Detailed information for compound 1734494

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.491 | Formula: C24H29NO4
  • H donors: 1 H acceptors: 1 LogP: 5.14 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/c2ccc(cc2)OC)c(c(c1)OC)/C=C/C(=O)NCC(C)C
  • InChi: 1S/C24H29NO4/c1-17(2)16-25-24(26)13-12-22-19(14-21(28-4)15-23(22)29-5)9-6-18-7-10-20(27-3)11-8-18/h6-15,17H,16H2,1-5H3,(H,25,26)/b9-6+,13-12+
  • InChiKey: JVYPRVCGLVRVIB-UXKPLKHMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Mus musculus prostaglandin-endoperoxide synthase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0667 0.2944
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0059 0.0216 0.0234
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0068 0.0312 0.131
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0365 0.3531 0.3525
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.041 0.0691
Echinococcus multilocularis serine:threonine protein kinase N2 0.0124 0.0923 0.1108
Loa Loa (eye worm) TK/ABL protein kinase 0.0257 0.2362 0.256
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0746 0.3292
Trichomonas vaginalis STE family protein kinase 0.0048 0.0101 0.0444
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0117 0.0847 0.3811
Echinococcus multilocularis casein kinase I delta 0.0055 0.0168 0.0193
Echinococcus granulosus growth factor receptor bound protein 2 0.0051 0.0131 0.0122
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Trypanosoma brucei polo-like protein kinase 0.0246 0.2242 0.9413
Echinococcus multilocularis serine:threonine protein kinase 38 0.0124 0.0923 0.1108
Schistosoma mansoni tyrosine kinase 0.0137 0.1063 0.179
Giardia lamblia Kinase, CMGC CDK 0.0101 0.0667 0.2932
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Schistosoma mansoni peroxidasin 0.0081 0.0456 0.0768
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0111
Echinococcus multilocularis ephrin type A receptor 4 A 0.0091 0.0564 0.0673
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0263 0.0285
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.022 0.196 0.2366
Brugia malayi Protein kinase domain containing protein 0.0101 0.0667 0.0723
Entamoeba histolytica protein kinase, putative 0.011 0.077 0.337
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0055 0.0168 0.0706
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0057 0.0191 0.1727
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0104 0.0703 0.2952
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0102 0.0113
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.021 0.1845 0.2
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0259 0.2381 0.401
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0061 0.0239 0.0279
Loa Loa (eye worm) hypothetical protein 0.0636 0.6464 0.7006
Schistosoma mansoni ste20-related kinase 0.0184 0.1565 0.2635
Giardia lamblia Kinase, AGC PKA 0.0057 0.0191 0.0809
Echinococcus multilocularis rac serine:threonine kinase 0.0142 0.1118 0.1344
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0254 0.0428
Entamoeba histolytica cell division protein kinase 2, putative 0.0101 0.0667 0.2915
Onchocerca volvulus 0.0063 0.0263 0.0432
Loa Loa (eye worm) hypothetical protein 0.0073 0.0365 0.0395
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Echinococcus multilocularis cyclin dependent kinase 1 0.0101 0.0667 0.0798
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.0182
Echinococcus granulosus NDR protein kinase 0.0124 0.0923 0.0915
Echinococcus granulosus activin receptor type 0.0048 0.0096 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0191 0.0321
Echinococcus multilocularis cyclin dependent kinase 1 0.0101 0.0667 0.0798
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Schistosoma mansoni growth factor receptor-bound protein 0.0051 0.0131 0.0221
Toxoplasma gondii hypothetical protein 0.0059 0.0216 0.0939
Leishmania major extracellular receptor, putative 0.0049 0.0102 0.0392
Brugia malayi Protein kinase domain containing protein 0.0096 0.0618 0.067
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0065 0.0279 0.0302
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Onchocerca volvulus 0.0111 0.0781 0.1451
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.0388 0.042
Entamoeba histolytica PH domain containing protein kinase, putative 0.0062 0.0248 0.1058
Trichomonas vaginalis STE family protein kinase 0.0247 0.2253 0.9943
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.004 0.001 0.0011
Entamoeba histolytica protein kinase domain containing protein 0.011 0.077 0.337
Schistosoma mansoni carbonic anhydrase-related 0.0059 0.0216 0.0363
Schistosoma mansoni protein kinase 0.0083 0.0473 0.0796
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.014 0.1086 0.4541
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0137 0.106 0.4453
Loa Loa (eye worm) hypothetical protein 0.0097 0.063 0.0683
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0126 0.0938 0.0929
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0246 0.2242 0.243
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0233 0.2102 0.2279
Brugia malayi Protein kinase domain containing protein 0.0058 0.0205 0.0222
Schistosoma mansoni tyrosine kinase 0.0343 0.3287 0.5535
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0055 0.0168 0.0182
Echinococcus multilocularis insulin receptor 0.0416 0.4083 0.4941
Echinococcus granulosus receptor type guanylyl cyclase 0.0078 0.0424 0.0415
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.2242 0.9895
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0096 0.0386
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0137 0.1063 0.1278
Echinococcus granulosus rho-associated protein kinase 1 0.0299 0.2813 0.2806
Entamoeba histolytica protein kinase, putative 0.0104 0.0703 0.3073
Brugia malayi Protein kinase domain containing protein 0.0058 0.0205 0.0222
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0049 0.0102 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.018 0.1519 0.2559
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.2242 0.9895
Trypanosoma cruzi polo-like protein kinase, putative 0.0246 0.2242 0.9416
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0057 0.0191 0.0801
Echinococcus granulosus N chimaerin 0.0061 0.0239 0.023
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.004 0.001 0.0005
Brugia malayi Protein kinase domain containing protein 0.0124 0.0923 0.1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Echinococcus multilocularis myosin iiia 0.0068 0.0312 0.0367
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0168 0.0742
Onchocerca volvulus 0.0055 0.0168 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Giardia lamblia Aurora kinase 0.0126 0.0945 0.4168
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0279 0.047
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.011 0.077 0.1296
Loa Loa (eye worm) AGC/PKA protein kinase 0.0057 0.0191 0.0207
Giardia lamblia Kinase, STE STE20 0.0069 0.0326 0.1412
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0259 0.2381 0.2581
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0046 0.0072 0.0063
Trypanosoma brucei rac serine-threonine kinase, putative 0.0249 0.2266 0.9514
Loa Loa (eye worm) CAMK/PKD protein kinase 0.013 0.0979 0.1061
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0168 0.0742
Entamoeba histolytica PH domain containing protein kinase, putative 0.0062 0.0248 0.1058
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0137 0.1063 0.1278
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.001
