Detailed information for compound 1782705

Basic information

Technical information
  • TDR Targets ID: 1782705
  • Name: N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl- 2-[4-methyl-2,5-dioxo-4-(4-propan-2-ylphenyl) imidazolidin-1-yl]acetamide
  • MW: 445.914 | Formula: C23H25ClFN3O3
  • H donors: 1 H acceptors: 3 LogP: 3.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccc(cc1)C1(C)NC(=O)N(C1=O)CC(=O)N(Cc1c(F)cccc1Cl)C)C
  • InChi: 1S/C23H25ClFN3O3/c1-14(2)15-8-10-16(11-9-15)23(3)21(30)28(22(31)26-23)13-20(29)27(4)12-17-18(24)6-5-7-19(17)25/h5-11,14H,12-13H2,1-4H3,(H,26,31)
  • InChiKey: DQLRMEOLCOQQQD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(2-chloro-6-fluoro-phenyl)methyl]-2-[4-(4-isopropylphenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]-N-methyl-acetamide
  • N-[(2-chloro-6-fluorophenyl)methyl]-2-[4-(4-isopropylphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-methylacetamide
  • N-(2-chloro-6-fluoro-benzyl)-2-[4-(4-isopropylphenyl)-2,5-diketo-4-methyl-imidazolidin-1-yl]-N-methyl-acetamide
  • N-[(2-chloro-6-fluoro-phenyl)methyl]-N-methyl-2-[4-methyl-2,5-dioxo-4-(4-propan-2-ylphenyl)imidazolidin-1-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0205 0.0552
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.061 0.8651
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0522 0.1397
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0059 0.0159
Brugia malayi Smad1 0.001 0.0101 0.0271
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0522 0.1397
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0402 0.1075
Entamoeba histolytica protein kinase, putative 0.0031 0.06 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0601 0.0597
Loa Loa (eye worm) hypothetical protein 0.0028 0.0522 0.1406
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0402 0.0603
Loa Loa (eye worm) serotonin transporter b 0.0164 0.3716 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.061 0.8651
Loa Loa (eye worm) hypothetical protein 0.0033 0.0648 0.1743
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0113 0.0303
Onchocerca volvulus 0.0014 0.0205 0.0552
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0101 0.0269
Loa Loa (eye worm) hypothetical protein 0.0049 0.1008 0.2713
Schistosoma mansoni hypothetical protein 0.0015 0.023 0.0614
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.06 0.2648
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0205 0.0548
Echinococcus granulosus solute carrier family 22 0.0014 0.0205 0.0548
Loa Loa (eye worm) hypothetical protein 0.0015 0.023 0.0618
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2256 0.6034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0522 0.1406
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0402 0.6849
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0205 0.0894
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0028 0.0522 0.1397
Schistosoma mansoni smad 0.001 0.0101 0.0269
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0059 0.0247
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0101 0.0269
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0009 0.0076 0.0204
Echinococcus granulosus solute carrier family 22 0.0014 0.0205 0.0548
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0204
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0601 0.0903
Loa Loa (eye worm) hypothetical protein 0.0031 0.0585 0.1576
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0205 0.0548
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0585 0.2583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Loa Loa (eye worm) glutamate receptor 0.0009 0.0076 0.0204
Schistosoma mansoni hypothetical protein 0.0015 0.023 0.0614
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0402 0.7683
Trypanosoma brucei glucose transporter 2A 0.0032 0.061 0.8651
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.06 0.1615
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.06 0.1605
Echinococcus multilocularis Smad4 0.001 0.0101 0.0269
Loa Loa (eye worm) hypothetical protein 0.0028 0.0522 0.1406
Trypanosoma cruzi hexose transporter, putative 0.0032 0.061 0.8651
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0101 0.0271
Loa Loa (eye worm) hypothetical protein 0.0008 0.0059 0.016
Leishmania major glucose transporter, lmgt1 0.0032 0.061 0.8651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0004 0.001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0522 0.1397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Loa Loa (eye worm) hypothetical protein 0.0028 0.0522 0.1406
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0004 0.001
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0205 0.2874
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0028 0.0522 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.062 0.1668
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0402 0.5689
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0585 0.9752
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0601 0.0597
Plasmodium falciparum hexose transporter 0.0102 0.2256 0.2253
Loa Loa (eye worm) transcription factor SMAD2 0.0145 0.3265 0.8787
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.2012 0.5381
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.1406
Echinococcus multilocularis General substrate transporter 0.0088 0.1921 0.5136
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0585 0.1565
Onchocerca volvulus 0.0014 0.0205 0.0552
Onchocerca volvulus 0.0028 0.0522 0.1406
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0059 0.016
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0336 0.1477
