Detailed information for compound 1807849

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.495 | Formula: C22H26N8O
  • H donors: 3 H acceptors: 6 LogP: 3.58 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC[C@@H](Nc1nc(Nc2ccc(cc2)c2cncnc2)c2c(n1)n(cn2)C(C)C)O
  • InChi: 1S/C22H26N8O/c1-4-5-18(31)27-22-28-20(19-21(29-22)30(13-25-19)14(2)3)26-17-8-6-15(7-9-17)16-10-23-12-24-11-16/h6-14,18,31H,4-5H2,1-3H3,(H2,26,27,28,29)/t18-/m0/s1
  • InChiKey: LQYHWFFRRIMAPW-SFHVURJKSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Casein kinase 1, delta tv1 Starlite/ChEMBL No references
Asterina pectinifera G2/mitotic-specific cyclin-B Starlite/ChEMBL No references
Homo sapiens cyclin A2 No references
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 No references
Homo sapiens cyclin A1 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum casein kinase 1 Get druggable targets OG5_126780 All targets in OG5_126780
Toxoplasma gondii casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi casein kinase 1, delta Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium parvum casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania donovani casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K08959 casein kinase 1, delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium knowlesi casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum AFL091Wp, related Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Casein kinase I isoform delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Babesia bovis casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02218 casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium berghei casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Theileria parva casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CK1 Casein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium yoelii casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis casein kinase I, putative Casein kinase 1, delta tv1   415 aa 334 aa 44.6 %
Trichomonas vaginalis CK1 family protein kinase Casein kinase 1, delta tv1   415 aa 416 aa 44.7 %
Leishmania mexicana casein kinase I, putative Casein kinase 1, delta tv1   415 aa 339 aa 45.4 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Giardia lamblia Kinase, NEK Casein kinase 1, delta tv1   415 aa 393 aa 21.9 %
Leishmania infantum casein kinase I, putative Casein kinase 1, delta tv1   415 aa 336 aa 44.3 %
Leishmania braziliensis protein kinase, putative Casein kinase 1, delta tv1   415 aa 341 aa 20.8 %
Leishmania donovani casein kinase I, putative Casein kinase 1, delta tv1   415 aa 336 aa 44.6 %
Toxoplasma gondii CAM Kinase family, incomplete catalytic triad Casein kinase 1, delta tv1   415 aa 435 aa 23.0 %
Echinococcus multilocularis tyrosine protein kinase Fps85D Casein kinase 1, delta tv1   415 aa 403 aa 22.6 %
Onchocerca volvulus Casein kinase 1, delta tv1   415 aa 339 aa 21.5 %
Schistosoma japonicum Casein kinase I isoform alpha, putative Casein kinase 1, delta tv1   415 aa 357 aa 55.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclin dependent kinase 5 0.0106 0.0838 0.0838
Echinococcus granulosus dual specificity 0.011 0.0884 0.1045
Trypanosoma cruzi cyclin, putative 0.0141 0.1234 1
Schistosoma mansoni amine oxidase 0.0114 0.0933 0.1103
Toxoplasma gondii SWIRM domain-containing protein 0.0048 0.0188 0.0419
Trypanosoma cruzi UDP-galactopyranose mutase 0.0114 0.0933 0.7189
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0141 0.1234 1
Entamoeba histolytica cyclin family protein 0.0059 0.0314 0.1206
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.006 0.0329 0.1543
Loa Loa (eye worm) hypothetical protein 0.0082 0.0576 0.089
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0329 0.0389
Trypanosoma cruzi casein kinase, putative 0.0048 0.0195 0.029
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0114 0.0933 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0292 0.0451
Echinococcus granulosus microtubule associated protein 2 0.0788 0.8459 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0114 0.0933 0.1103
Echinococcus multilocularis cyclin B3 1 0.0059 0.0314 0.0314
Echinococcus granulosus protein kinase shaggy 0.006 0.0329 0.0389
Echinococcus multilocularis cyclins 0.0059 0.0314 0.0314
Trypanosoma brucei protein kinase, putative 0.006 0.0329 0.129
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0048 0.0188 0.0188
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0106 0.0838 0.1294
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0048 0.0188 0.0222
Plasmodium falciparum protoporphyrinogen oxidase 0.0114 0.0933 1
Schistosoma mansoni cyclin B 0.0141 0.1234 0.1459
