TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.581 | Formula: C28H24N4O2S
H donors: 0 H acceptors: 3 LogP: 6.52 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1cn(nc1c1sc(nc1c1ccccc1)N(c1ccccc1)C)c1ccccc1
InChi: 1S/C28H24N4O2S/c1-3-34-27(33)23-19-32(22-17-11-6-12-18-22)30-25(23)26-24(20-13-7-4-8-14-20)29-28(35-26)31(2)21-15-9-5-10-16-21/h4-19H,3H2,1-2H3
InChiKey: GGNKDNUOZCPJTI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.001	0.0015	0.0548
Schistosoma mansoni	regulator of G protein signaling	0.0187	0.0964	0.0964
Trypanosoma cruzi	cation-transporting ATPase, putative	0.001	0.0015	0.185
Echinococcus multilocularis	axis inhibition protein axin	0.0187	0.0964	0.1067
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0083	0.086
Echinococcus granulosus	cpg binding protein	0.0033	0.014	0.0151
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.007	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.007
Schistosoma mansoni	regulator of G protein signaling	0.0187	0.0964	0.0964
Giardia lamblia	Copper-transporting P-type ATPase	0.001	0.0015	0.185
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.007	1
Mycobacterium ulcerans	metal cation-transporting p-type ATPase CtpC	0.001	0.0015	0.185
Brugia malayi	Na,K-ATPase alpha subunit	0.001	0.0015	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.0964	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1876	1	1
Schistosoma mansoni	cation-transporting atpase worm	0.001	0.0015	0.0015
Brugia malayi	regulator of G-protein signaling rgs-7	0.0187	0.0964	0.0964
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0015	0.0012
Echinococcus granulosus	cation transporting ATPase 13A1	0.001	0.0015	0.0012
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0015	0.0154
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.001	0.0015	0.185
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0083	1
Schistosoma mansoni	eyes absent homolog	0.0103	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0187	0.0964	0.0964
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0187	0.0964	0.0964
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.001	0.0015	0.185
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.001	0.0015	0.0548
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0083	0.0088
Trypanosoma cruzi	copper-transporting ATPase, putative	0.001	0.0015	0.185
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.0964	1
Echinococcus multilocularis	copper transporting ATPase 1	0.001	0.0015	0.0012
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.001	0.0015	0.0548
Trypanosoma cruzi	phospholipid-transporting ATPase-like protein, putative	0.001	0.0015	0.185
Mycobacterium leprae	Probable metal cation-transporting P-type ATPase C CtpC	0.001	0.0015	0.5
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0015	0.0154
Echinococcus multilocularis	cation transporting atpase worm	0.001	0.0015	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0964	0.0964
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0015	0.0012
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.001	0.0015	0.0154
Plasmodium vivax	P-type ATPase4, putative	0.001	0.0015	0.2201
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.007	0.0073
Plasmodium falciparum	copper-transporting ATPase	0.001	0.0015	0.2201
Echinococcus multilocularis	expressed protein	0.0187	0.0964	0.1067
Echinococcus multilocularis	regulator of G protein signaling 3	0.0187	0.0964	0.1067
Trypanosoma cruzi	P-type H+-ATPase, putative	0.001	0.0015	0.185
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0083	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0131	0.0131
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0015	0.0011
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0192	0.0988	0.1094
Brugia malayi	E1-E2 ATPase family protein	0.001	0.0015	0.0015
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0083	1
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.001	0.0015	0.0012
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.001	0.0015	0.185
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.0964	1
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.001	0.0015	0.185
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0187	0.0964	0.0964
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0187	0.0964	0.0964
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0083	1
Trypanosoma brucei	unspecified product	0.0016	0.0046	0.55
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0131	0.0131
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0187	0.0964	0.0964
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0015	0.0011
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0083	1
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.001	0.0015	0.185
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.001	0.0015	0.185
Onchocerca volvulus		0.002	0.007	0.474