Schistosoma mansoni transient receptor potential channel 0.0064 0.1374 0.3675
Echinococcus multilocularis solute carrier family 22 0.0014 0.0205 0.0548
Brugia malayi MH1 domain containing protein 0.001 0.0101 0.0271
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0004 0.001
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0205 0.5052
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0205 0.0548
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0522 0.1397
Brugia malayi Cam kinase protein 1 0.0031 0.06 0.1615
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.023 0.0614
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0028 0.0522 0.1397
Schistosoma mansoni hypothetical protein 0.0015 0.023 0.0614
Echinococcus granulosus General substrate transporter 0.0088 0.1921 0.5136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.023 0.0618
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0036 0.0096
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0014 0.0186 0.0498
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0601 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Onchocerca volvulus 0.0014 0.0205 0.0552
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0585 0.1565
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0205 0.0305
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0205 0.0552
Plasmodium vivax hexose transporter 0.0102 0.2256 0.2253
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0402 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.023 0.0614
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0205 0.0548
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0522 0.1397
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0028 0.053 0.1426
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0585 0.1565
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2256 0.6034
Brugia malayi metabotropic glutamate receptor type 2 0.0017 0.0262 0.0704
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0122 0.2288
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0059 0.0159
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.06 0.1605
Loa Loa (eye worm) hypothetical protein 0.006 0.1262 0.3396
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0028 0.0522 0.1397
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0704 0.106
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2256 0.6034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0453 0.1218
Toxoplasma gondii sugar transporter ST3 0.0014 0.0205 0.0305
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0205 0.5052
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.06 0.1615
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0059 0.0159
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0028 0.053 0.1417
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0322 1
Loa Loa (eye worm) norepinephrine transporter 0.0164 0.3716 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Giardia lamblia Hexose transporter 0.0014 0.0205 0.346
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0704 1
Echinococcus multilocularis smad 0.001 0.0101 0.0269
Trichomonas vaginalis glucose transporter, putative 0.0032 0.061 0.269
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Brugia malayi hypothetical protein 0.0014 0.0205 0.0552
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.061 0.8651
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0101 0.0269
Trichomonas vaginalis sugar transporter, putative 0.0032 0.061 0.269
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.061 0.269
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0648 0.1743
Schistosoma mansoni protein kinase 0.0031 0.06 0.1605
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0059 0.0159
Schistosoma mansoni glucose transport protein 0.0102 0.2256 0.6034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1008 0.2713
Schistosoma mansoni sugar transporter 0.0014 0.0205 0.0548
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0059 0.016
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0113 0.0303
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0028 0.053 0.1426
Brugia malayi Latrophilin receptor protein 2 0.0015 0.023 0.0618
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2256 0.6034
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3726 0.5632
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0205 0.0894
Trypanosoma brucei glucose transporter 1E 0.0032 0.061 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Loa Loa (eye worm) hypothetical protein 0.0164 0.3716 1
Giardia lamblia Sugar-proton symporter 0.0014 0.0205 0.346
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0205 0.5052
Loa Loa (eye worm) hypothetical protein 0.0164 0.3716 1
Onchocerca volvulus 0.0014 0.0205 0.0552
Schistosoma mansoni sugar transporter 0.0014 0.0205 0.0548
Toxoplasma gondii sugar transporter ST1 0.0014 0.0205 0.0305
Loa Loa (eye worm) hypothetical protein 0.0031 0.06 0.1615
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.2125 0.5682
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0555 0.1484
Schistosoma mansoni protein kinase 0.0031 0.06 0.1605
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.06 0.1605
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0028 0.0522 0.1397
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0205 0.2874
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0274 0.386
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0113 0.0303
Schistosoma mansoni sodium/chloride dependent transporter 0.0164 0.3716 0.9936
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0585 0.1576
