Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.0059 | 0.0308 |
Echinococcus multilocularis | zinc finger protein | 0.0026 | 0.0017 | 0.0017 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0044 | 0.0044 |
Entamoeba histolytica | protein kinase, putative | 0.1181 | 0.3125 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0065 | 0.0594 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0092 | 0.0633 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0204 | 0.0204 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.0204 | 0.1718 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0204 | 0.0204 |
Brugia malayi | Bromodomain containing protein | 0.0088 | 0.0185 | 0.1531 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.0099 | 0.0099 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.0219 | 0.0219 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0029 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.004 | 0.0056 | 0.0516 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0318 | 0.0805 | 0.7539 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.008 | 0.0162 | 0.0162 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0219 | 0.0219 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0263 | 0.0655 | 0.0655 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0204 | 0.0204 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0058 | 0.0058 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0263 | 0.0655 | 0.0655 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.0655 | 0.6185 |
Onchocerca volvulus | 0.0105 | 0.023 | 0.1713 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0162 | 0.1519 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0033 | 0.0036 | 0.0085 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.3735 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.012 | 0.1121 |
Schistosoma mansoni | lamin | 0.0056 | 0.0099 | 0.0099 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0181 | 0.0435 | 0.0435 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.0021 | 0.0021 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.0099 | 0.0099 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0071 | 0.0139 | 0.0139 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0021 | 0.0005 | 0.0005 |
Schistosoma mansoni | cpg binding protein | 0.0061 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0101 | 0.0219 | 0.2057 |
Onchocerca volvulus | 0.0054 | 0.0092 | 0.0551 | |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.0099 | 0.0099 |
Echinococcus multilocularis | peregrin | 0.0032 | 0.0034 | 0.0034 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.008 | 0.0162 | 0.0162 |
Echinococcus granulosus | cpg binding protein | 0.0067 | 0.0128 | 0.0128 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0181 | 0.0435 | 0.0435 |
Onchocerca volvulus | 0.0056 | 0.0099 | 0.0608 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.0099 | 0.0922 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0057 | 0.0057 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0204 | 0.0204 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.1181 | 0.3125 | 0.3125 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0027 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.118 | 0.3124 | 0.3124 |
Schistosoma mansoni | microtubule-associated protein tau | 0.3735 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0027 | 0.024 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0318 | 0.0805 | 0.7598 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.118 | 0.3124 | 0.3124 |
Brugia malayi | Pre-SET motif family protein | 0.006 | 0.0111 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0099 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0072 | 0.0662 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.006 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.0204 | 0.1917 |
Loa Loa (eye worm) | histone methyltransferase | 0.0021 | 0.0005 | 0.003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.012 | 0.012 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1181 | 0.3125 | 0.3125 |
Schistosoma mansoni | alpha-glucosidase | 0.0156 | 0.0368 | 0.0368 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.0219 | 0.0219 |
Echinococcus granulosus | GPCR family 2 | 0.0101 | 0.0219 | 0.0219 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.1181 | 0.3125 | 0.3125 |
Schistosoma mansoni | alpha-glucosidase | 0.0156 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0253 | 0.0628 | 0.5932 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.012 | 0.0902 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0181 | 0.0435 | 0.4103 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0027 | 0.0027 |
Brugia malayi | RNA binding protein | 0.0064 | 0.012 | 0.0902 |
Brugia malayi | Bromodomain containing protein | 0.0032 | 0.0034 | 0.007 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0204 | 0.0204 |
Schistosoma mansoni | cpg binding protein | 0.0067 | 0.0128 | 0.0128 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0101 | 0.0219 | 0.1862 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0084 | 0.0774 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.012 | 0.1121 |
Echinococcus granulosus | peregrin | 0.0032 | 0.0034 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0263 | 0.0655 | 0.6091 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.0805 | 0.7598 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0029 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0534 | 0.5034 |
Onchocerca volvulus | 0.0469 | 0.1211 | 1 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0111 | 0.1036 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0253 | 0.0628 | 0.5932 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.0219 | 0.0219 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.0029 | 0.0019 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.0029 | 0.0258 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0011 | 0.0011 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.0099 | 0.0698 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0027 | 0.5 |
Echinococcus granulosus | lamin | 0.0056 | 0.0099 | 0.0099 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.012 | 0.012 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.0099 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0219 | 0.2057 |