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.0264	0.0289
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.001	0.0015	0.0012
Brugia malayi	hypothetical protein	0.0187	0.0964	0.0964
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0004	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0046	0.55
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0015	0.0012
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0083	0.0083
Trypanosoma brucei	P-type H+-ATPase, putative	0.001	0.0015	0.185
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0015	0.0154
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0015	0.0154
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0083	0.0083
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0192	0.0988	0.0988
Schistosoma mansoni	axis inhibition protein axin	0.0187	0.0964	0.0964
Trypanosoma cruzi	P-type H+-ATPase, putative	0.001	0.0015	0.185
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1689	0.8999	0.8999
Brugia malayi	hypothetical protein	0.002	0.007	0.007
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0083	1
Entamoeba histolytica	hypothetical protein	0.0187	0.0964	1
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0083	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0083	1
Echinococcus multilocularis	RUN	0.002	0.007	0.0073
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.001	0.0015	0.185
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.001	0.0015	0.0154
Treponema pallidum	hypothetical protein	0.001	0.0015	0.5
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.001	0.0015	0.185
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0964	0.0964
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.1689	0.8999	1
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0187	0.0964	0.1067
Loa Loa (eye worm)	E1-E2 ATPase	0.001	0.0015	0.0015
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.001	0.0015	0.0012
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0083	0.0717
Schistosoma mansoni	cation-transporting ATPase	0.001	0.0015	0.0015
Echinococcus multilocularis	axis inhibition protein axin	0.0187	0.0964	0.1067
Echinococcus granulosus	cation transporting atpase worm	0.001	0.0015	0.0012
Echinococcus multilocularis	regulator of G protein signaling 7	0.0187	0.0964	0.1067
Schistosoma mansoni	copper ABC transporter ATPase	0.001	0.0015	0.0015
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0187	0.0964	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.032	0.032
Schistosoma mansoni	hypothetical protein	0.0448	0.2361	0.2361
Brugia malayi	hypothetical protein	0.002	0.007	0.007
Schistosoma mansoni	type V p-type atpase isoform	0.001	0.0015	0.0015
Schistosoma mansoni	z-protein (S1r protein)	0.0187	0.0964	0.0964
Schistosoma mansoni	ATPase	0.001	0.0015	0.0015
Echinococcus granulosus	dna polymerase eta	0.0023	0.0083	0.0088
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.001	0.0015	0.2201
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Plasmodium vivax	copper-transporting ATPase, putative	0.001	0.0015	0.2201
Schistosoma mansoni	regulator of G protein signaling	0.0187	0.0964	0.0964
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Schistosoma mansoni	lipoxygenase	0.0056	0.0264	0.0264
Schistosoma mansoni	cpg binding protein	0.0033	0.014	0.014
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB	0.001	0.0015	0.5
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1689	0.8999	0.8999
Trypanosoma brucei	unspecified product	0.0016	0.0046	0.55
Mycobacterium ulcerans	cation transporter p-type ATPase a CtpA	0.001	0.0015	0.185
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0083	0.0088
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.001	0.0015	0.185
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0515	0.0515
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0083	0.0083
Echinococcus granulosus	expressed protein	0.0187	0.0964	0.1067
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.001	0.0015	0.185
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0083	0.0083
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.001	0.0015	0.0015
Mycobacterium ulcerans	metal cation transporter p-type ATPase, CtpV	0.001	0.0015	0.185
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0015	0.0154
Brugia malayi	hypothetical protein	0.001	0.0015	0.0015
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.001	0.0015	0.0154
Brugia malayi	Doublecortin family protein	0.002	0.007	0.007
Echinococcus multilocularis	regulator of G protein signaling 7	0.0187	0.0964	0.1067
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.001	0.0015	0.0015
Trypanosoma cruzi	proton motive ATPase 1, putative	0.001	0.0015	0.185
Brugia malayi	PXA domain containing protein	0.0187	0.0964	0.0964
Schistosoma mansoni	regulator of G protein signaling	0.0187	0.0964	0.0964
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.001	0.0015	0.0012
