.0074
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0059 0.0068
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Brugia malayi Neuralized family protein 0.0016 0.0063 0.0074
Brugia malayi hypothetical protein 0.0016 0.0063 0.0074
Mycobacterium tuberculosis Conserved protein 0.0035 0.0243 0.0943
Toxoplasma gondii hypothetical protein 0.0016 0.0063 0.0042
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0243 0.0294
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.088 0.8167 1
Echinococcus multilocularis 0.0016 0.0063 0.006
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0035 0.0018
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trypanosoma brucei hypothetical protein, conserved 0.0313 0.285 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0043 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0022 0.0023
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0243 0.0943
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2018 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0313 0.285 0.2847
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0313 0.285 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0059 0.0068
Brugia malayi hypothetical protein 0.0016 0.0063 0.0074
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0119 0.011
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0243 0.024
Echinococcus granulosus ring and YY1 binding protein 0.0313 0.285 0.2847
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0243 0.0943
Schistosoma mansoni RNA binding protein 0.0313 0.285 0.3487
Plasmodium vivax DNA repair protein RAD5, putative 0.0016 0.0063 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1818 0.2226
Trypanosoma cruzi WLM domain containing protein, putative 0.0313 0.285 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Schistosoma mansoni peter pan-related 0.0016 0.0063 0.0074
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0016 0.0063 0.0006
Plasmodium falciparum zinc finger protein, putative 0.0016 0.0063 0.0006
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0063 0.0074
Brugia malayi hypothetical protein 0.0016 0.0063 0.0074
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0035 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0063 0.012
Onchocerca volvulus 0.0231 0.2081 0.249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0286 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Onchocerca volvulus 0.0035 0.0243 0.0222
Leishmania major DNA repair protein-like protein 0.0016 0.0063 0.0102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.003 0.0032
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0063 0.0074
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0022 0.0018
Echinococcus granulosus cell growth regulator with ring finger domain 0.0016 0.0063 0.006
Schistosoma mansoni zinc finger protein 0.0313 0.285 0.3487
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0016 0.0063 0.006
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Loa Loa (eye worm) hypothetical protein 0.0313 0.285 0.3489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0016 0.0063 0.006
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0016 0.0063 0.012
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0016 0.0063 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Giardia lamblia GTOR 0.0022 0.0119 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.088 0.8167 1
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0063 0.012
Leishmania major hypothetical protein, conserved 0.0114 0.0982 0.3364
Schistosoma mansoni fusion 0.0313 0.285 0.3487
Echinococcus multilocularis SWI:SNF matrix associated 0.088 0.8167 0.8166
Schistosoma mansoni hypothetical protein 0.088 0.8167 1
Entamoeba histolytica hypothetical protein 0.0016 0.0063 0.3791
Leishmania major hypothetical protein 0.0016 0.0063 0.0102
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Toxoplasma gondii hypothetical protein 0.0016 0.0063 0.0042
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0016 0.0063 0.0042
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0016 0.0063 0.006
Echinococcus granulosus ring finger protein 170 0.0016 0.0063 0.006
Trichomonas vaginalis hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0063 0.012
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0059 0.0036
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0016 0.0063 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0119 0.0146
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0313 0.285 1
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.0294
Schistosoma mansoni TRABID protein (C64 family) 0.0313 0.285 0.3487
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0016 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0059 0.0072
Brugia malayi RING finger protein 20 0.0016 0.0063 0.0074
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Mycobacterium tuberculosis Conserved protein 0.0035 0.0243 0.0943
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0243 0.0298
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.0043 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0119 0.0317
Leishmania major hypothetical protein, conserved 0.0313 0.285 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0313 0.285 1
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0016 0.0063 0.0074
Brugia malayi Cytochrome P450 family protein 0.0013 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0313 0.285 0.3489
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0313 0.285 1
Chlamydia trachomatis SWIB complex protein 0.088 0.8167 0.5
Schistosoma mansoni hypothetical protein 0.088 0.8167 1
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0016 0.0063 0.006
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0012 0.003 0.0032
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Echinococcus granulosus ring finger protein 113a 0.0016 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0052
Echinococcus granulosus SWI:SNF matrix associated 0.088 0.8167 0.8166
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0119 0.0299
Brugia malayi hypothetical protein 0.0016 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0119 0.0142
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Toxoplasma gondii ABC1 family protein 0.0035 0.0243 0.0263
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0059 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0063 0.0074
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2081 0.2545
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0119 0.0317
Brugia malayi Pre-SET motif family protein 0.0203 0.1818 0.2223
Schistosoma mansoni cellular tumor antigen P53 0.0157 0.139 0.1699
Schistosoma mansoni hypothetical protein 0.088 0.8167 1
Trypanosoma cruzi hypothetical protein 0.0016 0.0063 0.012
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0243 0.0943
