Detailed information for compound 1806801

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.63 | Formula: C11H10ClN3Se
  • H donors: 1 H acceptors: 0 LogP: 2.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)/C=N/Nc1[se]cc(n1)C
  • InChi: 1S/C11H10ClN3Se/c1-8-7-16-11(14-8)15-13-6-9-2-4-10(12)5-3-9/h2-7H,1H3,(H,14,15)/b13-6+
  • InChiKey: QQGAQPVSGVUWST-AWNIVKPZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0531 0.3884 0.3884
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0043 0.0043
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0674 0.1735
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0162 0.0249
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0043 0.0043
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0007 0.0013 0.009
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0086 0.0086
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0278 0.2911
Trypanosoma brucei unspecified product 0.0017 0.0086 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.013 0.0335
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0097 0.0984
Echinococcus granulosus SPRY domain containing protein 0.0007 0.0013 0.0013
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0173 1
Brugia malayi Flap endonuclease-1 0.0029 0.0173 0.0444
Schistosoma mansoni smad 0.0009 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.215 0.6823
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0245 0.0765
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0432 0.3149 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0043 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0043 0.0112
Entamoeba histolytica DNA repair protein, putative 0.0007 0.0013 0.0027
Schistosoma mansoni hypothetical protein 0.0023 0.013 0.013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0349 0.0349
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0133 0.0944 0.2988
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0033
Echinococcus granulosus cpg binding protein 0.0035 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0142 0.1011 0.2603
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0043 0.0138
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0041
Schistosoma mansoni smad1 5 8 and 0.0009 0.0027 0.0027
Brugia malayi hypothetical protein 0.0028 0.0166 0.0427
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0041
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.007
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0007 0.0013 0.0033
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0297 0.215 0.5537
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0166 0.3816
Leishmania major hypothetical protein, conserved 0.0028 0.0166 0.1719
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0043 0.0043
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0006 0.0004 0.0004
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0022 0.0022
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0173 0.3976
Echinococcus multilocularis dna repair and recombination protein rad54 0.0007 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0041 0.0266 0.0833
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0033
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0173 0.0535
Brugia malayi steroid hormone receptor 0.0011 0.0043 0.0112
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0428 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.013 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0043 0.0112
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0761 0.196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0349 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1475 0.4676
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0097 0.2184
Schistosoma mansoni inositol monophosphatase 0.0043 0.0278 0.0278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0043 0.0043
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0432 0.3149 1
Brugia malayi hypothetical protein 0.0041 0.0266 0.0686
Loa Loa (eye worm) hypothetical protein 0.0071 0.0486 0.1252
Schistosoma mansoni hypothetical protein 0.0012 0.0053 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0041
Entamoeba histolytica hypothetical protein 0.0041 0.0266 0.0833
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0047 0.0455
Loa Loa (eye worm) hypothetical protein 0.0225 0.162 0.4171
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0043 0.0043
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0432 0.3149 1
Echinococcus multilocularis geminin 0.0148 0.1052 0.1052
Loa Loa (eye worm) hypothetical protein 0.0097 0.0674 0.1735
Loa Loa (eye worm) histone methyltransferase 0.001 0.0037 0.0096
Onchocerca volvulus 0.0097 0.0674 0.2139
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0043 0.0112
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0278 0.2911
Schistosoma mansoni hypothetical protein 0.0148 0.1052 0.1052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0043 0.0043
Onchocerca volvulus 0.0033 0.0207 0.0659
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0071 0.0486 0.0486
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Brugia malayi hypothetical protein 0.0006 0.0005 0.0012
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0162 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1398 0.443
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0071 0.0486 0.0486
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0483 0.0483
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0043 0.0043
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0043 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0278 0.2911
Echinococcus multilocularis dna repair and recombination protein rad54 0.0007 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0043 0.0112
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.013 0.013
Echinococcus granulosus smad 0.0009 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0043 0.0112
Brugia malayi hypothetical protein 0.0018 0.0093 0.024
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0027 0.007
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0097 0.0249
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0173 0.0173
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0162 0.1675
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0162 0.1675
Brugia malayi nuclear receptor NHR-88 0.0011 0.0043 0.0112
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0011
Schistosoma mansoni lipoxygenase 0.0096 0.0668 0.0668