Entamoeba histolytica casein kinase, putative 0.0083 0.0473 0.2054
Brugia malayi SH2 domain containing protein 0.0058 0.0205 0.0222
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.0302 0.1236
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0847 0.374
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0059 0.0216 0.0234
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0155 0.1254 0.1246
Echinococcus multilocularis c src tyrosine kinase 0.0081 0.0453 0.0539
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.0096 0.0405
Echinococcus multilocularis calcium activated potassium channel 0.0077 0.041 0.0486
Brugia malayi ephrin receptor 1 precursor 0.0059 0.0212 0.023
Echinococcus multilocularis raf serine:threonine protein kinase 0.0063 0.0254 0.0297
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0104 0.0706 0.2939
Onchocerca volvulus Serine\/threonine kinase homolog 0.0246 0.2242 0.4328
Brugia malayi Variant SH3 domain containing protein 0.0051 0.0131 0.0142
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0108 0.0747 0.0738
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0172 0.1436 0.2741
Leishmania major protein kinase A catalytic subunit isoform 2 0.0057 0.0191 0.0765
Loa Loa (eye worm) hypothetical protein 0.0082 0.0469 0.0508
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0119 0.0862 0.1035
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0058 0.0205 0.0238
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0069 0.0326 0.0317
Schistosoma mansoni protein kinase 0.0247 0.2253 0.3795
Schistosoma mansoni serine/threonine kinase 0.0124 0.0923 0.1554
Loa Loa (eye worm) hypothetical protein 0.0166 0.1375 0.1491
Brugia malayi serine/threonine-protein kinase PAK 7 0.021 0.1845 0.2
Brugia malayi Furin-like cysteine rich region family protein 0.0573 0.5774 0.6258
Loa Loa (eye worm) RGC/RGC protein kinase 0.0078 0.0424 0.046
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Entamoeba histolytica protein kinase domain containing protein 0.011 0.077 0.337
Schistosoma mansoni protein kinase 0.004 0.001 0.0016
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0159 0.1292 0.14
Loa Loa (eye worm) hypothetical protein 0.0084 0.0484 0.0525
Brugia malayi Kinase associated domain 1 family protein 0.0059 0.0212 0.023
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0101 0.0667 0.2773
Echinococcus granulosus tyrosine protein kinase Fyn 0.0137 0.1063 0.1055
Onchocerca volvulus 0.0049 0.0102 0.0115
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0302 0.1335
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0069 0.0326 0.0317
Onchocerca volvulus 0.0467 0.4627 0.9024
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0119 0.0862 0.0854
Trichomonas vaginalis STE family protein kinase 0.0069 0.0326 0.1439
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0587 0.5926 0.6423
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0051 0.0131 0.0221
Brugia malayi SH2 domain containing protein 0.0058 0.0205 0.0222
Giardia lamblia Kinase, CK1 Casein kinase 0.0055 0.0168 0.0708
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0081 0.0453 0.0763
Trichomonas vaginalis CMGC family protein kinase 0.011 0.077 0.3397
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.218 0.3671
Brugia malayi Protein kinase domain containing protein 0.018 0.1519 0.1647
Brugia malayi Immunoglobulin I-set domain containing protein 0.0236 0.2134 0.2313
Onchocerca volvulus 0.0058 0.0205 0.0318
Plasmodium falciparum protein kinase, putative 0.0048 0.0096 0.0829
Echinococcus granulosus protein kinase c epsilon type 0.0159 0.1292 0.1284
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0126 0.0945 0.8898
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Plasmodium falciparum protein kinase 5 0.0101 0.0667 0.6259
Loa Loa (eye worm) hypothetical protein 0.0057 0.0191 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Giardia lamblia Kinase, CMGC GSK 0.011 0.077 0.3389
Echinococcus granulosus mitogen activated protein kinase 14 0.014 0.1086 0.1078
Onchocerca volvulus 0.0063 0.0263 0.0432
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0468 0.4645 0.5034
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0137 0.106 1
Trichomonas vaginalis STE family protein kinase 0.0247 0.2253 0.9943
Giardia lamblia Kinase, AGC AKT 0.0099 0.0649 0.2851
Loa Loa (eye worm) hypothetical protein 0.0114 0.0813 0.0881
Echinococcus multilocularis cyclin dependent kinase 5 0.0101 0.0667 0.0798
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0068 0.0312 0.1342
Trypanosoma cruzi extracellular receptor, putative 0.0049 0.0102 0.043
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.0706
Brugia malayi Sex muscle abnormal protein 5 0.0051 0.0131 0.0142
Echinococcus granulosus dual specificity 0.0104 0.0703 0.0694
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0057 0.0191 0.0801
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0137 0.106 1
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.2242 0.3776
Echinococcus granulosus tyrosine protein kinase Src42A 0.0085 0.0493 0.0484
Entamoeba histolytica protein kinase, putative 0.0048 0.0101 0.0405
Loa Loa (eye worm) hypothetical protein 0.0059 0.0216 0.0234
Echinococcus granulosus cyclin dependent kinase 0.0101 0.0667 0.0658
Onchocerca volvulus Poor gastrulation protein homolog 0.0084 0.0484 0.0867
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0111
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0197 0.1713 0.1706
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Brugia malayi serine/threonine-protein kinase 6 0.0126 0.0945 0.1024
Echinococcus multilocularis nmda type glutamate receptor 0.0049 0.0102 0.0113
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0073 0.0363 0.0429
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0279 0.1231
Giardia lamblia Kinase, NEK 0.0117 0.0847 0.3735
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0618 0.2729
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0257 0.2362 0.2854
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0155 0.1254 0.151
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0302 0.1335
Schistosoma mansoni protein kinase 0.004 0.001 0.0016
Schistosoma mansoni serine/threonine-protein kinase 0.0142 0.1118 0.1882
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0249 0.2266 1
Echinococcus granulosus serine/threonine protein kinase 0.0142 0.1118 0.1109
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0068 0.0312 0.131
Echinococcus multilocularis activin receptor type 0.0048 0.0096 0.0106
Loa Loa (eye worm) TK/ROR protein kinase 0.0046 0.0072 0.0078
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Echinococcus multilocularis aurora kinase A 0.0126 0.0945 0.1135
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0246 0.2242 0.2709
Echinococcus granulosus protein kinase C gamma type 0.0164 0.1348 0.134
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0197 0.1713 0.2067
Entamoeba histolytica protein kinase, putative 0.0054 0.0158 0.0658
Echinococcus granulosus carbonic anhydrase II 0.0259 0.2381 0.2374
Onchocerca volvulus Peroxidasin homolog 0.008 0.044 0.0779
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0104 0.0703 0.2924
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0068 0.0312 0.1277
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0945 0.4168
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0197 0.1704 0.2056
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0126 0.0938 0.1126
Brugia malayi Protein kinase domain containing protein 0.0892 0.9227 1
