Detailed information for compound 1791685

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.519 | Formula: C22H35NO2
  • H donors: 2 H acceptors: 2 LogP: 5.46 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCC[C@@H](C/C=C/CCC(=O)NCCc1ccccc1)O
  • InChi: 1S/C22H35NO2/c1-2-3-4-5-10-15-21(24)16-11-7-12-17-22(25)23-19-18-20-13-8-6-9-14-20/h6-9,11,13-14,21,24H,2-5,10,12,15-19H2,1H3,(H,23,25)/b11-7+/t21-/m0/s1
  • InChiKey: XBITUHSXOOKGCA-AKERNLMBSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0585 0.1198
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0393 0.0599
Echinococcus multilocularis BC026374 protein (S09 family) 0.0088 0.1392 0.1392
Echinococcus granulosus zinc finger protein 0.0024 0.0125 0.0125
Brugia malayi Bromodomain containing protein 0.0082 0.1287 0.1255
Schistosoma mansoni ap endonuclease 0.002 0.0037 0.0037
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0037 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0115 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0268 0.0268
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0585 0.0927
Giardia lamblia GTOR 0.0047 0.0585 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0626 0.0626
Brugia malayi jmjC domain containing protein 0.01 0.1645 0.1614
Schistosoma mansoni hypothetical protein 0.0022 0.0075 0.0075
Schistosoma mansoni zinc finger protein 0.0024 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0585 0.1198
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0905 0.0871
Brugia malayi Bromodomain containing protein 0.0037 0.0376 0.034
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0585 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.2634 0.2634
Brugia malayi Carboxylesterase family protein 0.0088 0.1392 0.1361
Onchocerca volvulus 0.0088 0.1392 0.2614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0343 0.067
Brugia malayi Pre-SET motif family protein 0.0031 0.0268 0.0232
Leishmania major sterol C-24 reductase, putative 0.005 0.0634 0.1006
Brugia malayi Carboxylesterase family protein 0.0088 0.1392 0.1361
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0085 0.0048
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0396 0.0396
Schistosoma mansoni acetylcholinesterase 0.0088 0.1392 0.1392
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0422 0.0422
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.5976 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.015 0.0249
Onchocerca volvulus 0.0088 0.1392 0.2614
Echinococcus granulosus para nitrobenzyl esterase 0.0088 0.1392 0.1392
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4007 0.3985
Schistosoma mansoni hypothetical protein 0.0038 0.0397 0.0397
Echinococcus granulosus acetylcholinesterase 0.0519 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0088 0.1392 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.0357
Onchocerca volvulus 0.0249 0.461 1
Brugia malayi Pre-SET motif family protein 0.0219 0.4007 0.3985
Loa Loa (eye worm) carboxylesterase 0.0088 0.1392 0.1361
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0533 0.0835
Echinococcus multilocularis zinc finger protein 0.0024 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1361
Brugia malayi hypothetical protein 0.0088 0.1392 0.1361
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0037 0.5
Loa Loa (eye worm) acetylcholinesterase 1 0.0519 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0557 0.1138
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0585 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0343 0.067
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0533 0.084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0422 0.0422
Echinococcus multilocularis para nitrobenzyl esterase 0.0088 0.1392 0.1392
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0585 0.0585
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0088 0.1392 0.1392
Onchocerca volvulus 0.0088 0.1392 0.2614
Brugia malayi Carboxylesterase family protein 0.0088 0.1392 0.1361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0206 0.0369
Mycobacterium ulcerans hypothetical protein 0.0167 0.2979 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0151 0.025
Entamoeba histolytica hypothetical protein 0.0038 0.0397 0.657
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0031 0.0254 0.0254
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0254 0.0254
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0037 0.0037
Trypanosoma cruzi sterol C-24 reductase, putative 0.005 0.0634 0.1006
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0254 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0206 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0343 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0151 0.025
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0585 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0392 0.0777
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0585 0.0923
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0393 0.0599
Echinococcus multilocularis lamin b receptor 0.005 0.0634 0.0634
Trichomonas vaginalis set domain proteins, putative 0.0249 0.461 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1126 0.1093
Trichomonas vaginalis spcc417.12 protein, putative 0.0088 0.1392 0.2964
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0557 0.83
Loa Loa (eye worm) acetyltransferase 0.015 0.2634 0.2607
Loa Loa (eye worm) carboxylesterase 0.0519 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0037 0.0005
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0557 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0254 0.0475
Entamoeba histolytica hypothetical protein 0.0038 0.0397 0.657
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.5976 1
Onchocerca volvulus 0.0052 0.068 0.0977
Echinococcus granulosus BC026374 protein S09 family 0.0088 0.1392 0.1392
Echinococcus multilocularis carboxylesterase 5A 0.0519 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0049 0.0626 0.0591
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0075 0.0038
Echinococcus multilocularis neuroligin 0.0088 0.1392 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0275 0.052
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.264 0.4386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0392 0.0777
Loa Loa (eye worm) hypothetical protein 0.0052 0.068 0.0645
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1361
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0397 0.0397
Loa Loa (eye worm) carboxylesterase 0.0088 0.1392 0.1361
Echinococcus multilocularis acetylcholinesterase 0.0519 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.2979 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1645 0.1645
Toxoplasma gondii hypothetical protein 0.0051 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0519 1 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0088 0.1392 0.4608
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0245 0.0245
Entamoeba histolytica hypothetical protein 0.0038 0.0397 0.657
Brugia malayi Carboxylesterase family protein 0.0519 1 1
Echinococcus multilocularis acetylcholinesterase 0.0519 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0585 0.055
Brugia malayi jmjC domain containing protein 0.0039 0.0422 0.0387
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0254 0.346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0626 0.0626
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0519 1 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0557 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0585 0.1198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.015 0.0249