Entamoeba histolytica protein kinase domain containing protein 0.011 0.0884 0.6652
Echinococcus granulosus cyclin dependent kinase 0.0106 0.0838 0.0991
Brugia malayi Protein kinase domain containing protein 0.011 0.0884 0.1366
Trichomonas vaginalis cyclin A, putative 0.0141 0.1234 1
Schistosoma mansoni protein kinase 0.0048 0.0195 0.023
Trichomonas vaginalis cyclins, putative 0.0059 0.0314 0.1206
Echinococcus multilocularis cyclin b3 0.0059 0.0314 0.0314
Giardia lamblia Kinase, CMGC CDK 0.0106 0.0838 0.6212
Echinococcus multilocularis casein kinase I delta 0.0048 0.0195 0.0195
Echinococcus granulosus lysine specific histone demethylase 1A 0.0563 0.5942 0.7025
Trypanosoma brucei cdc2-related kinase 3 0.0106 0.0838 0.6188
Leishmania major cyclin 0.0141 0.1234 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0114 0.0933 0.5
Echinococcus granulosus casein kinase I alpha 0.0048 0.0195 0.023
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0114 0.0933 0.5
Loa Loa (eye worm) hypothetical protein 0.0114 0.0933 0.1442
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0884 0.1045
Echinococcus multilocularis protein kinase shaggy 0.006 0.0329 0.0329
Entamoeba histolytica hypothetical protein 0.011 0.0884 0.6652
Trichomonas vaginalis cyclin B, putative 0.0059 0.0314 0.1206
Echinococcus multilocularis casein kinase I alpha 0.0048 0.0195 0.0195
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0106 0.0838 0.8774
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0114 0.0933 0.5
Echinococcus multilocularis casein kinase I delta 0.0048 0.0195 0.0195
Echinococcus granulosus casein kinase i 0.0048 0.0195 0.023
Trichomonas vaginalis cyclins, putative 0.0141 0.1234 1
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.3106 0.3672
Loa Loa (eye worm) hypothetical protein 0.0611 0.6474 1
Onchocerca volvulus 0.0048 0.0195 0.03
Trichomonas vaginalis cyclin B, putative 0.0141 0.1234 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0141 0.1234 1
Echinococcus multilocularis casein kinase I alpha 0.0048 0.0195 0.0195
Toxoplasma gondii casein kinase I 0.0048 0.0195 0.0505
Echinococcus multilocularis cyclin B 0.0141 0.1234 0.1234
Loa Loa (eye worm) hypothetical protein 0.0141 0.1234 0.1907
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0114 0.0933 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0329 0.0508
Trypanosoma cruzi UDP-galactopyranose mutase 0.0114 0.0933 0.7189
Echinococcus multilocularis casein kinase i 0.0048 0.0195 0.0195
Onchocerca volvulus 0.0045 0.0163 0.0252
Brugia malayi Protein kinase domain containing protein 0.0106 0.0838 0.1294
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.011 0.0884 0.1366
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0933 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0292 0.0451
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0048 0.0195 0.029
Loa Loa (eye worm) hypothetical protein 0.0048 0.0188 0.029
Brugia malayi cell division control protein 2 homolog 0.0106 0.0838 0.1294
Echinococcus granulosus casein kinase I alpha 0.0048 0.0195 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0314 0.1206
Schistosoma mansoni hypothetical protein 0.0039 0.0091 0.0107
Onchocerca volvulus 0.0141 0.1234 0.1907
Trichomonas vaginalis CK1 family protein kinase 0.0048 0.0195 0.0065
Trypanosoma cruzi cdc2-related kinase 3 0.0106 0.0838 0.6298
Echinococcus multilocularis cyclins 0.0059 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0148 0.1308 0.202
Loa Loa (eye worm) hypothetical protein 0.0309 0.3106 0.4798
Trypanosoma cruzi casein kinase, putative 0.0048 0.0195 0.029
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0048 0.0195 0.03
Brugia malayi amine oxidase, flavin-containing family protein 0.0162 0.1465 0.2263
Brugia malayi casein kinase 1, delta 0.0048 0.0195 0.03
Trypanosoma cruzi cdc2-related kinase 3 0.0106 0.0838 0.6298
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0106 0.0838 0.1294
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0106 0.0838 0.6188
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0838 0.6212
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0114 0.0933 1
Trypanosoma cruzi casein kinase, putative 0.0048 0.0195 0.029
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.014
Schistosoma mansoni cyclin B3 0.0059 0.0314 0.0371
Echinococcus granulosus cyclin dependent kinase 1 0.0106 0.0838 0.0991
Loa Loa (eye worm) hypothetical protein 0.0162 0.1465 0.2263
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0048 0.0195 0.03
Schistosoma mansoni cyclins 0.0059 0.0314 0.0371
Loa Loa (eye worm) hypothetical protein 0.0114 0.0933 0.1442
Entamoeba histolytica cyclin, putative 0.0059 0.0314 0.1206
