Detailed information for compound 1786905

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 531.553 | Formula: C29H27F2N5O3
  • H donors: 3 H acceptors: 4 LogP: 2.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CN1[C@@H](CNC(C1=O)(C)C)c1cc(F)cc(c1)F)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2c1cccn2
  • InChi: 1S/C29H27F2N5O3/c1-28(2)27(39)36(23(14-33-28)17-8-19(30)11-20(31)9-17)15-24(37)34-21-6-5-16-12-29(13-18(16)10-21)22-4-3-7-32-25(22)35-26(29)38/h3-11,23,33H,12-15H2,1-2H3,(H,34,37)(H,32,35,38)/t23-,29+/m0/s1
  • InChiKey: QBRQTPINXSSUJO-MUAVYFROSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcitonin receptor-like Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c calcitonin receptor-like 461 aa 434 aa 28.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0008 0.0008
Echinococcus granulosus Tolloid protein 1 0.0034 0.0117 0.0117
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0483 0.0914
Leishmania major hypothetical protein, conserved 0.0032 0.0102 0.0186
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0018 0.0032 0.006
Echinococcus granulosus GPCR family 2 0.0034 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0123 0.121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0081 0.0081
Mycobacterium ulcerans hydrolase 0.0013 0.0004 0.0016
Mycobacterium ulcerans epoxide hydrolase EphB 0.0013 0.0004 0.0016
Mycobacterium ulcerans lignin peroxidase LipJ 0.0013 0.0004 0.0016
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0483 0.0914
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0004 0.0007
Mycobacterium ulcerans hypothetical protein 0.0032 0.0102 0.0431
Brugia malayi beta-lactamase family protein 0.0032 0.0102 0.0193
Brugia malayi Protein-tyrosine phosphatase containing protein 0.017 0.0823 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Mycobacterium tuberculosis Conserved protein 0.0032 0.0102 0.0431
Echinococcus multilocularis leucyl aminopeptidase 0.0018 0.0032 0.0032
Schistosoma mansoni carbonic anhydrase 0.0413 0.2095 0.2095
Loa Loa (eye worm) AStacin protease 0.0022 0.0049 0.0093
Echinococcus multilocularis dnaJ subfamily B 0.1142 0.5902 0.5902
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0123 0.0232
Echinococcus multilocularis Tolloid protein 1 0.0034 0.0117 0.0117
Echinococcus granulosus leucyl aminopeptidase 0.0018 0.0032 0.0032
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0081 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0102 0.1006
Echinococcus multilocularis high affinity choline transporter 1 0.0334 0.1683 0.1683
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0018 0.0032 0.006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0413 0.2095 0.3964
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0102 0.0102
Schistosoma mansoni carbonic anhydrase-related 0.0413 0.2095 0.2095
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1025 0.5286 1
Loa Loa (eye worm) hydrolase 0.0013 0.0004 0.0007
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0085 0.6885
Loa Loa (eye worm) hypothetical protein 0.0413 0.2095 0.3964
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0004 0.0007
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0085 0.0403
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0123 0.0123
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0013 0.0004 0.0079
Loa Loa (eye worm) protein-tyrosine phosphatase 0.017 0.0823 0.1557
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0004 0.0016
Brugia malayi hydrolase, alpha/beta fold family protein 0.0013 0.0004 0.0007
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.0262 0.1235
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0013 0.0004 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0483 0.476
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0041 0.0152 0.15
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0091 0.0413 0.0775
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0483 0.0914
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.017 0.0823 0.0823
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0004 0.0093
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0081 0.0081
Brugia malayi isocitrate dehydrogenase 0.0014 0.0008 0.0016
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0013 0.0004 0.0016
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0008 0.0021
Mycobacterium tuberculosis Probable exported protease 0.0013 0.0004 0.0016
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0123 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0483 1
Mycobacterium ulcerans epoxide hydrolase EphE 0.0013 0.0004 0.0016
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0018 0.0032 0.0032
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0018 0.0032 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0032 0.0315
Echinococcus granulosus high affinity choline transporter 1 0.0334 0.1683 0.1683
Echinococcus multilocularis microtubule associated protein 2 0.1927 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0502 0.0949
Giardia lamblia ENC6 protein 0.0013 0.0004 0.0313
Plasmodium vivax alpha/beta hydrolase, putative 0.0013 0.0004 0.0093
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0123 0.121
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0123 0.0123
Brugia malayi MH2 domain containing protein 0.0115 0.0537 0.1015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0032 0.0102 0.0431
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0013 0.0004 0.0016
Mycobacterium tuberculosis Probable lipase LipE 0.0032 0.0102 0.0431
