Detailed information for compound 1807978

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 784.611 | Formula: C37H51BBrN5O6S
  • H donors: 3 H acceptors: 3 LogP: 6.58 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: N/N=C(/CCCC(B1O[C@H]2[C@](O1)(C)C1CC(C2)C1(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)\S.Br
  • InChi: 1S/C37H50BN5O6S.BrH/c1-36(2)26-21-29(36)37(3)30(22-26)48-38(49-37)31(17-10-18-32(50)42-39)41-33(44)28-16-11-19-43(28)34(45)27(20-24-12-6-4-7-13-24)40-35(46)47-23-25-14-8-5-9-15-25;/h4-9,12-15,26-31H,10-11,16-23,39H2,1-3H3,(H,40,46)(H,41,44)(H,42,50);1H/t26?,27-,28-,29?,30+,31?,37-;/m0./s1
  • InChiKey: UAQQNLPTVQXSEN-OIAZJYILSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Trypsin I Starlite/ChEMBL References
Bos taurus Alpha-chymotrypsin Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens plasminogen activator, urokinase Starlite/ChEMBL References
Homo sapiens plasminogen Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Sus scrofa Elastase 2A Starlite/ChEMBL References
Homo sapiens cathepsin G Starlite/ChEMBL References
Homo sapiens kallikrein 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 247 aa 31.6 %
Schistosoma mansoni aminopeptidase PILS (M01 family) Alpha-chymotrypsin   245 aa 300 aa 23.3 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 251 aa 22.3 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 240 aa 27.5 %
Drosophila melanogaster CG14990 gene product from transcript CG14990-RA Alpha-chymotrypsin   245 aa 245 aa 29.0 %
Schistosoma mansoni cercarial elastase (S01 family) cathepsin G 255 aa 209 aa 25.8 %
Drosophila melanogaster betaTrypsin Alpha-chymotrypsin   245 aa 239 aa 40.6 %
Schistosoma japonicum Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative Alpha-chymotrypsin   245 aa 220 aa 20.9 %
Echinococcus multilocularis transmembrane protease serine 3 Alpha-chymotrypsin   245 aa 266 aa 32.7 %
Drosophila melanogaster Jonah 99Ci Alpha-chymotrypsin   245 aa 234 aa 29.5 %
Drosophila melanogaster CG9673 gene product from transcript CG9673-RB Alpha-chymotrypsin   245 aa 243 aa 25.9 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 213 aa 26.8 %
Mycobacterium tuberculosis Membrane-associated serine protease Trypsin I   246 aa 203 aa 20.7 %
Brugia malayi Trypsin family protein Alpha-chymotrypsin   245 aa 245 aa 24.5 %
Brugia malayi Trypsin family protein Alpha-chymotrypsin   245 aa 256 aa 21.5 %
Brugia malayi Trypsin family protein kallikrein 1 262 aa 247 aa 22.7 %
Loa Loa (eye worm) hypothetical protein Alpha-chymotrypsin   245 aa 252 aa 21.8 %
Drosophila melanogaster CG3916 gene product from transcript CG3916-RA Alpha-chymotrypsin   245 aa 235 aa 35.3 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 218 aa 22.9 %
Drosophila melanogaster Jonah 66Ci Alpha-chymotrypsin   245 aa 231 aa 31.6 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 237 aa 24.5 %
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family Alpha-chymotrypsin   245 aa 300 aa 27.3 %
Drosophila melanogaster CG31267 gene product from transcript CG31267-RA Alpha-chymotrypsin   245 aa 235 aa 31.5 %
Drosophila melanogaster CG4815 gene product from transcript CG4815-RA Alpha-chymotrypsin   245 aa 216 aa 24.1 %
Drosophila melanogaster CG10405 gene product from transcript CG10405-RB Alpha-chymotrypsin   245 aa 237 aa 31.6 %
Drosophila melanogaster Trypsin 29F Alpha-chymotrypsin   245 aa 238 aa 38.2 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 239 aa 36.8 %
Drosophila melanogaster CG30083 gene product from transcript CG30083-RB Alpha-chymotrypsin   245 aa 246 aa 29.7 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 250 aa 25.2 %
Drosophila melanogaster Jonah 65Aiii Alpha-chymotrypsin   245 aa 232 aa 32.8 %
Echinococcus granulosus enteropeptidase Alpha-chymotrypsin   245 aa 279 aa 26.5 %
Drosophila melanogaster CG4914 gene product from transcript CG4914-RA Alpha-chymotrypsin   245 aa 238 aa 34.9 %
Drosophila melanogaster CG31326 gene product from transcript CG31326-RA Alpha-chymotrypsin   245 aa 270 aa 25.9 %
