Detailed information for compound 1762633

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 330.461 | Formula: C21H30O3
  • H donors: 0 H acceptors: 1 LogP: 4.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@]1(C)CCC[C@]2([C@H]1CC[C@@H]1[C@@H]2Cc2c([C@@H]1C)cco2)C
  • InChi: 1S/C21H30O3/c1-13-15-6-7-19-20(3,9-5-10-21(19,4)24-14(2)22)17(15)12-18-16(13)8-11-23-18/h8,11,13,15,17,19H,5-7,9-10,12H2,1-4H3/t13-,15+,17+,19-,20-,21+/m1/s1
  • InChiKey: YUAQBFTWNHXSHR-MEOKCCQFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.0155 0.1494 0.2011
Echinococcus granulosus microtubule associated protein 2 0.0698 0.7117 0.9579
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0822 0.1156
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0051 0.0258
Echinococcus granulosus aurora kinase A 0.0174 0.1692 0.2277
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0481 0.2819
Loa Loa (eye worm) Smad1 0.0017 0.0069 0.0069
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Trypanosoma brucei glucosidase, putative 0.0037 0.027 0.1375
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0175 0.1707 1
Schistosoma mansoni hypothetical protein 0.0149 0.1429 0.2008
Echinococcus granulosus caspase 3 0.0082 0.0742 0.0999
Brugia malayi MH1 domain containing protein 0.0017 0.0069 0.0069
Trypanosoma brucei metacaspase 5, putative 0.005 0.0409 0.2081
Entamoeba histolytica cyclin family protein 0.0125 0.1185 0.6033
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0409 0.2395
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.1056 0.2011
Toxoplasma gondii hypothetical protein 0.0095 0.0873 0.5114
Echinococcus multilocularis cyclins 0.0125 0.1185 0.1464
Entamoeba histolytica hypothetical protein 0.0035 0.0254 0.1295
Brugia malayi hypothetical protein 0.0029 0.0193 0.0193
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.7117 0.8795
Toxoplasma gondii exonuclease III APE 0.0018 0.0081 0.0475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0413 0.0413
Plasmodium falciparum metacaspase-like protein 0.005 0.0409 0.2395
Trichomonas vaginalis cyclin B, putative 0.0125 0.1185 0.4303
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0069 0.0085
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0699 0.2398
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.027 0.1582
Trichomonas vaginalis cyclin A, putative 0.02 0.1964 0.7133
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0351 0.2054
Schistosoma mansoni Cyclin fold protein 0.003 0.0204 0.0286
Trypanosoma cruzi cdc2-related kinase 1 0.0175 0.1707 0.8689
Schistosoma mansoni cyclin l 0.003 0.0204 0.0286
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0699 0.0941
Plasmodium falciparum glutathione reductase 0.0044 0.0351 0.2054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0822 0.1156
Schistosoma mansoni smad 0.0017 0.0069 0.0096
Brugia malayi MH1 domain containing protein 0.0017 0.0069 0.0069
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0051 0.0296
Brugia malayi MH2 domain containing protein 0.0017 0.0069 0.0069
Brugia malayi Latrophilin receptor protein 2 0.005 0.0413 0.0413
Echinococcus multilocularis cyclin dependent kinase 1 0.0175 0.1707 0.2109
Schistosoma mansoni alpha glucosidase 0.0037 0.027 0.0379
Brugia malayi hypothetical protein 0.0729 0.743 0.743
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0481 0.1593
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0373 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0701
Leishmania major mitotic cyclin, putative 0.003 0.0204 0.1037
Echinococcus granulosus G protein coupled receptor kinase 1 0.0256 0.2541 0.3421
Schistosoma mansoni caspase-7 (C14 family) 0.0132 0.1259 0.1769
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0051 0.0184
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.003 0.0204 0.1193
Trypanosoma cruzi metacaspase, putative 0.005 0.0409 0.2081
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0193 0.0239
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0069 0.0092
Echinococcus granulosus cyclins 0.0125 0.1185 0.1595
Loa Loa (eye worm) hypothetical protein 0.0075 0.0671 0.0671
Echinococcus granulosus cyclin G2 0.003 0.0204 0.0274
Schistosoma mansoni cpg binding protein 0.0029 0.0187 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.2843 0.3995
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0699 0.2538
Echinococcus multilocularis cyclins 0.0125 0.1185 0.1464
Toxoplasma gondii ABC1 family protein 0.0078 0.0699 0.4094
Schistosoma mansoni protein kinase 0.0174 0.1692 0.2377
Echinococcus granulosus cyclin t1 0.003 0.0204 0.0274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0481 0.1593
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0884 0.1242
Schistosoma mansoni cyclin G2 0.003 0.0204 0.0286
Leishmania major trypanothione reductase 0.0044 0.0351 0.1785
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0351 0.0472
Plasmodium falciparum serine/threonine protein kinase, putative 0.0174 0.1692 0.9911
Giardia lamblia Hypothetical protein 0.0125 0.1185 0.5928
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0822 0.0822
Trichomonas vaginalis cyclin B3, putative 0.0125 0.1185 0.4303
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.0193 0.0271