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0113 0.0305
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0122 0.2978
Loa Loa (eye worm) hypothetical protein 0.0037 0.0732 0.1971
Schistosoma mansoni sodium-dependent amino acid transporter 0.0028 0.0522 0.1397
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0402 0.1769
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0601 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1008 0.2713
Brugia malayi Metabotropic glutamate receptor precursor. 0.0009 0.0076 0.0204
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Echinococcus granulosus GPCR family 2 0.0015 0.023 0.0614
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0163 0.0439
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0601 0.0597
Schistosoma mansoni smad1 5 8 and 0.001 0.0101 0.0269
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0732 0.1971
Echinococcus granulosus serotonin transporter 0.0164 0.3716 0.9936
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0704 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0059 0.0159
Echinococcus granulosus Smad4 0.001 0.0101 0.0269
Echinococcus granulosus solute carrier family 22 0.0014 0.0205 0.0548
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0704 1
Onchocerca volvulus 0.0014 0.0205 0.0552
Loa Loa (eye worm) Smad1 0.001 0.0101 0.0271
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.06 0.1605
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0417 0.1837
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0322 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0402 0.1075
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0585 1
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0584 0.1561
Brugia malayi Sugar transporter family protein 0.0014 0.0205 0.0552
Brugia malayi major facilitator superfamily protein 0.0014 0.0205 0.0552
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Schistosoma mansoni hypothetical protein 0.0165 0.3739 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0164 0.3716 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0732 0.1959
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2256 0.6034
Echinococcus multilocularis solute carrier family 22 0.0014 0.0205 0.0548
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0028 0.053 0.1417
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2256 0.3408
Schistosoma mansoni glucose transporter 0.0014 0.0205 0.0548
Echinococcus multilocularis glycyl tRNA synthetase 0.0006 0.0004 0.001
Toxoplasma gondii hypothetical protein 0.0028 0.0522 0.0785
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0205 0.2874
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.0785
Loa Loa (eye worm) hypothetical protein 0.0096 0.2125 0.5718
Echinococcus granulosus calcium activated potassium channel 0.0007 0.0027 0.0073
Schistosoma mansoni hypothetical protein 0.0165 0.3739 1
Toxoplasma gondii protein kinase, putative 0.0288 0.6613 1
Echinococcus granulosus Threonyl tRNA synthetase C 0.0006 0.0004 0.001
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.2125 0.5682
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0205 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1374 0.3675
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0009 0.0076 0.0204
Schistosoma mansoni smad1 5 8 and 0.001 0.0101 0.0269
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.023 0.0614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1008 0.2713
Brugia malayi major facilitator superfamily protein 0.0014 0.0205 0.0552
Trichomonas vaginalis sugar transporter, putative 0.0032 0.061 0.269
Loa Loa (eye worm) solute carrier family 6 member 4 0.0164 0.3716 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0059 0.0159
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0522 0.1397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Schistosoma mansoni glucose transport protein 0.0102 0.2256 0.6034
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) hypothetical protein 0.0031 0.0585 0.1576
Echinococcus granulosus glycyl tRNA synthetase 0.0006 0.0004 0.001
Onchocerca volvulus 0.0014 0.0205 0.0552
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0402 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0113 0.0303
Onchocerca volvulus 0.0028 0.0522 0.1406
Loa Loa (eye worm) hypothetical protein 0.0028 0.0522 0.1406
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0004 0.001
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0402 0.1082
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.06 0.8517
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0059 0.0159
Brugia malayi Receptor family ligand binding region containing protein 0.0009 0.0076 0.0204
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0732 0.1959
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.06 0.1605
Leishmania major glucose transporter, lmgt2 0.0032 0.061 0.8651
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0122 0.032
Onchocerca volvulus 0.0014 0.0205 0.0552
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.06 0.1605
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0059 0.0159
Brugia malayi MH2 domain containing protein 0.001 0.0101 0.0271
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0205 0.0201
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0059 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0205 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0402 0.1075
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0205 0.0552
Leishmania major protein kinase, putative 0.0031 0.06 0.8517
