TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 666.831 | Formula: C34H46N6O6S
H donors: 6 H acceptors: 6 LogP: 2.62 Rotable bonds: 18
Rule of 5 violations (Lipinski): 3
SMILES: CSCC[C@H](C(=O)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C1CC2(C)C(C(N1C)Cc1c2cc(O)cc1)C
InChi: 1S/C34H46N6O6S/c1-20-27-15-22-10-11-23(41)16-24(22)34(20,2)17-28(40(27)3)33(46)37-18-29(42)36-19-30(43)38-26(14-21-8-6-5-7-9-21)32(45)39-25(31(35)44)12-13-47-4/h5-11,16,20,25-28,41H,12-15,17-19H2,1-4H3,(H2,35,44)(H,36,42)(H,37,46)(H,38,43)(H,39,45)/t20?,25-,26+,27?,28?,34?/m1/s1
InChiKey: XDEWTAYBHFQFTJ-LTIKIPGZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cavia porcellus	Mu opioid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	98 aa	35.7 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	88 aa	23.9 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	90 aa	28.9 %
Loa Loa (eye worm)	TYRA-2 protein	Mu opioid receptor	98 aa	87 aa	31.0 %
Echinococcus granulosus	allatostatin A receptor	Mu opioid receptor	98 aa	99 aa	33.3 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Mu opioid receptor	98 aa	96 aa	32.3 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Mu opioid receptor	98 aa	89 aa	30.3 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	98 aa	85 aa	32.9 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	87 aa	32.2 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Mu opioid receptor	98 aa	93 aa	33.3 %
Loa Loa (eye worm)	neuropeptide F receptor	Mu opioid receptor	98 aa	80 aa	33.8 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	88 aa	37.5 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	93 aa	30.1 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	21.5 %
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Echinococcus granulosus	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	33.3 %
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	Mu opioid receptor	98 aa	97 aa	36.1 %
Schistosoma mansoni	thyrotropin-releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	27.0 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	34.0 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	36.1 %
Brugia malayi	Serotonin/octopamine receptor family protein 7	Mu opioid receptor	98 aa	85 aa	32.9 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	34.0 %
Echinococcus granulosus	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma mansoni	growth hormone secretagogue receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Mu opioid receptor	98 aa	97 aa	37.1 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Mu opioid receptor	98 aa	79 aa	36.7 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	31.5 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	79 aa	29.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	88 aa	39.8 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Mu opioid receptor	98 aa	85 aa	34.1 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	85 aa	37.6 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	100 aa	29.0 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	33.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	86 aa	33.7 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Mu opioid receptor	98 aa	80 aa	28.8 %
Echinococcus multilocularis	allatostatin A receptor	Mu opioid receptor	98 aa	99 aa	33.3 %
Schistosoma japonicum	Muscarinic acetylcholine receptor M1, putative	Mu opioid receptor	98 aa	95 aa	30.5 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	96 aa	31.2 %
Brugia malayi	ORL1-like opioid receptor	Mu opioid receptor	98 aa	85 aa	32.9 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Mu opioid receptor	98 aa	92 aa	21.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	100 aa	25.0 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	91 aa	38.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	28.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	85 aa	32.9 %
Echinococcus multilocularis	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Mu opioid receptor	98 aa	98 aa	34.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	101 aa	20.8 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Mu opioid receptor	98 aa	92 aa	32.6 %
Schistosoma japonicum	Probable G-protein coupled receptor No9, putative	Mu opioid receptor	98 aa	95 aa	28.4 %
Echinococcus multilocularis	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	81 aa	35.8 %
Echinococcus multilocularis	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	35.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	93 aa	36.6 %
Brugia malayi	G protein-coupled receptor	Mu opioid receptor	98 aa	90 aa	31.1 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	40.4 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	98 aa	37.8 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Mu opioid receptor	98 aa	80 aa	23.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	25.9 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	22.5 %
Schistosoma japonicum	Rhodopsin, putative	Mu opioid receptor	98 aa	122 aa	22.1 %
Schistosoma mansoni	adenoreceptor	Mu opioid receptor	98 aa	88 aa	38.6 %
Brugia malayi	Melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	85 aa	24.7 %
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Mu opioid receptor	98 aa	80 aa	31.2 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	24.0 %
Schistosoma japonicum	Neuropeptide Y receptor type 2, putative	Mu opioid receptor	98 aa	79 aa	31.6 %
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Schistosoma mansoni	hypothetical protein	Mu opioid receptor	98 aa	100 aa	23.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	89 aa	31.5 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Mu opioid receptor	98 aa	85 aa	25.9 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	Mu opioid receptor	98 aa	80 aa	37.5 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Mu opioid receptor	98 aa	96 aa	36.5 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	97 aa	38.1 %
Brugia malayi	larval opioid receptor	Mu opioid receptor	98 aa	100 aa	24.0 %
Schistosoma mansoni	opsin-like receptor	Mu opioid receptor	98 aa	80 aa	25.0 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	23.9 %
Echinococcus granulosus	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Schistosoma japonicum	ko:K04165 Oamb gene product from transcript, putative	Mu opioid receptor	98 aa	79 aa	34.2 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Echinococcus multilocularis	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma japonicum	FMRFamide receptor, putative	Mu opioid receptor	98 aa	109 aa	28.4 %
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Schistosoma japonicum	ko:K04282 thyrotropin-releasing hormone receptor, putative	Mu opioid receptor	98 aa	100 aa	28.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	31.6 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Mu opioid receptor	98 aa	96 aa	31.2 %
