TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.354 | Formula: C16H25N2O5P
H donors: 1 H acceptors: 2 LogP: 1.89 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOP(=O)([C@@H]1C[C@@H](ON1C)C(=O)Nc1ccc(cc1)C)OCC
InChi: 1S/C16H25N2O5P/c1-5-21-24(20,22-6-2)15-11-14(23-18(15)4)16(19)17-13-9-7-12(3)8-10-13/h7-10,14-15H,5-6,11H2,1-4H3,(H,17,19)/t14-,15-/m1/s1
InChiKey: DBZFIKFTEDSEIC-HUUCEWRRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0463	0.6951	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0194	0.2311	0.2802
Loa Loa (eye worm)	lethal protein 805	0.0134	0.1272	0.1405
Echinococcus granulosus	Immunoglobulin	0.0329	0.4636	0.4626
Loa Loa (eye worm)	CAMK/CAMKL/NUAK protein kinase	0.0512	0.7794	1
Echinococcus multilocularis	peroxidasin	0.0073	0.021	0.0233
Brugia malayi	Peroxidasin	0.0073	0.021	0.0005
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0061	0.0019	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0206	0.252	0.2506
Echinococcus granulosus	roundabout 2	0.0206	0.252	0.2506
Schistosoma mansoni	cell adhesion molecule	0.0169	0.1878	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Echinococcus granulosus	hemicentin 1	0.0072	0.0206	0.0188
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0134	0.1272	0.1405
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0095	0.0602	0.0588
Echinococcus granulosus	Fibronectin type III	0.0134	0.1272	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1878	0.2203
Schistosoma mansoni	nephrin	0.0498	0.7557	0.9951
Echinococcus multilocularis	tyrosine protein kinase otk	0.0072	0.0206	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0329	0.4636	0.5839
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0134	0.1272	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0134	0.1272	1
Schistosoma mansoni	hypothetical protein	0.0169	0.1878	0.2454
Schistosoma mansoni	hypothetical protein	0.0134	0.1272	0.1654
Brugia malayi	Lethal protein 805	0.0134	0.1272	0.158
Brugia malayi	Fibronectin type III domain containing protein	0.0134	0.1272	0.158
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0171	0.1915	0.2533
Echinococcus multilocularis	Immunoglobulin	0.0329	0.4636	0.5644
Loa Loa (eye worm)	TK protein kinase	0.0095	0.0602	0.0522
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0169	0.1878	0.2203
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0169	0.1878	0.2479
Echinococcus granulosus	anosmin 1	0.0134	0.1272	0.1255
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0134	0.1272	0.1654
Echinococcus multilocularis	anosmin 1	0.0134	0.1272	0.1532
Brugia malayi	Fibronectin type III domain containing protein	0.0134	0.1272	0.158
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0206	0.252	0.3058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0206	0.252	0.3058
Echinococcus granulosus	defective proboscis extension response	0.0329	0.4636	0.4626
Loa Loa (eye worm)	hypothetical protein	0.0463	0.6951	0.8889
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0171	0.1915	0.2317
Brugia malayi	Protein kinase domain containing protein	0.0168	0.186	0.2453
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0072	0.0206	0.0229
Echinococcus granulosus	titin	0.017	0.19	0.1885
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Brugia malayi	Fibronectin type III domain containing protein	0.0134	0.1272	0.158
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0169	0.1878	0.2479
Onchocerca volvulus		0.0134	0.1272	0.6292
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0134	0.1272	0.1654
Schistosoma mansoni	myosin-binding protein-related	0.0169	0.1878	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0463	0.6951	0.8889
Echinococcus granulosus	Netrin receptor DCC	0.0134	0.1272	0.1255
Brugia malayi	Protein-tyrosine phosphatase	0.0134	0.1272	0.158
Schistosoma mansoni	factor for adipocyte differentiation	0.0134	0.1272	0.1654
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0169	0.1878	0.2479
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0072	0.0206	0.0247
Echinococcus granulosus	usherin	0.0134	0.1272	0.1255
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0206	0.252	0.305
Echinococcus multilocularis	usherin	0.0134	0.1272	0.1532
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0134	0.1272	0.1255
Loa Loa (eye worm)	myotactin form A	0.0134	0.1272	0.1405
Schistosoma mansoni	hemicentin	0.0169	0.1878	0.2454
Echinococcus granulosus	STE20 serine:threonine protein kinase	0.0483	0.7294	0.7289
Onchocerca volvulus		0.0169	0.1878	0.9868
Echinococcus granulosus	contactin	0.0206	0.252	0.2506
Loa Loa (eye worm)	projectin	0.0169	0.1878	0.2203
Echinococcus granulosus	roundabout 2	0.0535	0.8199	0.8196
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0169	0.1878	0.2203
Echinococcus granulosus	neuroglian	0.0364	0.5242	0.5233
Echinococcus multilocularis	titin	0.0134	0.1272	0.1532
