Detailed information for compound 183566

Basic information

Technical information
  • TDR Targets ID: 183566
  • Name: dodecyl(trimethyl)azanium bromide
  • MW: 308.341 | Formula: C15H34BrN
  • H donors: 0 H acceptors: 0 LogP: 6.83 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCC[N+](C)(C)C.[Br-]
  • InChi: 1S/C15H34N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16(2,3)4;/h5-15H2,1-4H3;1H/q+1;/p-1
  • InChiKey: XJWSAJYUBXQQDR-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • dodecyl(trimethyl)ammonium bromide
  • lauryl(trimethyl)ammonium bromide
  • dodecyltrimethylammonium
  • decyltrimethylammonium
  • dodecyl-trimethylazanium bromide
  • dodecyl-trimethyl-ammonium bromide
  • dodecyl-trimethylammonium bromide
  • lauryl-trimethyl-ammonium bromide
  • dodecyl-trimethyl-azanium bromide
  • 157929-06-1
  • 1119-94-4
  • D8638_SIGMA
  • D5047_SIGMA
  • 44239_FLUKA
  • 1-Dodecanaminium, N,N,N-trimethyl-, bromide
  • AI3-14973
  • AMMONIUM, DODECYLTRIMETHYL-, BROMIDE
  • DTAB
  • DTAB (surfactant)
  • Dctab
  • Dodecyltrimethylammonium bromide
  • EINECS 214-290-3
  • FSM 23
  • LTAB
  • Laurtrimonium bromide
  • Lauryltrimethylammonium bromide
  • Morpan D
  • N,N,N-Trimethyl-1-dodecanaminiuim bromide
  • N,N,N-Trimethyldodecan-1-ammonium bromide
  • N-Lauryl-N,N,N-trimethylammonium bromide
  • Trimethyldodecylammonium bromide
  • Trimethyllaurylammonium bromide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references
Homo sapiens dynamin 1 Starlite/ChEMBL References
Homo sapiens androgen receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dynamin 1 Get druggable targets OG5_126660 All targets in OG5_126660
Brugia malayi Dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium berghei dynamin-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Echinococcus granulosus dynamin 1 protein Get druggable targets OG5_126660 All targets in OG5_126660
Trypanosoma brucei dynamin-1-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium falciparum dynamin-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Brugia malayi Dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Giardia lamblia Dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis dynamin, putative Get druggable targets OG5_126660 All targets in OG5_126660
Loa Loa (eye worm) DRP-1 protein Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium yoelii dynamin-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Trypanosoma brucei gambiense dynamin, putative,vacuolar sortin protein 1, putative Get druggable targets OG5_126660 All targets in OG5_126660
Trypanosoma cruzi dynamin-1-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum Dynamin-2, putative Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium knowlesi dynamin-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Toxoplasma gondii dynamin gtpase Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum Dynamin-1, putative Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium berghei dynamin-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Cryptosporidium parvum dynamin-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis mgm1, putative Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis dynamin, putative Get druggable targets OG5_126660 All targets in OG5_126660
Neospora caninum dynamin-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum Dynamin-1, putative Get druggable targets OG5_126660 All targets in OG5_126660
Echinococcus multilocularis dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Cryptosporidium hominis dynactin 4 (p62) Get druggable targets OG5_126660 All targets in OG5_126660
Toxoplasma gondii dynamin-related protein DRPA Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma mansoni dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis dynamin, putative Get druggable targets OG5_126660 All targets in OG5_126660
Entamoeba histolytica dynamin-1-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium vivax dynamin-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Neospora caninum Strain CBS138 chromosome D complete sequence, related Get druggable targets OG5_126660 All targets in OG5_126660
Trypanosoma brucei gambiense dynamin, putative,vacuolar sortin protein 1, putative Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium yoelii dynamin-like protein-related Get druggable targets OG5_126660 All targets in OG5_126660
Candida albicans GTP-binding protein/GTPase Get druggable targets OG5_126660 All targets in OG5_126660
Babesia bovis dynamin-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Leishmania donovani dynamin-1-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum ko:K01528 dynamin GTPase [EC3.6.5.5], putative Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma mansoni dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Brugia malayi Dynamin central region family protein Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium vivax dynamin protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Babesia bovis dynamin central region family protein Get druggable targets OG5_126660 All targets in OG5_126660
