Detailed information for compound 174671

Basic information

Technical information
  • TDR Targets ID: 174671
  • Name: 3-amino-4-ethoxybenzonitrile
  • MW: 162.188 | Formula: C9H10N2O
  • H donors: 1 H acceptors: 1 LogP: 1.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1N)C#N
  • InChi: 1S/C9H10N2O/c1-2-12-9-4-3-7(6-10)5-8(9)11/h3-5H,2,11H2,1H3
  • InChiKey: DVPQVOPYTZSSMA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-amino-4-ethoxy-benzonitrile
  • 3-azanyl-4-ethoxy-benzenecarbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, unknown function 0.0081 0.0429 0.0373
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0081 0.0429 0.0368
Echinococcus granulosus dual specificity 0.009 0.0503 0.0503
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0058 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.6632 0.6612
Brugia malayi beta-lactamase 0.0036 0.0058 0.0049
Echinococcus granulosus cyclin dependent kinase 7 0.0078 0.0405 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.32 0.316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0429 0.0373
Entamoeba histolytica hypothetical protein 0.009 0.0503 0.0447
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0081 0.0429 0.0421
Loa Loa (eye worm) phosphatidylinositol 3 0.1259 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0049
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0429 0.0373
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0135 0.0862 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.32 0.316
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 1 1
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0078 0.0405 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.1002 0.7907 0.7894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.5285 0.5257
Loa Loa (eye worm) gastrulation defective protein 1 0.0129 0.0816 0.0808
Entamoeba histolytica hypothetical protein 0.0081 0.0429 0.0373
Echinococcus granulosus casein kinase ii subunit alpha 0.0135 0.0862 0.0862
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0429 0.0373
Echinococcus granulosus cyclin dependent kinase 9 0.0055 0.0213 0.0213
Entamoeba histolytica hypothetical protein 0.0238 0.1704 0.1656
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0081 0.0429 0.0421
Echinococcus multilocularis cyclin dependent kinase 9 0.0047 0.015 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.32 0.316
Echinococcus multilocularis cyclin dependent kinase 7 0.0078 0.0405 0.0396
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0862 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.5293 0.5266
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.0373
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0238 0.1704 0.1697
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0429 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.0837 0.0829
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0862 0.0809
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1259 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Loa Loa (eye worm) hypothetical protein 0.0081 0.0429 0.0421
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0081 0.0429 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.1044 0.0992
Entamoeba histolytica hypothetical protein 0.0081 0.0429 0.0373
Echinococcus multilocularis cyclin dependent kinase 19 0.0131 0.0837 0.0829
Echinococcus multilocularis 0.0081 0.0429 0.0421
Echinococcus multilocularis serine protein kinase ATM 0.0238 0.1704 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.1002 0.7907 0.7894
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0081 0.0429 0.0421
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.1704 0.1697
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.4927
Entamoeba histolytica protein kinase, putative 0.009 0.0503 0.0447
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1003 0.7915 0.7903
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0009 0.0009
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0429 0.0421
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Schistosoma mansoni hypothetical protein 0.0048 0.0156 0.0148
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0058 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0752 0.5882 0.5858
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0422 0.32 0.316
Loa Loa (eye worm) beta-lactamase 0.0036 0.0058 0.0049
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0862 0.0809
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1259 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0862 0.0809
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0058 0.0579
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0862 0.0809
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0429 0.4927
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0049
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1259 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0429 0.0421
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0081 0.0429 0.0429
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0081 0.0429 0.0421
Entamoeba histolytica protein kinase domain containing protein 0.009 0.0503 0.0447
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0081 0.0429 0.0429
Plasmodium vivax unspecified product 0.0135 0.0862 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0422 0.32 0.3194
Echinococcus multilocularis cyclin dependent kinase 9 0.0055 0.0213 0.0205
Loa Loa (eye worm) phosphatidylinositol 3 0.0422 0.32 0.3194
Brugia malayi cyclin-dependent kinase 7 homolog 0.0086 0.0468 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.1002 0.7907 0.7894
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0422 0.32 0.316
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0058 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0503 0.0494
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.0503 0.0494
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0063 0.0328
Leishmania major phosphatidylinositol kinase, putative 0.0081 0.0429 0.0373
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.1002 0.7907 0.7894
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0429 0.4927
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.7378 0.7363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.7378 0.7363
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0429 0.4582
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0081 0.0429 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0338 0.2514 0.247
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1259 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0429 0.0571
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0429 0.0421
Schistosoma mansoni hypothetical protein 0.0167 0.1129 0.1121
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0081 0.0429 0.0429
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0429 0.0373
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0157 0.1044 0.0992
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0429 0.0421
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0058 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 1 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.0373
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.1704 0.1697