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0206	0.252	0.3432
Loa Loa (eye worm)	TK/ROR protein kinase	0.0095	0.0602	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Plasmodium falciparum	protein kinase, putative	0.0061	0.0019	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0134	0.1272	0.1255
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.017	0.19	0.2233
Echinococcus granulosus	neuroglian	0.0206	0.252	0.2506
Brugia malayi	SPRY domain containing protein	0.0134	0.1272	0.158
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.19	0.2484
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0169	0.1878	0.2203
Echinococcus granulosus	titin	0.017	0.19	0.1885
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0169	0.1878	0.2479
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0206	0.252	0.3058
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0463	0.6951	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0208	0.2543	0.308
Echinococcus multilocularis	anosmin 1	0.0134	0.1272	0.1532
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0134	0.1272	0.1255
Echinococcus multilocularis	cell adhesion molecule	0.0134	0.1272	0.1532
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0134	0.1272	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0095	0.0602	0.0585
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0171	0.1915	0.2252
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0134	0.1272	0.158
Onchocerca volvulus		0.0169	0.1878	0.9868
Brugia malayi	hypothetical protein	0.0134	0.1272	0.158
Echinococcus multilocularis	Netrin receptor DCC	0.0134	0.1272	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0134	0.1272	0.1532
Onchocerca volvulus		0.0134	0.1272	0.6292
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0134	0.1272	0.1532
Onchocerca volvulus		0.0134	0.1272	0.6292
Schistosoma mansoni	neuroglian	0.0206	0.252	0.3303
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0134	0.1272	0.1532
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0426	0.6318	0.9062
Loa Loa (eye worm)	UNCoordinated family member	0.0134	0.1272	0.1405
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0206	0.252	0.3432
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0206	0.252	0.3303
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0134	0.1272	0.1405
Echinococcus granulosus	anosmin 1	0.0134	0.1272	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0401	0.5885	0.7485
Echinococcus granulosus	EG95	0.0134	0.1272	0.1255
Brugia malayi	myotactin form A	0.0134	0.1272	0.158
Onchocerca volvulus		0.0134	0.1272	0.6292
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0169	0.1878	0.1863
Schistosoma mansoni	factor for adipocyte differentiation	0.0134	0.1272	0.1654
Echinococcus multilocularis	hemicentin 1	0.0072	0.0206	0.0229
Onchocerca volvulus		0.017	0.19	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Echinococcus multilocularis	hemicentin 1	0.0072	0.0206	0.0229
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0171	0.1915	0.1899
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0134	0.1272	0.1654
Brugia malayi	Lethal protein 805	0.0134	0.1272	0.158
Echinococcus granulosus	twitchin	0.0365	0.5264	0.5256
Onchocerca volvulus		0.0134	0.1272	0.6292
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Schistosoma mansoni	cell adhesion molecule	0.0206	0.252	0.3303
Schistosoma mansoni	titin	0.017	0.19	0.2484
Schistosoma mansoni	vesicular amine transporter	0.0329	0.4636	0.6096
Loa Loa (eye worm)	CAMK protein kinase	0.017	0.19	0.2233
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.19	0.2512
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0329	0.4636	0.6096
Echinococcus granulosus	cell adhesion molecule	0.0134	0.1272	0.1255
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0134	0.1272	0.1405
Schistosoma mansoni	roundabout	0.0072	0.0206	0.0247
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0426	0.6318	0.8055
Schistosoma mansoni	titin	0.0134	0.1272	0.1654
Brugia malayi	myotactin form B	0.0134	0.1272	0.158
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0134	0.1272	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1878	0.2203
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0134	0.1272	0.1532
Echinococcus multilocularis	transfer RNA-Phe	0.0169	0.1878	0.2272
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0366	0.5279	0.527
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Schistosoma mansoni	factor for adipocyte differentiation	0.0134	0.1272	0.1654
Echinococcus multilocularis	neuroglian	0.0206	0.252	0.3058
Echinococcus granulosus	lachesin	0.0072	0.0206	0.0188
Leishmania major	hypothetical protein, conserved	0.0134	0.1272	1
Echinococcus granulosus	Netrin receptor DCC	0.0134	0.1272	0.1255
Schistosoma mansoni	tyrosine kinase	0.0132	0.1245	0.1619