Trypanosoma congolense dynamin-1-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum Dynamin-1, putative Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium knowlesi dynamin-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Theileria parva dynamin, putative Get druggable targets OG5_126660 All targets in OG5_126660
Cryptosporidium hominis dynamin-related protein Get druggable targets OG5_126660 All targets in OG5_126660
Cryptosporidium parvum dynamin-related protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Echinococcus granulosus dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis dynamin, putative Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma mansoni dynamin Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium falciparum dynamin-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Candida albicans GTP-binding protein/GTPase Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum ko:K01528 dynamin GTPase [EC3.6.5.5], putative Get druggable targets OG5_126660 All targets in OG5_126660
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum expressed protein Get druggable targets OG5_126660 All targets in OG5_126660
Trypanosoma brucei dynamin-1-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Leishmania major GTP-binding protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Echinococcus granulosus dynamin 1 Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis dynamin, putative Get druggable targets OG5_126660 All targets in OG5_126660
Toxoplasma gondii dynamin-related protein DRPB Get druggable targets OG5_126660 All targets in OG5_126660
Theileria parva hypothetical protein Get druggable targets OG5_126660 All targets in OG5_126660
Echinococcus multilocularis dynamin 1 protein Get druggable targets OG5_126660 All targets in OG5_126660
Entamoeba histolytica dynamin-like protein Get druggable targets OG5_126660 All targets in OG5_126660
Plasmodium yoelii dynamin like protein-related Get druggable targets OG5_126660 All targets in OG5_126660
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126660 All targets in OG5_126660
Trichomonas vaginalis dynamin, putative Get druggable targets OG5_126660 All targets in OG5_126660
Schistosoma japonicum Dynamin-1-like protein, putative Get druggable targets OG5_126660 All targets in OG5_126660
Candida albicans dynamin-related protein Get druggable targets OG5_126660 All targets in OG5_126660
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.031132 0.0814165 0.0814165
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00699957 0.0139695 0.0139695
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0382352 0.101269 0.101269
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Plasmodium vivax histone deacetylase 1, putative 0.3598 1 1
Echinococcus granulosus histone deacetylase 0.272019 0.754663 0.753638
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.00939988 0.020678 0.0165851
Brugia malayi BRCA1-associated protein 2 containing protein 0.00939988 0.020678 0.020678
Leishmania major hypothetical protein, conserved 0.00939988 0.020678 0.020678
Toxoplasma gondii histone deacetylase HDAC2 0.3598 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Echinococcus granulosus serine:threonine protein kinase SMG1 0.00699957 0.0139695 0.00984847
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0231588 0.0591325 0.0591325
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.17825 0.492593 0.489803
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0129293 0.0305422 0.0277153
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.00699957 0.0139695 0.0139695
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0231588 0.0591325 0.0552003
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0129293 0.0305422 0.0252116
Brugia malayi Kelch motif family protein 0.0411781 0.109494 0.109494
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.023176 0.0591805 0.0591805
Echinococcus granulosus BRCA1 associated protein 0.00939988 0.020678 0.0165851
Loa Loa (eye worm) calcium channel 0.0382352 0.101269 0.101269
Brugia malayi histone deacetylase 11 0.157184 0.433715 0.433715
Echinococcus multilocularis histone deacetylase 1 0.3598 1 1
Loa Loa (eye worm) hypothetical protein 0.157184 0.433715 0.433715
Schistosoma mansoni voltage-gated cation channel 0.0382352 0.101269 0.0975129
Plasmodium falciparum histone deacetylase 2 0.272019 0.754663 0.753314
Trypanosoma brucei histone deacetylase 4 0.272019 0.754663 0.754663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0153822 0.0373977 0.0345907
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.11101 0.304664 0.300841
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.00395794 0.0054685 0.001312
Leishmania major histone deacetylase, putative 0.3598 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.01049 0.0237248 0.0196446
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Brugia malayi Histone deacetylase family protein 0.272019 0.754663 0.754663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Trypanosoma cruzi histone deacetylase, putative 0.157184 0.433715 0.433715
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.119089 0.327244 0.325282
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.00395794 0.0054685 0.001312
