TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 425.43 | Formula: C22H16FNO5S
H donors: 0 H acceptors: 3 LogP: 4.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(c1ccccc1F)N1C(=O)S/C(=C\c2ccc3c(c2)OCO3)/C1=O)C1CC1
InChi: 1S/C22H16FNO5S/c23-15-4-2-1-3-14(15)19(20(25)13-6-7-13)24-21(26)18(30-22(24)27)10-12-5-8-16-17(9-12)29-11-28-16/h1-5,8-10,13,19H,6-7,11H2/b18-10-
InChiKey: ISQDWPKOVPQLEP-ZDLGFXPLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	ecdysteroid receptor	0.0044	0.0107	0.042
Plasmodium falciparum	importin beta, putative	0.0035	0.006	0.5174
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0141	0.0305
Leishmania major	C-14 sterol reductase, putative	0.0095	0.0367	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0061
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0044	0.0105	0.0582
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0107	0.0593
Echinococcus multilocularis	geminin	0.0206	0.0938	0.0938
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0166	0.0651
Brugia malayi	Nuclear hormone receptor-like 1	0.0044	0.0107	0.042
Schistosoma mansoni	lozenge	0.0065	0.0215	0.1191
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0044	0.0107	0.0593
Schistosoma mansoni	chromobox protein	0.0085	0.0315	0.1749
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0013	0.0028
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0044	0.0107	0.0107
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0044	0.0105	0.0581
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0513	0.2521	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.0292	0.0292
Echinococcus multilocularis	lamin b receptor	0.0095	0.0367	0.0367
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0198	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0373	0.1801	0.3904
Entamoeba histolytica	hypothetical protein	0.0044	0.0105	0.0175
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0095	0.0367	1
Onchocerca volvulus		0.0037	0.0071	0.0171
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Plasmodium vivax	importin-beta 2, putative	0.0035	0.006	0.5174
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0105	0.0227
Onchocerca volvulus	Protein ultraspiracle homolog	0.0044	0.0107	0.0312
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.0292	0.1623
Echinococcus multilocularis	Protein lozenge	0.0065	0.0215	0.0215
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.0292	0.1149
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.006	0.256
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0044	0.0107	0.042
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0028	0.0438
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0044	0.0107	0.0593
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.2593
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0026	0.0026
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0013	0.0013
Echinococcus multilocularis	FTZ F1 alpha	0.0044	0.0107	0.0107
Schistosoma mansoni	RAR-like nuclear receptor	0.0044	0.0107	0.0593
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0105	0.0174
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0044	0.0107	0.0593
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0059	0.0181	0.0713
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0044	0.0107	0.0232
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0028	0.0438
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1356	0.2939
Brugia malayi	hypothetical protein	0.0044	0.0105	0.0412
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.006	0.006
Leishmania major	sterol C-24 reductase, putative	0.0095	0.0367	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Brugia malayi	Heterochromatin protein 1	0.0085	0.0315	0.1238
Trypanosoma brucei	protein kinase, putative	0.0062	0.0198	0.5241
Echinococcus granulosus	ecdysone induced protein 78C	0.0044	0.0107	0.0593
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0044	0.0107	0.0232
Schistosoma mansoni	hypothetical protein	0.0206	0.0938	0.5206
Treponema pallidum	fructose-bisphosphate aldolase	0.1051	0.5286	0.5
Echinococcus granulosus	lamin b receptor	0.0095	0.0367	0.2036
Echinococcus granulosus	snurportin 1	0.0373	0.1801	1
Echinococcus granulosus	chromobox protein 1	0.0085	0.0315	0.1749
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1051	0.5286	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0029	0.0028	0.0029
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.0292	0.7895
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0026	0.0026
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.0044	0.0105	0.0174
Schistosoma mansoni	ran	0.0026	0.0013	0.0071
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0035	0.006	0.0131
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1051	0.5286	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0058	0.0127
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0143	0.0246
Plasmodium vivax	polyprenol reductase, putative	0.0044	0.0105	1
Loa Loa (eye worm)	hypothetical protein	0.0518	0.2544	0.5515
Entamoeba histolytica	hypothetical protein	0.0044	0.0105	0.0174
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0044	0.0107	0.0312
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0198	0.5241
Echinococcus granulosus	importin subunit beta 1	0.0035	0.006	0.0335
Schistosoma mansoni	hypothetical protein	0.0059	0.0181	0.1007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0166	0.092
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0058	0.023
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0028	0.0111
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0107	0.042
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0198	0.0352
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0044	0.0107	0.0107
Brugia malayi	photoreceptor-specific nuclear receptor	0.0044	0.0107	0.042
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0141	0.0554
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0044	0.0105	0.0174
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0044	0.0105	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.2593
