Detailed information for compound 174674

Basic information

Technical information
  • TDR Targets ID: 174674
  • Name: (2R,4S)-2-[(1R)-2-(benzylamino)-2-oxo-1-[(2-p henylacetyl)amino]ethyl]-N-[(2R)-1-hydroxypro pan-2-yl]-5,5-dimethyl-1,3-thiazolidine-4-car boxamide
  • MW: 498.638 | Formula: C26H34N4O4S
  • H donors: 5 H acceptors: 4 LogP: 1.91 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](NC(=O)[C@@H]1N[C@H](SC1(C)C)[C@@H](C(=O)NCc1ccccc1)NC(=O)Cc1ccccc1)C
  • InChi: 1S/C26H34N4O4S/c1-17(16-31)28-24(34)22-26(2,3)35-25(30-22)21(23(33)27-15-19-12-8-5-9-13-19)29-20(32)14-18-10-6-4-7-11-18/h4-13,17,21-22,25,30-31H,14-16H2,1-3H3,(H,27,33)(H,28,34)(H,29,32)/t17-,21-,22+,25-/m1/s1
  • InChiKey: SSQONQKUEJFTBA-SQTZCGGWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,4S)-2-[(1R)-2-(benzylamino)-2-oxo-1-[(2-phenylacetyl)amino]ethyl]-N-[(1R)-2-hydroxy-1-methyl-ethyl]-5,5-dimethyl-thiazolidine-4-carboxamide
  • (2R,4S)-2-[(1R)-2-(benzylamino)-2-oxo-1-[(1-oxo-2-phenylethyl)amino]ethyl]-N-[(1R)-2-hydroxy-1-methylethyl]-5,5-dimethyl-4-thiazolidinecarboxamide
  • (2R,4S)-N-[(2R)-1-hydroxypropan-2-yl]-5,5-dimethyl-2-[(1R)-2-oxo-1-(2-phenylethanoylamino)-2-(phenylmethylamino)ethyl]-1,3-thiazolidine-4-carboxamide
  • (2R,4S)-2-[(1R)-2-(benzylamino)-2-keto-1-[(2-phenylacetyl)amino]ethyl]-N-[(1R)-2-hydroxy-1-methyl-ethyl]-5,5-dimethyl-thiazolidine-4-carboxamide
  • (2R,4S)-N-[(2R)-1-hydroxypropan-2-yl]-5,5-dimethyl-2-[(1R)-2-oxo-1-[(2-phenylacetyl)amino]-2-(phenylmethylamino)ethyl]-1,3-thiazolidine-4-carboxamide
  • (2R,4S)-N-[(1R)-2-hydroxy-1-methyl-ethyl]-5,5-dimethyl-2-[(1R)-2-oxo-1-[(2-phenylacetyl)amino]-2-(phenylmethylamino)ethyl]thiazolidine-4-carboxamide
  • (2R,4S)-N-[(1R)-2-hydroxy-1-methylethyl]-5,5-dimethyl-2-[(1R)-2-oxo-1-[(1-oxo-2-phenylethyl)amino]-2-(phenylmethylamino)ethyl]-4-thiazolidinecarboxamide
  • AIDS-005479
  • AIDS005479
  • penicillin deriv. 61
  • [2R-[2.alpha.(R*),4.beta.(R)]]-5,5-Dimethyl-.alpha.-[(phenylacetyl)amino]-N-(phenylmethyl)-4-[[[1-(hydroxymethyl)ethyl]amino]carbonyl]-2-thiazolidineacetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0068 0.0059
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0053
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0068 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0084 0.0413 0.0352
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0068 0.0006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0353
Brugia malayi Pre-SET motif family protein 0.0229 0.1549 0.1541
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.015 0.0928 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1307 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0438 0.3189 0.3182
Brugia malayi beta-lactamase 0.004 0.0063 0.0053
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.4393
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0928 0.0871
Giardia lamblia Hypothetical protein 0.0084 0.0413 0.0347
Echinococcus granulosus dual specificity 0.0101 0.0541 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.1307 1 1
Brugia malayi cyclin-dependent kinase 9 0.0052 0.0162 0.0152
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0618 0.4598 0.4564
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0413 0.0352
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0084 0.0413 0.0347
Entamoeba histolytica hypothetical protein 0.0101 0.0541 0.0482
Leishmania major phosphatidylinositol 3-kinase, putative 0.0438 0.3189 0.3146
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0084 0.0413 0.0352
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0162 0.01
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1307 1 1
Mycobacterium ulcerans beta-lactamase 0.004 0.0063 0.5
Onchocerca volvulus 0.0053 0.0168 0.0888
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.1549 0.1541
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0438 0.3189 0.3146
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0084 0.0413 0.0404
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0084 0.0413 0.0404
Mycobacterium leprae conserved hypothetical protein 0.0084 0.0413 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.169 0.1638
Leishmania major phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.0352
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0068 0.0005
Echinococcus granulosus cyclin dependent kinase 9 0.0052 0.0162 0.0162
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0541 0.0481
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0068 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0063 0.0053
Brugia malayi FAT domain containing protein 0.0191 0.125 0.1242
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0084 0.0413 0.0404
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0084 0.0413 0.4011
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0084 0.0413 0.0413
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.1116 0.8501 0.8492
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0413 0.0548
Echinococcus granulosus serine protein kinase ATM 0.0247 0.169 0.169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0413 0.0404
Mycobacterium ulcerans lipase LipD 0.004 0.0063 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0413 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.7374 0.7357
Leishmania major phosphatidylinositol kinase related protein, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Leishmania major casein kinase II, putative 0.015 0.0928 0.0871
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0928 0.0871
Loa Loa (eye worm) hypothetical protein 0.0098 0.0518 0.0509
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0084 0.0413 0.0352
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0084 0.0413 0.0413
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1307 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0068 0.0068
