TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 449.308 | Formula: C26H19Cl2OP
H donors: 0 H acceptors: 1 LogP: 6.49 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(c(c1)Cl)Cl)C=P(c1ccccc1)(c1ccccc1)c1ccccc1
InChi: 1S/C26H19Cl2OP/c27-24-17-16-20(18-25(24)28)26(29)19-30(21-10-4-1-5-11-21,22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-19H
InChiKey: IFCTYLDTQXMKQY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.007	0.1161	0.1275
Onchocerca volvulus		0.003	0.0279	0.0287
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0035	0.0373	0.0058
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0279	0.0307
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0035	0.0373	0.0468
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.013	0.2505	0.6116
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0279	0.0279
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0279	0.0279
Echinococcus granulosus	lamin	0.0024	0.013	0.013
Leishmania major	hypothetical protein, conserved	0.0035	0.0373	0.0058
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0279	0.0307
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0279	0.0151
Brugia malayi	hypothetical protein	0.0033	0.0336	0.0369
Schistosoma mansoni	hypothetical protein	0.0129	0.2488	0.2488
Schistosoma mansoni	voltage-gated potassium channel	0.0035	0.0386	0.0386
Loa Loa (eye worm)	inositol-1	0.0032	0.0322	0.0224
Trypanosoma cruzi	cAMP binding protein, putative	0.0035	0.0373	0.0058
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0255	0.5308	0.5828
Echinococcus granulosus	vesicular acetylcholine transporter	0.0255	0.5308	0.5308
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0279	0.0151
Trypanosoma brucei	protein kinase A regulatory subunit	0.0035	0.0373	0.041
Schistosoma mansoni	lamin	0.0024	0.013	0.013
Brugia malayi	putative neuropeptide receptor	0.003	0.0279	0.0307
Brugia malayi	G-protein coupled receptor	0.003	0.0279	0.0307
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.003	0.0279	0.0279
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0279	0.0279
Brugia malayi	Dopamine receptor protein 2	0.003	0.0279	0.0307
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus multilocularis	expressed conserved protein	0.0035	0.0373	0.0246
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0279	0.0279
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0052	0.0759	0.0759
Onchocerca volvulus		0.003	0.0279	0.0287
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0279	0.0279
Echinococcus granulosus	sex peptide receptor	0.003	0.0279	0.0279
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0279	0.0279
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0116	0.2203	0.2203
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0373	0.9071
Echinococcus multilocularis	serotonin receptor	0.003	0.0279	0.0151
Echinococcus granulosus	histone lysine methyltransferase setb	0.0025	0.0165	0.0165
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0113	0.2119	0.2119
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0035	0.0373	0.0373
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.0279	0.0287
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0035	0.0373	0.0246
Echinococcus granulosus	voltage gated potassium channel	0.007	0.1161	0.1161
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0033	0.0336	0.0336
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0035	0.0378	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0279	0.0176
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0035	0.0373	1
Echinococcus granulosus	g protein coupled receptor	0.003	0.0279	0.0279
Brugia malayi	Intermediate filament tail domain containing protein	0.0024	0.013	0.0143
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0279	0.0279
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0035	0.0373	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0032	0.0322	0.0786
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0035	0.0373	0.041
Schistosoma mansoni	biogenic amine receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0279	0.0151
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0373	0.0373
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0425	0.9108	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0208	0.4268	0.4686
Entamoeba histolytica	hypothetical protein	0.0033	0.0336	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0279	0.0279
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0025	0.0165	0.0035
Schistosoma mansoni	opsin-like receptor	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0191	0.3882	0.9478
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0279	0.0279
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0373	0.0911
Trypanosoma brucei	cAMP binding protein, putative	0.0035	0.0373	0.041
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0279	0.0176
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0116	0.2203	0.21
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0035	0.0373	0.9604
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0279	0.0279
Schistosoma mansoni	voltage-gated potassium channel	0.0052	0.0759	0.0759
Schistosoma mansoni	hypothetical protein	0.0148	0.2918	0.2918
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0279	0.0279
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0279	0.0279
Schistosoma mansoni	myosin xvIII	0.003	0.0279	0.0279
Treponema pallidum	catabolite gene activator (Crp)	0.0035	0.0373	0.5