Echinococcus multilocularis cyclin A3 4 0.003 0.0204 0.0252
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0174 0.1692 0.8612
Entamoeba histolytica cyclin, domain containing protein 0.003 0.0204 0.1037
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0699 0.2398
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0481 0.2449
Entamoeba histolytica hypothetical protein 0.0029 0.0193 0.0983
Echinococcus multilocularis caspase 8 0.005 0.0409 0.0505
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0822 0.1107
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.003 0.0204 0.1193
Trichomonas vaginalis cyclins, putative 0.02 0.1964 0.7133
Loa Loa (eye worm) hypothetical protein 0.0078 0.0699 0.0699
Brugia malayi PXA domain containing protein 0.0029 0.0193 0.0193
Loa Loa (eye worm) cyclin domain-containing protein 0.0977 1 1
Schistosoma mansoni ap endonuclease 0.0018 0.0081 0.0114
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0884 0.4498
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0481 0.0861
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0081 0.01
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.8092 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0409 0.1485
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0204 0.074
Schistosoma mansoni axis inhibition protein axin 0.0029 0.0193 0.0271
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0699 0.2538
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0051 0.0051
Leishmania major mitotic cyclin, putative 0.003 0.0204 0.1037
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0032 0.0118
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0125 0.1185 0.1595
Echinococcus granulosus cyclin 0.003 0.0204 0.0274
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0254 0.0357
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Echinococcus multilocularis caspase 0.0132 0.1259 0.1556
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0699 0.0864
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0699 0.3557
Onchocerca volvulus 0.0149 0.1429 0.7229
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0193 0.0271
Schistosoma mansoni alpha-glucosidase 0.0142 0.136 0.1911
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Echinococcus multilocularis beta adrenergic receptor kinase 0.0285 0.2843 0.3513
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0081 0.0109
Echinococcus multilocularis G1:S specific cyclin D1 0.003 0.0204 0.0252
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1597 0.1974
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0032 0.0118
Brugia malayi glutaminase DH11.1 0.0277 0.2754 0.2754
Trypanosoma brucei metacaspase 0.005 0.0409 0.2081
Onchocerca volvulus Protein CNPPD1 homolog 0.003 0.0204 0.0886
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0884 0.4498
Trichomonas vaginalis cyclin D, putative 0.003 0.0204 0.074
Echinococcus granulosus axis inhibition protein axin 0.0029 0.0193 0.026
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.027 0.1375
Loa Loa (eye worm) hypothetical protein 0.0171 0.1663 0.1663
Loa Loa (eye worm) hypothetical protein 0.0078 0.0699 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0701
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0699 0.0699
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0403 0.1464
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0884 0.0884
Echinococcus granulosus regulator of G protein signaling 3 0.0029 0.0193 0.026
Echinococcus multilocularis cyclin dependent kinase 1 0.0175 0.1707 0.2109
Brugia malayi Cyclin, N-terminal domain containing protein 0.003 0.0204 0.0204
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0451 0.2641
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Loa Loa (eye worm) hypothetical protein 0.0109 0.1018 0.1018
Loa Loa (eye worm) hypothetical protein 0.0078 0.0699 0.0699
Trichomonas vaginalis cyclin B, putative 0.02 0.1964 0.7133
Entamoeba histolytica protein kinase , putative 0.0174 0.1692 0.8612
Trichomonas vaginalis CMGC family protein kinase 0.0175 0.1707 0.6198
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0174 0.1692 0.2277
Brugia malayi cell division control protein 2 homolog 0.0175 0.1707 0.1707
Trypanosoma cruzi cyclin, putative 0.02 0.1964 1
Echinococcus granulosus Smad4 0.0017 0.0069 0.0092
Echinococcus granulosus cyclins 0.0125 0.1185 0.1595
Loa Loa (eye worm) AUR protein kinase 0.0174 0.1692 0.1692
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0884 0.4498
Giardia lamblia Kinase, PLK 0.0096 0.0884 0.4353
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0032 0.0118
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0193 0.026
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0699 0.1297
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0351 0.0351
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0699 0.4094
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1597 0.215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.1539 0.1539
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0204 0.074
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0032 0.0032
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0884 0.4498
Brugia malayi MH2 domain containing protein 0.0251 0.2492 0.2492