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.5976 1
Brugia malayi hypothetical protein 0.0038 0.0397 0.0361
Brugia malayi PHD-finger family protein 0.003 0.0237 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0602 0.0602
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.264 0.4383
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0585 0.0923
Leishmania major C-14 sterol reductase, putative 0.005 0.0634 0.1006
Echinococcus granulosus tumor protein p63 0.0355 0.6729 0.6729
Trypanosoma cruzi C-14 sterol reductase, putative 0.005 0.0634 0.1006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.264 0.4383
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.068 0.068
Trypanosoma brucei C-14 sterol reductase, putative 0.005 0.0634 0.101
Echinococcus granulosus acetylcholinesterase 0.0519 1 1
Echinococcus granulosus peregrin 0.0037 0.0376 0.0376
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0967 0.0967
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0254 0.0254
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0088 0.1392 0.1392
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0268 0.3693
Giardia lamblia PHD finger protein 15 0.0031 0.0254 0.3959
Loa Loa (eye worm) hypothetical protein 0.0048 0.0609 0.0574
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0493 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0343 0.067
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0088 0.1392 0.4608
Schistosoma mansoni neuroligin 3 (S09 family) 0.0088 0.1392 0.1392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0268 0.0268
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0382 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0343 0.067
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0436 0.7276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0343 0.067
Brugia malayi PHD-finger family protein 0.0031 0.0254 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0602 0.0602
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0422 0.0422
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0585 0.055
Loa Loa (eye worm) hypothetical protein 0.0519 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0585 0.0923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0602 0.0602
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0585 0.0923
Echinococcus granulosus neuroligin 0.0088 0.1392 0.1392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0602 0.0602
Brugia malayi Bromodomain containing protein 0.0044 0.0518 0.0483
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0422 0.0387
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0436 0.7276
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.2634 0.2607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0396 0.0396
Schistosoma mansoni jumonji domain containing protein 0.008 0.1233 0.1233
Schistosoma mansoni gliotactin 0.0088 0.1392 0.1392
Loa Loa (eye worm) hypothetical protein 0.0053 0.0691 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.0357
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0728 0.1163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0484 0.9295 0.9292
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0585 0.0585
Echinococcus multilocularis peregrin 0.0037 0.0376 0.0376
Onchocerca volvulus 0.0031 0.0268 0.0034
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0037 0.0037
Schistosoma mansoni Lamin B receptor (ERG24) 0.005 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1361
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0397 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0206 0.0369
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0626 0.0626
Echinococcus granulosus carboxylesterase 5A 0.0519 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.5976 1
Echinococcus granulosus lamin b receptor 0.005 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.0218
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0088 0.0091
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1361
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0343 0.4888
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0115 0.0115
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0493 0.0493
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0046 0.0569 0.0534
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0602 0.0567
Loa Loa (eye worm) hypothetical protein 0.004 0.0447 0.0412
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.2502 0.2502
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0967 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.015 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0151 0.025
Schistosoma mansoni ap endonuclease 0.002 0.0037 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0254 0.4169
Brugia malayi Carboxylesterase family protein 0.0088 0.1392 0.1361
Schistosoma mansoni BC026374 protein (S09 family) 0.0088 0.1392 0.1392
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0254 0.346
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0088 0.1392 0.2964
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1361
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0088 0.1392 0.4608
Plasmodium falciparum phd finger protein, putative 0.0031 0.0254 0.5442
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0533 0.0835
Trypanosoma cruzi sterol C-24 reductase, putative 0.005 0.0634 0.1006
Entamoeba histolytica hypothetical protein 0.0038 0.0397 0.657
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0447 0.0897
Schistosoma mansoni bromodomain containing protein 0.007 0.1042 0.1042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0626 0.0626
Trypanosoma cruzi C-14 sterol reductase, putative 0.005 0.0634 0.1006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0088 0.1392 0.1392
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0393 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0392 0.0777
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0557 0.83
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0585 0.0585
Mycobacterium ulcerans carboxylesterase, LipT 0.0088 0.1392 0.4608
Onchocerca volvulus 0.0088 0.1392 0.2614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0343 0.067
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0533 0.0835
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0602 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0151 0.025
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0436 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0088 0.1392 0.1392
Onchocerca volvulus 0.0088 0.1392 0.2614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0392 0.0777
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1361
Echinococcus multilocularis tumor protein p63 0.0355 0.6729 0.6729
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0557 0.0557
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.2634 0.2634
Plasmodium vivax SET domain protein, putative 0.0031 0.0268 0.445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0392 0.0777
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0268 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0602 0.0602

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Cytotoxicity against Homo sapiens (human) HOP62 cells assessed as growth inhibition after 48 hr by trypan blue exclusion assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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