Brugia malayi	ORL1-like opioid receptor	0.003	0.0279	0.0307
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0279	0.0279
Brugia malayi	Serotonin receptor	0.003	0.0279	0.0307
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0035	0.0373	1
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0255	0.5308	0.5246
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0032	0.0322	0.7543
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0279	0.0279
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0032	0.0322	0.0786
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0024	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0759	0.071
Entamoeba histolytica	hypothetical protein	0.0033	0.0336	1
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0279	0.0279
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0035	0.0373	0.9604
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0032	0.0322	0.0353
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0035	0.0373	0.0281
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0032	0.0322	0.5
Echinococcus multilocularis	voltage gated potassium channel	0.007	0.1161	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0165	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Echinococcus granulosus	hypothetical protein	0.003	0.0279	0.0279
Echinococcus multilocularis	geminin	0.0148	0.2918	0.2825
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0259	0.5395	0.5334
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0373	0.9071
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0035	0.0373	0.0373
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0035	0.0373	0.5
Echinococcus multilocularis	inositol monophosphatase 1	0.0032	0.0322	0.0194
Brugia malayi	GnHR receptor homolog	0.003	0.0279	0.0307
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0217	0.4459	0.4827
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0052	0.0759	0.0759
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0035	0.0373	0.0373
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0035	0.0373	0.0246
Schistosoma mansoni	hypothetical protein	0.0033	0.0336	0.0336
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0255	0.5308	1
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0035	0.0373	0.0058
Schistosoma mansoni	neuropeptide receptor	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Brugia malayi	AKH receptor	0.003	0.0279	0.0307
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	opsin-like receptor	0.003	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Mycobacterium leprae	Conserved hypothetical protein	0.0035	0.0373	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0052	0.0759	0.1853
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0052	0.0759	0.0759
Leishmania major	hypothetical protein, unknown function	0.0035	0.0373	0.0058
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0279	0.0307
Schistosoma mansoni	hypothetical protein	0.003	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.007	0.1161	0.1044
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0279	0.0151
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0035	0.0373	0.0911
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0035	0.0373	0.0246
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0116	0.2203	0.21
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0035	0.0373	0.0373
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0035	0.0373	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0279	0.0151
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0279	0.0279
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.007	0.1161	0.1161
Brugia malayi	neuropeptide F receptor	0.003	0.0279	0.0307
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0035	0.0373	1
Trichomonas vaginalis	set domain proteins, putative	0.0201	0.4096	1
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0035	0.0373	0.5
Onchocerca volvulus		0.0035	0.0373	0.0468
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0035	0.0373	0.0373
Brugia malayi	Dopamine receptor protein 1	0.003	0.0279	0.0307
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0035	0.0373	0.0373
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0035	0.0373	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0373	0.0281
Brugia malayi	neuropeptide F receptor	0.003	0.0279	0.0307
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0035	0.0373	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.0279	0.0151
Leishmania major	protein kinase, putative	0.0035	0.0373	0.0058
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0116	0.2203	0.2419
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0279	0.0279
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0035	0.0373	0.0373
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0279	0.0279
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0052	0.0759	0.0759
Mycobacterium ulcerans	regulatory protein	0.0035	0.0373	0.9071
Onchocerca volvulus		0.003	0.0279	0.0287
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0373	0.0911
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0279	0.0279
Brugia malayi	sulfakinin receptor protein	0.003	0.0279	0.0307
Schistosoma mansoni	biogenic amine receptor	0.003	0.0279	0.0279
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0035	0.0373	0.0058
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0052	0.0759	0.0759
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0279	0.0151
