Detailed information for compound 1753776

Basic information

Technical information
  • TDR Targets ID: 1753776
  • Name: 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2 E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimin oacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabic yclo[4.2.0]oct-2-ene-2-carboxylate hydrochlor ide
  • MW: 548.033 | Formula: C20H26ClN5O7S2
  • H donors: 2 H acceptors: 5 LogP: 3 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO/N=C(\c1csc(n1)N)/C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)OCOC(=O)C(C)(C)C)C.Cl
  • InChi: 1S/C20H25N5O7S2.ClH/c1-9-6-33-16-12(23-14(26)11(24-30-5)10-7-34-19(21)22-10)15(27)25(16)13(9)17(28)31-8-32-18(29)20(2,3)4;/h7,12,16H,6,8H2,1-5H3,(H2,21,22)(H,23,26);1H/b24-11+;/t12-,16-;/m1./s1
  • InChiKey: XAAOHMIKXULDKJ-LZRHLYMTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
  • (6R,7R)-7-[[(2E)-2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester hydrochloride
  • (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-keto-3-methyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid pivaloyloxymethyl ester hydrochloride
  • 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
  • Ro 15-8075
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-methyl-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R-(6-alpha,7-beta(Z)))-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0029 0.0152 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0042 0.0083
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0653 0.5807
Echinococcus granulosus dna polymerase eta 0.002 0.0042 0.0052
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.035 0.0328
Brugia malayi Serotonin receptor 0.0048 0.0372 0.074
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.035 0.044
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Brugia malayi Sugar transporter family protein 0.0029 0.0152 0.0301
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0094 0.0493
Schistosoma mansoni sugar transporter 0.0029 0.0152 0.0191
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Schistosoma mansoni hypothetical protein 0.0414 0.4635 0.5832
Toxoplasma gondii sugar transporter ST1 0.0029 0.0152 0.0095
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Schistosoma mansoni neuropeptide receptor 0.0048 0.0372 0.0469
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1497 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0094 0.0186
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.035 0.2218
Echinococcus granulosus solute carrier family 22 0.0029 0.0152 0.0191
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.2214 0.2786
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.0372 0.0565
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0295 0.0371
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.016 0.0138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0094 0.0162
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0372 0.0469
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1497 1
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.0372 0.0469
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0153 0.0303
Schistosoma mansoni opsin-like receptor 0.0048 0.0372 0.0469
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0794 0.0999
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1095 0.3275
Giardia lamblia Hexose transporter 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.0549 0.109
Plasmodium falciparum phd finger protein, putative 0.0031 0.0177 0.0154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Plasmodium falciparum protein kinase 7 0.0582 0.6595 0.6587
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.009 0.0453
Echinococcus granulosus g protein coupled receptor 0.0048 0.0372 0.0469
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0372 0.0469
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0402 0.0798
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.0549 0.109
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0042 0.0202
Schistosoma mansoni opsin-like receptor 0.0048 0.0372 0.0469
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0042 0.0052
Trypanosoma brucei glucose transporter 2A 0.0064 0.0558 0.4905
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0042 0.0127
Brugia malayi jmjC domain containing protein 0.0102 0.1003 0.1992
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0504 0.0634
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Onchocerca volvulus 0.0029 0.0152 0.0117
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0372 0.074
Echinococcus granulosus somatostatin receptor 0.0048 0.0372 0.0469
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.0372 0.0469
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1095 0.3275
Loa Loa (eye worm) sugar transporter 0.0029 0.0152 0.0301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Onchocerca volvulus 0.0029 0.0152 0.0117
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1095 1
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0653 0.0632
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0152 0.0943
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0152 0.0191
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0269 0.1734
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.016 0.0108
Schistosoma mansoni lozenge 0.0056 0.0469 0.059
Schistosoma mansoni hypothetical protein 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0352
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0042 0.0127
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0372 0.0469
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Brugia malayi Dopamine receptor 0.0048 0.0372 0.074
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1095 0.3275
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Schistosoma mansoni bromodomain containing protein 0.0066 0.0579 0.0729
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0372 0.0469
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.0372 0.0469
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0372 0.074
Schistosoma mansoni amine GPCR 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0558 0.4905
Loa Loa (eye worm) runx1 0.0056 0.0469 0.0931
Echinococcus granulosus allatostatin A receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0372 0.074
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0099 0.0125
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.016 0.0369
Schistosoma mansoni metabotropic glutamate receptor 0.0135 0.1389 0.1747
Echinococcus granulosus General substrate transporter 0.0177 0.1877 0.2361
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0372 0.074