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0166 0.9597
Echinococcus multilocularis exonuclease 1 0.0006 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0043 0.0112
Echinococcus multilocularis 0.0007 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0086 0.0865
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0043 0.0112
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.013 0.7487
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0173 0.1791
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0349 0.0349
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0027 0.0164 0.377
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0278 0.087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0086 0.0086
Brugia malayi nuclear hormone receptor 0.0011 0.0043 0.0112
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0041 0.0266 0.0266
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0173 0.0444
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0432 0.3149 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Echinococcus multilocularis RUN 0.0023 0.013 0.013
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0674 0.0674
Echinococcus granulosus dna polymerase eta 0.0039 0.0249 0.0249
Schistosoma mansoni cpg binding protein 0.0033 0.0207 0.0207
Trypanosoma brucei DNA repair and recombination protein RAD54, putative 0.0007 0.0013 0.009
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0005
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0133 0.0944 1
Echinococcus multilocularis flap endonuclease GEN 1 0.0006 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.215 0.6823
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0043 0.0043
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0043 0.0112
Schistosoma mansoni hypothetical protein 0.0108 0.0761 0.0761
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.215 0.6823
Leishmania major DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0047 0.0455
Brugia malayi hypothetical protein 0.0006 0.0005 0.0012
Echinococcus multilocularis 0.0007 0.0013 0.0013
Echinococcus granulosus geminin 0.0148 0.1052 0.1052
Plasmodium falciparum flap endonuclease 1 0.0029 0.0173 1
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0086 0.022
Brugia malayi hypothetical protein 0.0142 0.1011 0.2603
Echinococcus granulosus Smad4 0.0009 0.0027 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1398 0.443
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0043 0.0043
Brugia malayi XPG I-region family protein 0.0006 0.0004 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.215 0.6823
Schistosoma mansoni cpg binding protein 0.0035 0.0221 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0173 0.1791
Schistosoma mansoni loxhd1 0.0023 0.013 0.013
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0006 0.0004 0.0004
Plasmodium falciparum DNA repair and recombination protein RAD54, putative 0.0007 0.0013 0.0502
Brugia malayi CXXC zinc finger family protein 0.0033 0.0207 0.0534
Loa Loa (eye worm) latrophilin receptor protein 2 0.0071 0.0486 0.1252
Schistosoma mansoni cpg binding protein 0.0035 0.0221 0.0221
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0097 0.5493
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0086 0.0865
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0027 0.0027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0043 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.093 0.2394
Brugia malayi isocitrate dehydrogenase 0.0018 0.0097 0.0249
Loa Loa (eye worm) doublecortin family protein 0.0023 0.013 0.0335
Trypanosoma brucei unspecified product 0.0012 0.0047 0.0455
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0005 0.0012
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0005
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0097 0.0097
Echinococcus multilocularis survival motor neuron protein 1 0.0531 0.3884 0.3884
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0037 0.0037
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0043 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0041
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0097 0.0984
Brugia malayi hypothetical protein 0.0531 0.3884 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0037 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0249 0.2609
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0043 0.0043
Echinococcus granulosus dnaJ subfamily B 0.0475 0.3466 0.3466
Leishmania major DNA repair and recombination protein RAD54, putative 0.0007 0.0013 0.009
Echinococcus granulosus SPRY domain containing protein 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Echinococcus granulosus flap endonuclease 1 0.0029 0.0173 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.0142 0.1011 0.321
Schistosoma mansoni smad1 5 8 and 0.0009 0.0027 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0043 0.0043
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0278 0.0628
Echinococcus granulosus SPRY domain containing protein 0.0007 0.0013 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0225 0.162 0.4171
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0012
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.013 0.7487
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.215 0.6823
Echinococcus multilocularis dna polymerase eta 0.0039 0.0249 0.0249
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0166 0.1719
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0133 0.0944 0.2988
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0006 0.0004 0.0004
Brugia malayi hypothetical protein 0.0023 0.013 0.0335
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0278 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0043 0.0112
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0432 0.3149 1
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0278 0.0278
Onchocerca volvulus 0.0432 0.3149 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0017 0.0041
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.007
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0137 0.0972 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0043 0.0112
Loa Loa (eye worm) XPG I-region family protein 0.0006 0.0004 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0043 0.0112
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1398 0.443
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0043 0.0043
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0043 0.0043