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.0102 0.0102
Schistosoma mansoni inositol transporter 0.0037 0.013 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0102 0.0193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0116 0.0219
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0018 0.0032 0.006
Echinococcus multilocularis solute carrier family 5 0.0037 0.013 0.013
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1025 0.5286 1
Schistosoma mansoni hypothetical protein 0.0034 0.0116 0.0116
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0013 0.0004 0.0079
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0193
Echinococcus granulosus abhydrolase domain containing protein 0.0013 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0034 0.0116 0.0116
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0483 0.0483
Plasmodium falciparum alpha/beta hydrolase, putative 0.0013 0.0004 0.0018
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1025 0.5286 0.5286
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0049 0.0234
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0085 0.0833
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0091 0.0413 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0413 0.2095 0.3964
Mycobacterium ulcerans beta-lactamase 0.0032 0.0102 0.0431
Trypanosoma cruzi hydrolase-like protein, putative 0.0013 0.0004 0.0007
Brugia malayi UPF0017 protein CG3488 0.0013 0.0004 0.0007
Echinococcus multilocularis carbonic anhydrase II 0.1025 0.5286 0.5286
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0081 0.0081
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0062 0.0262 0.6347
Mycobacterium ulcerans lipase LipD 0.0032 0.0102 0.0431
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0032 0.0315
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0123 0.0123
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0182 0.0885 0.1674
Mycobacterium ulcerans exported protease 0.0013 0.0004 0.0016
Onchocerca volvulus 0.0206 0.1015 1
Echinococcus multilocularis cpg binding protein 0.0085 0.038 0.038
Echinococcus granulosus leucine aminopeptidase protein 0.0091 0.0413 0.0413
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0536 0.2733 0.2733
Echinococcus multilocularis abhydrolase domain containing protein 0.0013 0.0004 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0046 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0032 0.0315
Echinococcus granulosus polycomb protein SCMH1 0.0041 0.0152 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0081 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0102 0.0193
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.017 0.0823 0.0823
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0013 0.0004 0.0007
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0091 0.0413 0.1743
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.0262 0.6347
Loa Loa (eye worm) CXXC zinc finger family protein 0.008 0.0356 0.0673
Chlamydia trachomatis cytosol aminopeptidase 0.0091 0.0413 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.013 0.013
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0008 0.0008
Mycobacterium ulcerans epoxide hydrolase EphF 0.0013 0.0004 0.0016
Mycobacterium ulcerans hypothetical protein 0.0013 0.0004 0.0016
Schistosoma mansoni hypothetical protein 0.0034 0.0116 0.0116
Mycobacterium leprae Probable exported protease 0.0013 0.0004 0.0079
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0041 0.015 0.3109
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0207
Schistosoma mansoni leucine aminopeptidase 0.0018 0.0032 0.0032
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0013 0.0004 0.0016
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.013 0.013
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0123 0.2542
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.011 0.0509
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0034 0.0117 0.0117
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0085 0.2047
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0085 0.2047
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0483 0.0483
Echinococcus granulosus SAM and MBT domain containing protein 0.0041 0.0152 0.0152
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Loa Loa (eye worm) hypothetical protein 0.0536 0.2733 0.517
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.017 0.0823 0.0823
Mycobacterium ulcerans exported protease 0.0013 0.0004 0.0016
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.011 0.0209
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0123 0.0225
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0013 0.0004 0.0016
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0123 0.2967
Loa Loa (eye worm) MBCTL1 0.0047 0.0182 0.0344
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0537 0.1015
Loa Loa (eye worm) hypothetical protein 0.0413 0.2095 0.3964
Mycobacterium ulcerans proline iminopeptidase PIP 0.0013 0.0004 0.0016
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.011 0.0209
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0502 0.0949
Echinococcus multilocularis leucyl aminopeptidase 0.0018 0.0032 0.0032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0483 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0014 0.0008 0.0035
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.013 0.013
Plasmodium falciparum epoxide hydrolase 1 0.0013 0.0004 0.0018
Mycobacterium ulcerans hypothetical protein 0.0013 0.0004 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0123 0.0232