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0046	0.55
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0015	0.0015
Echinococcus granulosus	copper transporting ATPase 1	0.001	0.0015	0.0012
Schistosoma mansoni	cpg binding protein	0.0033	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0964	0.0964
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0083	1
Giardia lamblia	Phospholipid-transporting ATPase IA, putative	0.001	0.0015	0.185
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0964	0.0964
Trypanosoma brucei	P-type H+-ATPase, putative	0.001	0.0015	0.185
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0083	0.0088
Echinococcus granulosus	regulator of G protein signaling 3	0.0187	0.0964	0.1067
Echinococcus granulosus	Regulator of G protein signaling 20	0.0187	0.0964	0.1067
Treponema pallidum	cation-transporting ATPase, P-type	0.001	0.0015	0.5
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.007	0.0073
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0083	1
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.001	0.0015	0.0015
Onchocerca volvulus		0.0031	0.0131	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.0264	0.0289
Echinococcus granulosus	phospholipid transporting ATPase VA	0.001	0.0015	0.0012
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0083	0.0088
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0015	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0515	0.0515
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.001	0.0015	0.185
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0964	0.0964
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0187	0.0964	0.0964
Leishmania major	P-type H -ATPase, putative	0.001	0.0015	0.185
Schistosoma mansoni	lipoxygenase	0.002	0.007	0.007
Echinococcus granulosus	cation transporting ATPase 13A3	0.001	0.0015	0.0012
Loa Loa (eye worm)	RGS-3 protein	0.0187	0.0964	0.0964
Brugia malayi	regulator of G-protein signaling egl-10	0.0187	0.0964	0.0964
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0187	0.0964	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0964	0.0964
Mycobacterium ulcerans	cation-transporter p-type ATPase B CtpB	0.001	0.0015	0.185
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0083	0.0088
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.0988	0.0988
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.001	0.0015	0.0012
Plasmodium vivax	calcium-transporting ATPase, putative	0.001	0.0015	0.2201
Brugia malayi	hypothetical protein	0.0103	0.0515	0.0515
Entamoeba histolytica	hypothetical protein	0.0187	0.0964	1
Schistosoma mansoni	loxhd1	0.002	0.007	0.007
Schistosoma mansoni	phosphoserine phosphatase	0.001	0.0015	0.0015
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0192	0.0988	0.1094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0083	1
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.1689	0.8999	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Echinococcus multilocularis	cpg binding protein	0.0033	0.014	0.0151
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.001	0.0015	0.0015
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0083	0.0083
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0083	1
Leishmania major	proton motive ATPase, putative	0.001	0.0015	0.185
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.001	0.0015	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.0964	1
Schistosoma mansoni	ATPase	0.001	0.0015	0.0015
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0281	1
Schistosoma mansoni	regulator of G protein signaling	0.0187	0.0964	0.0964
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0083	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.1689	0.8999	0.8999
Echinococcus multilocularis	regulator of G protein signaling	0.0187	0.0964	0.1067
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.001	0.0015	0.5
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.001	0.0015	0.0012
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0083	1
Schistosoma mansoni	rab6-interacting	0.002	0.007	0.007
Onchocerca volvulus		0.002	0.007	0.474
Mycobacterium ulcerans	cation transporter p-type ATPase D CtpD	0.001	0.0015	0.185
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.001	0.0015	0.0015
Echinococcus multilocularis	cation transporting ATPase 13A1	0.001	0.0015	0.0012
Entamoeba histolytica	hypothetical protein	0.0187	0.0964	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0083	0.0083
Brugia malayi	A-kinase anchor protein 10, precursor	0.0187	0.0964	0.0964
Schistosoma mansoni	hypothetical protein	0.002	0.007	0.007
Schistosoma mansoni	axis inhibition protein axin	0.0187	0.0964	0.0964
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0015	0.0154
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0015	0.0154
Echinococcus granulosus	regulator of G protein signaling 7	0.0187	0.0964	0.1067