Trypanosoma cruzi cdc2-related kinase 1 0.0101 0.0667 0.2802
Loa Loa (eye worm) hypothetical protein 0.0117 0.0838 0.0908
Brugia malayi hypothetical protein 0.0058 0.0205 0.0222
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0124 0.0923 0.1108
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0133 0.1012 0.1003
Echinococcus multilocularis GPCR, family 3, C terminal 0.0084 0.0484 0.0576
Brugia malayi Hr1 repeat family protein 0.0124 0.0923 0.1
Entamoeba histolytica casein kinase 1, putative 0.0055 0.0168 0.0704
Entamoeba histolytica protein kinase, putative 0.0124 0.0923 0.4049
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0667 0.1124
Echinococcus multilocularis 0.0167 0.1382 0.1665
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0117 0.0847 0.7974
Brugia malayi SRC-1 0.0137 0.1063 0.1152
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0084 0.0484 0.0867
Schistosoma mansoni growth factor receptor-bound protein 0.0051 0.0131 0.0221
Brugia malayi casein kinase I 0.0055 0.0168 0.0182
Schistosoma mansoni protein kinase 0.0078 0.0424 0.0714
Echinococcus granulosus glutamate receptor 2 0.0049 0.0102 0.0093
Schistosoma mansoni tyrosine kinase 0.0373 0.3609 0.6078
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0172 0.1436 0.1557
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0126 0.0945 0.4144
Brugia malayi Guanylyl cyclase protein 23 0.0078 0.0424 0.046
Echinococcus multilocularis carbonic anhydrase II 0.0259 0.2381 0.2877
Loa Loa (eye worm) hypothetical protein 0.0133 0.101 0.1095
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0473 0.2054
Echinococcus multilocularis N chimaerin 0.0061 0.0239 0.0279
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0259 0.2381 0.2581
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Schistosoma mansoni serine/threonine protein kinase 0.004 0.001 0.0016
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.0302 0.1236
Loa Loa (eye worm) hypothetical protein 0.0051 0.0131 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0945 0.1591
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0191 0.0842
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.0302 0.127
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0057 0.0191 0.1727
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.011 0.077 0.3457
Schistosoma mansoni adapter molecule crk 0.0051 0.0131 0.0221
Echinococcus multilocularis death associated protein kinase 1 0.0802 0.8253 1
Echinococcus granulosus twitchin 0.0107 0.0735 0.0726
Entamoeba histolytica casein kinase, putative 0.0055 0.0168 0.0704
Plasmodium falciparum calcium-dependent protein kinase 3 0.004 0.001 0.0005
Giardia lamblia Kinase, CMGC CDK 0.0101 0.0667 0.2932
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0097 0.0623 0.0675
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0279 0.1231
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0126 0.0945 0.0936
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0295 0.2768 0.3001
Echinococcus granulosus casein kinase I delta 0.0055 0.0168 0.0159
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0133 0.1012 0.1096
Loa Loa (eye worm) hypothetical protein 0.0059 0.0216 0.0234
Entamoeba histolytica protein kinase, putative 0.0249 0.2266 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0069 0.0326 0.0384
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0179 0.1519 0.1831
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Echinococcus multilocularis casein kinase i 0.0055 0.0168 0.0193
Echinococcus multilocularis serine:threonine protein kinase 3 0.0233 0.2102 0.2539
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0172 0.1436 0.1428
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.1798 0.3027
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.011 0.077 0.3232
Entamoeba histolytica PH domain containing protein kinase, putative 0.0142 0.1118 0.4911
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0168 0.0193
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.004 0.0009 0.001
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0247 0.2253 0.2442
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0945 0.1024
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.2813 0.4737
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0247 0.2253 0.946
Echinococcus multilocularis dual specificity mitogen activated protein 0.0247 0.2253 0.2722
Loa Loa (eye worm) hypothetical protein 0.0059 0.0216 0.0234
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Schistosoma mansoni protein kinase 0.0069 0.0326 0.0549
Brugia malayi P38 map kinase family protein 2 0.014 0.1086 0.1177
Plasmodium vivax calcium-dependent protein kinase, putative 0.004 0.001 0.0005
Entamoeba histolytica protein kinase , putative 0.0126 0.0945 0.4144
Echinococcus granulosus carbonic anhydrase 0.0059 0.0216 0.0207
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0137 0.1063 0.1055
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0205 0.1798 0.179
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0102 0.0172
Trypanosoma cruzi Protein kinase B 0.0142 0.1118 0.4693
Trichomonas vaginalis STE family protein kinase 0.0069 0.0326 0.1439
Trypanosoma cruzi aurora B kinase, putative 0.0126 0.0945 0.3967
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.1704 0.287
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0433 0.4263 0.516
Echinococcus multilocularis receptor type guanylyl cyclase 0.0078 0.0424 0.0503
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0263 0.0285
Echinococcus granulosus glycogen synthase kinase 3 beta 0.011 0.077 0.0761
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0111
Echinococcus granulosus tyrosine protein kinase Srms 0.0058 0.0205 0.0196
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Echinococcus granulosus cyclin dependent kinase 1 0.0101 0.0667 0.0658
Plasmodium falciparum serine/threonine protein kinase, putative 0.0126 0.0945 0.8898
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0259 0.2381 1
Echinococcus multilocularis protein kinase shaggy 0.011 0.077 0.0922
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.0302 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.041 0.181
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0137 0.106 0.1275
Echinococcus granulosus serine:threonine protein kinase 3 0.0233 0.2102 0.2095
Echinococcus granulosus ephrin type A receptor 4 A 0.0091 0.0564 0.0555
Loa Loa (eye worm) blistered cuticle protein 3 0.0063 0.0263 0.0285
Echinococcus multilocularis carbonic anhydrase 0.0059 0.0216 0.025
Trypanosoma cruzi cdc2-related kinase 3 0.0101 0.0667 0.2802
Brugia malayi STE20-like kinase MST 0.0233 0.2102 0.2279
Schistosoma mansoni nck2/grb4 0.0051 0.0131 0.0221
Loa Loa (eye worm) TK/INSR protein kinase 0.0416 0.4083 0.4425
Trichomonas vaginalis STE family protein kinase 0.0068 0.0312 0.1377
Onchocerca volvulus Chorion peroxidase homolog 0.0063 0.0263 0.0432
Schistosoma mansoni tyrosine kinase 0.0081 0.0453 0.0763
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0068 0.0312 0.1342
Echinococcus granulosus tyrosine protein kinase ABL1 0.0257 0.2362 0.2355
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0083 0.0473 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0191 0.0321
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0259 0.2381 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0241 0.218 0.2633
Loa Loa (eye worm) glutamate receptor 0.0203 0.1777 0.1926
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.041 0.0691
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0259 0.2381 0.2581