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0483 0.0914
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.013 0.013
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0013 0.0004 0.0038
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0483 0.0483
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1025 0.5286 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1025 0.5286 0.5286
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0483 0.476
Echinococcus multilocularis leucine aminopeptidase protein 0.0091 0.0413 0.0413
Mycobacterium leprae Probable exported protease 0.0013 0.0004 0.0079
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0536 0.2733 0.517
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0013 0.0004 0.0016
Schistosoma mansoni hypothetical protein 0.0413 0.2095 0.2095
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.0262 0.1235
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Trichomonas vaginalis helicase, putative 0.0018 0.0032 0.0315
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.0008 0.0201
Brugia malayi Pre-SET motif family protein 0.0028 0.0081 0.0153
Onchocerca volvulus 0.0037 0.013 0.1277
Loa Loa (eye worm) hypothetical protein 0.0074 0.0323 0.0611
Schistosoma mansoni inositol monophosphatase 0.0036 0.0123 0.0123
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0123 0.2537
Mycobacterium ulcerans esterase/lipase LipP 0.0032 0.0102 0.0431
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0413 0.2095 0.3964
Echinococcus multilocularis GPCR, family 2 0.0034 0.0116 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0102 0.0193
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0123 0.0225
Schistosoma mansoni hydrolase 0.0013 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0833
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0018 0.0032 0.006
Brugia malayi GH02984p 0.0334 0.1683 0.3184
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0008 0.0008
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0123 0.0232
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0334 0.1683 0.3184
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0123 0.0232
Echinococcus multilocularis polycomb protein SCMH1 0.0041 0.0152 0.0152
Schistosoma mansoni microtubule-associated protein tau 0.1927 1 1
Brugia malayi 6-phosphofructokinase 0.0105 0.0483 0.0914
Mycobacterium ulcerans lipase/esterase 0.0013 0.0004 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0123 0.0232
Schistosoma mansoni hypothetical protein 0.0074 0.0323 0.0323
Schistosoma mansoni inositol monophosphatase 0.0036 0.0123 0.0123
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0008 0.004
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0062 0.0262 0.6347
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0019
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.011 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0047 0.0182 0.0182
Brugia malayi Probable ClpP-like protease 0.0062 0.0262 0.0496
Mycobacterium ulcerans haloalkane dehalogenase 0.0013 0.0004 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0102 0.1006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0116 0.0116
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0153
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0193
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0091 0.0413 0.0781
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.011 0.0209
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0091 0.0413 0.8552
Echinococcus multilocularis abhydrolase domain containing 3 0.0013 0.0004 0.0004
Mycobacterium ulcerans hydrolase 0.0013 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0193
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0466 0.237 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0062 0.0262 0.5428
Onchocerca volvulus 0.0032 0.0102 0.1006
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.011 0.0509
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0123 0.1208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0081 0.0081
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0013 0.0004 0.0004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0123 0.1208
Mycobacterium ulcerans leucyl aminopeptidase 0.0091 0.0413 0.1743
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0193
Trichomonas vaginalis hydrolase, putative 0.0013 0.0004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0062 0.0262 0.0496
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0013 0.0004 0.0004
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0123 0.0123
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0046 0.0046
Mycobacterium ulcerans haloalkane dehalogenase 0.0013 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0193
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0413 0.2095 0.3964
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0062 0.0262 0.5428
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0085 0.2047
Brugia malayi alpha/beta hydrolase 0.0013 0.0004 0.0007
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0013 0.0004 0.0079
Echinococcus multilocularis carbonic anhydrase 0.0413 0.2095 0.2095
Leishmania major carbonic anhydrase-like protein 0.1025 0.5286 1
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.007 0.0132
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0123 0.0568
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0483 0.0914
Mycobacterium leprae Probable lipase LipE 0.0032 0.0102 0.2114
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0004 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0032 0.0102 0.0431