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0265 0.1925 0.26
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.015 0.0142
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Loa Loa (eye worm) hypothetical protein 0.0252 0.1817 0.181
Onchocerca volvulus 0.0081 0.0429 0.2531
Echinococcus multilocularis geminin 0.0167 0.1129 0.1121
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0429 0.0421
Brugia malayi hypothetical protein 0.0234 0.1667 0.166
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0429 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.7378 0.7363
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0081 0.0429 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.7378 0.7363
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0429 0.0421
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0238 0.1704 0.1656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.7378 0.7363
Echinococcus granulosus cyclin dependent kinase 19 0.0131 0.0837 0.0837
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0063 0.0074
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1265 0.1214
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0238 0.1704 0.1704
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0862 0.0809
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0429 0.0421
Plasmodium falciparum casein kinase 2, alpha subunit 0.0135 0.0862 1
Plasmodium vivax hypothetical protein 0.0081 0.0429 0.4927
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0429 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.5285 0.5257
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0063 0.0005
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.1002 0.7907 0.7894
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.5293 0.5266
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0081 0.0429 0.4582
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0058 0.0049
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0081 0.0429 0.0373
Brugia malayi beta-lactamase family protein 0.0036 0.0058 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.1704 0.1656
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0063 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.32 0.316
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0058 0.0049
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0081 0.0429 0.0373
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0429 0.0571
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0135 0.0862 0.0854
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Loa Loa (eye worm) hypothetical protein 0.0257 0.1854 0.1847
Trichomonas vaginalis set domain proteins, putative 0.0234 0.167 0.1622
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0429 0.0571
Toxoplasma gondii ck2 beta subunit 0.0036 0.0063 0.0074
Schistosoma mansoni survival motor neuron protein 0.0048 0.0156 0.0148
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0063 0.0054
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0081 0.0429 0.0421
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0429 0.0421
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1667 0.166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0429 0.0421
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0184 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0265 0.1925 0.1918
Trypanosoma brucei Casein kinase II 0.0135 0.0862 0.0809
Leishmania major phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0063 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0752 0.5882 0.5858
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0063 0.0054
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.32 0.3194
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.4927
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0156 0.0148
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Toxoplasma gondii ABC1 family protein 0.0036 0.0058 0.0067
Giardia lamblia Kinase, CMGC CK2 0.0135 0.0862 0.0804
Brugia malayi hypothetical protein 0.0036 0.0058 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0058 0.5
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0047 0.015 0.0142
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0238 0.1704 0.1697
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.0473
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Loa Loa (eye worm) hypothetical protein 0.0157 0.1044 0.1036
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0422 0.32 0.316
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0131 0.0837 0.0829
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1259 1 1
Brugia malayi Protein kinase domain containing protein 0.0131 0.0837 0.0829
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0429 0.0421
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.0503 0.0447
Brugia malayi Protein kinase domain containing protein 0.009 0.0503 0.0494
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1113 0.8815 0.8814
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0238 0.1704 0.1656
Entamoeba histolytica protein kinase, putative 0.009 0.0503 0.0447
Trypanosoma cruzi target of rapamycin kinase 3 0.1003 0.7915 0.7903
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0081 0.0429 0.0373
Schistosoma mansoni hypothetical protein 0.0036 0.0058 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.1704 0.1656
Mycobacterium ulcerans hypothetical protein 0.0036 0.0058 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.5822 0.5797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.7378 0.7363
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0184 0.1265 0.1257
Brugia malayi FAT domain containing protein 0.0184 0.1265 0.1257
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.5293 0.5266
Entamoeba histolytica protein kinase rad3, putative 0.0238 0.1704 0.1656
Toxoplasma gondii target of rapamycin (TOR), putative 0.0937 0.7378 1
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0063 0.0638
Leishmania major phosphatidylinositol kinase related protein, putative 0.0081 0.0429 0.0373
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1259 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0049
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0429 0.0373
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.4927
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0081 0.0429 0.0373
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0429 0.0373
Trypanosoma cruzi casein kinase II, putative 0.0135 0.0862 0.0809
Echinococcus granulosus geminin 0.0167 0.1129 0.1129
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0429 0.0571
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.0503 0.0447
Loa Loa (eye worm) hypothetical protein 0.0234 0.1667 0.166
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1667 0.1667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0752 0.5882 0.5858
Schistosoma mansoni hypothetical protein 0.0167 0.1129 0.1121
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0049
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0058 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.5822 0.5797
Giardia lamblia Phosphatidylinositol 4-kinase 0.0081 0.0429 0.0368
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0429 0.0373
Echinococcus multilocularis casein kinase ii subunit alpha 0.0135 0.0862 0.0854