Echinococcus multilocularis 0.0114 0.0933 0.0933
Mycobacterium tuberculosis Conserved hypothetical protein 0.0114 0.0933 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0091 0.014
Entamoeba histolytica cell division protein kinase 2, putative 0.0106 0.0838 0.6212
Trichomonas vaginalis cyclins, putative 0.0141 0.1234 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0106 0.0838 0.6188
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0838 0.0991
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0838 0.0991
Giardia lamblia Kinase, CK1 Casein kinase 0.0048 0.0195 0.0065
Toxoplasma gondii histone lysine-specific demethylase 0.0114 0.0933 1
Echinococcus multilocularis cyclins 0.0059 0.0314 0.0314
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0329 0.0508
Echinococcus multilocularis microtubule associated protein 2 0.0788 0.8459 0.8459
Giardia lamblia Cyclin A 0.0059 0.0314 0.1206
Entamoeba histolytica casein kinase 1, putative 0.0048 0.0195 0.0065
Brugia malayi hypothetical protein 0.0114 0.0933 0.1442
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0048 0.0195 0.03
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0106 0.0838 0.1294
Trichomonas vaginalis cyclin B3, putative 0.0059 0.0314 0.1206
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0329 0.1346
Brugia malayi intracellular kinase 0.006 0.0329 0.0508
Brugia malayi casein kinase I 0.0048 0.0195 0.03
Echinococcus multilocularis cyclins 0.0059 0.0314 0.0314
Echinococcus granulosus cyclins 0.0059 0.0314 0.0371
Loa Loa (eye worm) hypothetical protein 0.0148 0.1308 0.202
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0314 0.0485
Mycobacterium tuberculosis Possible oxidoreductase 0.0114 0.0933 0.5
Loa Loa (eye worm) hypothetical protein 0.0563 0.5942 0.9179
Mycobacterium ulcerans oxidoreductase 0.0114 0.0933 0.5
Entamoeba histolytica cell division protein kinase 2, putative 0.0106 0.0838 0.6212
Echinococcus multilocularis cyclin dependent kinase 1 0.0106 0.0838 0.0838
Echinococcus multilocularis cyclins 0.0059 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0141 0.1234 0.1907
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.3106 0.3672
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.011 0.0884 0.663
Echinococcus granulosus casein kinase I delta 0.0048 0.0195 0.023
Entamoeba histolytica casein kinase, putative 0.0048 0.0195 0.0065
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0059 0.0314 0.0371
Plasmodium vivax protein kinase Crk2 0.0106 0.0838 0.8709
Giardia lamblia Kinase, CMGC GSK 0.006 0.0329 0.1346
Giardia lamblia Hypothetical protein 0.0059 0.0314 0.1206
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.3106 0.3106
Plasmodium falciparum cyclin 0.0059 0.0314 0.1617
Trypanosoma cruzi cyclin 6, putative 0.0141 0.1234 1
Echinococcus multilocularis cyclins 0.0059 0.0314 0.0314
Trypanosoma brucei cdc2-related kinase 1 0.0106 0.0838 0.6188
Echinococcus granulosus cyclins 0.0059 0.0314 0.0371
Trichomonas vaginalis cyclin B, putative 0.0141 0.1234 1
Echinococcus multilocularis cyclin dependent kinase 0.0106 0.0838 0.0838
Giardia lamblia Kinase, CMGC CDK 0.0106 0.0838 0.6212
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0114 0.0933 0.5
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0329 0.1346
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0329 0.1346
Schistosoma mansoni SWI/SNF complex-related 0.0048 0.0188 0.0222
Brugia malayi Cyclin, N-terminal domain containing protein 0.0141 0.1234 0.1907
Echinococcus multilocularis cyclin dependent kinase 1 0.0106 0.0838 0.0838
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0106 0.0838 0.0991
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0563 0.5942 0.7025
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0838 0.6212
Trichomonas vaginalis cyclin B, putative 0.0141 0.1234 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0141 0.1234 0.1907
Trypanosoma brucei mitotic cyclin 6 0.0141 0.1234 1
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0195 0.023
Echinococcus granulosus cyclin B 0.0141 0.1234 0.1459
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0059 0.0314 0.0314
Entamoeba histolytica cyclin family protein 0.0059 0.0314 0.1206
Trichomonas vaginalis CK1 family protein kinase 0.0048 0.0195 0.0065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0292 0.0451
Trichomonas vaginalis cyclin B, putative 0.0141 0.1234 1
Echinococcus multilocularis casein kinase I alpha 0.0048 0.0195 0.0195
Echinococcus granulosus cyclins 0.0059 0.0314 0.0371
Entamoeba histolytica protein kinase, putative 0.011 0.0884 0.6652
Trypanosoma cruzi cyclin, putative 0.0141 0.1234 1
Brugia malayi hypothetical protein 0.0148 0.1308 0.202