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1307 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.0413 0.0404
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0068 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0063 0.0053
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0413 0.0548
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.4393
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1041 0.7912 0.7898
Brugia malayi beta-lactamase family protein 0.004 0.0063 0.0053
Brugia malayi hypothetical protein 0.026 0.1794 0.1786
Toxoplasma gondii FATC domain-containing protein 0.0247 0.169 0.2282
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0063 0.0063
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0084 0.0413 0.0352
Schistosoma mansoni hypothetical protein 0.004 0.0062 0.0053
Echinococcus multilocularis casein kinase ii subunit alpha 0.015 0.0928 0.0919
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0543 0.4008 0.3971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.169 0.1638
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1307 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0084 0.0413 0.0352
Trypanosoma brucei Casein kinase II 0.015 0.0928 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.5277 0.5247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0849 0.6405 0.6382
Echinococcus granulosus cyclin dependent kinase 7 0.0087 0.0435 0.0435
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0413 0.0404
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0052 0.0162 0.0152
Toxoplasma gondii ABC1 family protein 0.004 0.0063 0.0072
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0247 0.169 0.1638
Echinococcus granulosus survival motor neuron protein 1 0.026 0.1794 0.1794
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0084 0.0413 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.1307 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0247 0.169 0.1682
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0438 0.3189 0.3146
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0084 0.0413 0.0404
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0438 0.3189 0.3189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.3189 0.3146
Entamoeba histolytica hypothetical protein 0.0084 0.0413 0.0353
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1738 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0084 0.0413 0.4393
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0435 0.0426
Giardia lamblia Kinase, CMGC CK2 0.015 0.0928 0.0866
Leishmania major phosphatidylinositol kinase, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0084 0.0413 0.0352
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0084 0.0413 0.0413
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0084 0.0413 0.0404
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0275 0.1911 0.2583
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0413 0.0404
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0247 0.169 0.1638
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0541 0.0481
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0247 0.169 0.1682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0781 0.5875 0.5849
Echinococcus multilocularis geminin 0.0187 0.1215 0.1207
Onchocerca volvulus 0.004 0.0063 0.0297
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0063 0.0053
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0084 0.0413 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0773 0.5815 0.5788
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0928 0.0871
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0353
Loa Loa (eye worm) hypothetical protein 0.0163 0.1029 0.102
Loa Loa (eye worm) hypothetical protein 0.0191 0.125 0.1242
Leishmania major hypothetical protein, unknown function 0.0084 0.0413 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0706 0.5285 0.5256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0706 0.5285 0.5256
Schistosoma mansoni hypothetical protein 0.0191 0.125 0.1242
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0247 0.169 0.169
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1307 1 1
Leishmania major hypothetical protein, conserved 0.0084 0.0413 0.0352
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.4393
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0062 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.7374 0.7357
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0063 0.5
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0084 0.0413 0.0352
Loa Loa (eye worm) phosphatidylinositol kinase 0.0084 0.0413 0.0404
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0353
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0084 0.0413 0.0352
Schistosoma mansoni hypothetical protein 0.0187 0.1215 0.1207
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0084 0.0413 0.0404
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0928 0.0871
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0084 0.0413 0.0352
Echinococcus multilocularis dual specificity 0.0101 0.0541 0.0532
Trypanosoma cruzi target of rapamycin kinase 3 0.1041 0.7912 0.7898
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0247 0.169 0.1682
Loa Loa (eye worm) Csnk2b protein 0.004 0.0068 0.0059
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0063 0.0053
Onchocerca volvulus 0.0261 0.1797 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0773 0.5815 0.5788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.7374 0.7357
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0191 0.125 0.125
Loa Loa (eye worm) hypothetical protein 0.0098 0.0518 0.0509
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0068 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0413 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1029 0.0972
Echinococcus multilocularis cyclin dependent kinase 19 0.0147 0.09 0.0892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.3189 0.3146