Drosophila melanogaster CG33465 gene product from transcript CG33465-RC Alpha-chymotrypsin   245 aa 221 aa 19.0 %
Drosophila melanogaster CG30287 gene product from transcript CG30287-RA Alpha-chymotrypsin   245 aa 247 aa 32.0 %
Drosophila melanogaster CG18420 gene product from transcript CG18420-RA Alpha-chymotrypsin   245 aa 233 aa 26.2 %
Drosophila melanogaster CG18180 gene product from transcript CG18180-RA Alpha-chymotrypsin   245 aa 232 aa 31.0 %
Drosophila melanogaster Jonah 65Aii Alpha-chymotrypsin   245 aa 234 aa 31.2 %
Drosophila melanogaster CG33458 gene product from transcript CG33458-RA Alpha-chymotrypsin   245 aa 255 aa 27.1 %
Brugia malayi Trypsin family protein Alpha-chymotrypsin   245 aa 249 aa 25.7 %
Drosophila melanogaster CG9733 gene product from transcript CG9733-RB Alpha-chymotrypsin   245 aa 261 aa 29.1 %
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Alpha-chymotrypsin   245 aa 239 aa 33.5 %
Schistosoma japonicum Transmembrane protease, serine 9, putative Alpha-chymotrypsin   245 aa 231 aa 22.5 %
Drosophila melanogaster CG11313 gene product from transcript CG11313-RC Alpha-chymotrypsin   245 aa 255 aa 29.0 %
Drosophila melanogaster CG5909 gene product from transcript CG5909-RA Alpha-chymotrypsin   245 aa 259 aa 29.3 %
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Alpha-chymotrypsin   245 aa 225 aa 32.4 %
Schistosoma japonicum Enteropeptidase, putative Alpha-chymotrypsin   245 aa 268 aa 23.9 %
Drosophila melanogaster CG13744 gene product from transcript CG13744-RA Alpha-chymotrypsin   245 aa 265 aa 34.0 %
Onchocerca volvulus Elastase 2A   269 aa 242 aa 23.6 %
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 300 aa 27.7 %
Echinococcus granulosus Mastin Alpha-chymotrypsin   245 aa 302 aa 26.2 %
Echinococcus multilocularis enteropeptidase Alpha-chymotrypsin   245 aa 279 aa 27.2 %
Drosophila melanogaster CG31220 gene product from transcript CG31220-RB Alpha-chymotrypsin   245 aa 268 aa 23.9 %
Brugia malayi hypothetical protein Elastase 2A   269 aa 234 aa 23.5 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 300 aa 25.7 %
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Alpha-chymotrypsin   245 aa 314 aa 24.5 %
Schistosoma japonicum ko:K09637 transmembrane protease, serine 6, putative Alpha-chymotrypsin   245 aa 240 aa 30.4 %
Drosophila melanogaster CG32277 gene product from transcript CG32277-RA Alpha-chymotrypsin   245 aa 237 aa 27.0 %
Echinococcus granulosus glycoprotein Antigen 5 Alpha-chymotrypsin   245 aa 297 aa 22.2 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 213 aa 26.8 %
Drosophila melanogaster CG34436 gene product from transcript CG34436-RA Alpha-chymotrypsin   245 aa 244 aa 24.6 %
Drosophila melanogaster CG3505 gene product from transcript CG3505-RA Alpha-chymotrypsin   245 aa 252 aa 28.2 %
Echinococcus multilocularis Mastin Alpha-chymotrypsin   245 aa 302 aa 26.2 %
Drosophila melanogaster CG30323 gene product from transcript CG30323-RB Alpha-chymotrypsin   245 aa 218 aa 21.6 %
Neospora caninum glycine cleavage T-protein domain containing protein, putative Trypsin I   246 aa 203 aa 21.7 %
Echinococcus granulosus Mastin plasminogen activator, urokinase 414 aa 340 aa 24.4 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 237 aa 23.6 %
Loa Loa (eye worm) hypothetical protein Alpha-chymotrypsin   245 aa 287 aa 21.6 %
Drosophila melanogaster Spatzle-Processing Enzyme Alpha-chymotrypsin   245 aa 275 aa 29.1 %
Drosophila melanogaster CG17239 gene product from transcript CG17239-RB Alpha-chymotrypsin   245 aa 225 aa 32.9 %
Drosophila melanogaster CG30288 gene product from transcript CG30288-RC Alpha-chymotrypsin   245 aa 236 aa 30.1 %
Echinococcus multilocularis glycoprotein Antigen 5 Alpha-chymotrypsin   245 aa 296 aa 23.0 %
Echinococcus granulosus transmembrane protease serine 3 Alpha-chymotrypsin   245 aa 270 aa 31.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0259 0.3094 0.5127