Trypanosoma cruzi casein kinase, putative 0.0048 0.0195 0.029
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0329 0.0389
Echinococcus granulosus cyclin dependent kinase 5 0.0106 0.0838 0.0991
Trichomonas vaginalis cyclins, putative 0.0141 0.1234 1
Echinococcus multilocularis cyclins 0.0059 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0563 0.5942 0.9179
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.0884 0.6728
Trypanosoma cruzi casein kinase, putative 0.0048 0.0195 0.029
Entamoeba histolytica protein kinase, putative 0.006 0.0329 0.1346
Entamoeba histolytica cyclin, putative 0.0141 0.1234 1
Plasmodium falciparum protein kinase 5 0.0106 0.0838 0.8709
Plasmodium falciparum glycogen synthase kinase 3 0.006 0.0329 0.1816
Mycobacterium ulcerans monoamine oxidase 0.0114 0.0933 0.5
Onchocerca volvulus 0.0611 0.6474 1
Echinococcus granulosus cyclins 0.0059 0.0314 0.0371
Loa Loa (eye worm) hypothetical protein 0.0107 0.0853 0.1318
Trichomonas vaginalis CK1 family protein kinase 0.0048 0.0195 0.0065
Giardia lamblia Kinase, CMGC GSK 0.006 0.0329 0.1346
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0563 0.5942 0.5942
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0292 0.0451
Echinococcus granulosus lysine specific histone demethylase 1A 0.0114 0.0933 0.1103
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0933 1
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0838 0.6212
Trypanosoma cruzi cdc2-related kinase 1 0.0106 0.0838 0.6298
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0329 0.1346
Schistosoma mansoni amine oxidase 0.0114 0.0933 0.1103
Brugia malayi SWIRM domain containing protein 0.0611 0.6474 1
Echinococcus granulosus casein kinase I delta 0.0048 0.0195 0.023
Echinococcus granulosus casein kinase I alpha 0.0048 0.0195 0.023
Echinococcus granulosus cyclin B3 1 0.0059 0.0314 0.0371
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.011 0.0884 0.663
Echinococcus granulosus cyclin b3 0.0059 0.0314 0.0371
Echinococcus granulosus cyclins 0.0059 0.0314 0.0371
Plasmodium vivax glycogen synthase kinase 3, putative 0.006 0.0329 0.1816
Onchocerca volvulus 0.006 0.0329 0.0508
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0114 0.0933 0.5
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0114 0.0933 1
Trichomonas vaginalis cyclin D, putative 0.0059 0.0314 0.1206
Giardia lamblia G2/mitotic-specific cyclin B 0.0141 0.1234 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0314 0.0485
Trichomonas vaginalis cyclin D, putative 0.0059 0.0314 0.1206
Trichomonas vaginalis cyclins, putative 0.0141 0.1234 1
Echinococcus multilocularis dual specificity 0.011 0.0884 0.0884
Echinococcus multilocularis protoporphyrinogen oxidase 0.0114 0.0933 0.0933
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.006 0.0329 0.2229
Entamoeba histolytica protein kinase, putative 0.011 0.0884 0.6652
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0114 0.0933 1
Schistosoma mansoni microtubule-associated protein tau 0.0788 0.8459 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.0884 0.6728
Loa Loa (eye worm) hypothetical protein 0.0103 0.0807 0.1246
Brugia malayi SWIRM domain containing protein 0.0048 0.0188 0.029
Trichomonas vaginalis cyclins, putative 0.0097 0.0735 0.5231
Trypanosoma cruzi cdc2-related kinase 1 0.0106 0.0838 0.6298
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0329 0.0329
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.006 0.0329 0.129
Leishmania major UDP-galactopyranose mutase 0.0114 0.0933 0.7105
Loa Loa (eye worm) hypothetical protein 0.0107 0.0853 0.1318
Mycobacterium ulcerans dehydrogenase 0.0114 0.0933 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.07 uM Inhibition of Asteroidea (starfish) Cyclin-dependent kinase 1/cyclin B isolated from oocyte using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 0.2 uM Inhibition of human recombinant CDK2/cyclin A using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 0.2 uM Inhibition of human recombinant CDK5/p25 using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 1.2 uM Inhibition of Homo sapiens (human) recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 1.3 uM Inhibition of Sus scrofa (pig) casein kinase 1delta/epsilon isolated from brain using RRKHAAIGpSAYSITA and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 100 uM Inhibition of Sus scrofa (pig) glycogen synthase kinase 3alpha/beta isolated from brain using YRRAAVPPSPSLSRHSSPHQpSEDEEE and [gamma33P]ATP as substrate after 30 min by liquid scintillation counting ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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