TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 460.392 | Formula: C23H14F2N6O3
H donors: 2 H acceptors: 5 LogP: 3.23 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)n1cccc(c1=O)C(=O)Nc1ccc(c(c1)F)Oc1ncnc2c1nc[nH]2
InChi: 1S/C23H14F2N6O3/c24-13-3-1-4-15(9-13)31-8-2-5-16(23(31)33)21(32)30-14-6-7-18(17(25)10-14)34-22-19-20(27-11-26-19)28-12-29-22/h1-12H,(H,30,32)(H,26,27,28,29)
InChiKey: XQLXHIGCGPBKTR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	TYRO3 protein tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	AXL receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	MER proto-oncogene, tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_132328	All targets in OG5_132328
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	titin	0.0014	0.0022	0.0015
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.002	0.0111	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Onchocerca volvulus		0.0017	0.0075	0.494
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0204
Schistosoma mansoni	cell adhesion molecule	0.0021	0.0129	0.0358
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0014	0.0022	0.0027
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.002	0.0111	0.0261
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0014	0.0022	0.0059
Treponema pallidum	polypeptide deformylase (def)	0.0688	1	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0129	0.0358
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0041	0.0068
Leishmania major	polypeptide deformylase-like protein, putative	0.0262	0.3705	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0025	0.0188	0.0826
Schistosoma mansoni	tyrosine kinase	0.0013	0.0016	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0188	0.0515
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0075	0.0208
Brugia malayi	protein unc-22	0.0017	0.0075	0.0282
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0017	0.0075	0.0204
Schistosoma mansoni	cell adhesion molecule	0.0017	0.0075	0.0208
Mycobacterium ulcerans	peptide deformylase	0.0688	1	0.5
Schistosoma mansoni	hemicentin	0.0017	0.0075	0.0208
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0014	0.0022	0.0015
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0014	0.0022	0.006
Onchocerca volvulus		0.0021	0.0129	1
Schistosoma mansoni	cell adhesion molecule	0.0028	0.0242	0.0673
Echinococcus granulosus	neuroglian	0.0021	0.0129	0.0311
Echinococcus multilocularis	titin	0.0017	0.0075	0.0161
Schistosoma mansoni	hypothetical protein	0.0014	0.0022	0.006
Schistosoma mansoni	cell adhesion molecule	0.0017	0.0075	0.0208
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0014	0.0022	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0188	0.0515
Schistosoma mansoni	hypothetical protein	0.0014	0.0022	0.006
Schistosoma mansoni	tyrosine kinase	0.0013	0.0017	0.0047
Echinococcus multilocularis	roundabout 2	0.0021	0.0129	0.0311
Loa Loa (eye worm)	myotactin form A	0.0014	0.0022	0.0059
Brugia malayi	Protein-tyrosine phosphatase	0.0014	0.0022	0.0027
Brugia malayi	Fibronectin type III domain containing protein	0.0014	0.0022	0.0027
Brugia malayi	Lethal protein 805	0.0014	0.0022	0.0027
Loa Loa (eye worm)	plexin A	0.0025	0.0185	0.0508
Echinococcus granulosus	anosmin 1	0.0014	0.0022	0.0015
Echinococcus multilocularis	usherin	0.0014	0.0022	0.0015
Echinococcus multilocularis	Fibronectin, type III	0.0014	0.0022	0.0015
Schistosoma mansoni	factor for adipocyte differentiation	0.0014	0.0022	0.006
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0021	0.0129	0.0311
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0017	0.0076	0.0165
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0014	0.0022	0.0015
Schistosoma mansoni	titin	0.0017	0.0075	0.0208
Onchocerca volvulus		0.0017	0.0075	0.494
Brugia malayi	plexin A	0.0025	0.0185	0.0815
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.2097	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Echinococcus multilocularis	cell adhesion molecule	0.0014	0.0022	0.0015
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0075	0.0282
Echinococcus multilocularis	plexin a4	0.0025	0.0185	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0353
Schistosoma mansoni	nephrin	0.0021	0.0129	0.0358
Schistosoma mansoni	cell adhesion molecule	0.0021	0.0129	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Schistosoma mansoni	plexin	0.0021	0.0129	0.0359
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0017	0.0076	0.0165
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0075	0.0204
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Echinococcus granulosus	Netrin receptor DCC	0.0014	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0014	0.0022	0.006
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0014	0.0022	0.0015
Echinococcus granulosus	neuroglian	0.0015	0.004	0.0065
Echinococcus multilocularis	anosmin 1	0.0014	0.0022	0.0015
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0021	0.0129	0.0353
Echinococcus granulosus	nephrin	0.0017	0.0075	0.0161