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0183 0.2134 0.3714
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Schistosoma mansoni glutamine synthetase bacteria 0.0183 0.2134 0.2359
Brugia malayi Protein kinase domain containing protein 0.0083 0.0862 0.1429
Brugia malayi ecdysone receptor 0.0231 0.2741 0.4543
Loa Loa (eye worm) trypsin family protein 0.0052 0.0459 0.0761
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.0761
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0231 0.2741 0.3031
Brugia malayi Fibulin-1 precursor 0.0016 0.0007 0.0011
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0241 0.0419
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Brugia malayi Nuclear hormone receptor E75 0.0231 0.2741 0.4543
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0183 0.2134 0.3102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.049 0.6033 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.049 0.6033 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.2127 0.3701
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0587 0.0567
Toxoplasma gondii microneme protein MIC4 0.0017 0.002 0.0035
Onchocerca volvulus 0.013 0.1453 0.2283
Toxoplasma gondii microneme protein MIC17B 0.0017 0.002 0.0035
Onchocerca volvulus 0.0052 0.0459 0.0714
Echinococcus granulosus Tolloid protein 1 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0017 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Brugia malayi orphan nuclear receptor NR2E1 0.0231 0.2741 0.4543
Brugia malayi Nuclear hormone receptor family member nhr-40 0.049 0.6033 1
Leishmania major basic transcription factor 3a, putative 0.0035 0.0241 0.0267
Schistosoma mansoni nuclear receptor 0.0231 0.2741 0.3031
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0231 0.2741 0.2741
Onchocerca volvulus 0.0017 0.002 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0158 0.1813 0.2005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0231 0.2741 0.3031
Onchocerca volvulus Bile acid receptor homolog 0.049 0.6033 0.9513
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.049 0.6033 0.6033
Echinococcus granulosus thyroid hormone receptor alpha 0.0231 0.2741 0.3031
Toxoplasma gondii subtilisin SUB12 0.0017 0.002 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.049 0.6033 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.0761
Echinococcus multilocularis nuclear receptor nhr 48 0.0231 0.2741 0.2741
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0007 0.0011
Chlamydia trachomatis dihydrofolate reductase 0.0053 0.0475 0.5
Toxoplasma gondii PAN/Apple domain-containing protein 0.0017 0.002 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.049 0.6033 1
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0862 0.0953
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.049 0.6033 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0259 0.3094 0.3421
Echinococcus multilocularis cpg binding protein 0.003 0.0183 0.0183
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.5617 0.5617
Echinococcus granulosus dnaJ subfamily B 0.0404 0.4946 0.5468
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.5617 0.5617
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Echinococcus multilocularis muscleblind protein 0.0148 0.168 0.168
Mycobacterium ulcerans glutamine synthetase 0.0467 0.5746 1
Echinococcus granulosus transmembrane protease serine 3 0.0052 0.0459 0.0508
Schistosoma mansoni RAR-like nuclear receptor 0.049 0.6033 0.6671
Brugia malayi Dihydrofolate reductase 0.0053 0.0475 0.0787
Echinococcus multilocularis transmembrane protease serine 3 0.0052 0.0459 0.0459
Echinococcus multilocularis thyroid hormone receptor alpha 0.049 0.6033 0.6033
Echinococcus multilocularis transcription factor btf3 0.0035 0.0241 0.0241
Echinococcus granulosus cpg binding protein 0.003 0.0183 0.0202
Onchocerca volvulus 0.0065 0.0632 0.0988
Schistosoma mansoni hypothetical protein 0.0083 0.0862 0.0953
Schistosoma mansoni retinoid-x-receptor (RXR) 0.049 0.6033 0.6671