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0123 0.0517
Mycobacterium ulcerans hypothetical protein 0.0013 0.0004 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0072 0.0072
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0483 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0004 0.0038
Echinococcus granulosus dnaJ subfamily B 0.1142 0.5902 0.5902
Onchocerca volvulus 0.0032 0.0102 0.1006
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.0008 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.0102 0.0193
Schistosoma mansoni cpg binding protein 0.008 0.0356 0.0356
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.013 0.013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0067 0.0067
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0018 0.0032 0.006
Echinococcus granulosus carbonic anhydrase 0.0413 0.2095 0.2095
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0004 0.0007
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0013 0.0004 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0116 0.0219
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0008 0.0016
Mycobacterium ulcerans peroxidase BpoB 0.0013 0.0004 0.0016
Echinococcus multilocularis peptidase Clp (S14 family) 0.0041 0.015 0.015
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0041 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0047 0.0182 0.0344
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0833
Echinococcus granulosus carbonic anhydrase II 0.1025 0.5286 0.5286
Brugia malayi hydrolase, alpha/beta fold family protein 0.0013 0.0004 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0081 0.0368
Brugia malayi Inositol-1 0.0036 0.0123 0.0232
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0013 0.0004 0.0079
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.011 0.0526
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0047 0.0182 0.0344
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0013 0.0004 0.0007
Brugia malayi Pre-SET motif family protein 0.0182 0.0885 0.1674
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.017 0.0823 0.0823
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0483 0.0907
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0008 0.0008
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0013 0.0004 0.0016
Echinococcus multilocularis SAM and MBT domain containing protein 0.0041 0.0152 0.0152
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0018 0.0032 0.0053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0032 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0081 0.0081
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0018 0.0032 0.0032
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0013 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0193
Echinococcus granulosus leucyl aminopeptidase 0.0018 0.0032 0.0032
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0041 0.015 0.0634
Schistosoma mansoni sodium/solute symporter 0.0037 0.013 0.013
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.013 0.013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0032 0.0315
Schistosoma mansoni carbonic anhydrase-related 0.0413 0.2095 0.2095
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0008 0.0016
Plasmodium vivax SET domain protein, putative 0.0028 0.0081 0.1957
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0483 0.2038
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0123 0.0123
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.0262 0.1106
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0008 0.0008
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0072 0.0135
Loa Loa (eye worm) mbt repeat family protein 0.0041 0.0152 0.0288
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0004 0.0093
Brugia malayi 6-phosphofructokinase 0.0105 0.0483 0.0914
Mycobacterium ulcerans epoxide hydrolase EphA 0.0466 0.237 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0062 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0413 0.2095 0.3964
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0091 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0502 0.0949
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0833
Loa Loa (eye worm) hypothetical protein 0.0034 0.0116 0.0219
Schistosoma mansoni cpg binding protein 0.0085 0.038 0.038
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0021 0.0049 0.1188
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0483 0.2038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0502 0.0949
Mycobacterium ulcerans oxidoreductase 0.0013 0.0004 0.0016
Trichomonas vaginalis esterase, putative 0.0032 0.0102 0.1006
Trypanosoma brucei carbonic anhydrase-like protein 0.1025 0.5286 1
Trichomonas vaginalis set domain proteins, putative 0.0206 0.1015 1
Plasmodium falciparum carbonic anhydrase 0.0413 0.2095 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0046 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0008 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0102 0.1006
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0323 0.0611
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.011 0.2668
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0483 0.476
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0047 0.0182 0.0182
Brugia malayi Sodium:solute symporter family protein 0.0037 0.013 0.0245
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0013 0.0004 0.0007
Onchocerca volvulus 0.008 0.0356 0.3507
Onchocerca volvulus Lipase homolog 0.0013 0.0004 0.0038