Echinococcus multilocularis histone deacetylase 6 0.272019 0.754663 0.753638
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.051848 0.139315 0.139315
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.00939988 0.020678 0.0165851
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0129293 0.0305422 0.0252116
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.00939988 0.020678 0.0152931
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.00699957 0.0139695 0.00984847
Loa Loa (eye worm) hypothetical protein 0.00390902 0.00533178 0.00533178
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0271741 0.0703545 0.0703545
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.00939988 0.020678 0.0165851
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Loa Loa (eye worm) phosphatidylinositol 3 0.023176 0.0591805 0.0591805
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0129293 0.0305422 0.0264905
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.17825 0.492593 0.489803
Toxoplasma gondii hypothetical protein 0.00704005 0.0140826 0.00866145
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.023176 0.0591805 0.0591805
Echinococcus multilocularis histone deacetylase 0.272019 0.754663 0.753638
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0129293 0.0305422 0.0277153
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.0172849 0.0131778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Toxoplasma gondii transporter, cation channel family protein 0.00800569 0.0167814 0.0113751
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.01049 0.0237248 0.0196446
Brugia malayi Stress-activated protein kinase jnk-1 0.0231588 0.0591325 0.0591325
Schistosoma mansoni histone deacetylase hda2 0.281419 0.780935 0.780019
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.00939988 0.020678 0.020678
Schistosoma mansoni alpha-l-fucosidase 0.0241763 0.0619761 0.0580557
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.00939988 0.020678 0.0152931
Echinococcus multilocularis Zinc finger, PHD finger 0.0129293 0.0305422 0.0264905
Loa Loa (eye worm) carboxylesterase 0.00818585 0.0172849 0.0172849
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0129293 0.0305422 0.0252116
Echinococcus multilocularis histone deacetylase 7 0.272019 0.754663 0.753638
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.17825 0.492593 0.489803
Trypanosoma brucei histone deacetylase 2 0.157184 0.433715 0.433715
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0722398 0.196307 0.191888
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.126402 0.347685 0.347685
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.023176 0.0591805 0.0552484
Echinococcus granulosus integrin beta 2 0.192028 0.5311 0.52914
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.0152931
Entamoeba histolytica protein kinase rad3, putative 0.00699957 0.0139695 0.00854769
Trypanosoma brucei histone deacetylase 3 0.272019 0.754663 0.754663
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Loa Loa (eye worm) histone deacetylase 3 0.3598 1 1
Entamoeba histolytica hypothetical protein 0.00699957 0.0139695 0.00854769
Loa Loa (eye worm) histone deacetylase 1 0.3598 1 1
Echinococcus granulosus acetylcholinesterase 0.00818585 0.0172849 0.0131778
Loa Loa (eye worm) hypothetical protein 0.00349047 0.00416196 0.00416196
Brugia malayi Carboxylesterase family protein 0.00818585 0.0172849 0.0172849
Loa Loa (eye worm) phosphatidylinositol 3 0.0271741 0.0703545 0.0703545
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.00797042 0.0166828 0.0166828
Giardia lamblia Hypothetical protein 0.00939988 0.020678 0.0152931
Leishmania major hypothetical protein, conserved 0.00395794 0.0054685 0.0054685
Loa Loa (eye worm) hypothetical protein 0.00704005 0.0140826 0.0140826
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.00395794 0.0054685 0.001312
Loa Loa (eye worm) integrin beta-2 0.262273 0.727426 0.727426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0382352 0.101269 0.0975129
Loa Loa (eye worm) phosphatidylinositol 3 0.150739 0.415703 0.415703
Echinococcus multilocularis voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.00797042 0.0166828 0.0166828
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.119089 0.327244 0.325282
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.023176 0.0591805 0.0591805
Loa Loa (eye worm) hypothetical protein 0.0590429 0.159424 0.159424
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Schistosoma mansoni histone deacetylase 4 5 0.272019 0.754663 0.753638
Echinococcus multilocularis dual specificity mitogen activated protein 0.00797042 0.0166828 0.0125732
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.023176 0.0591805 0.0540073
Toxoplasma gondii non-specific serine/threonine protein kinase 0.00744841 0.0152239 0.00980904
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.00939988 0.020678 0.0355158
Schistosoma mansoni histone deacetylase 4 5 0.272019 0.754663 0.753638
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.119089 0.327244 0.324432
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0162191 0.0397368 0.0357235