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Onchocerca volvulus 0.0029 0.0152 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.0372 0.0469
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0216 0.0429
Schistosoma mansoni protein kinase 0.0063 0.0549 0.0691
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.016 0.0369
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0534 0.0672
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0045
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.2214 0.2786
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1095 0.1378
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0064 0.0081
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0549 0.0528
Onchocerca volvulus 0.0048 0.0372 0.0565
Brugia malayi neuropeptide F receptor 0.0048 0.0372 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0152 0.0342
Entamoeba histolytica protein kinase, putative 0.0063 0.0549 0.1577
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.035 0.2925
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0558 0.4905
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0152 0.0129
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0094 0.0479
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0549 0.0528
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0068 0.1393
Brugia malayi jmjC domain containing protein 0.0041 0.0295 0.0586
Schistosoma mansoni sugar transporter 0.0029 0.0152 0.0191
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0152 0.0301
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0152 0.0301
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0094 0.0162
Loa Loa (eye worm) hypothetical protein 0.0039 0.0266 0.0529
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0094 0.0186
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.016 0.0108
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0372 0.0469
Brugia malayi sulfakinin receptor protein 0.0048 0.0372 0.074
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0152 0.0301
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0022 0.0044
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.7948 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.0372 0.0469
Echinococcus multilocularis solute carrier family 22 0.0029 0.0152 0.0191
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0177 0.0223
Schistosoma mansoni glucose transport protein 0.0206 0.2214 0.2786
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0094 0.0027
Loa Loa (eye worm) hypothetical protein 0.0062 0.0534 0.1061
Echinococcus multilocularis GPCR, family 3, C terminal 0.0026 0.0119 0.015
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Brugia malayi lysyl-tRNA synthetase 0.0046 0.035 0.0695
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.035 0.2218
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0372 0.074
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.3259 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0549 0.0528
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0206 0.2214 0.2786
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1095 0.1378
Brugia malayi CXXC zinc finger family protein 0.0029 0.0153 0.0303
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0042 0.0083
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1003 0.1262
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0372 0.0469
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.016 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0023 0.0077
Giardia lamblia PHD finger protein 15 0.0031 0.0177 0.0421
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0319 0.0402
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2214 0.2786
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Schistosoma mansoni hypothetical protein 0.0021 0.0057 0.0072
Schistosoma mansoni cpg binding protein 0.0033 0.0194 0.0245
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Trypanosoma cruzi hexose transporter 0.0064 0.0558 0.4905
Brugia malayi putative neuropeptide receptor 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Echinococcus multilocularis peregrin 0.0034 0.0205 0.0258
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0042 0.0052
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0094 0.0552
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0558 0.4905
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Schistosoma mansoni glucose transport protein 0.0206 0.2214 0.2786
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0152 0.1044
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.2214 0.2786
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0532 0.0669
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0372 0.0469
Echinococcus granulosus neuropeptide receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0563 0.1119
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0022 0.0028
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1095 1
Schistosoma mansoni histamine h1 receptor 0.0048 0.0372 0.0469
Echinococcus granulosus hypothetical protein 0.0048 0.0372 0.0469
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1095 0.3275
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0549 0.0691
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0549 0.0691
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.0372 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Echinococcus granulosus solute carrier family 22 0.0029 0.0152 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Echinococcus multilocularis General substrate transporter 0.0177 0.1877 0.2361
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1497 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0549 0.0528
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.0372 0.0469
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0372 0.0469
Onchocerca volvulus Poor gastrulation protein homolog 0.0026 0.0119 0.0052
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0269 0.1734
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Brugia malayi Cam kinase protein 1 0.0063 0.0549 0.109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.035 0.2925
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Onchocerca volvulus 0.0029 0.0152 0.0117
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0177 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0022 0.0028
Loa Loa (eye worm) glutamate receptor 0.0161 0.1694 0.3364
Onchocerca volvulus 0.0048 0.0372 0.0565
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.009 0.0453
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0045
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.016 0.0369
Onchocerca volvulus 0.0029 0.0152 0.0117
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Schistosoma mansoni glucose transporter 0.0029 0.0152 0.0191