Brugia malayi Protein kinase domain containing protein 0.0065 0.0279 0.0302
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0058 0.0205 0.0868
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.014 0.1086 0.1177
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0945 0.4168
Echinococcus granulosus epidermal growth factor receptor 0.0373 0.3609 0.3603
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0057 0.0191 0.0801
Loa Loa (eye worm) hypothetical protein 0.0075 0.0388 0.042
Plasmodium falciparum calcium-dependent protein kinase 1 0.004 0.001 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1254 0.2112
Loa Loa (eye worm) hypothetical protein 0.0106 0.0723 0.0783
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0473 0.2086
Schistosoma mansoni protein kinase 0.0197 0.1713 0.2885
Echinococcus granulosus c src tyrosine kinase 0.0081 0.0453 0.0444
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0205 0.1798 0.2169
Brugia malayi Protein kinase domain containing protein 0.0416 0.4083 0.4425
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0172 0.1436 0.1557
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0085 0.0493 0.0587
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0065 0.0279 0.0302
Schistosoma mansoni protein kinase C mu 0.013 0.0979 0.1649
Leishmania major casein kinase II, putative 0.0083 0.0473 0.1954
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0945 0.4168
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1086 0.1307
Echinococcus granulosus nervana 2 0.0119 0.0862 0.0854
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0102 0.0113
Loa Loa (eye worm) hypothetical protein 0.0138 0.1069 0.1159
Onchocerca volvulus 0.0058 0.0205 0.0318
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0137 0.1063 0.1055
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0101 0.0667 0.0723
Loa Loa (eye worm) hypothetical protein 0.0051 0.0128 0.0139
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0703 0.1184
Schistosoma mansoni hypothetical protein 0.0059 0.0216 0.0363
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.0182
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0058 0.0205 0.0196
Schistosoma mansoni metabotropic glutamate receptor 0.0252 0.2303 0.3879
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0055 0.0168 0.0182
Brugia malayi Receptor family ligand binding region containing protein 0.0078 0.0424 0.046
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.0302 0.127
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0247 0.2253 0.9462
Schistosoma mansoni serine/threonine kinase 0.0077 0.041 0.0691
Echinococcus granulosus casein kinase i 0.0055 0.0168 0.0159
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.0706
Loa Loa (eye worm) hypothetical protein 0.0073 0.0363 0.0393
Brugia malayi metabotropic glutamate receptor type 2 0.0252 0.2303 0.2496
Brugia malayi Protein kinase domain containing protein 0.0124 0.0923 0.1
Leishmania major protein kinase, putative 0.0126 0.0945 0.3943
Trichomonas vaginalis AGC family protein kinase 0.0249 0.2266 1
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0155 0.1254 0.151
Echinococcus granulosus tyrosine kinase 0.0078 0.0424 0.0415
Loa Loa (eye worm) hypothetical protein 0.0058 0.0205 0.0222
Trypanosoma cruzi polo-like protein kinase, putative 0.0246 0.2242 0.9416
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0263 0.0285
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.0302 0.0356
Schistosoma mansoni ephrin receptor 0.0091 0.0564 0.095
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0058 0.02 0.0217
Loa Loa (eye worm) TK/EGFR protein kinase 0.0573 0.5774 0.6258
Echinococcus granulosus serine:threonine protein kinase 0.0096 0.0618 0.061
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.0096 0.0367
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0051 0.0131 0.0142
Giardia lamblia Kinase, AGC PKA 0.0137 0.106 0.4685
Schistosoma mansoni tyrosine kinase 0.0373 0.3609 0.6078
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0373 0.3609 0.3603
Echinococcus granulosus mitogen activated protein kinase 11 0.014 0.1086 0.1078
Trichomonas vaginalis AGC family protein kinase 0.0249 0.2266 1
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0133 0.1012 0.1216
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0302 0.127
Echinococcus multilocularis protein kinase c iota type 0.0237 0.2141 0.2586
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0137 0.1063 0.1278
Brugia malayi Stress-activated protein kinase jnk-1 0.0241 0.218 0.2362
Giardia lamblia Kinase, STE STE20 0.0247 0.2253 1
Echinococcus granulosus tyrosine protein kinase shark 0.0058 0.0205 0.0196
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0209 0.184 0.2221
Echinococcus granulosus tyrosine protein kinase Blk 0.0114 0.0815 0.0806
Giardia lamblia Kinase, NEK 0.0117 0.0847 0.3735
Schistosoma mansoni peroxidasin 0.0063 0.0263 0.0444
Echinococcus granulosus casein kinase I delta 0.0055 0.0168 0.0159
Brugia malayi Tyrosine-protein kinase abl-1 0.0123 0.0908 0.0984
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0083 0.0473 0.4409
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0191 0.0321
Echinococcus multilocularis protein kinase c epsilon type 0.0159 0.1292 0.1556
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0124 0.0923 0.1
Echinococcus granulosus peroxidasin 0.0097 0.063 0.0621
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0419 0.4108 0.4103
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.0706
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1254 0.2112
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.0302 0.0293
Plasmodium falciparum carbonic anhydrase 0.0059 0.0216 0.1964
Entamoeba histolytica protein kinase, putative 0.004 0.001 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Schistosoma mansoni atypical protein kinase C 0.0243 0.2204 0.3712
Loa Loa (eye worm) hypothetical protein 0.0096 0.0618 0.067
Plasmodium falciparum calcium-dependent protein kinase 4 0.004 0.001 0.0005
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0104 0.0703 0.2924
Schistosoma mansoni vav2 0.0067 0.0296 0.0499
Trypanosoma brucei protein kinase, putative 0.0067 0.0302 0.1236
Plasmodium falciparum NIMA related kinase 1 0.0117 0.0847 0.7974
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0246 0.2242 0.9413
Echinococcus granulosus roundabout 2 0.0109 0.0752 0.0743
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.0096 0.0405
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0102 0.0093
Trypanosoma cruzi cdc2-related kinase 3 0.0101 0.0667 0.2802
Trichomonas vaginalis AGC family protein kinase 0.0124 0.0923 0.4073
Brugia malayi Fibronectin type III domain containing protein 0.0075 0.0388 0.042
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Leishmania major protein kinase, putative 0.0068 0.0312 0.1277
Onchocerca volvulus Peroxidase homolog 0.0063 0.0263 0.0432
Trichomonas vaginalis AGC family protein kinase 0.013 0.098 0.4325
Loa Loa (eye worm) hypothetical protein 0.0075 0.0388 0.042
Brugia malayi Protein kinase domain containing protein 0.0058 0.0205 0.0222
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0172 0.1436 0.1557
Onchocerca volvulus 0.0058 0.0205 0.0318
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0061 0.0239 0.023
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0473 0.2086
Echinococcus granulosus serine:threonine protein kinase 0.0096 0.0618 0.061
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0073 0.0363 0.0611
