Detailed information for compound 1888361

Basic information

Technical information
  • TDR Targets ID: 1888361
  • Name: N-[(3-methoxy-4-propoxyphenyl)methylideneamin o]pyridin-2-amine
  • MW: 285.341 | Formula: C16H19N3O2
  • H donors: 1 H acceptors: 1 LogP: 3.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1OC)/C=N/Nc1ccccn1
  • InChi: 1S/C16H19N3O2/c1-3-10-21-14-8-7-13(11-15(14)20-2)12-18-19-16-6-4-5-9-17-16/h4-9,11-12H,3,10H2,1-2H3,(H,17,19)/b18-12+
  • InChiKey: BEYZNQYVAQORRK-LDADJPATSA-N  


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Synonyms

  • N-[(3-methoxy-4-propoxy-phenyl)methyleneamino]pyridin-2-amine
  • N-[(3-methoxy-4-propoxyphenyl)methyleneamino]-2-pyridinamine
  • [(3-methoxy-4-propoxy-benzylidene)amino]-(2-pyridyl)amine
  • N-[(3-methoxy-4-propoxy-phenyl)methylideneamino]pyridin-2-amine
  • MLS000771863
  • SMR000344236
  • T5339150

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei trypanothione reductase 0.0057 0.0314 0.1082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0011 0.0012
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0229 0.0554
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0314 0.0834
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.024 0.0265
Echinococcus multilocularis geminin 0.0205 0.1309 0.1452
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0122 0.0198
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1093 0.4431
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0073 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0011 0.0012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0274 0.0913
Onchocerca volvulus 0.0058 0.0321 0.2704
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0179 0.1133 0.1197
Brugia malayi Thioredoxin reductase 0.0057 0.0314 0.0348
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.1346 0.9009 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1075 0.1192
Loa Loa (eye worm) glutathione reductase 0.0057 0.0314 0.0347
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0162 0.0179
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0011 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.326 0.3618
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0273 0.0302
Chlamydia trachomatis dihydrofolate reductase 0.0052 0.0277 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0011 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0043 0.0222 0.0112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0425 0.0414
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0222 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0122 0.0135
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0127 0.0784 0.2238
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0198 0.045
Brugia malayi hypothetical protein 0.0286 0.1855 0.2059
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0229 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0274 0.0913
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0314 0.0347
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1224 0.3849
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.0134
Echinococcus multilocularis cpg binding protein 0.0037 0.0176 0.0194
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0466 0.1737
Schistosoma mansoni dihydrofolate reductase 0.0052 0.0277 0.0267
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0062 0.0051
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0179 0.1133 0.1197
Schistosoma mansoni hypothetical protein 0.0049 0.026 0.025
Brugia malayi thymidylate synthase 0.0127 0.0784 0.087
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0467 0.3081 0.3374
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0273 0.0235
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0052 0.0277 0.0526
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0466 0.1737
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0011 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0011 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0011 0.0011
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0122 0.0198
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0229 0.0254
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0127 0.0784 0.0774
Echinococcus granulosus expressed conserved protein 0.0112 0.0682 0.0756
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.073 0.081
Plasmodium vivax glutathione reductase, putative 0.0057 0.0314 0.0281
Loa Loa (eye worm) hypothetical protein 0.0051 0.0273 0.0302
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0466 0.0456
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0179 0.1133 0.1197
Mycobacterium ulcerans hypothetical protein 0.0192 0.1224 0.3849
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0011 0.0012
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0314 0.0347
Brugia malayi dUTP diphosphatase 0.1346 0.9009 1
Brugia malayi steroid hormone receptor 0.0012 0.0011 0.0012
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0467 0.3081 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1855 0.2058
Mycobacterium ulcerans thymidylate synthase 0.0127 0.0784 0.2391
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0065 0.001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0073 0.0012
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0905 0.2647
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0273 0.0302
Brugia malayi hypothetical protein 0.0182 0.1159 0.1287
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0062 0.0068
Loa Loa (eye worm) hypothetical protein 0.0062 0.035 0.0388
Entamoeba histolytica hypothetical protein 0.1346 0.9009 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0229 0.0187
Wolbachia endosymbiont of Brugia malayi dUTPase 0.1346 0.9009 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0011 0.0011
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0052 0.0277 0.0713
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0222 0.0245
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.2388 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1855 0.2058
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0807 0.2468
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.008