Brugia malayi Nuclear hormone receptor family member nhr-19 0.049 0.6033 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.023 0.0381
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.049 0.6033 0.6671
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Echinococcus granulosus Mastin 0.0052 0.0459 0.0508
Echinococcus multilocularis Mastin 0.0052 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0459 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-41 0.049 0.6033 1
Plasmodium vivax SET domain protein, putative 0.0065 0.0632 0.1101
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.049 0.6033 0.6671
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0467 0.5746 1
Brugia malayi conserved hypotetical protein 0.0231 0.2741 0.4543
Onchocerca volvulus 0.0028 0.0162 0.0246
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Entamoeba histolytica glutamine synthetase, putative 0.0183 0.2134 1
Echinococcus multilocularis geminin 0.0367 0.4475 0.4475
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0231 0.2741 0.3031
Echinococcus multilocularis muscleblind protein 1 0.0148 0.168 0.168
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.049 0.6033 0.6033
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0053 0.0475 0.0826
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0052 0.0459 0.0508
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0007 0.0011
Schistosoma mansoni nuclear receptor 0.0231 0.2741 0.3031
Schistosoma mansoni nuclear receptor nhr-48 0.0231 0.2741 0.3031
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0587 0.1022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0516 0.0898
Onchocerca volvulus 0.0052 0.0459 0.0714
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.4946 0.4946
Toxoplasma gondii microneme protein, putative 0.0017 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0148 0.168 0.2785
Brugia malayi nuclear receptor NHR-88 0.0231 0.2741 0.4543
Leishmania major hypothetical protein, conserved 0.0083 0.0862 0.0953
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Echinococcus granulosus Nuclear hormone receptor HR96 0.0231 0.2741 0.3031
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.0761
Loa Loa (eye worm) hypothetical protein 0.0049 0.0428 0.071
Echinococcus multilocularis enteropeptidase 0.0052 0.0459 0.0459
Brugia malayi hypothetical protein 0.0052 0.0459 0.0761
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0052 0.0459 0.0459
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.049 0.6033 0.6033
Schistosoma mansoni hypothetical protein 0.0367 0.4475 0.4948
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Onchocerca volvulus 0.0231 0.2741 0.4316
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Brugia malayi nuclear receptor RXR 0.0231 0.2741 0.4543
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0726 0.9044 1
Loa Loa (eye worm) hypothetical protein 0.0259 0.3094 0.5127
Loa Loa (eye worm) hypothetical protein 0.0065 0.0632 0.1048
Echinococcus multilocularis ecdysone induced protein 78C 0.049 0.6033 0.6033
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.002 0.0033
Leishmania major glutamine synthetase, putative 0.0726 0.9044 1
Toxoplasma gondii PAN domain-containing protein 0.0017 0.002 0.0035
Echinococcus multilocularis tissue type plasminogen activator 0.0083 0.0862 0.0862
Brugia malayi nuclear receptor NHR-67 0.0231 0.2741 0.4543
Brugia malayi Nuclear hormone receptor family member nhr-31 0.049 0.6033 1
Toxoplasma gondii PAN domain-containing protein 0.0017 0.002 0.0035
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.2127 0.2351
Toxoplasma gondii PAN domain-containing protein 0.0017 0.002 0.0035
Echinococcus granulosus geminin 0.0367 0.4475 0.4948
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0231 0.2741 0.4543
Brugia malayi nuclear hormone receptor family member odr-7 0.0231 0.2741 0.4543
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0052 0.0459 0.0508
Loa Loa (eye worm) hypothetical protein 0.0158 0.1813 0.3006