Onchocerca volvulus	Phospholipase d-related homolog	Mu opioid receptor	98 aa	82 aa	25.6 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	81 aa	34.6 %
Loa Loa (eye worm)	melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Echinococcus multilocularis	serotonin receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	38.2 %
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	Mu opioid receptor	98 aa	99 aa	36.4 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Mu opioid receptor	98 aa	96 aa	32.3 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	98 aa	31.6 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Schistosoma mansoni	amine GPCR	Mu opioid receptor	98 aa	86 aa	32.6 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	93 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0105	0.3574	0.3574
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0105	0.3574	0.3574
Onchocerca volvulus	Bile acid receptor homolog	0.0092	0.2324	0.2324
Schistosoma mansoni	vav2	0.0105	0.3574	0.3574
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0068	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0173	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0105	0.3574	0.3574
Plasmodium falciparum	protein kinase, putative	0.0068	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0092	0.2324	0.2324
Schistosoma mansoni	GTPase activating protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine kinase	0.0173	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0105	0.3574	0.3574
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0173	1	1
Brugia malayi	hypothetical protein	0.0105	0.3574	0.3574
Echinococcus granulosus	ecdysone induced protein 78C	0.0092	0.2324	0.2324
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	hypothetical protein	0.0105	0.3574	0.3574
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Schistosoma mansoni	SH2A	0.0105	0.3574	0.3574
Schistosoma mansoni	adapter molecule crk	0.0105	0.3574	0.3574
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	N chimaerin	0.0105	0.3574	0.3574
Trypanosoma cruzi	protein kinase, putative	0.0068	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0092	0.2324	0.2324
Echinococcus granulosus	SH2 motif	0.0105	0.3574	0.3574
Schistosoma mansoni	thyroid hormone receptor	0.0092	0.2324	0.2324
Echinococcus multilocularis	signal transduction protein lnk realted	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	tensin-related	0.0105	0.3574	0.3574
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0092	0.2324	0.2324
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0105	0.3574	0.3574
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0173	1	1
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Echinococcus granulosus	hypothetical protein	0.0105	0.3574	0.3574
Onchocerca volvulus		0.0173	1	1
Loa Loa (eye worm)	STAT protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK protein kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	N chimaerin	0.0105	0.3574	0.3574
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0092	0.2324	0.2324
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0173	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0068	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0068	0	0.5
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0173	1	1
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Onchocerca volvulus	Protein ultraspiracle homolog	0.0092	0.2324	0.2324
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	nck2/grb4	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0092	0.2324	0.2324
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0173	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0092	0.2324	0.2324
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0092	0.2324	0.2324
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0105	0.3574	0.3574
Brugia malayi	RhoGAP domain containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0105	0.3574	0.3574
Echinococcus granulosus	c src tyrosine kinase	0.0173	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0092	0.2324	0.2324
Brugia malayi	Sex muscle abnormal protein 5	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0092	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Schistosoma mansoni	coup transcription factor	0.0092	0.2324	0.2324
Plasmodium falciparum	tyrosine kinase-like protein	0.0068	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Plasmodium falciparum	tyrosine kinase-like protein	0.0068	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0173	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Entamoeba histolytica	SH2 domain containing protein	0.0105	0.3574	0.3574
Leishmania major	protein kinase, putative	0.0068	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	SH2 motif	0.0105	0.3574	0.3574
Echinococcus granulosus	tyrosine protein kinase shark	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0105	0.3574	0.3574
Plasmodium vivax	protein kinase, putative	0.0068	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0068	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0105	0.3574	0.3574
Echinococcus granulosus	tyrosine kinase	0.0173	1	1
Echinococcus multilocularis	SH2 motif	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0173	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0092	0.2324	0.2324
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0105	0.3574	0.3574
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0105	0.3574	0.3574
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0092	0.2324	0.2324
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0105	0.3574	0.3574
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0105	0.3574	0.3574
Brugia malayi	photoreceptor-specific nuclear receptor	0.0092	0.2324	0.2324
Echinococcus granulosus	SH2 domain containing protein 7	0.0105	0.3574	0.3574
Brugia malayi	protein-tyrosine kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0092	0.2324	0.2324
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	tensin	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0105	0.3574	0.3574
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0173	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0092	0.2324	0.2324
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0092	0.2324	0.2324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0092	0.2324	0.2324
Brugia malayi	hypothetical protein	0.0173	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Brugia malayi	Tensin	0.0105	0.3574	0.3574
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	shc transforming protein	0.0105	0.3574	0.3574
Onchocerca volvulus		0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Entamoeba histolytica	protein kinase, putative	0.0105	0.3574	0.3574
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0173	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0092	0.2324	0.2324