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0522 0.1397
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0522 0.1397
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0601 0.0597
Schistosoma mansoni transient receptor potential channel 0.0064 0.1374 0.3675
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0205 0.0894
Onchocerca volvulus 0.0014 0.0205 0.0552
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0028 0.0522 0.1397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.2125 0.5682
Loa Loa (eye worm) hypothetical protein 0.0028 0.0522 0.1406
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.2012 0.5381
Loa Loa (eye worm) hypothetical protein 0.001 0.0113 0.0305
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2256 0.6034
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0601 0.0903
Brugia malayi MH1 domain containing protein 0.001 0.0101 0.0271
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0059 0.0247
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Schistosoma mansoni metabotropic glutamate receptor 0.0113 0.2504 0.6697
Loa Loa (eye worm) hypothetical protein 0.0023 0.0402 0.1082
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0522 0.0519
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.061 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0522 0.1397
Trypanosoma cruzi hexose transporter, putative 0.0032 0.061 0.8651
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.1406
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0059 0.0159
Echinococcus granulosus metabotropic glutamate receptor 5 0.0017 0.0262 0.07
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0205 0.0552
Onchocerca volvulus 0.0014 0.0205 0.0552
Loa Loa (eye worm) hypothetical protein 0.0028 0.0522 0.1406
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0101 0.0271
Schistosoma mansoni protein kinase 0.0031 0.06 0.1605
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Trypanosoma cruzi hexose transporter 0.0032 0.061 0.8651
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.061 0.269
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0402 0.0399
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0322 0.5469
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.1406
Echinococcus granulosus solute carrier family 22 0.0014 0.0205 0.0548
Plasmodium vivax sugar transporter, putative 0.0014 0.0205 0.0201
Echinococcus multilocularis serotonin transporter 0.0164 0.3716 0.9936
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Brugia malayi hypothetical protein 0.0014 0.0205 0.0552
Trichomonas vaginalis sugar transporter, putative 0.0032 0.061 0.269
Loa Loa (eye worm) sugar transporter 0.0014 0.0205 0.0552
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.023 0.0614
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1374 0.3675
Schistosoma mansoni Smad4 0.001 0.0101 0.0269
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0205 0.0894
Plasmodium falciparum amino acid transporter, putative 0.0028 0.0522 0.0519
Schistosoma mansoni hypothetical protein 0.0033 0.0648 0.1732
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0205 0.0548
Mycobacterium ulcerans sugar transporter 0.0014 0.0205 0.5052
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0004 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0059 0.0159
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0585 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Schistosoma mansoni 60S ribosomal protein L21 0.0007 0.0036 0.0096
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3726 0.3724
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0402 0.1075
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0568 0.1519
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0555 0.1484
Schistosoma mansoni sugar transporter 0.0014 0.0205 0.0548
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0059 0.0159
Plasmodium vivax amine transporter, putative 0.0028 0.0522 0.0519
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0113 0.0303
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0402 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0205 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0205 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0402 0.5689
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0601 0.0597
Echinococcus multilocularis calcium activated potassium channel 0.0007 0.0027 0.0073
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) glutamate receptor 0.0014 0.0186 0.0501
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0059 0.0159
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0017 0.0262 0.07
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.023 0.0614
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0205 0.0894
Brugia malayi hypothetical protein 0.0014 0.0205 0.0552
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0164 0.3716 0.9936
Brugia malayi MH2 domain containing protein 0.0145 0.3265 0.8787
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1374 0.3675
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0028 0.0522 0.1406
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0402 0.6849
Echinococcus granulosus smad 0.001 0.0101 0.0269
Schistosoma mansoni hypothetical protein 0.0102 0.2256 0.6034
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.0785
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 1 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0522 0.1397
Onchocerca volvulus 0.0014 0.0205 0.0552
Onchocerca volvulus 0.0164 0.3716 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0262 0.0704