Entamoeba histolytica protein kinase, putative 0.0069 0.0326 0.1404
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0168 0.0193
Toxoplasma gondii aurora kinase 0.0126 0.0945 0.4252
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0137 0.1063 0.1278
Echinococcus granulosus GPCR family 3 C terminal 0.0084 0.0484 0.0475
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0302 0.1335
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.2242 0.9895
Loa Loa (eye worm) AGC/AKT protein kinase 0.0249 0.2266 0.2456
Loa Loa (eye worm) animal heme peroxidase 0.008 0.0437 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.1012 0.1704
Toxoplasma gondii AGC kinase 0.0243 0.2209 1
Entamoeba histolytica hypothetical protein 0.0104 0.0703 0.3073
Schistosoma mansoni hypothetical protein 0.0059 0.0212 0.0357
Onchocerca volvulus 0.0117 0.0838 0.1564
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0945 0.1024
Echinococcus multilocularis tyrosine protein kinase shark 0.0058 0.0205 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0249 0.2266 1
Brugia malayi serine/threonine protein kinase 6 0.0126 0.0945 0.1024
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0923 0.1554
Echinococcus multilocularis roundabout 2 0.0109 0.0752 0.0901
Brugia malayi Protein kinase domain containing protein 0.0077 0.041 0.0445
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0209 0.184 0.1833
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0101 0.0667 0.2773
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0473 0.2086
Onchocerca volvulus 0.0063 0.0263 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.1704 0.287
Echinococcus granulosus protein kinase shaggy 0.011 0.077 0.0761
Onchocerca volvulus 0.0058 0.0205 0.0318
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0137 0.1063 0.1278
Brugia malayi Animal haem peroxidase family protein 0.008 0.0437 0.0474
Onchocerca volvulus Tyrosine kinase homolog 0.0512 0.5123 1
Leishmania major protein kinase A catalytic subunit 0.0057 0.0191 0.0765
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.018 0.1519 0.1647
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0102 0.0113
Loa Loa (eye worm) RGC/RGC protein kinase 0.0078 0.0424 0.046
Echinococcus multilocularis nervana 2 0.0119 0.0862 0.1035
Schistosoma mansoni tyrosine kinase 0.006 0.0224 0.0378
Brugia malayi Protein kinase domain containing protein 0.0168 0.1391 0.1508
Brugia malayi Protein kinase domain containing protein 0.0058 0.0205 0.0222
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0243 0.2209 0.2394
Brugia malayi Protein kinase domain containing protein 0.0058 0.0205 0.0222
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0059 0.0216 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0249 0.2266 1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Schistosoma mansoni tyrosine kinase 0.0343 0.3287 0.5535
Schistosoma mansoni tyrosine kinase 0.0416 0.4083 0.6876
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.2242 0.9895
Trypanosoma brucei casein kinase I, isoform 2 0.0055 0.0168 0.067
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.014 0.1086 0.4541
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0747 0.1258
Echinococcus granulosus Protein kinase C brain isozyme 0.0197 0.1704 0.1697
Echinococcus granulosus metabotropic glutamate receptor 2 0.0433 0.4263 0.4258
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.004 0.001 0.0002
Entamoeba histolytica protein kinase, putative 0.0041 0.0023 0.0061
Echinococcus granulosus tyrosine protein kinase HCK 0.0086 0.0508 0.0499
Plasmodium falciparum calcium-dependent protein kinase 2 0.004 0.001 0.0005
Echinococcus multilocularis tyrosine protein kinase Abl 0.0157 0.1278 0.1539
Schistosoma mansoni tyrosine kinase 0.0058 0.0205 0.0345
Brugia malayi protein kinase C3,putative 0.0131 0.0992 0.1076
Trypanosoma brucei cdc2-related kinase 3 0.0101 0.0667 0.2773
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.004 0.001 0.0011
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0246 0.2242 0.2235
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0059 0.0216 0.0234
Echinococcus granulosus dual specificity mitogen activated protein 0.0247 0.2253 0.2246
Trichomonas vaginalis CAMK family protein kinase 0.004 0.001 0.0043
Loa Loa (eye worm) glutamate receptor 0.0517 0.5171 0.5605
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0133 0.1012 0.1096
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0124 0.0923 0.1108
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1086 0.1307
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0114 0.0815 0.0806
Echinococcus multilocularis growth factor receptor bound protein 2 0.0051 0.0131 0.0148
Brugia malayi map kinase activated protein kinase protein 2 0.0365 0.3531 0.3827
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0137 0.1063 0.1278
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.1292 0.2176
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0073 0.0363 0.0611
Loa Loa (eye worm) hypothetical protein 0.0071 0.0344 0.0373
Loa Loa (eye worm) hypothetical protein 0.0078 0.0425 0.0461
Schistosoma mansoni tyrosine kinase 0.022 0.196 0.33
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0057 0.0191 0.0207
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0137 0.1063 0.1278
Brugia malayi p70 ribosomal S6 kinase beta 0.0243 0.2209 0.2394
Brugia malayi serine/threonine-protein kinase plk-2 0.0246 0.2242 0.243
Plasmodium falciparum casein kinase 1 0.0055 0.0168 0.1511
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0365 0.3531 0.3827
Loa Loa (eye worm) hypothetical protein 0.0106 0.0727 0.0788
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0055 0.0168 0.0159
Loa Loa (eye worm) TK/EPH protein kinase 0.0108 0.0746 0.0809
Loa Loa (eye worm) TK protein kinase 0.0114 0.0815 0.0883
Echinococcus multilocularis carbonic anhydrase 0.0059 0.0216 0.025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0111
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.004 0.001 0.0002
Brugia malayi Protein kinase domain containing protein 0.0172 0.1436 0.1557
Schistosoma mansoni protein kinase 0.004 0.001 0.0016
Loa Loa (eye worm) SRC-1 0.0137 0.1063 0.1152
Echinococcus granulosus protein kinase c iota type 0.0237 0.2141 0.2134
Echinococcus granulosus aurora kinase A 0.0126 0.0945 0.0936
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0473 0.2086
Schistosoma mansoni hypothetical protein 0.0059 0.0212 0.0357
Brugia malayi Receptor family ligand binding region containing protein 0.0133 0.101 0.1095
Loa Loa (eye worm) hypothetical protein 0.0133 0.1019 0.1105
Trypanosoma cruzi casein kinase II, putative 0.0083 0.0473 0.1985
Onchocerca volvulus 0.0062 0.0242 0.039
Brugia malayi Protein kinase domain containing protein 0.0249 0.2266 0.2456
Echinococcus multilocularis Glutaredoxin protein 5 0.0119 0.0862 0.1035
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0703 0.3073
Schistosoma mansoni tyrosine kinase 0.0078 0.0424 0.0714
Loa Loa (eye worm) carbonic anhydrase 3 0.0259 0.2381 0.2581
Brugia malayi hypothetical protein 0.0075 0.0388 0.042
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0057 0.0191 0.0801
Entamoeba histolytica cell division protein kinase 2, putative 0.0101 0.0667 0.2915
Echinococcus granulosus tyrosine protein kinase Src42A 0.0137 0.1063 0.1055
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0249 0.2266 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.0302 0.0356
Echinococcus granulosus casein kinase I alpha 0.0055 0.0168 0.0159