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.09 0.0892
Loa Loa (eye worm) phosphatidylinositol 3 0.1307 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0101 0.0541 0.0532
Entamoeba histolytica protein kinase, putative 0.0101 0.0541 0.0482
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0353
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0084 0.0413 0.0404
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1241 0.9485 0.9484
Toxoplasma gondii CMGC kinase, CK2 family 0.015 0.0928 0.1247
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0068 0.0328
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0068 0.0328
Trichomonas vaginalis set domain proteins, putative 0.0261 0.1797 0.1746
Schistosoma mansoni kinase 0.0052 0.0162 0.0152
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0247 0.169 0.1638
Loa Loa (eye worm) hypothetical protein 0.0275 0.1911 0.1904
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.125 0.1195
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0084 0.0413 0.0404
Entamoeba histolytica protein kinase domain containing protein 0.015 0.0928 0.0871
Onchocerca volvulus 0.004 0.0063 0.0297
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0781 0.5875 0.5849
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.3189 0.3146
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0063 0.0053
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0084 0.0413 0.0413
Schistosoma mansoni hypothetical protein 0.0053 0.0168 0.0159
Onchocerca volvulus 0.004 0.0063 0.0297
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0413 0.0548
Schistosoma mansoni survival motor neuron protein 0.0053 0.0168 0.0159
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0068 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0084 0.0413 0.0352
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0084 0.0413 0.0404
Plasmodium vivax hypothetical protein, conserved 0.004 0.0063 0.0579
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0087 0.0435 0.0426
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0084 0.0413 0.0404
Entamoeba histolytica casein kinase, putative 0.015 0.0928 0.0871
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0084 0.0413 0.0353
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0247 0.169 0.1682
Trichomonas vaginalis conserved hypothetical protein 0.0275 0.1911 0.186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.5277 0.5247
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0413 0.0352
Toxoplasma gondii ck2 beta subunit 0.004 0.0068 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.104 0.7903 0.789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0706 0.5285 0.5256
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.0413 0.0404
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0084 0.0413 0.0404
Loa Loa (eye worm) beta-lactamase 0.004 0.0063 0.0053
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0438 0.3189 0.3146
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.169 0.1638
Entamoeba histolytica protein kinase rad3, putative 0.0247 0.169 0.1638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.7374 0.7357
Brugia malayi Protein kinase domain containing protein 0.0147 0.09 0.0892
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0191 0.125 0.1242
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0063 0.5
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.1794 0.1786
Plasmodium vivax hypothetical protein 0.0084 0.0413 0.4393
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0928 0.0871
Onchocerca volvulus 0.0084 0.0413 0.2256
Brugia malayi Casein kinase II, alpha chain 0.015 0.0928 0.0919
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0247 0.169 0.1638
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.0413 0.0404
Toxoplasma gondii target of rapamycin (TOR), putative 0.0972 0.7374 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.7374 0.7357
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.0413 0.209
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0084 0.0413 0.0413
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0068 0.0005
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1307 1 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.169 0.1682
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0084 0.0413 0.0404
Echinococcus multilocularis cyclin dependent kinase 9 0.0052 0.0162 0.0152
Loa Loa (eye worm) hypothetical protein 0.0281 0.1955 0.1948
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0068 0.0638
Loa Loa (eye worm) hypothetical protein 0.0266 0.184 0.1832
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0404
Schistosoma mansoni hypothetical protein 0.0187 0.1215 0.1207
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0084 0.0413 0.0352
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0084 0.0413 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.2501 0.2454
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1307 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.0413 0.0404
Echinococcus granulosus geminin 0.0187 0.1215 0.1215
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0084 0.0413 0.0352
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0084 0.0413 0.4011
Mycobacterium ulcerans hypothetical protein 0.004 0.0063 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0353
Leishmania major phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0352
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0163 0.1029 0.0972
Echinococcus multilocularis Zinc finger, PHD finger 0.0084 0.0413 0.0404
Brugia malayi Csnk2b protein 0.004 0.0068 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0541 0.0532
Brugia malayi beta-lactamase family protein 0.004 0.0063 0.0053
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0541 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.104 0.7903 0.789