Entamoeba histolytica histone deacetylase, putative 0.3598 1 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0129293 0.0305422 0.0277153
Plasmodium vivax histone deacetylase, putative 0.157184 0.433715 0.430601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.031132 0.0814165 0.0787379
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Loa Loa (eye worm) acetylcholinesterase 1 0.00818585 0.0172849 0.0172849
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Schistosoma mansoni serine/threonine protein kinase 0.0231588 0.0591325 0.0552003
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Echinococcus multilocularis carboxylesterase 5A 0.00818585 0.0172849 0.0131778
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904426 0.247182 0.247182
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.023176 0.0591805 0.0552484
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.119089 0.327244 0.327244
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.031132 0.0814165 0.0775774
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0129293 0.0305422 0.0252116
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.168942 0.466577 0.464347
Leishmania major hypothetical protein, conserved 0.0224432 0.0571323 0.0571323
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0763656
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.023176 0.0591805 0.0591805
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Trypanosoma brucei histone deacetylase, putative 0.272019 0.754663 0.754663
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.11101 0.304664 0.304664
Schistosoma mansoni histone deacetylase 0.3598 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0113332 0.0260815 0.0260815
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0408401 0.108549 0.103648
Leishmania major phosphatidylinositol kinase related protein, putative 0.00395794 0.0054685 0.0054685
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.00939988 0.020678 0.0152931
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0221607 0.0563427 0.051154
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.051848 0.139315 0.139315
Trypanosoma cruzi Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Trichomonas vaginalis conserved hypothetical protein 0.00349047 0.00416196 0.00125811
Loa Loa (eye worm) hypothetical protein 0.00704005 0.0140826 0.0140826
Echinococcus granulosus voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Echinococcus multilocularis histone deacetylase 8 0.157184 0.433715 0.431348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904426 0.247182 0.247182
Brugia malayi Histone deacetylase family protein 0.272019 0.754663 0.754663
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Brugia malayi FAT domain containing protein 0.00349047 0.00416196 0.00416196
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.019267 0.0482552 0.0482552
Loa Loa (eye worm) hypothetical protein 0.0382352 0.101269 0.101269
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Giardia lamblia GTOR 0.023176 0.0591805 0.0540073
Plasmodium falciparum histone deacetylase 1 0.3598 1 1
Brugia malayi Integrin beta pat-3 precursor 0.262273 0.727426 0.727426
Loa Loa (eye worm) hypothetical protein 0.0411781 0.109494 0.109494
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.00939988 0.020678 0.0165851
Loa Loa (eye worm) phosphatidylinositol 3 0.01049 0.0237248 0.0237248
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0672407 0.182335 1
Trypanosoma brucei Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.00939988 0.020678 0.020678
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.023176 0.0591805 0.0591805
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.17825 0.492593 0.492593
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.031132 0.0814165 0.0814165
Loa Loa (eye worm) phosphatidylinositol kinase 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0382352 0.101269 0.0975129
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.00395794 0.0054685 0.0054685
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0504952 0.135534 0.131921
Schistosoma mansoni protein kinase 0.00797042 0.0166828 0.0125732
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Loa Loa (eye worm) hypothetical protein 0.00800569 0.0167814 0.0167814
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0129293 0.0305422 0.0264905
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0382352 0.101269 0.0975129
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.00939988 0.020678 0.0165851
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.023176 0.0591805 0.0591805
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0129293 0.0305422 0.0264905
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0382352 0.101269 0.0975129
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0382352 0.101269 0.0975129
Schistosoma mansoni integrin beta subunit 0.15085 0.416013 0.413572
Leishmania major hypothetical protein, conserved 0.00939988 0.020678 0.020678
Echinococcus multilocularis serine protein kinase ATM 0.00699957 0.0139695 0.00984847
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Echinococcus granulosus acetylcholinesterase 0.00818585 0.0172849 0.0131778