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0402 0.5689
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0101 0.0269
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.061 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Echinococcus multilocularis solute carrier family 22 0.0014 0.0205 0.0548
Onchocerca volvulus 0.0014 0.0205 0.0552
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2256 0.6034
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0059 0.016
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0522 0.1397
Loa Loa (eye worm) hypothetical protein 0.0025 0.0451 0.1214
Onchocerca volvulus 0.0028 0.0522 0.1406
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1374 0.3675
Brugia malayi Sugar transporter family protein 0.0102 0.2256 0.6072
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Loa Loa (eye worm) sugar transporter 0.0102 0.2256 0.6072
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.06 0.1605
Brugia malayi MH2 domain containing protein 0.001 0.0101 0.0271
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0585 0.1565
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.06 0.1605
Toxoplasma gondii sugar transporter ST2 0.0014 0.0205 0.0305
Onchocerca volvulus 0.0014 0.0205 0.0552
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0059 0.0159
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0205 0.2874
Echinococcus multilocularis solute carrier family 22 0.0014 0.0205 0.0548
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0417 0.1837
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.001
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0704 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.3716 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Onchocerca volvulus 0.0014 0.0205 0.0552
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0601 0.0597
Brugia malayi Sugar transporter family protein 0.0014 0.0205 0.0552
Leishmania major hypothetical protein, conserved 0.0014 0.0205 0.2874
Echinococcus multilocularis geminin 0.0165 0.3739 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0522 0.1397
Schistosoma mansoni transient receptor potential channel 0.0096 0.2125 0.5682
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2256 0.6034
Trichomonas vaginalis glucose transporter, putative 0.0032 0.061 0.269
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0601 0.0597
Schistosoma mansoni hypothetical protein 0.0015 0.023 0.0614
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0704 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0522 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0205 0.0894
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.1406
Loa Loa (eye worm) hypothetical protein 0.0014 0.0205 0.0552
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0205 0.6328
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0704 0.0701
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0006 0.0004 0.001
Schistosoma mansoni sugar transporter 0.0014 0.0205 0.0548
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0205 0.0552
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0205 0.0552
Plasmodium falciparum protein kinase 7 0.0288 0.6613 0.6612
Leishmania major glucose transporter, lmgt3 0.0032 0.061 0.8651
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0205 0.6328
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0059 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2256 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0059 0.0159
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0585 0.1576
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.023 0.0618
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0059 0.0159
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0522 0.1406
Entamoeba histolytica protein kinase, putative 0.0031 0.06 1
Plasmodium falciparum transporter, putative 0.0028 0.0522 0.0519
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) MH2 domain-containing protein 0.0145 0.3265 0.8787
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0522 0.1397
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3726 0.3724
Echinococcus granulosus geminin 0.0165 0.3739 1
Onchocerca volvulus 0.0014 0.0205 0.0552
Schistosoma mansoni glucose transport protein 0.0102 0.2256 0.6034
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0704 0.0701
Trypanosoma brucei glucose transporter, putative 0.0032 0.061 0.8651
Brugia malayi hypothetical protein 0.0028 0.0522 0.1406
Trypanosoma brucei sugar transporter, putative 0.0014 0.0205 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.06 0.1615
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Toxoplasma gondii hypothetical protein 0.0028 0.0522 0.0785
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0164 0.3716 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0205 0.0894
Onchocerca volvulus Putative transporter 0.0014 0.0205 0.0552
Echinococcus granulosus voltage gated potassium channel 0.001 0.0113 0.0303
Entamoeba histolytica hypothetical protein 0.0023 0.0402 0.6679
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0004 0.001
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0601 0.0903
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.06 0.1605
Onchocerca volvulus 0.0014 0.0205 0.0552
Schistosoma mansoni smad1 5 8 and 0.001 0.0101 0.0269
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0101 0.0269
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0584 0.1561
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0522 0.1397

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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