Echinococcus multilocularis geminin 0.0331 0.3314 0.4096
Trypanosoma cruzi mitotic cyclin, putative 0.003 0.0204 0.1037
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0081 0.0295
Brugia malayi cyclin fold protein 1 variant b 0.003 0.0204 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0174 0.1692 0.6143
Onchocerca volvulus Cyclin L homolog 0.003 0.0204 0.0886
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0081 0.0413
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.003 0.0204 0.0252
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.003 0.0204 0.0286
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.02 0.1964 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0204 0.1193
Schistosoma mansoni Smad4 0.0017 0.0069 0.0096
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Echinococcus multilocularis cyclins 0.0125 0.1185 0.1464
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0051 0.0296
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0193
Trypanosoma brucei Metacaspase-4 0.005 0.0409 0.2081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0187 0.0187
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.005 0.0409 0.0574
Schistosoma mansoni cpg binding protein 0.003 0.0204 0.0286
Echinococcus multilocularis smad 0.0017 0.0069 0.0085
Schistosoma mansoni hypothetical protein 0.0035 0.0254 0.0357
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0481 0.0676
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0051 0.0258
Trichomonas vaginalis cyclins, putative 0.02 0.1964 0.7133
Loa Loa (eye worm) hypothetical protein 0.0078 0.0699 0.0699
Mycobacterium ulcerans hypothetical protein 0.0078 0.0699 0.2398
Echinococcus granulosus cyclin A3 4 0.003 0.0204 0.0274
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0051 0.0258
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0174 0.1692 0.8612
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0029 0.0193 0.0701
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0032 0.0118
Brugia malayi Cell death protein 3 precursor 0.0097 0.0891 0.0891
Echinococcus multilocularis cyclin y 0.003 0.0204 0.0252
Brugia malayi beta-lactamase 0.0078 0.0699 0.0699
Loa Loa (eye worm) glutathione reductase 0.0044 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.003 0.0204 0.0286
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0699 0.1297
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0008 0.0008
Echinococcus multilocularis GPCR, family 2 0.005 0.0413 0.051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0699 0.1297
Echinococcus multilocularis cyclin B3 1 0.0125 0.1185 0.1464
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0193
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0351 0.0433
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0033 0.0237 0.0237
Giardia lamblia Hypothetical protein 0.003 0.0204 0.08
Loa Loa (eye worm) hypothetical protein 0.0078 0.0699 0.0699
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.0939 0.1777
Loa Loa (eye worm) CYL-1 protein 0.003 0.0204 0.0204
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0409 0.2395
Schistosoma mansoni cyclin B3 0.0125 0.1185 0.1665
Entamoeba histolytica cyclin family protein 0.0125 0.1185 0.6033
Echinococcus multilocularis expressed protein 0.0029 0.0193 0.0239
Echinococcus granulosus cyclin B3 1 0.0125 0.1185 0.1595
Echinococcus multilocularis muscleblind protein 0.0155 0.1494 0.1846
Giardia lamblia Cyclin B-like protein 0.003 0.0204 0.08
Onchocerca volvulus 0.0095 0.0878 0.4377
Loa Loa (eye worm) hypothetical protein 0.0159 0.1539 0.1539
Plasmodium falciparum cyclin 1 0.003 0.0204 0.1193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Echinococcus granulosus Cyclin L1 0.003 0.0204 0.0274
Loa Loa (eye worm) glutaminase 0.0277 0.2754 0.2754
Loa Loa (eye worm) hypothetical protein 0.005 0.0413 0.0413
Schistosoma mansoni hypothetical protein 0.005 0.0413 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0884 0.3209
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1597 0.1974
Onchocerca volvulus 0.0078 0.0699 0.3449
Mycobacterium ulcerans lipase LipD 0.0078 0.0699 0.2398
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4096 0.5062
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0175 0.1707 0.8689
Loa Loa (eye worm) hypothetical protein 0.003 0.0204 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0174 0.1692 0.6143
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0193 0.0271
Echinococcus granulosus smad 0.0017 0.0069 0.0092
Trypanosoma cruzi CYC2-like cyclin, putative 0.02 0.1964 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0409 0.1485
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0351 0.1785
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0193 0.0271
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0081 0.0413
Schistosoma mansoni hypothetical protein 0.0047 0.0373 0.0525
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0204 0.0204
Giardia lamblia Kinase, CMGC CDK 0.0175 0.1707 0.8655
Echinococcus granulosus regulator of G protein signaling 3 0.0029 0.0193 0.026
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.027 0.0981
Brugia malayi CXXC zinc finger family protein 0.0029 0.0187 0.0187