Schistosoma mansoni myosin xvIII 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0372 0.074
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.009 0.0457
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.0372 0.0469
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0094 0.0493
Onchocerca volvulus 0.0048 0.0372 0.0565
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0269 0.1274
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0537 0.0676
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0177 0.0134
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0072 0.0648 0.1286
Echinococcus granulosus fmrfamide receptor 0.0048 0.0372 0.0469
Brugia malayi Bromodomain containing protein 0.0039 0.0266 0.0527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0336 0.0667
Loa Loa (eye worm) hypothetical protein 0.005 0.0399 0.0793
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.035 0.0328
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.3259 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1095 0.3275
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0152 0.0301
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0094 0.0493
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0549 0.0528
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0372 0.0469
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0549 0.0691
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.0372 0.0565
Loa Loa (eye worm) hypothetical protein 0.0124 0.1258 0.2499
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0549 0.0707
Onchocerca volvulus 0.0048 0.0372 0.0565
Echinococcus multilocularis Protein lozenge 0.0056 0.0469 0.059
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0271
Onchocerca volvulus 0.0029 0.0152 0.0117
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.0372 0.0469
Onchocerca volvulus Alhambra homolog 0.0031 0.0177 0.0169
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.0372 0.0469
Brugia malayi Bromodomain containing protein 0.0078 0.0717 0.1425
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Entamoeba histolytica hypothetical protein 0.0024 0.009 0.015
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0372 0.074
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0042 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0504 0.0634
Schistosoma mansoni hypothetical protein 0.0206 0.2214 0.2786
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0146 0.1517 0.3013
Schistosoma mansoni opsin-like receptor 0.0048 0.0372 0.0469
Schistosoma mansoni glucose transport protein 0.0206 0.2214 0.2786
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0099 0.0125
Echinococcus granulosus microtubule associated protein 2 0.0699 0.7948 1
Loa Loa (eye worm) hypothetical protein 0.0448 0.5035 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0199 0.2128 0.2678
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0152 0.0095
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0152 0.0342
Mycobacterium ulcerans hypothetical protein 0.0024 0.0094 0.0479
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0653 0.5807
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.035 0.0958
Loa Loa (eye worm) hypothetical protein 0.0124 0.1258 0.2499
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.016 0.0369
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0296 0.0588
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0558 0.1606
Brugia malayi GnHR receptor homolog 0.0048 0.0372 0.074
Schistosoma mansoni cpg binding protein 0.0033 0.0194 0.0245
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.035 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0094 0.0027
Onchocerca volvulus 0.0029 0.0152 0.0117
Loa Loa (eye worm) hypothetical protein 0.0041 0.0294 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0558 0.1606
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0534 0.0672
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0372 0.0469
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1095 0.1378
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0372 0.0469
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0549 0.0691
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1095 0.3275
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0372 0.0469
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0152 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0177 0.0223
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1095 1
Brugia malayi Bromodomain containing protein 0.0034 0.0205 0.0407
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0549 0.0691
Onchocerca volvulus 0.0048 0.0372 0.0565
Onchocerca volvulus 0.0048 0.0372 0.0565
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Toxoplasma gondii sugar transporter ST2 0.0029 0.0152 0.0095
Echinococcus granulosus solute carrier family 22 0.0029 0.0152 0.0191
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0015 0.0019
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0284 0.0753
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0372 0.074
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0152 0.0191
Onchocerca volvulus 0.0448 0.5035 1
Echinococcus granulosus solute carrier family 22 0.0029 0.0152 0.0191
Plasmodium vivax hexose transporter 0.0206 0.2214 0.2196
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0457
Echinococcus granulosus peregrin 0.0034 0.0205 0.0258
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0372 0.074
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0152 0.0342
Echinococcus multilocularis solute carrier family 22 0.0029 0.0152 0.0191
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0063 0.0549 0.109
Echinococcus granulosus metabotropic glutamate receptor 5 0.0199 0.2128 0.2678
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0558 0.4905
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0372 0.0469
Brugia malayi Dopamine receptor protein 1 0.0048 0.0372 0.074
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0534 0.1531
Brugia malayi Sugar transporter family protein 0.0206 0.2214 0.4398
Onchocerca volvulus 0.0048 0.0372 0.0565
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.0372 0.0469
Schistosoma mansoni neuropeptide receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0558 0.1606
Brugia malayi phosphofructokinase 0.011 0.1095 0.2175
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.3259 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0372 0.074
Brugia malayi hypothetical protein 0.0029 0.0152 0.0301
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1095 0.2175
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.009 0.0067