Schistosoma mansoni thyroid hormone receptor 0.049 0.6033 0.6671
Schistosoma mansoni nuclear hormone receptor 0.049 0.6033 0.6671
Schistosoma mansoni nuclear hormone receptor 0.0231 0.2741 0.3031
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.2127 0.2351
Onchocerca volvulus Protein ultraspiracle homolog 0.049 0.6033 0.9513
Echinococcus granulosus tissue type plasminogen activator 0.0083 0.0862 0.0953
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0007 0.0012
Schistosoma mansoni egf-like domain protein 0.0016 0.0007 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0428 0.071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0011
Echinococcus granulosus ecdysone induced protein 78C 0.049 0.6033 0.6671
Schistosoma mansoni hypothetical protein 0.0061 0.0577 0.0638
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0162 0.0269
Schistosoma mansoni hypothetical protein 0.0367 0.4475 0.4948
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0231 0.2741 0.2741
Onchocerca volvulus 0.0052 0.0459 0.0714
Plasmodium falciparum cysteine repeat modular protein 1 0.0083 0.0862 0.15
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.049 0.6033 0.6033
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Echinococcus granulosus dihydrofolate reductase 0.0053 0.0475 0.0525
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2127 0.3701
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.0761
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0467 0.5746 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0459 0.0508
Echinococcus granulosus retinoic acid receptor rxr beta a 0.049 0.6033 0.6671
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0241 0.0267
Trypanosoma cruzi glutamine synthetase, putative 0.0726 0.9044 1
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0007 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0428 0.071
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0587 0.0649
Echinococcus multilocularis dihydrofolate reductase 0.0053 0.0475 0.0475
Brugia malayi Trypsin family protein 0.0052 0.0459 0.0761
Brugia malayi hypothetical protein 0.0231 0.2741 0.4543
Toxoplasma gondii kringle domain-containing protein 0.0083 0.0862 0.15
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0231 0.2741 0.4316
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0241 0.0267
Schistosoma mansoni zinc finger protein 0.0231 0.2741 0.3031
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Brugia malayi Nuclear hormone receptor E75 0.0231 0.2741 0.4543
Schistosoma mansoni hypothetical protein 0.0052 0.0459 0.0508
Schistosoma mansoni hypothetical protein 0.0052 0.0459 0.0508
Brugia malayi Nuclear hormone receptor-like 1 0.049 0.6033 1
Loa Loa (eye worm) hypothetical protein 0.0259 0.3094 0.5127
Mycobacterium ulcerans hypothetical protein 0.0183 0.2134 0.3168
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0598 0.0661
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.049 0.6033 0.6671
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0231 0.2741 0.3031
Onchocerca volvulus Glutamine synthetase homolog 0.0467 0.5746 0.9059
Echinococcus granulosus enteropeptidase 0.0052 0.0459 0.0508
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.049 0.6033 0.6033
Brugia malayi steroid hormone receptor 0.049 0.6033 1
Onchocerca volvulus 0.0083 0.0862 0.135
Echinococcus multilocularis glutamine synthetase 0.0726 0.9044 0.9044
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0459 0.0459
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Brugia malayi hypothetical protein 0.0259 0.3094 0.5127
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.049 0.6033 0.9513
Schistosoma mansoni steroid hormone receptor ad4bp 0.049 0.6033 0.6671
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0011
Trichomonas vaginalis glutamine synthetase, putative 0.0183 0.2134 0.3102
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Loa Loa (eye worm) steroid hormone receptor 0.049 0.6033 1