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0085 0.175
Mycobacterium tuberculosis Probable esterase LipL 0.0032 0.0102 0.0431
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.0102 0.0193
Schistosoma mansoni hypothetical protein 0.0251 0.1245 0.1245
Brugia malayi CXXC zinc finger family protein 0.008 0.0356 0.0673
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0123 0.1208
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0018 0.0032 0.006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0085 0.175
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.0008 0.0016
Mycobacterium tuberculosis Conserved protein 0.0032 0.0102 0.0431
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0483 0.0483
Mycobacterium ulcerans lipase/esterase 0.0013 0.0004 0.0016
Toxoplasma gondii hypothetical protein 0.0413 0.2095 1
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0483 1
Loa Loa (eye worm) beta-lactamase 0.0032 0.0102 0.0193
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0116 0.0219
Mycobacterium tuberculosis Probable lipase LipD 0.0032 0.0102 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0315
Schistosoma mansoni hypothetical protein 0.0034 0.0116 0.0116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0116 0.0116
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0123 0.121
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0004 0.0093
Echinococcus granulosus peptidase Clp S14 family 0.0041 0.015 0.015
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0102 0.2472
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.013 0.0601
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0091 0.0413 0.0781
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0013 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0833
Onchocerca volvulus 0.0041 0.0152 0.15
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0123 0.0232
Mycobacterium tuberculosis Conserved protein 0.0032 0.0102 0.0431
Brugia malayi Augmenter of liver regeneration 0.0033 0.011 0.0209
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0123 0.0123
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0013 0.0004 0.0016
Leishmania major hypothetical protein, conserved 0.0033 0.011 0.0201
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0004 0.0038
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0021 0.0049 0.1016
Schistosoma mansoni inositol transporter 0.0037 0.013 0.013
Trypanosoma cruzi hydrolase-like protein 0.0013 0.0004 0.0007
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0483 1
Mycobacterium ulcerans hypothetical protein 0.0013 0.0004 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0008 0.0008
Echinococcus granulosus cpg binding protein 0.0085 0.038 0.038
Toxoplasma gondii ABC1 family protein 0.0032 0.0102 0.047
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0085 0.0386
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.0262 0.6347
Entamoeba histolytica hypothetical protein 0.0013 0.0004 0.0079
Onchocerca volvulus 0.0028 0.0081 0.0797
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0013 0.0004 0.0004
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.011 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0002 0.0002
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0123 0.0123
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1025 0.5286 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0152 0.0288
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0013 0.0004 0.0004
Brugia malayi phosphofructokinase 0.0105 0.0483 0.0914
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0013 0.0004 0.0016
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0162 0.0785 0.0785
Brugia malayi mbt repeat family protein 0.0041 0.0152 0.0288
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0062 0.0262 0.1251
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0013 0.0004 0.0018
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0013 0.0004 0.0079
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0008 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0537 0.1015
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.011 0.011
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0102 0.2114
Echinococcus granulosus carbonic anhydrase 0.0413 0.2095 0.2095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0102 0.0102
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0413 0.2095 0.3964
Brugia malayi beta-lactamase 0.0032 0.0102 0.0193
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0013 0.0004 0.0016
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0008 0.0016
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0013 0.0004 0.0079
Echinococcus granulosus abhydrolase domain containing protein 3 0.0013 0.0004 0.0004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0085 0.0403
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0013 0.0004 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0032 0.0102 0.0431
Echinococcus granulosus carbonic anhydrase 0.0413 0.2095 0.2095
Schistosoma mansoni carbonic anhydrase-related 0.0413 0.2095 0.2095
Echinococcus multilocularis histone acetyltransferase MYST2 0.0047 0.0182 0.0182
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0041 0.015 0.0634
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0102 0.1006
Schistosoma mansoni high-affinity choline transporter 0.0334 0.1683 0.1683
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0032 0.0315
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0202 0.0992 0.4184