Echinococcus granulosus carboxylesterase 5A 0.00818585 0.0172849 0.0131778
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.168942 0.466577 0.464347
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis histone deacetylase 6 0.272019 0.754663 0.753638
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.00939988 0.020678 0.0152931
Leishmania major histone deacetylase, putative 0.3598 1 1
Echinococcus multilocularis histone deacetylase 6 0.281419 0.780935 0.780019
Echinococcus granulosus histone deacetylase 6 0.272019 0.754663 0.753638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.126402 0.347685 0.347685
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.00797042 0.0166828 0.0166828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Leishmania major phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.023176 0.0591805 0.0552484
Echinococcus granulosus histone deacetylase 8 0.157184 0.433715 0.431348
Leishmania major histone deacetylase, putative 0.272019 0.754663 0.754663
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.17825 0.492593 0.5
Echinococcus multilocularis histone deacetylase 3 0.3598 1 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.119089 0.327244 0.327244
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129293 0.0305422 0.0252116
Trypanosoma cruzi Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0129293 0.0305422 0.0264905
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Leishmania major phosphatidylinositol 3-kinase, putative 0.01049 0.0237248 0.0237248
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.17825 0.492593 0.5
Loa Loa (eye worm) histone deacetylase 7A 0.272019 0.754663 0.754663
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.031132 0.0814165 0.0787379
Trichomonas vaginalis BRCA1-associated protein, putative 0.00939988 0.020678 0.0178223
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Giardia lamblia Kinase, STE STE20 0.00797042 0.0166828 0.011276
Onchocerca volvulus Histone deacetylase 10 homolog 0.157184 0.433715 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.01049 0.0237248 0.0196446
Echinococcus granulosus histone deacetylase 7 0.272019 0.754663 0.753638
Trichomonas vaginalis PIKK family atypical protein kinase 0.00395794 0.0054685 0.00256846
Schistosoma mansoni histone deacetylase 1 2 3 0.157184 0.433715 0.431348
Echinococcus multilocularis BRCA1 associated protein 0.00939988 0.020678 0.0165851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0411781 0.109494 0.109494
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0784993 0.213802 0.213802
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0382352 0.101269 0.0975129
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0382352 0.101269 0.0975129
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0590429 0.159424 0.155911
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0117518 0.0272513 0.0272513
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00939988 0.020678 0.0152931
Onchocerca volvulus 0.0224432 0.0571323 0.12064
Loa Loa (eye worm) hypothetical protein 0.119089 0.327244 0.327244
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00699957 0.0139695 0.0139695
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.00939988 0.020678 0.0152931
Toxoplasma gondii histone deacetylase HDAC5 0.157184 0.433715 0.430601
Echinococcus multilocularis sodium channel protein 0.0162191 0.0397368 0.0357235
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.00797042 0.0166828 0.0166828
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.00939988 0.020678 0.0165851
Trypanosoma cruzi target of rapamycin kinase 3 0.019267 0.0482552 0.0482552
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.00395794 0.0054685 0.00256846
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.044329 0.1183 0.113452
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0382352 0.101269 0.0975129
Schistosoma mansoni hypothetical protein 0.00395794 0.0054685 0.001312
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.168942 0.466577 0.464347
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.031132 0.0814165 0.0787379
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.051848 0.139315 0.139315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0153822 0.0373977 0.0345907
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.051848 0.139315 0.139315
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.051848 0.139315 0.139315
Echinococcus granulosus c-Jun N-terminal kinases 0.0231588 0.0591325 0.0552003
Echinococcus granulosus dual specificity mitogen activated protein 0.00797042 0.0166828 0.0125732
Giardia lamblia Histone deacetylase 0.3598 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.00699957 0.0139695 0.00854769
Loa Loa (eye worm) hypothetical protein 0.00818585 0.0172849 0.0172849
Trypanosoma cruzi histone deacetylase, putative 0.157184 0.433715 0.433715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Loa Loa (eye worm) hypothetical protein 0.00744841 0.0152239 0.0152239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.17825 0.492593 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.00256846