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0279	0.0151
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0035	0.0373	0.0373
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0279	0.0176
Brugia malayi	RE15519p	0.003	0.0279	0.0307
Onchocerca volvulus		0.003	0.0279	0.0287
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0279	0.0151
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0035	0.0373	0.041
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0035	0.0373	0.0373
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0373	0.0373
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0025	0.0165	0.0035
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0035	0.0373	0.9604
Brugia malayi	larval opioid receptor	0.003	0.0279	0.0307
Echinococcus granulosus	lamin dm0	0.0024	0.013	0.013
Leishmania major	C-8 sterol isomerase-like protein	0.0425	0.9108	1
Echinococcus granulosus	fmrfamide receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0279	0.0151
Echinococcus granulosus	g protein coupled receptor	0.003	0.0279	0.0279
Brugia malayi	Dopamine receptor	0.003	0.0279	0.0307
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0279	0.0151
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0279	0.0151
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0116	0.2203	0.2203
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0035	0.0373	0.0246
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Onchocerca volvulus		0.003	0.0279	0.0287
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Entamoeba histolytica	hypothetical protein	0.0033	0.0336	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0373	0.0058
Loa Loa (eye worm)	intermediate filament protein	0.0024	0.013	0.0011
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0425	0.9108	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0279	0.0151
Echinococcus multilocularis	serotonin receptor	0.003	0.0279	0.0151
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0279	0.0176
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0052	0.0759	0.0759
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0035	0.0373	0.0281
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0279	0.0279
Schistosoma mansoni	histamine h1 receptor	0.003	0.0279	0.0279
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0208	0.4268	0.4268
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0035	0.0373	0.0058
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0279	0.0279
Echinococcus granulosus	neuropeptide receptor	0.003	0.0279	0.0279
Echinococcus granulosus	Ion_trans_N domain containing protein	0.0129	0.2488	0.2488
Schistosoma mansoni	voltage-gated potassium channel	0.0226	0.467	0.467
Schistosoma mansoni	amine GPCR	0.003	0.0279	0.0279
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0279	0.0279
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0279	0.0151
Schistosoma mansoni	vesicular acetylcholine transporter	0.0255	0.5308	0.5308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Echinococcus multilocularis	somatostatin receptor	0.003	0.0279	0.0151
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0279	0.0151
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0035	0.0373	0.0246
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0024	0.013	0.0011
Echinococcus granulosus	geminin	0.0148	0.2918	0.2918
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0373	0.9071
Brugia malayi	Pre-SET motif family protein	0.0025	0.0165	0.0181
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0425	0.9108	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0279	0.0279
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0035	0.0373	0.0373
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0279	0.0279
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0116	0.2203	0.2317
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0279	0.0151
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Leishmania major	protein kinase, putative	0.0035	0.0373	0.0058
Schistosoma mansoni	voltage-gated potassium channel	0.007	0.1161	0.1161
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0208	0.4268	0.4192
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0279	0.0176
Schistosoma mansoni	voltage-gated potassium channel	0.0226	0.467	0.467
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0279	0.0151
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0259	0.5395	0.5395
Echinococcus granulosus	allatostatin A receptor	0.003	0.0279	0.0279
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0025	0.0165	0.0165
Schistosoma mansoni	inositol monophosphatase	0.0032	0.0322	0.0322
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0279	0.0151
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0279	0.0307
Onchocerca volvulus		0.003	0.0279	0.0287
Onchocerca volvulus		0.0201	0.4096	0.7658
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0279	0.0151
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0279	0.0151
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Brugia malayi	Inositol-1	0.0032	0.0322	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0425	0.9108	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	hypothetical protein	0.003	0.0279	0.0279
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0259	0.5395	0.5395
Schistosoma mansoni	voltage-gated potassium channel	0.007	0.1161	0.1161
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0116	0.2203	0.2203
Schistosoma mansoni	hypothetical protein	0.0148	0.2918	0.2918