Trichomonas vaginalis	STE family protein kinase	0.0068	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0105	0.3574	0.3574
Giardia lamblia	Kinase, NEK	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0105	0.3574	0.3574
Plasmodium falciparum	protein kinase, putative	0.0068	0	0.5
Echinococcus multilocularis	SH2 motif	0.0105	0.3574	0.3574
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0092	0.2324	0.2324
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Brugia malayi	nuclear receptor NHR-88	0.0092	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0173	1	1
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Echinococcus multilocularis	tensin	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0173	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	tensin	0.0105	0.3574	0.3574
Onchocerca volvulus		0.0105	0.3574	0.3574
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0068	0	0.5
Leishmania major	protein kinase, putative	0.0068	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0092	0.2324	0.2324
Echinococcus multilocularis	tensin	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0105	0.3574	0.3574
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0092	0.2324	0.2324
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0068	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0173	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0105	0.3574	0.3574
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0173	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Toxoplasma gondii	protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0092	0.2324	0.2324
Schistosoma mansoni	retinoic acid receptor RXR	0.0092	0.2324	0.2324
Loa Loa (eye worm)	SH2 domain-containing protein	0.0105	0.3574	0.3574
Brugia malayi	nuclear hormone receptor	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0173	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0105	0.3574	0.3574
Echinococcus granulosus	tensin	0.0105	0.3574	0.3574
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0173	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0068	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0068	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0173	1	1
Echinococcus multilocularis		0.0105	0.3574	0.3574
Loa Loa (eye worm)	SRC-1	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0173	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0092	0.2324	0.2324
Echinococcus granulosus	NCK adaptor protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	tensin-related	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	SH2 domain-containing protein	0.0105	0.3574	0.3574
Schistosoma mansoni	RAR-like nuclear receptor	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	SH2 domain containing protein	0.0173	1	1
Brugia malayi	steroid hormone receptor	0.0092	0.2324	0.2324
Schistosoma mansoni	thyroid hormone receptor	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0173	1	1
Echinococcus granulosus	expressed conserved protein	0.0105	0.3574	0.3574
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0092	0.2324	0.2324
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0105	0.3574	0.3574
Onchocerca volvulus		0.0173	1	1
Brugia malayi	SH2 domain containing protein	0.0173	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0173	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Giardia lamblia	Kinase	0.0068	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0173	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0068	0	0.5
Brugia malayi	ecdysteroid receptor	0.0092	0.2324	0.2324
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0092	0.2324	0.2324
Echinococcus granulosus	FTZ F1 alpha	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0092	0.2324	0.2324
Echinococcus multilocularis	FTZ F1 alpha	0.0092	0.2324	0.2324
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0105	0.3574	0.3574
Trichomonas vaginalis	CAMK family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0092	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0173	1	1
Brugia malayi	SRC-1	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0173	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0173	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0092	0.2324	0.2324
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0173	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0173	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0092	0.2324	0.2324
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0092	0.2324	0.2324
Trichomonas vaginalis	TK family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0092	0.2324	0.2324
Loa Loa (eye worm)	SH2 domain-containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0105	0.3574	0.3574
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0105	0.3574	0.3574
Giardia lamblia	Kinase, NEK	0.0068	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0105	0.3574	0.3574
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Plasmodium falciparum	protein kinase, putative	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Toxoplasma gondii	STE kinase	0.0068	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0105	0.3574	0.3574
Schistosoma mansoni	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Onchocerca volvulus		0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Giardia lamblia	Protein 21.1	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Schistosoma mansoni	tensin	0.0105	0.3574	0.3574
Schistosoma mansoni	signal transduction protein lnk-related	0.0105	0.3574	0.3574
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0105	0.3574	0.3574
Echinococcus granulosus	SH2 motif	0.0105	0.3574	0.3574
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Onchocerca volvulus		0.0092	0.2324	0.2324
Onchocerca volvulus		0.0173	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0092	0.2324	0.2324
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Leishmania major	hypothetical protein, conserved	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0092	0.2324	0.2324
Echinococcus multilocularis	ecdysone induced protein 78C	0.0092	0.2324	0.2324
Echinococcus granulosus	growth factor receptor bound protein 2	0.0105	0.3574	0.3574
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0173	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.00000797 M	Mu opioid receptor agonist activity as inhibition of electrically stimulated mysenteric plexus in guinea pig ileum	ChEMBL.	7154002
Relative potency (functional)		Mu opioid receptor agonist activity was determined by inhibition of electrically stimulated myenteric plexus in guinea pig ileum; Inactive	ChEMBL.	7154002
Relative potency (functional)	= 0.007	Mu opioid receptor agonist activity was determined by inhibition of electrically stimulated myenteric plexus in guinea pig ileum	ChEMBL.	7154002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2372185

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1745883