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Toxoplasma gondii histone deacetylase HDAC3 0.3598 1 1
Loa Loa (eye worm) hypothetical protein 0.0313997 0.0821646 0.0821646
Loa Loa (eye worm) hypothetical protein 0.00304162 0.00290751 0.00290751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196855 0.0494251 0.0466532
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0232591 0.0594128 0.0594128
Echinococcus granulosus serine protein kinase ATM 0.00699957 0.0139695 0.00984847
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Brugia malayi histone deacetylase 1 (HD1) 0.3598 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0904426 0.247182 0.247182
Toxoplasma gondii UBA/TS-N domain-containing protein 0.00939988 0.020678 0.0152931
Loa Loa (eye worm) voltage-dependent calcium channel 0.00800569 0.0167814 0.0167814
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00971519 0.0215593 0.0187061
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.00797042 0.0166828 0.0166828
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.0054685
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.051848 0.139315 0.139315
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.17825 0.492593 0.5
Leishmania major histone deacetylase, putative 0.272019 0.754663 0.754663
Plasmodium vivax histone deacetylase, putative 0.272019 0.754663 0.753314
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0904426 0.247182 0.243042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00699957 0.0139695 0.0139695
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0590429 0.159424 0.155911
Schistosoma mansoni fkbp-rapamycin associated protein 0.00699957 0.0139695 0.00984847
Loa Loa (eye worm) hypothetical protein 0.124235 0.341627 0.341627
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.00699957 0.0139695 0.0139695
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00971519 0.0215593 0.0187061
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0814165
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.17825 0.492593 0.489803
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Loa Loa (eye worm) hypothetical protein 0.3598 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0129293 0.0305422 0.0305422
Loa Loa (eye worm) hypothetical protein 0.00818585 0.0172849 0.0172849
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0625317 0.169175 0.166752
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0504952 0.135534 0.131921
Mycobacterium ulcerans alpha-L-fucosidase 0.0504952 0.135534 0.275144
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.00939988 0.020678 0.0152931
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Loa Loa (eye worm) hypothetical protein 0.114835 0.315355 0.315355
Echinococcus multilocularis 0.00395794 0.0054685 0.001312
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.119089 0.327244 0.324432
Trichomonas vaginalis conserved hypothetical protein 0.00744841 0.0152239 0.0123523
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.023176 0.0591805 0.0540073
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00395794 0.0054685 0.0054685
Leishmania major hypothetical protein, unknown function 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Trypanosoma brucei histone deacetylase 1 0.3598 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00818585 0.0172849 0.0131778
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.01049 0.0237248 0.0237248
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.00939988 0.020678 0.0165851
Loa Loa (eye worm) hypothetical protein 0.00699957 0.0139695 0.0139695
Echinococcus granulosus histone deacetylase 6 0.281419 0.780935 0.780019
Leishmania major phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Leishmania major phosphatidylinositol 3-kinase, putative 0.0129293 0.0305422 0.0305422
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0625317 0.169175 0.166752
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.00699957 0.0139695 0.00984847
Loa Loa (eye worm) histone deacetylase 11 0.157184 0.433715 0.433715
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Loa Loa (eye worm) hypothetical protein 0.00395794 0.0054685 0.0054685
Plasmodium vivax histone deacetylase 2, putative 0.272019 0.754663 0.753314
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0129293 0.0305422 0.0305422
Brugia malayi histone deacetylase 3 (HD3) 0.3598 1 1
Trichomonas vaginalis brca1-associated protein, putative 0.00939988 0.020678 0.0178223
Toxoplasma gondii histone deacetylase HDAC1 0.272019 0.754663 0.753314
Trypanosoma brucei target of rapamycin kinase 3, putative 0.019267 0.0482552 0.0482552
Brugia malayi Carboxylesterase family protein 0.00818585 0.0172849 0.0172849
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0904426 0.247182 0.244987
Brugia malayi hypothetical protein 0.0411781 0.109494 0.109494
Echinococcus granulosus histone deacetylase 3 0.3598 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.00395794 0.0054685 0.00256846
Brugia malayi Alpha-L-fucosidase family protein 0.0241763 0.0619761 0.0619761
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0129293 0.0305422 0.0264905