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0014	0.0014
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.001	0.0015	0.185
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.0988	0.0988
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.001	0.0015	0.0548
Schistosoma mansoni	atpase class VI type 11c	0.001	0.0015	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0083	1
Trypanosoma brucei	copper-transporting ATPase-like protein, putative	0.001	0.0015	0.185
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.001	0.0015	0.0548
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.001	0.0015	0.0015
Toxoplasma gondii	cation-transporting atpase family protein	0.001	0.0015	0.0548
Echinococcus granulosus	dnaJ subfamily B	0.0448	0.2361	0.262
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0015	0.0012
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0015	0.0154
Schistosoma mansoni	serine/threonine protein kinase	0.1876	1	1
Toxoplasma gondii	P-type ATPase PMA1	0.001	0.0015	0.0548
Brugia malayi	PXA domain containing protein	0.0187	0.0964	0.0964
Echinococcus multilocularis	regulator of G protein signaling 3	0.0187	0.0964	0.1067
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.007
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.007	0.0073
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.001	0.0015	0.0012
Echinococcus granulosus	RUN	0.002	0.007	0.0073
Leishmania major	DNA polymerase eta, putative	0.0023	0.0083	1
Loa Loa (eye worm)	doublecortin family protein	0.002	0.007	0.007
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0015	0.0154
Echinococcus multilocularis	dnaJ subfamily B	0.0448	0.2361	0.262
Schistosoma mansoni	rab6-interacting	0.002	0.007	0.007
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.001	0.0015	0.185
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0187	0.0964	0.1067
Trypanosoma brucei	unspecified product	0.0023	0.0083	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0083	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0187	0.0964	0.0964
Echinococcus granulosus	axis inhibition protein axin	0.0187	0.0964	0.1067
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0083	0.0083
Leishmania major	P-type H -ATPase, putative	0.001	0.0015	0.185
Brugia malayi	E1-E2 ATPase family protein	0.001	0.0015	0.0015
Schistosoma mansoni	polycystin 1-related	0.002	0.007	0.007
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0046	0.55
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.0964	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.007	0.0073
Echinococcus multilocularis	cation transporting ATPase 13A3	0.001	0.0015	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.0964	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.007	0.0073
Echinococcus granulosus	axis inhibition protein axin	0.0187	0.0964	0.1067
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.001	0.0015	0.0154
Leishmania major	calcium-translocating P-type ATPase	0.001	0.0015	0.185
Chlamydia trachomatis	metal transport ATPase	0.001	0.0015	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Echinococcus granulosus	regulator of G protein signaling 3	0.0187	0.0964	0.1067
Echinococcus granulosus	regulator of G protein signaling 7	0.0187	0.0964	0.1067
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.007	0.0073
Leishmania major	copper-transporting ATPase-like protein, putative	0.001	0.0015	0.185
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.001	0.0015	0.0012
Mycobacterium ulcerans	metal cation transporter ATPase p-type CtpE	0.001	0.0015	0.185
Loa Loa (eye worm)	calcium ATPase	0.001	0.0015	0.0015
Trypanosoma brucei	cation-transporting ATPase, putative	0.001	0.0015	0.185
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0015	0.0012
Toxoplasma gondii	P-type ATPase4, putative	0.001	0.0015	0.0548
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.001	0.0015	0.0548
Schistosoma mansoni	cation-transporting atpase worm	0.001	0.0015	0.0015
Loa Loa (eye worm)	PXA domain-containing protein	0.0187	0.0964	0.0964
Plasmodium vivax	cation transporting ATPase, putative	0.001	0.0015	0.2201
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0015	0.0154
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0083	0.086
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.001	0.0015	0.0015
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.001	0.0015	0.0548
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.001	0.0015	0.185
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.001	0.0015	0.185
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0083	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 52 %	Antiinflammatory activity in LPS-stimulated human THP1 cells assessed as inhibition of IL-6 release at 10 ug/ml after 24 hrs by ELISA relative to control	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2425135

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1788958