Trypanosoma cruzi DNA polymerase eta, putative 0.0027 0.0164 0.1698
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0173 0.0535
Brugia malayi ecdysteroid receptor 0.0011 0.0043 0.0112
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0086 0.0865
Echinococcus multilocularis smad 0.0009 0.0027 0.0027
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0097 0.0054
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0027 0.0027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0043 0.0043
Brugia malayi hypothetical protein 0.0023 0.013 0.0335
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0097 0.0097
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0007 0.0013 0.009
Echinococcus granulosus GPCR family 2 0.0071 0.0486 0.0486
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0043 0.0043
Brugia malayi nuclear receptor RXR 0.0006 0.0005 0.0012
Schistosoma mansoni hypothetical protein 0.0071 0.0486 0.0486
Echinococcus multilocularis Smad4 0.0009 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0043 0.0112
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0707 0.518 0.518
Schistosoma mansoni rab6-interacting 0.0023 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0043 0.0112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0225 0.162 0.4171
Schistosoma mansoni lipoxygenase 0.0137 0.0972 0.0972
Trypanosoma brucei unspecified product 0.0012 0.0047 0.0455
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0043 0.0043
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0022
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0225 0.162 0.4171
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0154 0.1095 0.1095
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0097 0.2184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0043 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Leishmania major hypothetical protein, conserved 0.0133 0.0944 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0097 0.0097
Entamoeba histolytica DNA repair protein, putative 0.0007 0.0013 0.0027
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0432 0.3149 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0297 0.215 0.5537
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1398 0.443
Loa Loa (eye worm) type III restriction enzyme 0.0007 0.0013 0.0033
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0043 0.0043
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0043 0.0138
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0207 0.0534
Schistosoma mansoni hypothetical protein 0.0071 0.0486 0.0486
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0278 0.087
Schistosoma mansoni hypothetical protein 0.0071 0.0486 0.0486
Entamoeba histolytica hypothetical protein 0.0041 0.0266 0.0833
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0944 1
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0007 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0043 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Schistosoma mansoni smad1 5 8 and 0.0009 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0071 0.0486 0.0486
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.013 0.013
Onchocerca volvulus 0.0108 0.0761 0.2417
Schistosoma mansoni flap endonuclease-1 0.0026 0.0152 0.0152
Echinococcus granulosus RUN 0.0023 0.013 0.013
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0007 0.0013 0.0013
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0148 0.1052 0.1052
Schistosoma mansoni microtubule-associated protein tau 0.136 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0086 0.0865
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0043 0.0112
Brugia malayi MH2 domain containing protein 0.0131 0.093 0.2394
Echinococcus granulosus dna repair and recombination protein rad54 0.0007 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0043 0.0112
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0027 0.0027
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0097 0.0984
Leishmania major DNA polymerase eta, putative 0.0027 0.0164 0.1698
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0166 0.1719
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0043 0.0112
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0097 0.5493
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0432 0.3149 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0036 0.0094
Loa Loa (eye worm) hypothetical protein 0.0531 0.3884 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0043 0.0043
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0071 0.0486 0.0486
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0097 0.0097
Echinococcus multilocularis SPRY domain containing protein 0.0007 0.0013 0.0013
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0007 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0043 0.0112
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0432 0.3149 1
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0006 0.0004 0.0004
Leishmania major DNA polymerase eta, putative 0.0039 0.0249 0.2609
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1398 0.443
Echinococcus granulosus dna polymerase kappa 0.0017 0.0086 0.0086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0349 0.0899
Schistosoma mansoni inositol monophosphatase 0.0043 0.0278 0.0278
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0432 0.3149 1
Loa Loa (eye worm) inositol-1 0.0043 0.0278 0.0715
Loa Loa (eye worm) Smad1 0.0009 0.0027 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Onchocerca volvulus Huntingtin homolog 0.0142 0.1011 0.321
Loa Loa (eye worm) hypothetical protein 0.0142 0.1011 0.2603
Onchocerca volvulus 0.0023 0.013 0.0414
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0166 0.9597
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0043 0.0112
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0137 0.0972 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0043 0.0112
Brugia malayi Smad1 0.0009 0.0027 0.007
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0249 0.2609
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0278 0.2911
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0349 0.0349
Brugia malayi recombination factor GdRad54 0.0007 0.0013 0.0033
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0097 0.0249
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0278 0.087
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0162 0.5
Brugia malayi MH2 domain containing protein 0.0009 0.0027 0.007