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0636 0.6464 0.783
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0746 0.3292
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.0302 0.0328
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0247 0.2253 0.946
Echinococcus granulosus NCK adaptor protein 0.0051 0.0131 0.0122
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0051 0.0131 0.0142
Leishmania major carbonic anhydrase-like protein 0.0259 0.2381 1
Brugia malayi hypothetical protein 0.0049 0.0102 0.0111
Brugia malayi protein kinase C II. 0.0159 0.1292 0.14
Brugia malayi putative serine/threonine kinase SADA gamma 0.004 0.0009 0.001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0102 0.0113
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0126 0.0945 0.1135
Trichomonas vaginalis AGC family protein kinase 0.0124 0.0923 0.4073
Schistosoma mansoni protein kinase 0.0055 0.0168 0.0283
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0104 0.0703 0.0762
Onchocerca volvulus 0.0299 0.2813 0.5451
Loa Loa (eye worm) hypothetical protein 0.0073 0.0363 0.0393
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0365 0.3531 0.4272
Echinococcus multilocularis hypothetical protein 0.0059 0.0212 0.0246
Brugia malayi Protein kinase domain 0.0069 0.0326 0.0354
Entamoeba histolytica protein kinase, putative 0.0054 0.0158 0.0658
Trichomonas vaginalis STE family protein kinase 0.0117 0.0847 0.374
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0102 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Schistosoma mansoni carbonic anhydrase-related 0.0059 0.0216 0.0363
Schistosoma mansoni kinase 0.0264 0.2434 0.4099
Echinococcus multilocularis fibroblast growth factor receptor 4 0.022 0.196 0.2366
Schistosoma mansoni hypothetical protein 0.0084 0.0484 0.0816
Brugia malayi casein kinase 1, delta 0.0055 0.0168 0.0182
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0473 0.2086
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0263 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0249 0.2266 1
Echinococcus multilocularis tyrosine kinase 0.0078 0.0424 0.0503
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.011 0.077 0.0922
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.2242 0.9895
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0055 0.0168 0.0159
Leishmania major casein kinase, putative 0.0055 0.0168 0.067
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0047 0.0081 0.032
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.0133 0.1019 0.1105
Echinococcus granulosus Glutaredoxin protein 5 0.0119 0.0862 0.0854
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Plasmodium vivax unspecified product 0.0083 0.0473 0.4409
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0101 0.0667 0.0723
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0168 0.0742
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011 0.077 0.0834
Brugia malayi intracellular kinase 0.011 0.077 0.0834
Schistosoma mansoni tyrosine kinase 0.0137 0.1063 0.179
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0104 0.0703 0.2952
Loa Loa (eye worm) hypothetical protein 0.009 0.0553 0.0599
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.004 0.001 0.0005
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0078 0.0424 0.0749
Echinococcus granulosus serine:threonine protein kinase N2 0.0124 0.0923 0.0915
Loa Loa (eye worm) hypothetical protein 0.0086 0.0505 0.0547
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.009 0.0553 0.0544
Entamoeba histolytica protein kinase, putative 0.0126 0.0945 0.4144
Echinococcus granulosus epidermal growth factor receptor 0.0573 0.5774 0.577
Schistosoma mansoni tyrosine kinase 0.0081 0.0453 0.0763
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0102 0.0113
Loa Loa (eye worm) hypothetical protein 0.0086 0.0505 0.0547
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0168 0.0284
Brugia malayi RhoGAP domain containing protein 0.0061 0.0239 0.0259
Echinococcus granulosus insulin receptor 0.0416 0.4083 0.4078
Plasmodium vivax protein kinase Crk2 0.0101 0.0667 0.6259
Schistosoma mansoni tyrosine kinase 0.0078 0.0424 0.0714
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0048 0.0096 0.0396
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0263 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Schistosoma mansoni protein kinase 0.0048 0.0101 0.017
Echinococcus granulosus carbonic anhydrase 0.0059 0.0216 0.0207
Schistosoma mansoni serine/threonine-protein kinase 0.0142 0.1118 0.1882
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0126 0.0945 0.4144
Entamoeba histolytica protein kinase, putative 0.0126 0.0945 0.4144
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0069 0.0326 0.0384
Trypanosoma cruzi cdc2-related kinase 1 0.0101 0.0667 0.2802
Loa Loa (eye worm) AGC/PKN protein kinase 0.0124 0.0923 0.1
Leishmania major protein kinase, putative 0.004 0.001 0.0002
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.011 0.077 0.3206
Brugia malayi hypothetical protein 0.0063 0.0263 0.0285
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1086 0.4562
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0137 0.1056 0.1144
Entamoeba histolytica protein kinase, putative 0.0055 0.0168 0.0705
Brugia malayi Casein kinase II, alpha chain 0.0083 0.0473 0.0512
Echinococcus granulosus raf serine:threonine protein kinase 0.0063 0.0254 0.0245
Echinococcus granulosus nervana 2 0.0119 0.0862 0.0854
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0137 0.1063 0.1278
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0069 0.0326 0.0384
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.004 0.001 0.0005
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0096 0.0618 0.067
Loa Loa (eye worm) AGC/PKA protein kinase 0.0057 0.0191 0.0207
Echinococcus multilocularis casein kinase I delta 0.0055 0.0168 0.0193
Toxoplasma gondii AGC kinase 0.0057 0.0191 0.0825
Echinococcus multilocularis serine:threonine protein kinase N2 0.0124 0.0923 0.1108
Onchocerca volvulus Peroxidasin homolog 0.008 0.0437 0.0775
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0667 0.2944
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0057 0.0191 0.0825
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0061 0.0239 0.0403
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0172 0.1436 0.1731
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0945 0.1024
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0168 0.0283
Echinococcus multilocularis tyrosine protein kinase HCK 0.0086 0.0508 0.0605
Brugia malayi Immunoglobulin I-set domain containing protein 0.0587 0.5926 0.6423
Plasmodium vivax glycogen synthase kinase 3, putative 0.011 0.077 0.7235
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0114 0.0815 0.0977
Echinococcus granulosus defective proboscis extension response 0.0073 0.0363 0.0354
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0101 0.0667 0.0723
Onchocerca volvulus 0.0281 0.2614 0.5061
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.0945 0.4144
Echinococcus granulosus casein kinase I alpha 0.0055 0.0168 0.0159
Echinococcus granulosus tyrosine kinase 0.0058 0.0205 0.0196
Echinococcus multilocularis serine:threonine protein kinase 0.0096 0.0618 0.0739
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0046 0.0072 0.0076
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.022 0.196 0.1952
Echinococcus granulosus carbonic anhydrase 0.0059 0.0216 0.0207
Echinococcus granulosus casein kinase I alpha 0.0055 0.0168 0.0159
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0084 0.0484 0.0525