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.027 0.0981
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.1429 0.1429
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.1018 0.1018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0699 0.0982
Schistosoma mansoni alpha-glucosidase 0.0142 0.136 0.1911
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0822 0.1016
Echinococcus multilocularis Smad4 0.0017 0.0069 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0701
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0032 0.0165
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0051 0.0258
Toxoplasma gondii cyclin 4, putative 0.003 0.0204 0.1193
Leishmania major metacaspase, putative 0.005 0.0409 0.2081
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0029 0.0193 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0409 0.1485
Loa Loa (eye worm) hypothetical protein 0.02 0.1964 0.1964
Trichomonas vaginalis glutaminase, putative 0.0277 0.2754 1
Entamoeba histolytica protein kinase, putative 0.0174 0.1692 0.8612
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0051 0.0258
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0174 0.1692 0.9911
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.027 0.1375
Loa Loa (eye worm) hypothetical protein 0.0729 0.743 0.743
Loa Loa (eye worm) hypothetical protein 0.003 0.0204 0.0204
Trichomonas vaginalis cyclin B3, putative 0.003 0.0204 0.074
Loa Loa (eye worm) cyclin domain-containing protein 0.0125 0.1185 0.1185
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0032 0.0118
Echinococcus multilocularis aurora kinase A 0.0174 0.1692 0.209
Trichomonas vaginalis cyclin B, putative 0.02 0.1964 0.7133
Brugia malayi Cyclin, N-terminal domain containing protein 0.003 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0193
Trichomonas vaginalis cyclin B, putative 0.003 0.0204 0.074
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0409 0.2081
Plasmodium falciparum protein kinase 5 0.0175 0.1707 1
Brugia malayi beta-lactamase family protein 0.0078 0.0699 0.0699
Echinococcus multilocularis cyclin G2 0.003 0.0204 0.0252
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.1056 0.2011
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0081 0.0081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0081 0.0113
Trichomonas vaginalis cyclin D, putative 0.0125 0.1185 0.4303
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0403 0.1464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0174 0.1692 0.8612
Entamoeba histolytica cyclin C, putative 0.003 0.0204 0.1037
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0204 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0204 0.074
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0481 0.0648
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0699 0.1297
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0081 0.016
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0409 0.1485
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0254 0.0314
Loa Loa (eye worm) PXA domain-containing protein 0.0029 0.0193 0.0193
Leishmania major hypothetical protein, conserved 0.0078 0.0699 0.3557
Trypanosoma brucei metacaspase MCA3 0.005 0.0409 0.2081
Entamoeba histolytica hypothetical protein 0.0029 0.0193 0.0983
Loa Loa (eye worm) hypothetical protein 0.005 0.0409 0.0409
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0081 0.0413
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0081 0.0413
Brugia malayi Thioredoxin reductase 0.0044 0.0351 0.0351
Echinococcus granulosus oligomeric golgi complex subunit 3 0.003 0.0204 0.0274
Brugia malayi Cyclin C 0.003 0.0204 0.0204
Echinococcus granulosus caspase 8 0.005 0.0409 0.055
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.003 0.0204 0.1193
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.003 0.0204 0.1193
Echinococcus multilocularis cyclin k 0.003 0.0204 0.0252
Onchocerca volvulus 0.003 0.0204 0.0886
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0413 0.0556
Trichomonas vaginalis cyclin A, putative 0.003 0.0204 0.074
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0051 0.0071
Brugia malayi glutathione reductase 0.0044 0.0351 0.0351
Entamoeba histolytica protein kinase domain containing protein 0.0174 0.1692 0.8612
Loa Loa (eye worm) RGS-3 protein 0.0029 0.0193 0.0193
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0081 1
Echinococcus granulosus cyclins 0.0125 0.1185 0.1595
Echinococcus granulosus expressed protein 0.0029 0.0193 0.026
Plasmodium falciparum thioredoxin reductase 0.0015 0.0051 0.0296
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0081 0.0081
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.0939 0.1777
Schistosoma mansoni hypothetical protein 0.0109 0.1018 0.143
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0051 0.0296
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0069 0.0085
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0193 0.0271
Echinococcus granulosus beta-adrenergic receptor kinase 0.0285 0.2843 0.3827
Trypanosoma cruzi metacaspase, putative 0.005 0.0409 0.2081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0822 0.1156
Trichomonas vaginalis cyclins, putative 0.0125 0.1185 0.4303