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0198	0.5241
Trichomonas vaginalis	chromobox protein, putative	0.0085	0.0315	0.0573
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0198	0.5241
Echinococcus multilocularis	survival motor neuron protein 1	0.0287	0.1356	0.1356
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0198	0.5241
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0044	0.0107	0.0593
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0166	0.092
Brugia malayi	hypothetical protein	0.0518	0.2544	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0044	0.0107	0.0593
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0044	0.0105	0.0174
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0044	0.0107	0.0593
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0044	0.0105	0.4948
Echinococcus multilocularis	chromobox protein 1	0.0085	0.0315	0.0315
Schistosoma mansoni	coup transcription factor	0.0044	0.0107	0.0593
Brugia malayi	RNA, U transporter 1	0.0099	0.0392	0.1541
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.006	0.1342
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0026	0.0381
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0044	0.0107	0.0232
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0143	0.0454
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0198	0.1101
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.0292	0.1623
Brugia malayi	Importin beta-1 subunit	0.0035	0.006	0.0237
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0028	0.0111
Schistosoma mansoni	Lamin B receptor (ERG24)	0.0095	0.0367	0.2036
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0198	0.5241
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0141	0.0305
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0166	0.0166
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.0174
Onchocerca volvulus		0.0059	0.0181	0.0608
Trypanosoma brucei	C-14 sterol reductase, putative	0.0095	0.0367	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0198	1
Onchocerca volvulus		0.0044	0.0107	0.0312
Entamoeba histolytica	acyl-coA synthetase, putative	0.0029	0.0028	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0044	0.0107	0.0232
Brugia malayi	steroid hormone receptor	0.0044	0.0107	0.042
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0107	0.0107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0044	0.0107	0.0232
Onchocerca volvulus		0.0518	0.2544	1
Brugia malayi	Steroid receptor seven-up type 2	0.0044	0.0107	0.042
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0198	0.0352
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0198	0.5241
Echinococcus granulosus	FTZ F1 alpha	0.0044	0.0107	0.0593
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.006	0.1342
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0044	0.0107	0.0593
Schistosoma mansoni	retinoic acid receptor RXR	0.0044	0.0107	0.0593
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0044	0.0105	0.0174
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.0174
Onchocerca volvulus	Bile acid receptor homolog	0.0044	0.0107	0.0312
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.2593
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0044	0.0107	0.0107
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0198	0.0198
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0095	0.0367	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0198	0.043
Brugia malayi	nuclear receptor NHR-88	0.0044	0.0107	0.042
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0107	0.0593
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0198	0.1101
Loa Loa (eye worm)	heterochromatin protein 1	0.0085	0.0315	0.0683
Schistosoma mansoni	hypothetical protein	0.0373	0.1801	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0028	0.0438
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0107	0.0107
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0044	0.0107	0.0593
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0026	0.0026
Echinococcus multilocularis	snurportin 1	0.0373	0.1801	0.1801
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Onchocerca volvulus		0.0044	0.0105	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0105	0.0227
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0044	0.0105	0.0581
Loa Loa (eye worm)	runx1	0.0065	0.0215	0.0465
Entamoeba histolytica	hypothetical protein	0.0044	0.0105	0.0175
Trichomonas vaginalis	chromobox protein, putative	0.0085	0.0315	0.0573
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.0044	0.0105	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Giardia lamblia	Synaptic glycoprotein SC2	0.0044	0.0105	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0107	0.042
Echinococcus granulosus	survival motor neuron protein 1	0.0287	0.1356	0.7528
Schistosoma mansoni	ran	0.0026	0.0013	0.0071
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0166	0.092
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0044	0.0105	0.2593
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0044	0.0105	0.4948
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0107	0.042
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0013	0.0071
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0513	0.2521	1
Schistosoma mansoni	chromobox protein	0.0085	0.0315	0.1749
Loa Loa (eye worm)	steroid hormone receptor	0.0044	0.0107	0.0232
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0044	0.0107	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0044	0.0107	0.042
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0071	0.0155
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0513	0.2521	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0107	0.042
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0141	0.0554
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0292	0.7895
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0292	0.7895
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0044	0.0107	0.0593
Brugia malayi	MAP kinase sur-1	0.0062	0.0198	0.0779