Trypanosoma cruzi histone deacetylase 1, putative 0.3598 1 1
Schistosoma mansoni histone deacetylase hda2 0.157184 0.433715 0.431348
Toxoplasma gondii histone deacetylase HDAC4 0.157184 0.433715 0.430601
Loa Loa (eye worm) alpha-L-fucosidase 0.0241763 0.0619761 0.0619761
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.00939988 0.020678 0.0165851
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Echinococcus granulosus voltage dependent calcium channel 0.00800569 0.0167814 0.0126722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00939988 0.020678 0.0152931
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0591617 0.159756 0.157306
Echinococcus multilocularis voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.01049 0.0237248 0.0237248
Schistosoma mansoni brca1-associated protein (brap2) 0.00939988 0.020678 0.0165851
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.00395794 0.0054685 0.001312
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0591617 0.159756 0.159756
Brugia malayi Histone deacetylase 1 0.3598 1 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0232591 0.0594128 0.0594128
Toxoplasma gondii target of rapamycin (TOR), putative 0.0182839 0.0455076 0.0402593
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129293 0.0305422 0.0252116
Echinococcus granulosus histone deacetylase 1 0.3598 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Schistosoma mansoni histone deacetylase 0.3598 1 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.00786697 0.0163937 0.0135255
Entamoeba histolytica hypothetical protein 0.0722398 0.196307 0.191888
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis integrin beta 2 0.192028 0.5311 0.52914
Plasmodium vivax hypothetical protein, conserved 0.00939988 0.020678 0.0152931
Plasmodium falciparum histone deacetylase, putative 0.272019 0.754663 0.753314
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0672407 0.182335 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Echinococcus granulosus histone deacetylase 6 0.272019 0.754663 0.753638
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0904426 0.247182 0.244987
Trypanosoma cruzi histone deacetylase 1, putative 0.3598 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Schistosoma mansoni phosphatidylinositol 4-kinase 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162496 0.0398219 0.0370221
Loa Loa (eye worm) histone deacetylase 0.272019 0.754663 0.754663
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.00395794 0.0054685 0.0054685
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00304162 0.00290751 0.00290751
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Leishmania major phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0158007 0.0385675 0.035764
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0904426 0.247182 0.244987
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.023176 0.0591805 0.0591805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0763656
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Schistosoma mansoni brca1-associated protein (brap2) 0.00939988 0.020678 0.0165851
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.00939988 0.020678 0.0152931
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0590429 0.159424 0.159424
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.0172849 0.0131778
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.17825 0.492593 0.492593
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0864846 0.23612 0.231919
Toxoplasma gondii FATC domain-containing protein 0.00699957 0.0139695 0.00854769
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.5 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (functional) = 0.5 uM Inhibitory activity against Plasmodium falciparum ChEMBL. 9357523
IC50 (functional) = 0.5 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (functional) = 0.5 uM Inhibitory activity against Plasmodium falciparum ChEMBL. 9357523
IC50 (binding) = 16.32 uM Concentration required against dynamin-1 GTPase activity of sheep brain. ChEMBL. 15149689
IC50 (binding) = 16.32 uM Concentration required against dynamin-1 GTPase activity of sheep brain. ChEMBL. 15149689
MBC (functional) = 250 uM Antibacterial activity against 5 x 10'5 CFU/mL Escherichia coli ATCC 25922 incubated for 72 hrs followed by growing of cells on trypticase soy agar plate for 24 hrs by CLSI M07-A8 broth microdilution method ChEMBL. 21794958
MIC (functional) = 250 uM Antibacterial activity against 5 x 10'5 CFU/mL Escherichia coli ATCC 25922 after 72 hrs by CLSI M07-A8 broth microdilution method ChEMBL. 21794958
Potency (functional) 6.1131 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.1645 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.6349 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.8006 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.8724 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.6448 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.6448 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 10669577

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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