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0794 0.1577
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0758 0.0954
Brugia malayi major facilitator superfamily protein 0.0029 0.0152 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0152 0.0342
Onchocerca volvulus Huntingtin homolog 0.0124 0.1258 0.2357
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2214 0.2786
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0372 0.0469
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Onchocerca volvulus 0.0029 0.0152 0.0117
Echinococcus granulosus sex peptide receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0372 0.0469
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0152 0.0943
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0372 0.0469
Schistosoma mansoni amine GPCR 0.0048 0.0372 0.0469
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Echinococcus granulosus serotonin receptor 0.0048 0.0372 0.0469
Onchocerca volvulus 0.0048 0.0372 0.0565
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0402 0.0798
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Onchocerca volvulus 0.0029 0.0152 0.0117
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0549 0.0528
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0295 0.0371
Plasmodium vivax CDK-related protein kinase 6, putative 0.0875 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0372 0.0469
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Brugia malayi neuropeptide F receptor 0.0048 0.0372 0.074
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.4635 0.5832
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Toxoplasma gondii 6-phosphofructokinase 0.003 0.016 0.0108
Echinococcus multilocularis dna polymerase eta 0.002 0.0042 0.0052
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0429
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0333 0.3692 0.3678
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.0372 0.0469
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0534 0.1061
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.0372 0.0469
Schistosoma mansoni hypothetical protein 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0186
Echinococcus multilocularis dna polymerase kappa 0.002 0.0042 0.0052
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1095 0.1378
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0094 0.0162
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Echinococcus granulosus neuropeptide s receptor 0.0048 0.0372 0.0469
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0549 0.0528
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.035 0.044
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0094 0.0479
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Schistosoma mansoni protein kinase 0.0063 0.0549 0.0691
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis serotonin receptor 0.0048 0.0372 0.0469
Onchocerca volvulus 0.0048 0.0372 0.0565
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0372 0.0469
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.0372 0.0469
Onchocerca volvulus 0.0029 0.0152 0.0117
Schistosoma mansoni biogenic amine receptor 0.0048 0.0372 0.0469
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0372 0.0469
Echinococcus granulosus GPCR family 3 C terminal 0.0026 0.0119 0.015
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Giardia lamblia Sugar-proton symporter 0.0029 0.0152 0.0342
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0549 0.0691
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Loa Loa (eye worm) hypothetical protein 0.0062 0.0534 0.1061
Toxoplasma gondii sugar transporter ST3 0.0029 0.0152 0.0095
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0534 0.1531
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Onchocerca volvulus 0.0029 0.0152 0.0117
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1095 0.3218
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0094 0.0186
Schistosoma mansoni DNA polymerase eta 0.002 0.0042 0.0052
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0794 0.0999
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0094 0.0552
Entamoeba histolytica hypothetical protein 0.0046 0.035 0.0958
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0549 0.0691
Brugia malayi 6-phosphofructokinase 0.011 0.1095 0.2175
Brugia malayi Sugar transporter family protein 0.0029 0.0152 0.0301
Schistosoma mansoni sugar transporter 0.0029 0.0152 0.0191
Schistosoma mansoni amine GPCR 0.0048 0.0372 0.0469
Echinococcus granulosus neuropeptide receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0558 0.1606
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0099 0.0125
Echinococcus granulosus dna polymerase kappa 0.002 0.0042 0.0052
Onchocerca volvulus 0.0048 0.0372 0.0565
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.0372 0.0469
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0483 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0152 0.0342
Brugia malayi G-protein coupled receptor 0.0048 0.0372 0.074
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.0549 0.0691
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0534 0.1061
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0199 0.2128 0.4227
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0063 0.0549 0.4816
Onchocerca volvulus Putative transporter 0.0029 0.0152 0.0117
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0068 0.0309
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0549 0.0528
Brugia malayi hypothetical protein 0.0448 0.5035 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0794 0.1577
Toxoplasma gondii protein kinase, putative 0.0582 0.6595 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0057 0.0114
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0534 0.1531
Onchocerca volvulus 0.0029 0.0153 0.012
Brugia malayi G-protein coupled receptor 0.0048 0.0372 0.074
Echinococcus multilocularis sex peptide receptor 0.0048 0.0372 0.0469
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0372 0.074
Schistosoma mansoni adenoreceptor 0.0048 0.0372 0.0469
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0177 0.0154
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.016 0.4201
Trypanosoma brucei glucose transporter 1E 0.0064 0.0558 0.4905
Echinococcus multilocularis orexin receptor type 2 0.0048 0.0372 0.0469
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0237
Schistosoma mansoni cpg binding protein 0.0029 0.0153 0.0192
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0372 0.074
Schistosoma mansoni sugar transporter 0.0029 0.0152 0.0191
Schistosoma mansoni hypothetical protein 0.0026 0.0119 0.015
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.035 0.044