Schistosoma mansoni hypothetical protein 0.0184 0.1265 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.1044 0.0992
Schistosoma mansoni hypothetical protein 0.0081 0.0429 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.5293 0.5266
Leishmania major hypothetical protein, conserved 0.0081 0.0429 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.32 0.316
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0081 0.0429 0.0429
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0422 0.32 0.3194
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0429 0.0429
Echinococcus granulosus serine protein kinase ATM 0.0238 0.1704 0.1704
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0862 0.0809
Loa Loa (eye worm) phosphatidylinositol kinase 0.0081 0.0429 0.0421
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0429 0.0373
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0429 0.0421
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0429 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0405 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.1925 0.1878
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0429 0.0373
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0063 0.0005
Schistosoma mansoni kinase 0.0047 0.015 0.0142
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0429 0.0373
Mycobacterium ulcerans beta-lactamase 0.0036 0.0058 0.5
Onchocerca volvulus 0.0234 0.167 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Loa Loa (eye worm) hypothetical protein 0.0238 0.1704 0.1697
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1259 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0238 0.1704 0.1656
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0081 0.0429 0.0373
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0422 0.32 0.32
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0063 0.0005
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0238 0.1704 0.1656
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0523 0.4019 0.3984
Leishmania major casein kinase II, putative 0.0135 0.0862 0.0809
Echinococcus multilocularis Zinc finger, PHD finger 0.0081 0.0429 0.0421
Giardia lamblia GTOR 0.1259 1 1
Brugia malayi Casein kinase II, alpha chain 0.0135 0.0862 0.0854
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.5285 0.5257
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0081 0.0429 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0818 0.6411 0.639
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0058 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0429 0.0421
Giardia lamblia Hypothetical protein 0.0081 0.0429 0.0368
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1003 0.7915 0.7903
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0058 0.0049
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0063 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0429 0.0373
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1615 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0238 0.1704 0.1697
Toxoplasma gondii CMGC kinase, CK2 family 0.0135 0.0862 0.1158
Loa Loa (eye worm) hypothetical protein 0.0088 0.0482 0.0473
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0063 0.0005
Schistosoma mansoni protein kinase 0.0135 0.0862 0.0854
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0429 0.2383
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0429 0.0571
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1259 1 1
Onchocerca volvulus 0.0036 0.0058 0.0297
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0063 0.0063
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0081 0.0429 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 1 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0063 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0429 0.0373
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0081 0.0429 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.8504 0.8495
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0429 0.0421
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0429 0.0421
Toxoplasma gondii FATC domain-containing protein 0.0238 0.1704 0.2301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.7378 0.7363
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0081 0.0429 0.0421
Brugia malayi cyclin-dependent kinase 9 0.0047 0.015 0.0142
Echinococcus multilocularis dual specificity 0.009 0.0503 0.0494
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Onchocerca volvulus 0.0036 0.0058 0.0297
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0429 0.0421
Loa Loa (eye worm) hypothetical protein 0.0184 0.1265 0.1257
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0081 0.0429 0.0373
Entamoeba histolytica hypothetical protein 0.0081 0.0429 0.0373
Echinococcus granulosus cyclin dependent kinase 9 0.0047 0.015 0.015
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0081 0.0429 0.4582
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1259 1 1
Brugia malayi beta-lactamase family protein 0.0036 0.0058 0.0049
Brugia malayi Pre-SET motif family protein 0.0206 0.144 0.1432
Onchocerca volvulus 0.0048 0.0156 0.0888
Onchocerca volvulus 0.0081 0.0429 0.2531
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0063 0.0328
Leishmania major phosphatidylinositol 3-kinase, putative 0.0422 0.32 0.316
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0429 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.1704 0.1656
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0081 0.0429 0.0373
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0862 0.0809
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.0503 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0405 0.0396
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.015 0.0093
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1259 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0429 0.0373
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0596 0.4608 0.4576
Entamoeba histolytica hypothetical protein 0.0081 0.0429 0.0373
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0422 0.32 0.316
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.0503 0.0447
Onchocerca volvulus 0.0036 0.0058 0.0297
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0063 0.0638
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0058 0.0058
Brugia malayi Csnk2b protein 0.0036 0.0063 0.0054
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0081 0.0429 0.0373
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0081 0.0429 0.0429
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0063 0.0005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.144 0.1432
Entamoeba histolytica casein kinase, putative 0.0135 0.0862 0.0809
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0081 0.0429 0.0368
Mycobacterium ulcerans lipase LipD 0.0036 0.0058 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0422 0.32 0.316
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1259 1 1

Activities

Activity type Activity value Assay description Source Reference
Log A (functional) = 2.63 Activity expressed by taste potency (taste intensity relative to sucrose on a mole/mole basis) ChEMBL. 7365747

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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