Schistosoma mansoni hypothetical protein 0.005 0.0413 0.058
Echinococcus granulosus Regulator of G protein signaling 20 0.0029 0.0193 0.026
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0699 0.1297
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0081 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.005 0.0409 0.0409
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.003 0.0204 0.0252
Brugia malayi Regulator of G protein signaling domain containing protein 0.0029 0.0193 0.0193
Echinococcus granulosus caspase 0.0132 0.1259 0.1695
Trichomonas vaginalis cyclins, putative 0.02 0.1964 0.7133
Echinococcus multilocularis regulator of G protein signaling 3 0.0029 0.0193 0.0239
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0081 0.0061
Echinococcus multilocularis cyclins 0.0125 0.1185 0.1464
Echinococcus granulosus cyclin y 0.003 0.0204 0.0274
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0051 0.0184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0822 0.0822
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0285 0.2843 0.2843
Echinococcus granulosus G1:S specific cyclin D1 0.003 0.0204 0.0274
Schistosoma mansoni smad1 5 8 and 0.0017 0.0069 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0699 0.2538
Loa Loa (eye worm) hypothetical protein 0.02 0.1964 0.1964
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0193 0.0271
Mycobacterium tuberculosis Conserved protein 0.0078 0.0699 0.1297
Plasmodium vivax glutathione reductase, putative 0.0044 0.0351 0.2054
Echinococcus multilocularis regulator of G protein signaling 0.0029 0.0193 0.0239
Echinococcus granulosus cyclin G2 0.003 0.0204 0.0274
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0499 0.5049 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0029 0.0193 0.0193
Brugia malayi serine/threonine protein kinase 6 0.0174 0.1692 0.1692
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1494 0.1846
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0413 0.051
Onchocerca volvulus 0.0078 0.0699 0.3449
Entamoeba histolytica cell division protein kinase 2, putative 0.0175 0.1707 0.8689
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0175 0.1707 0.8689
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0193
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0051 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0701
Giardia lamblia Cyclin A 0.0125 0.1185 0.5928
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0051 0.0296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0413 0.051
Schistosoma mansoni survival motor neuron protein 0.0149 0.1429 0.2008
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.1056 0.2011
Brugia malayi Cyclin, N-terminal domain containing protein 0.003 0.0204 0.0204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0822 0.1016
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0884 0.3209
Schistosoma mansoni hypothetical protein 0.0331 0.3314 0.4657
Onchocerca volvulus 0.02 0.1964 1
Trypanosoma cruzi metacaspase, putative 0.005 0.0409 0.2081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0193
Trypanosoma cruzi mitotic cyclin, putative 0.003 0.0204 0.1037
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0204 0.0204
Loa Loa (eye worm) AUR protein kinase 0.0174 0.1692 0.1692
Echinococcus multilocularis cyclin G2 0.003 0.0204 0.0252
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0051 0.0296
Trypanosoma brucei metacaspase MCA2 0.005 0.0409 0.2081
Toxoplasma gondii aurora kinase 0.0174 0.1692 0.9911
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0884 0.4406
Onchocerca volvulus 0.0029 0.0187 0.0799
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0193
Plasmodium vivax protein kinase Crk2 0.0175 0.1707 1
Schistosoma mansoni hypothetical protein 0.0406 0.4096 0.5756
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0884 0.3209
Trypanosoma brucei cdc2-related kinase 1 0.0175 0.1707 0.8689
Brugia malayi Cyclin, N-terminal domain containing protein 0.02 0.1964 0.1964
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0029 0.0193 0.0239
Trypanosoma brucei cyclin 3 0.003 0.0204 0.1037
Loa Loa (eye worm) hypothetical protein 0.0155 0.1494 0.1494
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.027 0.0981
Toxoplasma gondii cyclin dependent kinase binding protein 0.003 0.0204 0.1193
Echinococcus multilocularis cyclin dependent kinase 0.0175 0.1707 0.2109
Schistosoma mansoni smad1 5 8 and 0.0017 0.0069 0.0096
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0409 0.2081
Plasmodium falciparum glutathione reductase 0.0015 0.0051 0.0296
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0884 0.1189
Echinococcus multilocularis cyclin dependent kinase 5 0.0175 0.1707 0.2109
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0032 0.0165
Mycobacterium tuberculosis Conserved protein 0.0078 0.0699 0.1297
Schistosoma mansoni kinase 0.0051 0.0416 0.0584
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1597 0.1597
Giardia lamblia Kinase, CMGC CDK 0.0175 0.1707 0.8655
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.027 0.0981
Schistosoma mansoni hypothetical protein 0.0331 0.3314 0.4657
Brugia malayi Cyclin, N-terminal domain containing protein 0.003 0.0204 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0884 0.3209