Toxoplasma gondii glutamine synthetase, type I, putative 0.0467 0.5746 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.049 0.6033 1
Brugia malayi Trypsin family protein 0.0052 0.0459 0.0761
Onchocerca volvulus 0.0017 0.002 0.0021
Echinococcus granulosus thymidylate synthase 0.013 0.1453 0.1607
Loa Loa (eye worm) hypothetical protein 0.0034 0.023 0.0381
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0083 0.0862 0.1429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0632 0.0699
Onchocerca volvulus 0.0017 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0632 0.1101
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Brugia malayi nuclear hormone receptor 0.0231 0.2741 0.4543
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0183 0.2134 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.049 0.6033 1
Onchocerca volvulus 0.0158 0.1813 0.2852
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0231 0.2741 0.2741
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0241 0.0419
Brugia malayi ecdysteroid receptor 0.049 0.6033 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0632 0.0699
Onchocerca volvulus 0.0017 0.002 0.0021
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.2127 0.2351
Brugia malayi Pre-SET motif family protein 0.0065 0.0632 0.1048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.049 0.6033 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.049 0.6033 0.6671
Echinococcus granulosus laminin 0.0016 0.0007 0.0007
Brugia malayi Pre-SET motif family protein 0.0452 0.5549 0.9198
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0052 0.0459 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-49 0.049 0.6033 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0162 0.0269
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0459 0.0508
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1453 0.1607
Brugia malayi Trypsin-like protease protein 5 0.0052 0.0459 0.0761
Loa Loa (eye worm) thymidylate synthase 0.013 0.1453 0.2408
Echinococcus granulosus FTZ F1 alpha 0.049 0.6033 0.6671
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0259 0.3094 0.5127
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0011
Onchocerca volvulus 0.0017 0.002 0.0021
Echinococcus multilocularis thymidylate synthase 0.013 0.1453 0.1453
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-1 0.049 0.6033 1
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0241 0.0267
Loa Loa (eye worm) nuclear receptor NHR-67 0.0231 0.2741 0.4543
Brugia malayi hypothetical protein 0.0062 0.0587 0.0973
Echinococcus granulosus nuclear receptor nhr 48 0.0231 0.2741 0.3031
Onchocerca volvulus 0.0106 0.1155 0.1813
Schistosoma mansoni cpg binding protein 0.0028 0.0162 0.018
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2127 0.3701
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.0761
Brugia malayi thymidylate synthase 0.013 0.1453 0.2408
Echinococcus multilocularis laminin 0.0016 0.0007 0.0007
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0241 0.0419
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0452 0.5549 0.9198
Schistosoma mansoni cpg binding protein 0.003 0.0183 0.0202
Toxoplasma gondii hypothetical protein 0.0017 0.002 0.0035
Brugia malayi Kringle domain containing protein 0.0083 0.0862 0.1429
Brugia malayi Nuclear hormone receptor-like 1 0.0259 0.3094 0.5127
Echinococcus granulosus neuropeptide s receptor 0.0457 0.5617 0.6211
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0231 0.2741 0.4543
Brugia malayi Nuclear hormone receptor-like 1 0.0259 0.3094 0.5127
Onchocerca volvulus 0.0052 0.0459 0.0714
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0259 0.3094 0.3421
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0007 0.0007
Entamoeba histolytica glutamine synthetase, putative 0.0183 0.2134 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0083 0.0862 0.1429
Loa Loa (eye worm) DR-78 0.0231 0.2741 0.4543
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0148 0.168 0.2785