Onchocerca volvulus		0.003	0.0279	0.0287
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0279	0.0279
Echinococcus granulosus	somatostatin receptor	0.003	0.0279	0.0279
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0279	0.0176
Trypanosoma cruzi	cAMP response protein 1, putative	0.0035	0.0373	0.0058
Loa Loa (eye worm)	MH2 domain-containing protein	0.0098	0.1791	0.1859
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0464	1	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0052	0.0759	0.0637
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0035	0.0373	0.0373
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Brugia malayi	Egg laying defective protein 4	0.0035	0.0373	0.041
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0279	0.0151
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0035	0.0373	0.0373
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Echinococcus granulosus	neuropeptide receptor	0.003	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0279	0.0279
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0279	0.0279
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0279	0.0176
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0279	0.0151
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0279	0.0151
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0279	0.0307
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0035	0.0373	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0035	0.0373	0.041
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0035	0.0373	0.0373
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus granulosus	orexin receptor type 2	0.003	0.0279	0.0279
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0279	0.0279
Schistosoma mansoni	adenoreceptor	0.003	0.0279	0.0279
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0279	0.0176
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0279	0.0151
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0279	0.0307
Schistosoma mansoni	inositol monophosphatase	0.0032	0.0322	0.0322
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0279	0.0279
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0279	0.0176
Onchocerca volvulus		0.0025	0.0165	0.0067
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus multilocularis	sex peptide receptor	0.003	0.0279	0.0151
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0191	0.3882	0.9478
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0279	0.0307
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Schistosoma mansoni	opsin-like receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0052	0.0759	0.0637
Schistosoma mansoni	hypothetical protein	0.0035	0.0373	0.0373
Entamoeba histolytica	hypothetical protein	0.0033	0.0336	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	neuropeptide receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0033	0.0336	0.0208
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0279	0.0151
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0259	0.5395	0.5334
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0279	0.0279
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0279	0.0307
Treponema pallidum	catabolite gene activator	0.0035	0.0373	0.5
Plasmodium falciparum	cGMP-dependent protein kinase	0.0035	0.0373	0.5
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0035	0.0373	0.9604
Schistosoma mansoni	hypothetical protein	0.003	0.0279	0.0279
Leishmania major	protein kinase A regulatory subunit, putative	0.0035	0.0373	0.0058
Onchocerca volvulus		0.003	0.0279	0.0287
Mycobacterium ulcerans	transcriptional regulatory protein	0.0035	0.0373	0.9071
Loa Loa (eye worm)	hypothetical protein	0.0024	0.013	0.0011
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0279	0.0279
Brugia malayi	intermediate filament protein	0.0024	0.013	0.0143
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0279	0.0279
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0279	0.0279
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0035	0.0373	0.041
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0373	0.0373
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0279	0.0151
Brugia malayi	G-protein coupled receptor	0.003	0.0279	0.0307
Echinococcus granulosus	g protein coupled receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0279	0.0151
Schistosoma mansoni	amine GPCR	0.003	0.0279	0.0279
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0279	0.0151
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0029	0.0246	0.6596
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0035	0.0373	0.0373
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0035	0.0373	0.0246
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0035	0.0373	0.0058
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	hypothetical protein	0.003	0.0279	0.0279
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0035	0.0373	0.0911
Brugia malayi	Melatonin receptor type 1A	0.003	0.0279	0.0307
Brugia malayi	G protein-coupled receptor	0.003	0.0279	0.0307
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.0279	0.0287
Treponema pallidum	cyclic nucleotide binding protein	0.0035	0.0373	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Trypanosoma cruzi	Flagellar Member 6	0.0035	0.0373	0.0058
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0373	0.9604
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0035	0.0373	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	intermediate filament proteins	0.0024	0.013	0.013