Echinococcus granulosus	roundabout 2	0.0021	0.0129	0.0311
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0259	0.3649	1
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0014	0.0022	0.0015
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0014	0.0022	0.0015
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0129	0.0311
Schistosoma mansoni	tyrosine kinase	0.0013	0.0016	0.0044
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0262	0.3705	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0014	0.0022	0.0015
Loa Loa (eye worm)	SRC-1	0.0013	0.0016	0.0044
Schistosoma mansoni	tyrosine kinase	0.0255	0.3596	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0075	0.0282
Plasmodium falciparum	peptide deformylase	0.0688	1	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0014	0.0022	0.0015
Brugia malayi	Fibronectin type III domain containing protein	0.0025	0.0188	0.0826
Echinococcus granulosus	roundabout 2	0.0032	0.0295	0.0768
Schistosoma mansoni	ephrin receptor	0.002	0.0111	0.0309
Brugia malayi	hypothetical protein	0.0025	0.0188	0.0826
Loa Loa (eye worm)	CAMK protein kinase	0.0017	0.0075	0.0204
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0262	0.3705	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0094	0.0257
Echinococcus multilocularis	Netrin receptor DCC	0.0014	0.0022	0.0015
Loa Loa (eye worm)	UNCoordinated family member	0.0014	0.0022	0.0059
Echinococcus multilocularis	Netrin receptor DCC	0.0014	0.0022	0.0015
Echinococcus multilocularis	neuroglian	0.0015	0.004	0.0065
Echinococcus multilocularis	roundabout 2	0.0032	0.0295	0.0768
Schistosoma mansoni	titin	0.0017	0.0075	0.0208
Schistosoma mansoni	tyrosine kinase	0.0013	0.0016	0.0044
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0013	0.0016	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0353
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0014	0.0022	0.0027
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0014	0.0022	0.0015
Schistosoma mansoni	tyrosine kinase	0.0013	0.0016	0.0044
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0014	0.0022	0.006
Schistosoma mansoni	myosin-binding protein-related	0.0017	0.0075	0.0208
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0688	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0188	0.0515
Brugia malayi	myotactin form B	0.0014	0.0022	0.0027
Loa Loa (eye worm)	lethal protein 805	0.0014	0.0022	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0075	0.0161
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0014	0.0022	0.0015
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0129	0.0542
Onchocerca volvulus		0.0017	0.0075	0.494
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Brugia malayi	Plexin repeat family protein	0.0021	0.0129	0.0543
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0014	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Echinococcus granulosus	Netrin receptor DCC	0.0014	0.0022	0.0015
Brugia malayi	Tyrosine-protein kinase abl-1	0.0108	0.1425	0.6773
Echinococcus granulosus	cell adhesion molecule	0.0014	0.0022	0.0015
Loa Loa (eye worm)	projectin	0.0017	0.0075	0.0204
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0075	0.0282
Brugia malayi	myotactin form A	0.0014	0.0022	0.0027
Schistosoma mansoni	nephrin	0.0028	0.0241	0.067
Echinococcus granulosus	titin	0.0017	0.0075	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Echinococcus granulosus	Fibronectin type III	0.0014	0.0022	0.0015
Echinococcus multilocularis	transfer RNA-Phe	0.0017	0.0075	0.0161
Brugia malayi	hypothetical protein	0.0014	0.0022	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1319	0.3614
Schistosoma mansoni	tripartite motif protein trim9	0.0014	0.0022	0.006
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0021	0.013	0.0357
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0129	0.0542
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0014	0.0022	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Brugia malayi	Fibronectin type III domain containing protein	0.0014	0.0022	0.0027
Echinococcus granulosus	plexin a4	0.0025	0.0185	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Brugia malayi	Fibronectin type III domain containing protein	0.0014	0.0022	0.0027
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0014	0.0022	0.0015
Toxoplasma gondii	hypothetical protein	0.0688	1	0.5
Brugia malayi	Lethal protein 805	0.0014	0.0022	0.0027
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0262	0.3705	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0014	0.0022	0.0059
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0688	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0108	0.1425	0.3879
Schistosoma mansoni	titin	0.0014	0.0022	0.006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0129	0.0542
Brugia malayi	SPRY domain containing protein	0.0014	0.0022	0.0027
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0075	0.0282
Echinococcus multilocularis	anosmin 1	0.0014	0.0022	0.0015