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0243 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0016 0.0063 0.012
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0119 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0298
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0313 0.285 0.3487
Onchocerca volvulus 0.0029 0.0187 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0119 0.0317
Loa Loa (eye worm) RiNg Finger protein family member 0.0016 0.0063 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0187 0.0184
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0243 0.0943
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0243 0.0294
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0016 0.0063 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Toxoplasma gondii hypothetical protein 0.0016 0.0063 0.0042
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0119 0.0116
Leishmania major hypothetical protein, unknown function 0.0016 0.0063 0.0102
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0313 0.285 0.3438
Trypanosoma brucei hypothetical protein, conserved 0.0313 0.285 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0022 0.0023
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trypanosoma cruzi hypothetical protein, conserved 0.0313 0.285 1
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0035 0.0042
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0074
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0022 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0059 0.0055
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.032 0.0388
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.6226 0.6225
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0119 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0942 0.3237
Plasmodium vivax SET domain protein, putative 0.0029 0.0187 0.0159
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0119 0.0317
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0313 0.285 0.3487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0313 0.285 1
Trichomonas vaginalis conserved hypothetical protein 0.088 0.8167 1
Plasmodium falciparum RING zinc finger protein, putative 0.0016 0.0063 0.0006
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0119 0.0317
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0119 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Plasmodium vivax zinc finger protein, putative 0.0016 0.0063 0.0006
Brugia malayi hypothetical protein 0.0016 0.0063 0.0074
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0286 0.0346
Brugia malayi brahma associated protein 60 kDa 0.088 0.8167 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.003 0.0032
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0119 0.0142
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0016 0.0063 0.006
Schistosoma mansoni mind bomb 0.0016 0.0063 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Echinococcus granulosus Upstream activation factor subunit UAF30 0.088 0.8167 0.8166
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.088 0.8167 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0119 0.0142
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Echinococcus multilocularis SWI:SNF matrix associated 0.088 0.8167 0.8166
Echinococcus multilocularis SWI:SNF matrix associated 0.088 0.8167 0.8166
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0313 0.285 0.3487
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0313 0.285 1
Brugia malayi Cytochrome P450 family protein 0.0013 0.0035 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0187 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0294
Plasmodium vivax RING zinc finger protein, putative 0.0016 0.0063 0.0006
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0034 0.0237 0.029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0187 0.0225
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0243 0.0758
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0119 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Onchocerca volvulus 0.088 0.8167 1
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0016 0.0063 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0243 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Onchocerca volvulus 0.0313 0.285 0.3438
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.0055
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.003 0.0026
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Loa Loa (eye worm) RING finger protein 20 0.0016 0.0063 0.0078
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0187 0.0184
Trypanosoma brucei ring finger containing protein 0.0016 0.0063 0.012
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0119 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0298
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.088 0.8167 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Echinococcus multilocularis zinc finger protein Ran binding 0.0313 0.285 0.2847
Echinococcus granulosus RING finger protein 185 0.0016 0.0063 0.006
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0313 0.285 0.3487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0177 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0298
Onchocerca volvulus 0.0313 0.285 0.3438
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.032 0.0388
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0016 0.0063 0.0042
Echinococcus granulosus Zinc finger RanBP2 type 0.0313 0.285 0.2847
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0286 0.0283
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Loa Loa (eye worm) hypothetical protein 0.0313 0.285 0.3489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Entamoeba histolytica hypothetical protein 0.0016 0.0063 0.3791
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0243 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Giardia lamblia Ser/Thr protein kinase 0.0016 0.0063 0.0000020628
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Mycobacterium ulcerans beta-lactamase 0.0035 0.0243 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Loa Loa (eye worm) hypothetical protein 0.0313 0.285 0.3489
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0313 0.285 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0059 0.0103
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0119 0.0116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0298
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0294
Plasmodium falciparum trophozoite exported protein 1 0.0016 0.0063 0.0006
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0016 0.0063 0.006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0119 0.0317
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0059 0.0103
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0035 0.0042