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0035	0.0373	1
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Trypanosoma brucei	cAMP response protein 1, putative	0.0035	0.0373	0.041
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0035	0.0373	0.0373
Echinococcus granulosus	hyperpolarization activated cyclic	0.0259	0.5395	0.5395
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Brugia malayi	Serotonin receptor	0.003	0.0279	0.0307
Schistosoma mansoni	amine GPCR	0.003	0.0279	0.0279
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0279	0.0151
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0116	0.2203	0.2203
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.0279	0.0279
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0035	0.0373	0.9604
Brugia malayi	MH2 domain containing protein	0.0098	0.1791	0.1967
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0025	0.0165	0.0165
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0279	0.0279
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Schistosoma mansoni	neuropeptide receptor	0.003	0.0279	0.0279
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0208	0.4268	0.4615
Trichomonas vaginalis	inositol monophosphatase, putative	0.0032	0.0322	0.0786
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0279	0.0279
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0035	0.0373	0.041
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0373	0.0911
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0052	0.0759	0.071
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0279	0.0151
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	biogenic amine receptor	0.003	0.0279	0.0279
Schistosoma mansoni	lamin	0.0024	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3493	0.3752
Schistosoma mansoni	neuropeptide receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0035	0.0373	0.0246
Echinococcus granulosus	serotonin receptor	0.003	0.0279	0.0279
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0025	0.0165	0.0165
Echinococcus granulosus	intermediate filament protein	0.0024	0.013	0.013
Trypanosoma cruzi	cAMP response protein 1	0.0035	0.0373	0.0058
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0255	0.5308	0.5772
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0035	0.0373	0.0373
Schistosoma mansoni	60S ribosomal protein L21	0.0035	0.0386	0.0386
Mycobacterium ulcerans	transmembrane transport protein	0.0035	0.0378	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0176	0.355	0.3815
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0279	0.0279
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0035	0.0373	0.0373
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0035	0.0373	0.0058
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0279	0.0176
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0279	0.0307
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0279	0.0151
Trypanosoma brucei	Flagellar Member 6	0.0035	0.0373	0.041
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0259	0.5395	0.5395
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0259	0.5395	0.5334
Schistosoma mansoni	transcription factor LCR-F1	0.0033	0.0336	0.0336
Echinococcus granulosus	inositol monophosphatase 1	0.0032	0.0322	0.0322
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0052	0.0759	0.0833
Echinococcus granulosus	cGMP dependent protein kinase	0.0035	0.0373	0.0373
Leishmania major	hypothetical protein, conserved	0.0035	0.0373	0.0058
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0279	0.0151
Leishmania major	hypothetical protein, conserved	0.0035	0.0373	0.0058
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0052	0.0759	0.071
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0373	0.9071
Echinococcus multilocularis	hypothetical protein	0.0129	0.2488	0.2389
Echinococcus granulosus	hyperpolarization activated cyclic	0.0259	0.5395	0.5395
Onchocerca volvulus		0.003	0.0279	0.0287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0279	0.0151
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0279	0.0279
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0279	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0373	0.0281
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0025	0.0165	0.0165
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0464	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0279	0.0279
Treponema pallidum	cyclic nucleotide binding protein	0.0035	0.0373	0.5
Schistosoma mansoni	amine GPCR	0.003	0.0279	0.0279
Onchocerca volvulus		0.003	0.0279	0.0287
Loa Loa (eye worm)	hypothetical protein	0.007	0.1161	0.1157
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Brugia malayi	N-terminal motif family protein	0.0035	0.0373	0.041
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0279	0.0279
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0116	0.2203	0.2203
Loa Loa (eye worm)	hypothetical protein	0.003	0.0279	0.0176
Onchocerca volvulus		0.0035	0.0373	0.0468
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0279	0.0176
Loa Loa (eye worm)	transcription factor SMAD2	0.0098	0.1791	0.1859
Brugia malayi	Pre-SET motif family protein	0.0176	0.355	0.3897
Brugia malayi	hypothetical protein	0.003	0.0279	0.0307
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0035	0.0373	0.0246

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3247915

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1894023