Giardia lamblia Kinase, PLK 0.0246 0.2242 0.9951
Echinococcus multilocularis PAK box P21 Rho binding 0.0048 0.0101 0.0111
Plasmodium falciparum calcium-dependent protein kinase 5 0.004 0.001 0.0005
Echinococcus granulosus fibroblast growth factor receptor 4 0.022 0.196 0.1952
Echinococcus multilocularis epidermal growth factor receptor 0.0573 0.5774 0.6992
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.0258 0.2366 0.2564
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.0302 0.1307
Loa Loa (eye worm) hypothetical protein 0.0106 0.0727 0.0788
Brugia malayi protein-tyrosine kinase 0.0114 0.0815 0.0883
Echinococcus multilocularis tyrosine kinase 0.0058 0.0205 0.0238
Trypanosoma brucei cdc2-related kinase 1 0.0101 0.0667 0.2773
Trypanosoma brucei Casein kinase II 0.0083 0.0473 0.1954
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0279 0.1231
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1086 0.4562
Onchocerca volvulus Dual oxidase homolog 0.0063 0.0263 0.0432
Schistosoma mansoni protein kinase 0.0197 0.1713 0.2885
Echinococcus multilocularis dual specificity 0.0104 0.0703 0.0841
Trypanosoma cruzi SNF1-related protein kinases, putative 0.004 0.0009 0.0039
Schistosoma mansoni nephrin 0.0091 0.0562 0.0946
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0065 0.0279 0.0327
Loa Loa (eye worm) AGC/NDR protein kinase 0.0124 0.0923 0.1
Entamoeba histolytica protein kinase, putative 0.0065 0.0279 0.1195
Echinococcus granulosus serine threonine protein kinase nrc 0.0137 0.106 0.1052
Schistosoma mansoni tyrosine kinase 0.0186 0.1592 0.2681
Echinococcus granulosus Immunoglobulin 0.0073 0.0363 0.0354
Onchocerca volvulus 0.0133 0.1019 0.1921
Giardia lamblia Kinase, NEK 0.0117 0.0847 0.3735
Toxoplasma gondii AGC kinase 0.0057 0.0191 0.0825
Giardia lamblia Kinase, CMGC CK2 0.0083 0.0473 0.2066
Schistosoma mansoni cell adhesion molecule 0.0093 0.0578 0.0973
Loa Loa (eye worm) TK protein kinase 0.0236 0.2134 0.2313
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Onchocerca volvulus 0.0058 0.0205 0.0318
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0588 0.5938 1
Echinococcus granulosus cyclin dependent kinase 5 0.0101 0.0667 0.0658
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.013 0.0979 0.1061
Echinococcus multilocularis cyclin dependent kinase 0.0101 0.0667 0.0798
Brugia malayi phosphoinositide-dependent protein kinase I 0.0065 0.0279 0.0302
Leishmania major protein kinase, putative 0.0048 0.0096 0.0367
Plasmodium falciparum casein kinase 2, alpha subunit 0.0083 0.0473 0.4409
Onchocerca volvulus 0.011 0.077 0.1429
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Loa Loa (eye worm) TK protein kinase 0.0086 0.0508 0.055
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.0706
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0472 0.0796
Brugia malayi Blistered cuticle protein 3 0.0063 0.0263 0.0285
Entamoeba histolytica hypothetical protein 0.0049 0.0102 0.0412
Loa Loa (eye worm) hypothetical protein 0.0059 0.0212 0.023
Loa Loa (eye worm) hypothetical protein 0.004 0.001 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.004 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0101 0.0667 0.0658
Onchocerca volvulus 0.0078 0.0424 0.0749
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0419 0.4108 0.4972
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0205 0.1798 0.1948
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0168 0.0193
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0241 0.218 0.2362
Brugia malayi C1-like domain containing protein 0.013 0.0979 0.1061
Echinococcus multilocularis serine threonine protein kinase 0.0164 0.1348 0.1624
Schistosoma mansoni vesicular amine transporter 0.0073 0.0363 0.0611
Echinococcus granulosus metabotropic glutamate receptor 5 0.0636 0.6464 0.6461
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0099 0.0649 0.0704
Trypanosoma brucei aurora B kinase 0.0126 0.0945 0.3943
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.004 0.001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.041 0.0691
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0259 0.2381 0.401
Schistosoma mansoni tyrosine kinase 0.0229 0.2055 0.3461
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0054 0.0164 0.0177
Brugia malayi Tyrosine-protein kinase abl-1 0.0157 0.1278 0.1385
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0102 0.0093
Echinococcus granulosus tyrosine protein kinase Lyn 0.0156 0.1261 0.1253
Schistosoma mansoni metabotropic glutamate receptor 0.0433 0.4263 0.7179
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0069 0.0326 0.0317
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0302 0.127
Echinococcus multilocularis Immunoglobulin 0.0073 0.0363 0.0429
Entamoeba histolytica protein kinase, putative 0.0243 0.2209 0.9747
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0137 0.1063 0.1278
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0102 0.0093
Echinococcus granulosus glutamate receptor 2 0.0049 0.0102 0.0093
Brugia malayi Temporarily assigned gene name protein 59 0.0124 0.0918 0.0995
Loa Loa (eye worm) RGC/RGC protein kinase 0.0078 0.0424 0.046
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0049 0.0102 0.0111
Echinococcus multilocularis peroxidasin 0.0097 0.063 0.0753
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0126 0.0945 0.4144
Brugia malayi Cam kinase protein 1 0.004 0.001 0.0011
Echinococcus granulosus tyrosine kinase 0.0114 0.0815 0.0806
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.004 0.001 0.0011
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.0182
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0108 0.0747 0.0895
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0124 0.0923 0.0915
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0061 0.0239 0.0259
Echinococcus granulosus c-Jun N-terminal kinases 0.0241 0.218 0.2172
Onchocerca volvulus Peroxidase homolog 0.0063 0.0263 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0124 0.0923 0.4073
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0892 0.9227 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1086 0.1307
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0059 0.0216 0.0234
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0077 0.041 0.0445
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0133 0.101 0.1095
Brugia malayi Peroxidasin 0.0097 0.063 0.0683
Echinococcus multilocularis carbonic anhydrase 0.0059 0.0216 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0365 0.3531 0.5946
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0239 0.0259
Brugia malayi Metabotropic glutamate receptor precursor. 0.0517 0.5171 0.5605
Entamoeba histolytica p21-activated kinase 0.0075 0.0383 0.1658
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0101 0.0667 0.2991
Trichomonas vaginalis CMGC family protein kinase 0.011 0.077 0.3397
Toxoplasma gondii CMGC kinase, CK2 family 0.0083 0.0473 0.2107
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0302 0.0509
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0061 0.0239 0.0403
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0055 0.0168 0.0182
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0179 0.1519 0.1511
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.0706
Echinococcus granulosus atrial natriuretic peptide receptor 0.0049 0.0102 0.0093
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0133 0.101 0.1095
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0945 0.4168
Brugia malayi MAP kinase sur-1 0.0067 0.0302 0.0328