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0466 0.0517
Schistosoma mansoni hypothetical protein 0.0043 0.0222 0.0211
Echinococcus granulosus cpg binding protein 0.0037 0.0176 0.0194
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0229 0.0187
Schistosoma mansoni patched 1 0.0051 0.0273 0.0262
Brugia malayi dihydrofolate reductase family protein 0.0052 0.0277 0.0308
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0229 0.0254
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0011 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0122 0.0256
Schistosoma mansoni inositol monophosphatase 0.0045 0.0229 0.0219
Mycobacterium ulcerans hypothetical protein 0.0029 0.0122 0.0198
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0229 0.0187
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.2388 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0011 0.0011
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0466 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0011 0.0012
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0271 0.176 0.1751
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0011 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0073 0.0036
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0229 0.0719
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0011 0.0012
Schistosoma mansoni survival motor neuron protein 0.0058 0.0321 0.0311
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1346 0.9009 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0011 0.0011
Brugia malayi ecdysteroid receptor 0.0012 0.0011 0.0012
Brugia malayi hypothetical protein 0.0043 0.0222 0.0246
Loa Loa (eye worm) dihydrofolate reductase 0.0052 0.0277 0.0307
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0314 0.0281
Brugia malayi CHE-14 protein 0.0051 0.0273 0.0303
Schistosoma mansoni hypothetical protein 0.0049 0.026 0.025
Toxoplasma gondii thioredoxin reductase 0.0057 0.0314 0.0281
Loa Loa (eye worm) thymidylate synthase 0.0127 0.0784 0.0869
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0043 0.0222 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0011 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0011 0.0012
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0467 0.3081 1
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1346 0.9009 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0807 0.2316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0011 0.0011
Echinococcus multilocularis thymidylate synthase 0.0127 0.0784 0.0869
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0466 0.0517
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0274 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0205 0.1309 0.1299
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0122 0.0135
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0011 0.0011
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0027 0.003
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0073 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0065 0.001
Brugia malayi nuclear receptor NHR-88 0.0012 0.0011 0.0012
Echinococcus granulosus dnaJ subfamily B 0.0494 0.326 0.3618
Echinococcus granulosus thymidylate synthase 0.0127 0.0784 0.0869
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.0134
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0229 0.0187
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0229 0.0719
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0062 0.0069
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0905 0.2792
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0062 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.2388 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0222 0.0245
Schistosoma mansoni cpg binding protein 0.0037 0.0176 0.0165
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0179 0.1133 0.4602
Echinococcus granulosus transcription factor Dp 1 0.0046 0.024 0.0265
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1346 0.9009 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0179 0.1133 0.4602
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.008
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1346 0.9009 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0027 0.003
Mycobacterium tuberculosis Probable reductase 0.013 0.0807 0.2468
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.073 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0011 0.0012
Brugia malayi Dihydrofolate reductase 0.0052 0.0277 0.0308
Loa Loa (eye worm) dUTP diphosphatase 0.1346 0.9009 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.1855 0.2058
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0905 0.2792
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6533 0.7251
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0229 0.0719
Brugia malayi glutathione reductase 0.0057 0.0314 0.0348
Plasmodium falciparum glutathione reductase 0.0057 0.0314 0.0281
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0314 0.1082
Toxoplasma gondii hypothetical protein 0.0059 0.0325 0.0294
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0073 0.0012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0466 0.0388
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0122 0.0198
Entamoeba histolytica hypothetical protein 0.0043 0.0222 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0011 0.0012
Brugia malayi Inositol-1 0.0045 0.0229 0.0255
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0122 0.0198
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0198 0.0257
Echinococcus multilocularis protein dispatched 1 0.0058 0.0321 0.0356
Echinococcus multilocularis dUTP pyrophosphatase 0.1346 0.9009 1
Onchocerca volvulus 0.0029 0.0122 0.0965
Leishmania major trypanothione reductase 0.0057 0.0314 0.1082
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0466 0.1737
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0011 0.0012
Mycobacterium tuberculosis Hypothetical protein 0.006 0.0335 0.0906
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.006 0.0335 0.1176
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0273 0.0302
Echinococcus granulosus dUTP pyrophosphatase 0.1346 0.9009 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0122 0.0256