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.049 0.6033 0.6671
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0259 0.3094 0.5127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.049 0.6033 0.6033
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0632 0.0632
Schistosoma mansoni transcription factor btf3 0.0035 0.0241 0.0267
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.049 0.6033 0.6671
Schistosoma mansoni thyroid hormone receptor 0.049 0.6033 0.6671
Onchocerca volvulus 0.049 0.6033 0.9513
Brugia malayi Nuclear hormone receptor family member nhr-19 0.049 0.6033 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0231 0.2741 0.4543
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0467 0.5746 1
Trypanosoma brucei glutamine synthetase, putative 0.0726 0.9044 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.1453 0.1856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0231 0.2741 0.2741
Onchocerca volvulus 0.0017 0.002 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.049 0.6033 1
Echinococcus granulosus glycoprotein Antigen 5 0.0052 0.0459 0.0508
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0017 0.002 0.0035
Loa Loa (eye worm) dihydrofolate reductase 0.0053 0.0475 0.0787
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0083 0.0862 0.15
Onchocerca volvulus 0.0017 0.002 0.0021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.049 0.6033 0.6671
Echinococcus multilocularis glycoprotein Antigen 5 0.0052 0.0459 0.0459
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Toxoplasma gondii microneme protein MIC17A 0.0017 0.002 0.0035
Toxoplasma gondii hypothetical protein 0.0017 0.002 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0594 0.0657
Schistosoma mansoni cpg binding protein 0.003 0.0183 0.0202
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0428 0.071
Toxoplasma gondii PAN domain-containing protein 0.0017 0.002 0.0035
Brugia malayi beta-NAC-like protein 0.0035 0.0241 0.0399
Loa Loa (eye worm) nuclear hormone receptor 0.0231 0.2741 0.4543
Onchocerca volvulus 0.0514 0.6342 1
Schistosoma mansoni dihydrofolate reductase 0.0053 0.0475 0.0525
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.049 0.6033 0.6671
Brugia malayi tailless protein 0.0231 0.2741 0.4543
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0259 0.3094 0.3421
Brugia malayi dihydrofolate reductase family protein 0.0053 0.0475 0.0787
Plasmodium vivax glutamine synthetase, putative 0.0467 0.5746 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1813 0.3006
Schistosoma mansoni hypothetical protein 0.0034 0.023 0.0254
Schistosoma mansoni coup transcription factor 0.049 0.6033 0.6671
Loa Loa (eye worm) hypothetical protein 0.0231 0.2741 0.4543
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0259 0.3094 0.3094
Brugia malayi hypothetical protein 0.0259 0.3094 0.5127
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0231 0.2741 0.4316
Schistosoma mansoni nuclear hormone receptor 0.0231 0.2741 0.3031
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0052 0.0459 0.0761
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.002 0.0033
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0241 0.0399
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Brugia malayi nuclear receptor NHR-88 0.049 0.6033 1
Brugia malayi nuclear hormone receptor 0.049 0.6033 1
Onchocerca volvulus 0.0017 0.002 0.0021
Trypanosoma cruzi glutamine synthetase, putative 0.0726 0.9044 1
Onchocerca volvulus 0.0017 0.002 0.0021
Echinococcus multilocularis fibrillin 1 0.0016 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.5617 0.6211
Loa Loa (eye worm) Gln-2 protein 0.0467 0.5746 0.9524
Brugia malayi nuclear receptor RXR 0.0259 0.3094 0.5127
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.002 0.0033
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0459 0.0508
Toxoplasma gondii PAN domain-containing protein 0.0017 0.002 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.049 0.6033 0.6671