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0435 0.0426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0413 0.0404
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.7374 0.7357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.7374 0.7357
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0084 0.0413 0.0352
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.0353
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0928 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.3189 0.3146
Entamoeba histolytica protein kinase, putative 0.0101 0.0541 0.0482
Entamoeba histolytica hypothetical protein 0.0084 0.0413 0.0353
Echinococcus multilocularis cyclin dependent kinase 9 0.0061 0.023 0.022
Loa Loa (eye worm) phosphatidylinositol 3 0.0438 0.3189 0.3182
Trichomonas vaginalis PIKK family atypical protein kinase 0.104 0.7903 0.789
Brugia malayi cyclin-dependent kinase 7 homolog 0.0096 0.0503 0.0494
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0438 0.3189 0.3182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.3189 0.3146
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0781 0.5875 0.5849
Loa Loa (eye worm) hypothetical protein 0.0084 0.0413 0.0404
Giardia lamblia GTOR 0.1307 1 1
Schistosoma mansoni protein kinase 0.015 0.0928 0.0919
Echinococcus granulosus casein kinase ii subunit alpha 0.015 0.0928 0.0928
Brugia malayi hypothetical protein 0.004 0.0062 0.0053
Plasmodium falciparum casein kinase 2, alpha subunit 0.015 0.0928 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0413 0.0352
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0062 0.0053
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1307 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0413 0.0548
Giardia lamblia Phosphatidylinositol 4-kinase 0.0084 0.0413 0.0347
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0084 0.0413 0.0347
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0101 0.0541 0.0481
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1041 0.7912 0.7898
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0053
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0009 0.0009
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0084 0.0413 0.4011
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.0413 0.0404
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0168 0.0159
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0068 0.0059
Onchocerca volvulus 0.0084 0.0413 0.2256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.0413 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.1029 0.0972
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0084 0.0413 0.0413
Echinococcus granulosus cyclin dependent kinase 19 0.0147 0.09 0.09
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.0352
Schistosoma mansoni fkbp-rapamycin associated protein 0.0247 0.169 0.1682
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.104 0.7903 0.789
Entamoeba histolytica hypothetical protein 0.0247 0.169 0.1638
Echinococcus multilocularis 0.0084 0.0413 0.0404
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0162 0.0152
Echinococcus multilocularis serine protein kinase ATM 0.0247 0.169 0.1682
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0438 0.3189 0.3146
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0084 0.0413 0.0404
Trypanosoma cruzi casein kinase II, putative 0.015 0.0928 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0706 0.5285 0.5256
Loa Loa (eye worm) hypothetical protein 0.026 0.1794 0.1786
Echinococcus multilocularis cyclin dependent kinase 7 0.0087 0.0435 0.0426
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0084 0.0413 0.0352
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0084 0.0413 0.0352
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1307 1 1
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.015 0.0928 0.0919
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0147 0.09 0.0892
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.104 0.7903 0.789
Loa Loa (eye worm) gastrulation defective protein 1 0.0144 0.0878 0.0869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.5277 0.5247
Plasmodium vivax unspecified product 0.015 0.0928 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0413 0.0548
Schistosoma mansoni hypothetical protein 0.0084 0.0413 0.0404
Echinococcus granulosus cyclin dependent kinase 9 0.0061 0.023 0.023
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0084 0.0413 0.0404
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0068 0.008
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1307 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0084 0.0413 0.0404
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0928 0.0871
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0438 0.3189 0.3182
Entamoeba histolytica hypothetical protein 0.0084 0.0413 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.1307 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0877 0.6626 0.6605
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0084 0.0413 0.0352
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0413 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0413 0.4393
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0101 0.0541 0.0481
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0068 0.0006
Entamoeba histolytica hypothetical protein 0.0084 0.0413 0.0353
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0438 0.3189 0.3146
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0084 0.0413 0.0352
Brugia malayi Protein kinase domain containing protein 0.0101 0.0541 0.0532

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 20 uM Inhibitory activity against HIV-1 protease. ChEMBL. 8230099
IC50 (binding) > 20 uM Inhibitory activity against HIV-1 protease. ChEMBL. 8230099

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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