Schistosoma mansoni protein kinase 0.0126 0.0945 0.1591
Loa Loa (eye worm) hypothetical protein 0.0075 0.0388 0.042
Entamoeba histolytica protein kinase, putative 0.0047 0.0081 0.032
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0667 0.2944
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0055 0.0168 0.0193
Echinococcus multilocularis epidermal growth factor receptor 0.0373 0.3609 0.4366
Loa Loa (eye worm) hypothetical protein 0.0078 0.0425 0.0461
Echinococcus granulosus casein kinase ii subunit alpha 0.0083 0.0473 0.0464
Loa Loa (eye worm) hypothetical protein 0.0078 0.0424 0.046
Entamoeba histolytica PH domain containing protein kinase, putative 0.0142 0.1118 0.4911
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0923 0.1554
Echinococcus multilocularis tyrosine protein kinase Blk 0.0114 0.0815 0.0977
Schistosoma mansoni protein kinase 0.0069 0.0326 0.0549
Echinococcus multilocularis serine:threonine protein kinase 0.0096 0.0618 0.0739
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.2242 0.9895
Echinococcus granulosus tyrosine protein kinase Fyn 0.0137 0.1063 0.1055
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0055 0.0168 0.0193
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0246 0.2242 0.9895
Onchocerca volvulus 0.0058 0.0205 0.0318
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0747 0.1258
Schistosoma mansoni tyrosine kinase 0.0573 0.5774 0.9723
Schistosoma mansoni carbonic anhydrase-related 0.0059 0.0216 0.0363
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0142 0.1118 0.4693
Entamoeba histolytica protein kinase, putative 0.0086 0.0508 0.2209
Loa Loa (eye worm) hypothetical protein 0.0062 0.0242 0.0262
Brugia malayi Protein kinase domain containing protein 0.0165 0.1367 0.1482
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0059 0.0216 0.0234
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0057 0.0191 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0137 0.106 0.1052
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0057 0.0191 0.0765
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011 0.077 0.0834
Trichomonas vaginalis STE family protein kinase 0.0069 0.0326 0.1439
Echinococcus granulosus calcium activated potassium channel 0.0077 0.041 0.0401
Loa Loa (eye worm) hypothetical protein 0.0111 0.0781 0.0846
Plasmodium falciparum glycogen synthase kinase 3 0.011 0.077 0.7235
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Schistosoma mansoni protein kinase 0.0048 0.0096 0.0162
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.004 0.001 0.0002
Echinococcus multilocularis Immunoglobulin 0.0073 0.0363 0.0429
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0106 0.0725 0.3198
Echinococcus multilocularis casein kinase ii subunit alpha 0.0083 0.0473 0.0562
Onchocerca volvulus 0.0078 0.0425 0.075
Echinococcus granulosus neuroglian 0.0089 0.0537 0.0528
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0102 0.0113
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1086 0.1307
Brugia malayi Protein kinase domain containing protein 0.0104 0.0703 0.0762
Loa Loa (eye worm) hypothetical protein 0.0063 0.0263 0.0285
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0247 0.2253 0.2442
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0049 0.0102 0.0113
Giardia lamblia Kinase, CMGC GSK 0.011 0.077 0.3389
Brugia malayi Variant SH3 domain containing protein 0.0051 0.0131 0.0142
Schistosoma mansoni carbonic anhydrase 0.0059 0.0216 0.0363
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0667 0.1124
Entamoeba histolytica protein kinase, putative 0.0104 0.0703 0.3073
Brugia malayi Protein kinase c protein 2 0.0091 0.0556 0.0602
Schistosoma mansoni tyrosine kinase 0.0416 0.4083 0.6876
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Leishmania major protein kinase A catalytic subunit isoform 1 0.0057 0.0191 0.0765
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.0302 0.1236
Entamoeba histolytica serine/threonine protein kinase, putative 0.0246 0.2242 0.9894
Echinococcus multilocularis nervana 2 0.0119 0.0862 0.1035
Giardia lamblia Kinase, STE STE20 0.0068 0.0312 0.1349
Trypanosoma brucei carbonic anhydrase-like protein 0.0259 0.2381 1
Trichomonas vaginalis STE family protein kinase 0.0247 0.2253 0.9943
Plasmodium vivax casein kinase 1, putative 0.0055 0.0168 0.1511
Echinococcus multilocularis rho associated protein kinase 0.0299 0.2813 0.34
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0124 0.0923 0.0915
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0155 0.1254 0.1246
Schistosoma mansoni tyrosine kinase 0.0343 0.3287 0.5535
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Entamoeba histolytica protein kinase 2, putative 0.0137 0.106 0.4658
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0128 0.0564
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Echinococcus granulosus nmda type glutamate receptor 0.0049 0.0102 0.0093
Echinococcus granulosus tyrosine protein kinase Fyn 0.0137 0.1063 0.1055
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Trypanosoma brucei protein kinase, putative 0.011 0.077 0.3206
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0263 0.0285
Brugia malayi cell division control protein 2 homolog 0.0101 0.0667 0.0723
Schistosoma mansoni tyrosine kinase 0.0063 0.0262 0.0442
Entamoeba histolytica protein kinase, putative 0.0249 0.2266 1
Echinococcus multilocularis NCK adaptor protein 0.0051 0.0131 0.0148
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0473 0.2086
Entamoeba histolytica protein kinase, putative 0.0055 0.0168 0.0705
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0065 0.0279 0.027
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.1436 0.2419
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0057 0.0191 0.0765
Trichomonas vaginalis STE family protein kinase 0.0069 0.0326 0.1439
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0205 0.0222
Toxoplasma gondii casein kinase I 0.0055 0.0168 0.0722
Loa Loa (eye worm) hypothetical protein 0.0133 0.1019 0.1105
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.0302 0.1333
Echinococcus granulosus tyrosine protein kinase Src64B 0.0137 0.1063 0.1055
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0923 0.1554
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0302 0.1335
Brugia malayi serine/threonine kinase 12 0.0126 0.0945 0.1024
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0473 0.2086
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0263 0.0285
Echinococcus multilocularis neuroglian 0.0089 0.0537 0.064
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.0009 0.0039
Trypanosoma brucei protein kinase, putative 0.0048 0.0096 0.0367
Echinococcus multilocularis tyrosine protein kinase Srms 0.0114 0.0815 0.0977

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.12 uM Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production ChEMBL. 23353741
IC50 (functional) = 10.44 uM Antitumor activity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay ChEMBL. 23353741
IC50 (functional) = 12.65 uM Antitumor activity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay ChEMBL. 23353741
IC50 (binding) = 15.09 uM Inhibition of COX-2 (unknown origin) by chemiluminescence assay ChEMBL. 23353741
IC50 (binding) > 50 uM Inhibition of COX-1 (unknown origin) by chemiluminescence assay ChEMBL. 23353741

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23353741
Mus musculus ChEMBL23 23353741

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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