Schistosoma mansoni myelin transcription factor 1 myt1 0.0047 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0004 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0483 0.476
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0123 0.0123
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.0152 0.0152
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0032 0.0315
Onchocerca volvulus Lipase homolog 0.0013 0.0004 0.0038
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0123 1
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0123 0.0123
Mycobacterium ulcerans bromoperoxidase BpoC 0.0013 0.0004 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0153 0.0735 0.3498
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0018 0.0032 0.006
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0085 0.0386
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0102 0.1006
Echinococcus granulosus histone acetyltransferase MYST2 0.0047 0.0182 0.0182
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0116 0.0116
Onchocerca volvulus 0.0032 0.0102 0.1006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0032 0.0315
Loa Loa (eye worm) carbonic anhydrase 3 0.1025 0.5286 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0032 0.0102 0.0431
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0046 0.0046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0116 0.0116
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0034 0.0117 0.0221
Schistosoma mansoni hypothetical protein 0.1142 0.5902 0.5902
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0013 0.0004 0.0007
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0004 0.0038
Echinococcus granulosus abhydrolase domain containing protein 11 0.0013 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0004 0.0016
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0008 0.0016
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0013 0.0004 0.0016
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.0262 0.1106
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1025 0.5286 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0072 0.0072
Schistosoma mansoni peptidase Clp (S14 family) 0.0062 0.0262 0.0262
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0046 0.0046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0004 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0171 0.083 0.083
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0085 0.0386
Schistosoma mansoni cpg binding protein 0.0085 0.038 0.038
Brugia malayi cytosol aminopeptidase 0.0018 0.0032 0.006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0103 0.0435
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.0152 0.0152
Trypanosoma cruzi hydrolase-like protein, putative 0.0013 0.0004 0.0007
Echinococcus multilocularis carbonic anhydrase 0.0413 0.2095 0.2095
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0007
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0013 0.0004 0.0004
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0004 0.0038
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0162 0.0785 0.0785
Toxoplasma gondii leucyl aminopeptidase LAP 0.0091 0.0413 0.1957
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0103 0.2135
Plasmodium falciparum M17 leucyl aminopeptidase 0.0091 0.0413 0.1971
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0536 0.2733 0.2733
Loa Loa (eye worm) inositol-1 0.0036 0.0123 0.0232
Mycobacterium tuberculosis Conserved protein 0.0013 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0123 0.0232
Echinococcus granulosus solute carrier family 5 0.0037 0.013 0.013
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0062 0.0262 0.0262
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0413 0.2095 0.3964
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.011 0.0209
Trypanosoma brucei aminopeptidase, putative 0.0018 0.0032 0.006
Brugia malayi Alpha/beta hydrolase 0.0013 0.0004 0.0007
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.017 0.0823 0.0823
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0018 0.0032 0.006
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0091 0.0413 0.0781
Mycobacterium tuberculosis Probable hydrolase 0.0032 0.0102 0.0431
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0536 0.2733 0.2733
Echinococcus multilocularis carbonic anhydrase 0.0413 0.2095 0.2095
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0047 0.0089
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0013 0.0004 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0833
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0833
Brugia malayi mbt repeat family protein 0.0041 0.0152 0.0288
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0245
Brugia malayi beta-lactamase family protein 0.0032 0.0102 0.0193
Echinococcus multilocularis leucyl aminopeptidase 0.0018 0.0032 0.0032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0049 0.1016
Toxoplasma gondii hypothetical protein 0.0021 0.0049 0.0216
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0018 0.0032 0.0053
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0085 0.2047

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 34 pM Displacement of [125I]-hCGRP from human CGRP receptor expressed in HEK293 cells ChEMBL. 24900761
Ratio (ADMET) = 33 Efflux ratio of human MDR1-mediated drug transport from basolateral to apical side over apical to basolateral side in pig LLC cells expressing human MDR1 at 5 uM ChEMBL. 24900761

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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