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1095 0.3275
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis solute carrier family 22 0.0029 0.0152 0.0191
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0094 0.0479
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.016 0.0138
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0094 0.0479
Loa Loa (eye worm) phosphofructokinase 0.011 0.1095 0.2175
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.035 0.0958
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0152 0.1044
Echinococcus multilocularis cpg binding protein 0.0033 0.0194 0.0245
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.035 0.044
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.0549 0.109
Echinococcus multilocularis serotonin receptor 0.0048 0.0372 0.0469
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.035 0.04
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0372 0.0469
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0045
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1095 0.7275
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0152 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0152 0.0342
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Schistosoma mansoni biogenic amine receptor 0.0048 0.0372 0.0469
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.009 0.0067
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0152 0.1044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Plasmodium vivax sugar transporter, putative 0.0029 0.0152 0.0129
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.7948 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0184 0.1951 0.2455
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.0372 0.0469
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.016 0.4201
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.016 0.0369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0558 0.1606
Leishmania major protein kinase, putative 0.0063 0.0549 0.4816
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0238 0.0299
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0083
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1095 0.7296
Onchocerca volvulus 0.0029 0.0152 0.0117
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Schistosoma mansoni neuropeptide receptor 0.0048 0.0372 0.0469
Plasmodium falciparum hexose transporter 0.0206 0.2214 0.2196
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0094 0.0479
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0549 0.0691
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0372 0.0469
Echinococcus granulosus g-protein coupled receptor 0.0048 0.0372 0.0469
Entamoeba histolytica protein kinase, putative 0.0063 0.0549 0.1577
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0119 0.0237
Echinococcus granulosus metabotropic glutamate receptor 2 0.0135 0.1389 0.1747
Onchocerca volvulus 0.0029 0.0152 0.0117
Toxoplasma gondii facilitative glucose transporter GT1 0.0206 0.2214 0.3266
Loa Loa (eye worm) glutamate receptor 0.0064 0.0553 0.1099
Brugia malayi G protein-coupled receptor 0.0048 0.0372 0.074
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0253 0.0319
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0372 0.074
Brugia malayi hypothetical protein 0.0029 0.0152 0.0301
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0295 0.0371
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.0372 0.0469
Onchocerca volvulus 0.0048 0.0372 0.0565
Leishmania major glucose transporter, lmgt1 0.0064 0.0558 0.4905
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0402 0.0798
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0152 0.0873
Onchocerca volvulus 0.0029 0.0152 0.0117
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0372 0.0469
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0372 0.0469
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0094 0.0479
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0041 0.0296 0.0588
Echinococcus multilocularis allatostatin A receptor 0.0048 0.0372 0.0469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0436 0.0866
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0135 0.1389 0.1747
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.0372 0.0469
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Schistosoma mansoni protein kinase 0.0063 0.0549 0.0691
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.035 0.2925
Schistosoma mansoni zinc finger protein 0.0021 0.0064 0.0081
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0152 0.1044
Loa Loa (eye worm) sugar transporter 0.0206 0.2214 0.4398
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0558 0.4905
Echinococcus multilocularis somatostatin receptor 0.0048 0.0372 0.0469
Echinococcus granulosus zinc finger protein 0.0021 0.0064 0.0081
Brugia malayi Metabotropic glutamate receptor precursor. 0.0161 0.1694 0.3364
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0537 0.0676
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Onchocerca volvulus 0.0029 0.0152 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0177 0.0223
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0372 0.074
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.035 0.1848
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0372 0.0469
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0319 0.0402
Onchocerca volvulus 0.0048 0.0372 0.0565
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Onchocerca volvulus 0.0048 0.0372 0.0565
Leishmania major hypothetical protein, conserved 0.0029 0.0152 0.1044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Schistosoma mansoni amine GPCR 0.0048 0.0372 0.0469
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0558 0.4905
Leishmania major glucose transporter, lmgt2 0.0064 0.0558 0.4905
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0372 0.0469
Trypanosoma brucei glucose transporter, putative 0.0064 0.0558 0.4905
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0653 0.5807
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0042 0.0202
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0558 0.1606
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0653 0.0632
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.009 0.0527
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0221 0.1702
Schistosoma mansoni hypothetical protein 0.0048 0.0372 0.0469
Onchocerca volvulus 0.0084 0.0794 0.1418
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Brugia malayi hypothetical protein 0.0029 0.0152 0.0301
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0059 0.0116
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0653 0.5807
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0017 0.0021