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.1185 0.4303
Echinococcus granulosus cyclin k 0.003 0.0204 0.0274
Trichomonas vaginalis cyclins, putative 0.02 0.1964 0.7133
Schistosoma mansoni g1/s-specific cyclin C 0.003 0.0204 0.0286
Loa Loa (eye worm) AUR protein kinase 0.0174 0.1692 0.1692
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0125 0.1185 0.1464
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0175 0.1707 0.2297
Trichomonas vaginalis esterase, putative 0.0078 0.0699 0.2538
Echinococcus granulosus cyclin dependent kinase 0.0175 0.1707 0.2297
Trichomonas vaginalis AGC family protein kinase 0.0174 0.1692 0.6143
Trypanosoma brucei polo-like protein kinase 0.0096 0.0884 0.4498
Brugia malayi hypothetical protein 0.003 0.0204 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0481 0.1593
Schistosoma mansoni cyclin B 0.02 0.1964 0.276
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0033 0.0237 0.0237
Echinococcus granulosus cyclins 0.003 0.0204 0.0274
Plasmodium vivax cyclin homologue, putative 0.003 0.0204 0.1193
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.7117 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0081 0.0475
Trypanosoma cruzi cdc2-related kinase 3 0.0175 0.1707 0.8689
Entamoeba histolytica cell division protein kinase 2, putative 0.0175 0.1707 0.8689
Schistosoma mansoni ap endonuclease 0.0018 0.0081 0.0114
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.027 0.1375
Brugia malayi MH2 domain containing protein 0.0017 0.0069 0.0069
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0051 0.5
Echinococcus multilocularis cyclin b3 0.0125 0.1185 0.1464
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0032 0.0165
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.003 0.0204 0.0274
Brugia malayi Cyclin, N-terminal domain containing protein 0.003 0.0204 0.0204
Echinococcus multilocularis Regulator of G protein signaling 20 0.0029 0.0193 0.0239
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0699 0.2538
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0132 0.1259 0.1556
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.1539 0.1539
Echinococcus multilocularis cyclins 0.0125 0.1185 0.1464
Entamoeba histolytica cyclin, domain containing protein 0.003 0.0204 0.1037
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.027 0.1375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0699 0.0982
Echinococcus multilocularis Cyclin L1 0.003 0.0204 0.0252
Toxoplasma gondii hypothetical protein 0.003 0.0204 0.1193
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.0939 0.1777
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0132 0.1259 0.1695
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0069 0.0096
Trypanosoma cruzi cyclin 9, putative 0.003 0.0204 0.1037
Echinococcus multilocularis cyclin y 0.003 0.0204 0.0252
Plasmodium vivax metacaspase 1, putative 0.005 0.0409 0.2395
Loa Loa (eye worm) hypothetical protein 0.0097 0.0891 0.0891
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0193 0.026
Brugia malayi hypothetical protein 0.0029 0.0193 0.0193
Giardia lamblia G2/mitotic-specific cyclin B 0.02 0.1964 1
Trichomonas vaginalis cyclin B3, putative 0.003 0.0204 0.074
Echinococcus granulosus cyclin dependent kinase 1 0.0175 0.1707 0.2297
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.027 0.027
Trypanosoma brucei cdc2-related kinase 3 0.0175 0.1707 0.8689
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0822 0.1107
Onchocerca volvulus 0.0047 0.0373 0.1764
Onchocerca volvulus 0.0078 0.0699 0.3449
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0174 0.1692 0.8612
Toxoplasma gondii thioredoxin reductase 0.0044 0.0351 0.2054
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0884 0.3209
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0481 0.0595
Echinococcus multilocularis axis inhibition protein axin 0.0029 0.0193 0.0239
Leishmania major protein kinase, putative 0.0174 0.1692 0.8612
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0204 0.074
Plasmodium falciparum metacaspase 1 0.005 0.0409 0.2395
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0256 0.2541 0.3141
Plasmodium falciparum cyclin 0.0125 0.1185 0.6943
Echinococcus granulosus cyclin y 0.003 0.0204 0.0274
Mycobacterium ulcerans beta-lactamase 0.0078 0.0699 0.2398
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0032 0.0118
Brugia malayi A-kinase anchor protein 10, precursor 0.0029 0.0193 0.0193
Trypanosoma brucei mitotic cyclin 6 0.02 0.1964 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0081 0.0413
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0029 0.0193 0.0271
Brugia malayi Cyclin, N-terminal domain containing protein 0.02 0.1964 0.1964
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1707 0.2398
Echinococcus granulosus caspase 2 0.0097 0.0891 0.1199
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0175 0.1707 0.1707
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0699 0.3557
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0884 0.3209
Brugia malayi hypothetical protein 0.0047 0.0373 0.0373
Trichomonas vaginalis cyclin D, putative 0.0125 0.1185 0.4303
Echinococcus granulosus cpg binding protein 0.003 0.0204 0.0274