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0162 0.3719
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0166 0.1719
Giardia lamblia DINP protein human, muc B family 0.0017 0.0086 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0944 1
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0166 0.9597
Brugia malayi MH2 domain containing protein 0.0009 0.0027 0.007
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0432 0.3149 0.8109
Schistosoma mansoni rab6-interacting 0.0023 0.013 0.013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0086 0.0086
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0162 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0012
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.013 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0043 0.0043
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0173 0.1791
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0043 0.0043
Echinococcus multilocularis GPCR, family 2 0.0071 0.0486 0.0486
Schistosoma mansoni survival motor neuron protein 0.0108 0.0761 0.0761
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0017 0.0086 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1398 0.443
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0245 1
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.093 0.2394
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0427
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0022 0.0022
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0674 0.0674
Brugia malayi Latrophilin receptor protein 2 0.0071 0.0486 0.1252
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0071 0.0486 0.0486
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0432 0.3149 1
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.3466 0.3466
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0349 0.0349
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0162 0.0366
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0012
Onchocerca volvulus 0.0023 0.013 0.0414
Schistosoma mansoni exonuclease 0.0006 0.0004 0.0004
Echinococcus multilocularis dna repair and recombination protein rad54 0.0007 0.0013 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0043 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1475 0.4676
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0278 0.6463
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0432 0.3149 0.8109
Schistosoma mansoni Smad4 0.0009 0.0027 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0022 0.0022
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0642
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0086 0.0086
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0043 0.0112
Schistosoma mansoni polycystin 1-related 0.0023 0.013 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1398 0.443
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0162 0.9354
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0278 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0162 0.9354
Entamoeba histolytica hypothetical protein 0.0027 0.0162 0.0501
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0097 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0154 0.1095 0.2819
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0027 0.007
Echinococcus multilocularis SPRY domain containing protein 0.0007 0.0013 0.0013
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0674 0.0674
Plasmodium vivax DNA repair protein RAD54, putative 0.0007 0.0013 0.0502
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0266 0.0266
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0162 0.3719
Brugia malayi Inositol-1 0.0043 0.0278 0.0715
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0017 0.0041
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.0154 0.1095 0.2819
Echinococcus multilocularis microtubule associated protein 2 0.136 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0097 0.0097
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0173 0.0535
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0043 0.0043
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.013 0.013
Echinococcus multilocularis cpg binding protein 0.0035 0.0221 0.0221
Trichomonas vaginalis helicase, putative 0.0008 0.0017 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0097 0.0984
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0041
Schistosoma mansoni DNA polymerase eta 0.0039 0.0249 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0349 0.0349
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0086 0.022
Entamoeba histolytica hypothetical protein 0.0041 0.0266 0.0833
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0299 0.2167 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0086 0.0865
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0278 0.087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0349 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0043 0.0112
Brugia malayi Doublecortin family protein 0.0023 0.013 0.0335
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0053 0.0053
Schistosoma mansoni coup transcription factor 0.0011 0.0043 0.0043
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.013 0.013
Trichomonas vaginalis DNA polymerase eta, putative 0.0017 0.0086 0.0258
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0043 0.0043
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0097 0.0097
Echinococcus granulosus exonuclease 1 0.0006 0.0004 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0266 0.0266
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0249 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.215 0.6823
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0112
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0043 0.0043
Echinococcus granulosus flap endonuclease GEN 1 0.0006 0.0004 0.0004
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0086 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0047 0.0455
Schistosoma mansoni hypothetical protein 0.0475 0.3466 0.3466
Onchocerca volvulus Glucosylceramidase homolog 0.0195 0.1398 0.4437
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0071 0.0486 0.1252
Onchocerca volvulus 0.0011 0.0043 0.0138
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0097 0.0984

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 56.46 uM Cytotoxicity against human HepG2 cells after 72 hrs by XTT assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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