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.0372 0.0469
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0549 0.0707
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0549 0.0528
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0372 0.0469
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0534 0.0672
Echinococcus granulosus g protein coupled receptor 0.0048 0.0372 0.0469
Brugia malayi 6-phosphofructokinase 0.011 0.1095 0.2175
Echinococcus granulosus g protein coupled receptor 0.0048 0.0372 0.0469
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.009 0.0067
Echinococcus granulosus cpg binding protein 0.0033 0.0194 0.0245
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0152 0.0873
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0042 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.016 0.0369
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0152 0.1044
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.009 0.2044
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0372 0.0469
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0372 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2214 0.6752
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0152 0.0191
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0152 0.0301
Brugia malayi larval opioid receptor 0.0048 0.0372 0.074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0238 0.0299
Schistosoma mansoni hypothetical protein 0.0031 0.0177 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0026 0.0119 0.0052
Brugia malayi Dopamine receptor protein 2 0.0048 0.0372 0.074
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0041 0.0296 0.0588
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0046 0.035 0.0695
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2214 0.2786
Onchocerca volvulus Huntingtin homolog 0.0124 0.1258 0.2357
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0448 0.5035 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0402 0.0798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0372 0.0469
Schistosoma mansoni hypothetical protein 0.0048 0.0372 0.0469
Onchocerca volvulus 0.0048 0.0372 0.0565
Brugia malayi Serotonin receptor 0.0048 0.0372 0.074
Echinococcus granulosus dnaJ subfamily B 0.0414 0.4635 0.5832
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0152 0.0873
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0022 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0042 0.0052
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0372 0.074
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Onchocerca volvulus 0.0048 0.0372 0.0565
Echinococcus granulosus orexin receptor type 2 0.0048 0.0372 0.0469
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0534 0.0672
Loa Loa (eye worm) hypothetical protein 0.0041 0.0296 0.0588
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.0372 0.0469
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0094 0.0479
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Echinococcus multilocularis solute carrier family 22 0.0029 0.0152 0.0191
Schistosoma mansoni amine GPCR 0.0048 0.0372 0.0469
Brugia malayi RE15519p 0.0048 0.0372 0.074
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2214 0.2786
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0558 0.1606
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0333 0.3692 0.5538
Brugia malayi Melatonin receptor type 1A 0.0048 0.0372 0.074
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0794 0.0999
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.016 0.0369
Brugia malayi hypothetical protein 0.0124 0.1258 0.2499
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.016 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.0372 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Plasmodium falciparum mitogen-activated protein kinase 2 0.0333 0.3692 0.3678
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1095 0.7146
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.011 0.0218
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.016 0.0369
Brugia malayi major facilitator superfamily protein 0.0029 0.0152 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0549 0.1577
Brugia malayi AKH receptor 0.0048 0.0372 0.074
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Brugia malayi PHD-finger family protein 0.0027 0.0127 0.0252
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0558 0.4905
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0152 0.0191
Onchocerca volvulus 0.0048 0.0372 0.0565
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0549 0.0707
Schistosoma mansoni biogenic amine receptor 0.0048 0.0372 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.016 0.0288
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.073 0.0919
Onchocerca volvulus 0.0048 0.0372 0.0565
Loa Loa (eye worm) hypothetical protein 0.0048 0.0372 0.074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3259 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.3259 1
Leishmania major glucose transporter, lmgt3 0.0064 0.0558 0.4905
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0186
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0653 0.0867
Mycobacterium ulcerans sugar transporter 0.0029 0.0152 0.0873
Trypanosoma brucei sugar transporter, putative 0.0029 0.0152 0.1044
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0372 0.074
Brugia malayi ORL1-like opioid receptor 0.0048 0.0372 0.074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0372 0.0469
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0372 0.074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0372 0.0469
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0534 0.3158
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0295 0.0586
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0372 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0152 0.0342
Schistosoma mansoni neuropeptide receptor 0.0048 0.0372 0.0469
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1003 0.1262
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.016 0.0369
Brugia malayi hypothetical protein 0.0048 0.0372 0.074
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0177 0.0352
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0653 0.5807
Loa Loa (eye worm) hypothetical protein 0.0029 0.0152 0.0301
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0152 0.0342
Brugia malayi PHD-finger family protein 0.0031 0.0177 0.0352
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1095 0.2175
Brugia malayi metabotropic glutamate receptor type 2 0.0079 0.073 0.145

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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