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0122 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0335 0.0306
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0466 0.1737
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0807 0.2468
Entamoeba histolytica hypothetical protein 0.0879 0.5857 0.6453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0011 0.0011
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0467 0.3081 0.333
Echinococcus multilocularis dihydrofolate reductase 0.0052 0.0277 0.0307
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1346 0.9009 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0011 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0122 0.0198
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0011 0.0011
Echinococcus granulosus dihydrofolate reductase 0.0052 0.0277 0.0307
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1075 0.1192
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0122 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0011 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.035 0.1238
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0229 0.0719
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0321 0.0357
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1346 0.9009 1
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0314 0.0347
Schistosoma mansoni cpg binding protein 0.0037 0.0176 0.0165
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.073 0.0685
Echinococcus multilocularis protein patched 0.0051 0.0273 0.0302
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0905 0.2792
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0011 0.0011
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1346 0.9009 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0807 0.2468
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0807 0.2468
Loa Loa (eye worm) hypothetical protein 0.0119 0.073 0.081
Echinococcus multilocularis expressed conserved protein 0.0112 0.0682 0.0756
Entamoeba histolytica hypothetical protein 0.1346 0.9009 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0011 0.0011
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0273 0.0302
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0229 0.0121
Brugia malayi hypothetical protein 0.006 0.0335 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0011 0.0011
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0467 0.3081 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0122 0.0198
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0274 0.0913
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1346 0.9009 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0011 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0122 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0011 0.0012
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0179 0.1133 0.4602
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1346 0.9009 0.9008
Entamoeba histolytica hypothetical protein 0.0467 0.3081 0.333
Onchocerca volvulus 0.0127 0.0784 0.6731
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0065 0.001
Entamoeba histolytica hypothetical protein 0.0879 0.5857 0.6453
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0743 0.0733
Loa Loa (eye worm) inositol-1 0.0045 0.0229 0.0254
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0011 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.2388 1
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1346 0.9009 1
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0467 0.3081 0.333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0065 0.001
Schistosoma mansoni inositol monophosphatase 0.0045 0.0229 0.0219
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0122 0.0198
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0372 0.0346
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1346 0.9009 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.1159 0.1286
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1093 0.4431
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0466 0.0517
Schistosoma mansoni hypothetical protein 0.0494 0.326 0.3253
Entamoeba histolytica hypothetical protein 0.0043 0.0222 0.0112
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.008
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0127 0.0784 0.2391
Brugia malayi nuclear hormone receptor 0.0012 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0049 0.026 0.025
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0011 0.0011
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.073 0.081
Schistosoma mansoni cpg binding protein 0.0035 0.0162 0.0152
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0011 0.0012
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0467 0.3081 1
Echinococcus granulosus geminin 0.0205 0.1309 0.1452
Schistosoma mansoni hypothetical protein 0.0058 0.0321 0.0311
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.0467 0.3081 0.3374
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1093 0.4431
Schistosoma mansoni hypothetical protein 0.0049 0.026 0.025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.0134
Schistosoma mansoni hypothetical protein 0.0205 0.1309 0.1299
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0807 0.2468
Plasmodium falciparum thioredoxin reductase 0.0057 0.0314 0.0281
Onchocerca volvulus 0.0182 0.1159 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0162 0.018
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0052 0.0277 0.0713
Onchocerca volvulus 0.0035 0.0162 0.132
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0062 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0122 0.0198
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1346 0.9009 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4467 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.3808 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 4.609 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 5.1714 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.5068 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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