Chlamydia trachomatis DNA topoisomerase I 0.088 0.8167 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0016 0.0063 0.0074
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0016 0.0063 0.006
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Brugia malayi YY1-associated factor 2 0.0313 0.285 0.3487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0119 0.0142
Echinococcus multilocularis ring and YY1 binding protein 0.0313 0.285 0.2847
Brugia malayi MH2 domain containing protein 0.0116 0.1006 0.1228
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0119 0.0116
Brugia malayi Zinc finger protein 183 homolog 0.0016 0.0063 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0119 0.0317
Loa Loa (eye worm) hypothetical protein 0.0313 0.285 0.3489
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0074
Brugia malayi B-box zinc finger family protein 0.0016 0.0063 0.0074
Leishmania major hypothetical protein, conserved 0.0313 0.285 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.003 0.0032
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0043 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0016 0.0063 0.006
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Leishmania major hypothetical protein, conserved 0.0313 0.285 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.088 0.8167 0.8166
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0119 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0063 0.012
Brugia malayi SWIB/MDM2 domain containing protein 0.088 0.8167 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0059 0.0055
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0243 0.0943
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0243 0.0943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0016 0.0063 0.0042
Brugia malayi isocitrate dehydrogenase 0.0015 0.0059 0.0068
Trypanosoma cruzi hypothetical protein 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Echinococcus granulosus microtubule associated protein 2 0.0673 0.6226 0.6225
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0059 0.0055
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0313 0.285 1
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0016 0.0063 0.012
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0243 0.0228
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0078
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0119 1
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0063 0.0074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0187 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.003 0.0032
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0262 0.0316
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0063 0.012
Toxoplasma gondii helicase, putative 0.0016 0.0063 0.0042
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0313 0.285 0.3442
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Giardia lamblia Protein 21.1 0.0016 0.0063 0.0000020628
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0035 0.0018
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0063 0.0074
Schistosoma mansoni zinc finger protein 0.0016 0.0063 0.0074
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0022 0.0018
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0286 0.0283
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0313 0.285 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Brugia malayi Zinc finger, C2H2 type family protein 0.0016 0.0063 0.0074
Mycobacterium ulcerans hypothetical protein 0.0035 0.0243 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.088 0.8167 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0243 0.0294
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1006 0.1232
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0119 0.0146
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0243 0.0294
Echinococcus multilocularis tumor protein p63 0.1075 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0243 0.024
Schistosoma mansoni peter pan-related 0.0016 0.0063 0.0074
Echinococcus multilocularis ring finger protein 170 0.0016 0.0063 0.006
Leishmania major hypothetical protein, conserved 0.0035 0.0243 0.0741
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0298
Mycobacterium leprae Probable lipase LipE 0.0035 0.0243 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0063 0.0074
Brugia malayi beta-lactamase 0.0035 0.0243 0.0294
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0313 0.2854 0.2852
Trichomonas vaginalis ankyrin, putative 0.0016 0.0063 0.0074
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0313 0.285 0.2847
Schistosoma mansoni ring finger protein 151 0.0016 0.0063 0.0074
Leishmania major hypothetical protein, conserved 0.0016 0.0063 0.0102
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0016 0.0063 0.0074
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0063 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0187 0.0225
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0016 0.0063 0.0042
Leishmania major hypothetical protein, conserved 0.0313 0.285 1
Entamoeba histolytica SPRY domain protein 0.0016 0.0063 0.3791
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0298
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0243 0.0294
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0059 0.0103
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0313 0.2854 0.2852
Trypanosoma cruzi WLM domain containing protein, putative 0.0313 0.285 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0187 0.0225
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0313 0.285 0.2847
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0063 0.012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0059 0.0085
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Entamoeba histolytica zinc finger domain containing protein 0.0016 0.0063 0.3791
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0035 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0119 0.0142
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0063 0.012
Schistosoma mansoni brg-1 associated factor 0.088 0.8167 1
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0074
Echinococcus multilocularis RING finger protein 185 0.0016 0.0063 0.006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.28 uM In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells. ChEMBL. 12941339
IC50 (binding) = 0.28 uM Inhibition of DNA-PK in HeLa cell nuclear extracts ChEMBL. 17371003
IC50 (binding) = 0.28 uM In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells. ChEMBL. 12941339
IC50 (binding) = 0.28 uM Inhibition of DNA-PK in HeLa cell nuclear extracts ChEMBL. 17371003
IC50 (binding) = 0.28 uM Inhibition of DNA-PK ChEMBL. 22835870
IC50 (binding) = 0.28 uM Inhibition of DNA-PK (unknown origin) ChEMBL. 25387153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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