Schistosoma mansoni	survival motor neuron protein	0.0059	0.0181	0.1007
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0029	0.0028	0.0029
Entamoeba histolytica	hypothetical protein	0.0044	0.0105	0.0175
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	1
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0044	0.0105	0.0105
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0105	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0105	0.0227
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0013	0.005
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0044	0.0105	0.2593
Echinococcus granulosus	geminin	0.0206	0.0938	0.5206
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0124	0.0269
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0518	0.2544	0.5515
Brugia malayi	hypothetical protein	0.0287	0.1356	0.5329
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0166	0.0359
Schistosoma mansoni	transcription factor LCR-F1	0.0044	0.0105	0.0582
Brugia malayi	nuclear hormone receptor	0.0044	0.0107	0.042
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1051	0.5286	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0292	0.7895
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0028	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0124	0.0211
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0044	0.0107	0.042
Schistosoma mansoni	hypothetical protein	0.0035	0.0058	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0044	0.0107	0.042
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0044	0.0105	0.4948
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0044	0.0107	0.0593
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.0292	0.053
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.0119	0.0659
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0044	0.0107	0.042
Giardia lamblia	Fructose-bisphosphate aldolase	0.1051	0.5286	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0044	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0061
Schistosoma mansoni	importin beta-1	0.0035	0.006	0.0335
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0044	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0044	0.0105	0.0582
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0124	0.0211
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0095	0.0367	1
Brugia malayi	Synaptic glycoprotein SC2	0.0044	0.0105	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Brugia malayi	chromobox protein homolog 3	0.0047	0.0124	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0044	0.0107	0.042
Loa Loa (eye worm)	hypothetical protein	0.092	0.4614	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0105	0.0174
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0044	0.0105	0.0581
Schistosoma mansoni	nuclear hormone receptor	0.0044	0.0107	0.0593
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0095	0.0367	1
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0044	0.0105	0.2593
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0166	0.092
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0166	0.092
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0026	0.0026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0044	0.0107	0.0232
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0044	0.0105	0.0105
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0198	0.5241
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0107	0.0593
Plasmodium falciparum	polyprenol reductase, putative	0.0044	0.0105	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0044	0.0107	0.042
Echinococcus granulosus	chromobox protein 1	0.0085	0.0315	0.1749
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0107	0.0593
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0198	0.1101
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0107	0.042
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0044	0.0107	0.0107
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0044	0.0105	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0107	0.0232
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0026	0.0381
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0044	0.0107	0.0593
Echinococcus multilocularis	ecdysone induced protein 78C	0.0044	0.0107	0.0107
Entamoeba histolytica	hypothetical protein	0.0044	0.0105	0.0175
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0198	0.0352
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0053	0.0076
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0143	0.0246
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.0292	0.0633
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0053	0.0076
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0107	0.042
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0198	0.0352
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.0119	0.0119
Echinococcus multilocularis	chromobox protein 1	0.0085	0.0315	0.0315
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0124	0.0381
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0044	0.0107	0.0593
Schistosoma mansoni	hypothetical protein	0.0206	0.0938	0.5206
Echinococcus granulosus	synaptic glycoprotein sc2	0.0044	0.0105	0.0581

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 9 uM	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by Alamar Blue staining-based broth microdilution assay	ChEMBL.	24472146
EC90 (functional)	= 21 uM	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by Alamar Blue staining-based broth microdilution assay	ChEMBL.	24472146
MIC90 (functional)	= 25 uM	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by Alamar Blue staining-based broth microdilution assay	ChEMBL.	24472146
Ratio (functional)	= 4	Potency index, ratio of pyrimethamine MIC90 to compound MIC90 for Mycobacterium tuberculosis H37Rv	ChEMBL.	24472146

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mycobacterium tuberculosis		24472146

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3120381

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1833310