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0081 0.0295
Giardia lamblia Cyclin fold protein 1, putative 0.003 0.0204 0.08
Trypanosoma cruzi cyclin 6, putative 0.02 0.1964 1
Trichomonas vaginalis AGC family protein kinase 0.0174 0.1692 0.6143
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.027 0.0981
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.0939 0.6725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0518 0.0727
Brugia malayi Regulator of G protein signaling domain containing protein 0.0029 0.0193 0.0193
Brugia malayi Cyclin, N-terminal domain containing protein 0.0125 0.1185 0.1185
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.003 0.0204 0.1037
Schistosoma mansoni axis inhibition protein axin 0.0029 0.0193 0.0271
Entamoeba histolytica cyclin, putative 0.02 0.1964 1
Trypanosoma brucei cyclin 9 0.003 0.0204 0.1037
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.003 0.0204 0.1193
Trypanosoma cruzi cdc2-related kinase 3 0.0175 0.1707 0.8689
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.027 0.0981
Echinococcus multilocularis axis inhibition protein axin 0.0029 0.0193 0.0239
Schistosoma mansoni hypothetical protein 0.005 0.0413 0.058
Brugia malayi PXA domain containing protein 0.0029 0.0193 0.0193
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0699 0.1297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0254 0.0342
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.1692 0.2377
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0373 0.0502
Echinococcus granulosus survival motor neuron protein 1 0.0729 0.743 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0051 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0409 0.1485
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0193 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0701
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.0939 0.1777
Echinococcus multilocularis cyclin t1 0.003 0.0204 0.0252
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0699 0.0699
Giardia lamblia Aurora kinase 0.0174 0.1692 0.8575
Echinococcus granulosus GPCR family 2 0.005 0.0413 0.0556
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.027 0.0363
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.0939 0.1777
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0032 0.0118
Echinococcus multilocularis cpg binding protein 0.003 0.0204 0.0252
Schistosoma mansoni cyclin G 0.003 0.0204 0.0286
Brugia malayi Protein kinase domain containing protein 0.0175 0.1707 0.1707
Trypanosoma cruzi cyclin, putative 0.02 0.1964 1
Brugia malayi Muscleblind-like protein 0.0155 0.1494 0.1494
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0051 0.0258
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0413 0.0413
Trichomonas vaginalis cyclins, putative 0.003 0.0204 0.074
Mycobacterium tuberculosis Probable reductase 0.0101 0.0939 0.1777
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.0193 0.0193
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0069 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0051 0.0258
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.1056 1
Echinococcus multilocularis cyclin 0.003 0.0204 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0699 0.3557
Trypanosoma brucei aurora B kinase 0.0174 0.1692 0.8612
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4096 0.5513
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0409 0.1485
Trichomonas vaginalis CMGC family protein kinase 0.0175 0.1707 0.6198
Brugia malayi serine/threonine kinase 12 0.0174 0.1692 0.1692
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.027 0.0981
Echinococcus granulosus axis inhibition protein axin 0.0029 0.0193 0.026
Onchocerca volvulus Cyclin L homolog 0.003 0.0204 0.0886
Brugia malayi hypothetical protein 0.003 0.0204 0.0204
Schistosoma mansoni cpg binding protein 0.003 0.0204 0.0286
Entamoeba histolytica cyclin, putative 0.0125 0.1185 0.6033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0413 0.0556
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.027 0.027
Brugia malayi hypothetical protein 0.0035 0.0254 0.0254
Plasmodium falciparum thioredoxin reductase 0.0044 0.0351 0.2054
Plasmodium vivax cyclin 4, putative 0.003 0.0204 0.1193
Brugia malayi beta-lactamase family protein 0.0078 0.0699 0.0699
Loa Loa (eye worm) hypothetical protein 0.0047 0.0373 0.0373
Echinococcus granulosus cyclins 0.0125 0.1185 0.1595
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0032 0.0165
Loa Loa (eye worm) glutaminase 2 0.0277 0.2754 0.2754
Trypanosoma brucei trypanothione reductase 0.0044 0.0351 0.1785
Entamoeba histolytica hypothetical protein 0.0035 0.0254 0.1295
Trichomonas vaginalis cyclin B, putative 0.02 0.1964 0.7133
Entamoeba histolytica hypothetical protein 0.0029 0.0193 0.0983
Echinococcus granulosus cyclin dependent kinase 5 0.0175 0.1707 0.2297
Echinococcus multilocularis caspase 2 0.0097 0.0891 0.1101
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0237 0.0333
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0029 0.0193 0.026
Schistosoma mansoni caspase-3 (C14 family) 0.0132 0.1259 0.1769
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0032 0.0165