Brugia malayi	Fibronectin type III domain containing protein	0.0014	0.0022	0.0027
Echinococcus granulosus	G1Y162 protein	0.0014	0.0022	0.0015
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.013	0.0549
Schistosoma mansoni	hypothetical protein	0.0017	0.0075	0.0208
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0014	0.0022	0.0059
Echinococcus granulosus	roundabout 2	0.0021	0.0129	0.0311
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0262	0.3705	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0021	0.0129	0.0353
Plasmodium vivax	peptide deformylase, putative	0.0688	1	0.5
Trypanosoma brucei	Polypeptide deformylase 1	0.0262	0.3705	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0129	0.0311
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0075	0.0282
Echinococcus granulosus	EG95	0.0014	0.0022	0.0015
Echinococcus granulosus	anosmin 1	0.0014	0.0022	0.0015
Trypanosoma brucei	Peptide deformylase 2	0.0262	0.3705	1
Schistosoma mansoni	factor for adipocyte differentiation	0.0014	0.0022	0.006
Echinococcus multilocularis	roundabout 2	0.0021	0.0129	0.0311
Echinococcus granulosus	anosmin 1	0.0014	0.0022	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0014	0.0022	0.0015
Brugia malayi	Fibronectin type III domain containing protein	0.0014	0.0022	0.0027
Echinococcus granulosus	twitchin	0.0015	0.004	0.0065
Schistosoma mansoni	factor for adipocyte differentiation	0.0014	0.0022	0.006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0076	0.0287
Echinococcus multilocularis	neuroglian	0.0021	0.0129	0.0311
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0021	0.0129	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0059
Echinococcus multilocularis	anosmin 1	0.0014	0.0022	0.0015
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0075	0.0204
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0075	0.0282
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0076	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0041	0.0112
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0129	0.0311
Echinococcus granulosus	usherin	0.0014	0.0022	0.0015
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0688	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0094	0.0257
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0014	0.0022	0.006
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0075	0.0204
Echinococcus granulosus	contactin	0.0021	0.0129	0.0311
Schistosoma mansoni	protein tyrosine phosphatase	0.0014	0.0022	0.006
Schistosoma mansoni	neuroglian	0.0021	0.0129	0.0358
Echinococcus granulosus	titin	0.0017	0.0075	0.0161
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0259	0.3649	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0259	0.3649	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0075	0.0282

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 4 %	Binding affinity to phosphorylated ABL1 (unknown origin) at 1 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 18 %	Binding affinity to phosphorylated ABL1 (unknown origin) at 75 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 20 %	Binding affinity to TYRO3 (unknown origin) at 1 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 51 %	Binding affinity to MET (unknown origin) at 1 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 73 %	Binding affinity to non phosphorylated ABL1 (unknown origin) at 75 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 75 %	Binding affinity to non phosphorylated ABL1 (unknown origin) at 1 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 89 %	Binding affinity to MER (unknown origin) at 1 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 93 %	Binding affinity to AXL (unknown origin) at 1 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 94 %	Binding affinity to TYRO3 (unknown origin) at 75 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 97 %	Binding affinity to MET (unknown origin) at 75 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 97 %	Binding affinity to MER (unknown origin) at 75 uM after 1 hr relative to control	ChEMBL.	22749189
Activity (binding)	= 99 %	Binding affinity to AXL (unknown origin) at 75 uM after 1 hr relative to control	ChEMBL.	22749189
GI (functional)	< 10 %	Growth inhibition of human PC3 cells at 10 uM after 72 hrs by MTT assay relative to control	ChEMBL.	22749189
Kd (binding)	= 190 nM	Binding affinity to MER (unknown origin) after 1 hr	ChEMBL.	22749189
Kd (binding)	= 210 nM	Binding affinity to AXL (unknown origin) after 1 hr	ChEMBL.	22749189
Kd (binding)	= 320 nM	Binding affinity to non phosphorylated ABL1 (unknown origin) after 1 hr	ChEMBL.	22749189
Kd (binding)	= 440 nM	Binding affinity to MET (unknown origin) after 1 hr	ChEMBL.	22749189
Kd (binding)	= 900 nM	Binding affinity to TYRO3 (unknown origin) after 1 hr	ChEMBL.	22749189
Kd (binding)	= 3300 nM	Binding affinity to phosphorylated ABL1 (unknown origin) after 1 hr	ChEMBL.	22749189

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2348263

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1754047