Echinococcus granulosus	G1Y162 protein	0.0134	0.1272	0.1255
Schistosoma mansoni	septate junction protein	0.0072	0.0206	0.0247
Echinococcus multilocularis	Netrin receptor DCC	0.0134	0.1272	0.1532
Brugia malayi	protein unc-22	0.017	0.19	0.2512
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Schistosoma mansoni	cell adhesion molecule	0.0206	0.252	0.3303
Echinococcus granulosus	tyrosine protein kinase otk	0.0072	0.0206	0.0188
Schistosoma mansoni	protein tyrosine phosphatase	0.0134	0.1272	0.1654
Entamoeba histolytica	protein kinase domain containing protein	0.0061	0.0019	0.3473
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0169	0.1878	0.2479
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0134	0.1272	0.158
Loa Loa (eye worm)	hypothetical protein	0.0329	0.464	0.5844
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0134	0.1272	1
Schistosoma mansoni	nephrin	0.0206	0.252	0.3303
Onchocerca volvulus	Tyrosine kinase homolog	0.0095	0.0602	0.234
Loa Loa (eye worm)	STE/STE20/SLK protein kinase	0.0168	0.186	0.218
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0134	0.1272	0.1255
Brugia malayi	Fibronectin type III domain containing protein	0.0463	0.6951	1
Loa Loa (eye worm)	hypothetical protein	0.0401	0.5885	0.7485
Echinococcus granulosus	nephrin	0.0169	0.1878	0.1863
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0206	0.252	0.3432
Schistosoma mansoni	titin	0.0169	0.1878	0.2454
Schistosoma mansoni	tripartite motif protein trim9	0.0134	0.1272	0.1654
Echinococcus multilocularis	roundabout 2	0.0206	0.252	0.3058
Echinococcus multilocularis	Fibronectin, type III	0.0134	0.1272	0.1532
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0134	0.1272	0.1532
Schistosoma mansoni	ephrin receptor	0.0194	0.2311	0.3026
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0134	0.1272	0.1654
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0095	0.0602	0.0713
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0134	0.1272	0.158
Onchocerca volvulus		0.0134	0.1272	0.6292
Loa Loa (eye worm)	hypothetical protein	0.0329	0.4636	0.5839
Echinococcus multilocularis	Immunoglobulin	0.0329	0.4636	0.5644
Onchocerca volvulus		0.0134	0.1272	0.6292
Onchocerca volvulus		0.0134	0.1272	0.6292
Entamoeba histolytica	tyrosin kinase, putative	0.0063	0.0054	1
Echinococcus multilocularis	STE20 serine:threonine protein kinase	0.0483	0.7294	0.8894
Loa Loa (eye worm)	hypothetical protein	0.0206	0.252	0.305
Schistosoma mansoni	cell adhesion molecule	0.05	0.7594	1
Entamoeba histolytica	protein kinase domain containing protein	0.0063	0.0054	1
Schistosoma mansoni	septate junction protein	0.0072	0.0206	0.0247
Brugia malayi	Fibronectin type III domain containing protein	0.0134	0.1272	0.158
Schistosoma mansoni	cell adhesion molecule	0.0072	0.0206	0.0247
Echinococcus multilocularis	roundabout 2	0.0535	0.8199	1
Echinococcus multilocularis	roundabout 2	0.0206	0.252	0.3058
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0463	0.6951	0.8889
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Onchocerca volvulus		0.0134	0.1272	0.6292
Echinococcus multilocularis	anosmin 1	0.0134	0.1272	0.1532
Schistosoma mansoni	cell adhesion molecule	0.0169	0.1878	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0206	0.252	0.3058
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0134	0.1272	0.1405
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0329	0.4636	0.5644
Echinococcus multilocularis	lachesin	0.0072	0.0206	0.0229
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0169	0.1878	0.2479
Schistosoma mansoni	hypothetical protein	0.0134	0.1272	0.1654
Echinococcus granulosus	roundabout 2	0.0206	0.252	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0482	0.7272	0.9313
Echinococcus granulosus	anosmin 1	0.0134	0.1272	0.1255
Echinococcus multilocularis	neuroglian	0.0364	0.5242	0.6385
Onchocerca volvulus		0.0134	0.1272	0.6292
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0134	0.1272	0.1532
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0134	0.1272	0.1255
Echinococcus granulosus	peroxidasin	0.0073	0.021	0.0191
Echinococcus multilocularis	titin	0.017	0.19	0.23
Brugia malayi	Fibronectin type III domain containing protein	0.0134	0.1272	0.158
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Onchocerca volvulus		0.0134	0.1272	0.6292
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0329	0.4636	0.6096
Loa Loa (eye worm)	hypothetical protein	0.0073	0.021	0.0005
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0194	0.2311	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1272	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0366	0.5279	0.6686
Schistosoma mansoni	protein kinase	0.0168	0.186	0.2431
Schistosoma mansoni	titin	0.0072	0.0206	0.0247

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2338635

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1736077