Onchocerca volvulus | 0.0061 | 0.0113 | 0.0723 | |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0029 | 0.0026 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0412 | 0.1058 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.0021 | 0.0021 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0057 | 0.0057 |
Echinococcus multilocularis | musashi | 0.0056 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0087 | 0.0806 |
Trichomonas vaginalis | set domain proteins, putative | 0.0469 | 0.1211 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.006 | 0.0111 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0011 | 0.0085 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.0099 | 0.0099 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.004 | 0.0056 | 0.0056 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0218 | 0.0534 | 0.4912 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0027 | 0.0027 |
Echinococcus multilocularis | cpg binding protein | 0.0067 | 0.0128 | 0.0128 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.012 | 0.012 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0101 | 0.0219 | 0.1862 |
Onchocerca volvulus | 0.0056 | 0.0099 | 0.0608 | |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.004 | 0.0056 | 0.1185 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0057 | 0.0101 | 0.0101 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0121 | 0.0273 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.004 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0018 | 0.0156 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.0099 | 0.0922 |
Trypanosoma brucei | glucosidase, putative | 0.004 | 0.0056 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.0207 | 0.0207 |
Schistosoma mansoni | zinc finger protein | 0.0026 | 0.0017 | 0.0017 |
Echinococcus granulosus | zinc finger protein | 0.0026 | 0.0017 | 0.0017 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.004 | 0.0056 | 0.0283 |
Schistosoma mansoni | bromodomain containing protein | 0.0075 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0096 | 0.0896 |
Brugia malayi | CXXC zinc finger family protein | 0.0061 | 0.0113 | 0.083 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0061 | 0.0113 | 0.105 |
Echinococcus granulosus | tumor protein p63 | 0.0402 | 0.1031 | 0.1031 |
Brugia malayi | MH2 domain containing protein | 0.0253 | 0.0628 | 0.5831 |
Echinococcus multilocularis | lamin | 0.0056 | 0.0099 | 0.0099 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0181 | 0.0435 | 0.0435 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.012 | 0.1121 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.012 | 0.012 |
Brugia malayi | Pre-SET motif family protein | 0.0412 | 0.1058 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0027 | 0.0021 | 0.0021 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.012 | 0.012 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.008 | 0.0162 | 0.0162 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0027 | 0.0027 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0056 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.0207 | 0.1742 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.0534 | 0.0534 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0027 | 0.0027 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0059 | 0.0107 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0219 | 0.0219 |
Schistosoma mansoni | lamin | 0.0056 | 0.0099 | 0.0099 |
Echinococcus multilocularis | tumor protein p63 | 0.0402 | 0.1031 | 0.1031 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.0064 | 0.0361 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0132 | 0.0303 | 0.0303 |
Brugia malayi | PHD-finger family protein | 0.0032 | 0.0033 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0021 | 0.0182 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.012 | 0.0902 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0071 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0107 | 0.0993 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0021 | 0.0005 | 0.0005 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0059 | 0.0059 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0058 | 0.0058 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0163 | 0.1523 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.0059 | 0.0541 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0219 | 0.0219 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.0154 | 0.0154 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.012 | 0.012 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0027 | 0.024 |
Schistosoma mansoni | alpha glucosidase | 0.004 | 0.0056 | 0.0056 |
Schistosoma mansoni | cpg binding protein | 0.0067 | 0.0128 | 0.0128 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.006 | 0.0111 | 0.339 |
Echinococcus multilocularis | GPCR, family 2 | 0.0101 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0018 | 0.0156 |
Leishmania major | alpha glucosidase II subunit, putative | 0.004 | 0.0056 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.006 | 0.0111 | 0.0111 |
Entamoeba histolytica | protein kinase, putative | 0.1181 | 0.3125 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0318 | 0.0805 | 0.7539 |
Onchocerca volvulus | 0.006 | 0.0111 | 0.0704 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.008 | 0.0162 | 0.0162 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.0207 | 0.0207 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.0219 | 0.0219 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.0059 | 0.0059 |
Onchocerca volvulus | 0.0059 | 0.0107 | 0.0672 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0056 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0181 | 0.0435 | 0.3958 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.012 | 0.012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.3 nM | Agonist activity at S1P1R (unknown origin) assessed as [33P] binding activity | ChEMBL. | 24900589 |
Activity (binding) | = 650 nM | Agonist activity at S1P3R (unknown origin) assessed as [33P] binding activity | ChEMBL. | 24900589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.