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Plasmodium falciparum glutamine synthetase, putative 0.0467 0.5746 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0053 0.0475 0.003
Echinococcus multilocularis FTZ F1 alpha 0.049 0.6033 0.6033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.049 0.6033 0.6671
Brugia malayi Trypsin family protein 0.0052 0.0459 0.0761
Brugia malayi Trypsin family protein 0.0158 0.1813 0.3006
Echinococcus granulosus muscleblind protein 0.0148 0.168 0.1858
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0632 0.0699
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0459 0.0508
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0158 0.1813 0.2005
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0231 0.2741 0.3031
Echinococcus granulosus glutamine synthetase 0.0726 0.9044 1
Brugia malayi Steroid receptor seven-up type 2 0.049 0.6033 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.1453 0.2529
Brugia malayi hypothetical protein 0.0231 0.2741 0.4543
Onchocerca volvulus 0.0017 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Brugia malayi Muscleblind-like protein 0.0148 0.168 0.2785
Brugia malayi glutamine synthetase 0.0259 0.3099 0.5137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.049 0.6033 0.6671
Toxoplasma gondii microneme protein MIC17C 0.0017 0.002 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.049 0.6033 1
Loa Loa (eye worm) hypothetical protein 0.0259 0.3094 0.5127
Mycobacterium ulcerans thymidylate synthase 0.013 0.1453 0.188
Onchocerca volvulus 0.0231 0.2741 0.4316
Brugia malayi Nuclear hormone receptor family member nhr-14 0.049 0.6033 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0011
Echinococcus granulosus transcription factor btf3 0.0035 0.0241 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0632 0.0699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.049 0.6033 1
Trichomonas vaginalis set domain proteins, putative 0.0514 0.6342 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.049 0.6033 0.6671
Schistosoma mansoni hypothetical protein 0.0404 0.4946 0.5468
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0459 0.0508
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0231 0.2741 0.2741
Onchocerca volvulus 0.0052 0.0459 0.0714
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0632 0.0699
Brugia malayi photoreceptor-specific nuclear receptor 0.049 0.6033 1
Schistosoma mansoni glutamine synthetase bacteria 0.0183 0.2134 0.2359
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Toxoplasma gondii PAN domain-containing protein 0.0017 0.002 0.0035
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.049 0.6033 1
Brugia malayi PAN domain containing protein 0.0017 0.002 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.049 0.6033 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.0015 nM Binding affinity against alpha thrombin ChEMBL. 7739010
Ki (binding) = 0.0015 nM Binding affinity against Trypsin ChEMBL. 7739010
Ki (binding) = 0.0042 nM Binding affinity against Coagulation factor X ChEMBL. 7739010
Ki (binding) = 0.0049 nM Binding affinity against kallikrein ChEMBL. 7739010
Ki (binding) = 0.0065 nM Binding affinity against gamma thrombin ChEMBL. 7739010
Ki (binding) = 0.0086 nM Binding affinity against Urokinase plasminogen activator ChEMBL. 7739010
Ki (binding) = 0.01 nM Binding affinity against plasmin ChEMBL. 7739010
Ki (binding) = 0.437 nM Binding affinity against cathepsin G ChEMBL. 7739010
Ki (binding) = 0.848 nM Binding affinity against Chymotrypsin ChEMBL. 7739010
Ki (binding) = 1 nM Binding affinity against thrombin ChEMBL. 7739010
Ki (binding) = 15.8 nM Binding affinity of the compound towards porcine pancreatic elastase ChEMBL. 7739010
TT (binding) = 0.066 uM Concentration of inhibitor required to produce a 2-fold prolongation in Thrombin time (TT) ChEMBL. 7739010

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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