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0081 0.0475
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.027 0.0981
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0008 0.0008
Leishmania major cyclin 9, putative 0.003 0.0204 0.1037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0884 0.0884
Mycobacterium ulcerans glutaminase 0.0277 0.2754 1
Echinococcus granulosus geminin 0.0331 0.3314 0.4461
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0174 0.1692 0.209
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0884 0.1092
Echinococcus multilocularis cyclins 0.0125 0.1185 0.1464
Brugia malayi serine/threonine-protein kinase 6 0.0174 0.1692 0.1692
Loa Loa (eye worm) hypothetical protein 0.0078 0.0699 0.0699
Leishmania major cyclin 0.02 0.1964 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0051 0.0063
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Schistosoma mansoni hypothetical protein 0.003 0.0204 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.2843 0.3995
Mycobacterium tuberculosis Conserved protein 0.0078 0.0699 0.1297
Loa Loa (eye worm) hypothetical protein 0.0155 0.1494 0.1494
Schistosoma mansoni cyclin d 0.003 0.0204 0.0286
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.0193 0.0193
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0029 0.0193 0.0271
Echinococcus multilocularis survival motor neuron protein 1 0.0729 0.743 0.9182
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0409 0.1485
Trichomonas vaginalis CMGC family protein kinase 0.0175 0.1707 0.6198
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0032 0.0118
Schistosoma mansoni cyclin k 0.003 0.0204 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Plasmodium vivax hypothetical protein, conserved 0.005 0.0409 0.2395
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0409 0.2395
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0175 0.1707 0.1707
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0204 0.0204
Echinococcus multilocularis cyclins 0.0125 0.1185 0.1464
Schistosoma mansoni cyclins 0.0125 0.1185 0.1665
Echinococcus multilocularis regulator of G protein signaling 3 0.0029 0.0193 0.0239
Echinococcus granulosus cyclins 0.0125 0.1185 0.1595
Loa Loa (eye worm) cyclin domain-containing protein 0.003 0.0204 0.0204
Trichomonas vaginalis cyclins, putative 0.003 0.0204 0.074
Trypanosoma cruzi metacaspase, putative 0.005 0.0409 0.2081
Trichomonas vaginalis cyclin B, putative 0.02 0.1964 0.7133
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0701
Loa Loa (eye worm) beta-lactamase 0.0078 0.0699 0.0699
Brugia malayi Smad1 0.0017 0.0069 0.0069
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0699 0.1297
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1707 0.2398
Brugia malayi Cyclin, N-terminal domain containing protein 0.003 0.0204 0.0204
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.027 0.0981
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.2492 0.2492
Echinococcus multilocularis caspase 3 0.0082 0.0742 0.0917
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0051 0.0258
Entamoeba histolytica hypothetical protein 0.0035 0.0254 0.1295
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.0891 0.1251
Trichomonas vaginalis cyclin B, putative 0.003 0.0204 0.074
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1597 0.1597
Schistosoma mansoni glutaminase 0.0277 0.2754 0.3869
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.027 0.0334
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.1539 0.1539
Onchocerca volvulus Cell death protein 3 homolog 0.0097 0.0891 0.4442
Echinococcus granulosus cyclin b3 0.0125 0.1185 0.1595
Trypanosoma brucei mitotic cyclin 0.003 0.0204 0.1037
Schistosoma mansoni hypothetical protein 0.005 0.0413 0.058
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.027 0.1375
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0699 0.2538
Giardia lamblia Hypothetical protein 0.003 0.0204 0.08
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.003 0.0204 0.1037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0351 0.06
Schistosoma mansoni smad1 5 8 and 0.0017 0.0069 0.0096
Echinococcus multilocularis cyclin B 0.02 0.1964 0.2427
Trichomonas vaginalis cyclins, putative 0.0106 0.0983 0.3569
Trypanosoma cruzi aurora B kinase, putative 0.0174 0.1692 0.8612
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0051 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0884 0.3209
Echinococcus granulosus cyclin B 0.02 0.1964 0.2644
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0481 0.0676
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0051 0.0258
Entamoeba histolytica hypothetical protein 0.0035 0.0254 0.1295
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.003 0.0204 0.0204
Loa Loa (eye worm) cyclin C 0.003 0.0204 0.0204
Trypanosoma cruzi cdc2-related kinase 1 0.0175 0.1707 0.8689
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0175 0.1707 0.1707
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.2492 0.2492

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 30.33 uM Antiplasmodial activity against Plasmodium falciparum W2 ChEMBL. 23562058

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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