Detailed information for compound 1908992

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 387.225 | Formula: C15H19Cl2F3N2O2
  • H donors: 2 H acceptors: 1 LogP: 4.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)C(=O)NCC1CCCCN1)OCC(F)(F)F.Cl
  • InChi: 1S/C15H18ClF3N2O2.ClH/c16-10-4-5-13(23-9-15(17,18)19)12(7-10)14(22)21-8-11-3-1-2-6-20-11;/h4-5,7,11,20H,1-3,6,8-9H2,(H,21,22);1H
  • InChiKey: QSDWSJQCWSQFIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Furin 1 0.0019 0.0029 0.0029
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0019 0.0029 0.0029
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0052 0.2866
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Mycobacterium tuberculosis Conserved protein 0.0038 0.014 0.1045
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0027 0.0077 0.0222
Trypanosoma cruzi subtilisin peptidase 0.0019 0.0029 0.2003
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0077 0.0542
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.014 0.1045
Echinococcus granulosus ubiquitin specific protease 41 0.0027 0.0077 0.0077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Mycobacterium leprae Probable lipase LipE 0.0038 0.014 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0019 0.0029 0.0084
Toxoplasma gondii ABC1 family protein 0.0038 0.014 0.7849
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.014 0.0403
Loa Loa (eye worm) beta-lactamase 0.0038 0.014 0.0403
Brugia malayi Cytochrome P450 family protein 0.0052 0.0222 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.001
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0019 0.0029 0.0084
Loa Loa (eye worm) cytochrome P450 0.0014 0.0001 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0222 0.064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0084
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1735 1 1
Loa Loa (eye worm) proprotein convertase 2 0.0019 0.0029 0.0084
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0019 0.0029 0.2003
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0052 0.3652
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0052 0.3652
Toxoplasma gondii subtilisin SUB12 0.0019 0.0029 0.1572
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.014 0.1243
Brugia malayi Calcitonin receptor-like protein seb-1 0.0037 0.0132 0.038
Mycobacterium ulcerans lipase LipD 0.0038 0.014 0.7849
Toxoplasma gondii subtilisin SUB7 0.0019 0.0029 0.1572
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.1938
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.02 0.0575
Toxoplasma gondii subtilisin SUB6 0.0019 0.0029 0.1572
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0019 0.0029 0.1572
Toxoplasma gondii subtilisin SUB2 0.0019 0.0029 0.1572
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0028 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.014 0.1243
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0052 0.015
Brugia malayi Pre-SET motif family protein 0.0153 0.0807 0.2323
Trichomonas vaginalis set domain proteins, putative 0.0174 0.093 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0022 0.0047 0.0047
Brugia malayi neuroendocrine convertase 1 precursor 0.0019 0.0029 0.0084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0423 0.2378 0.6844
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0019 0.0029 0.0209
Entamoeba histolytica hypothetical protein 0.0036 0.0128 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.014 0.1243
Brugia malayi beta-lactamase 0.0038 0.014 0.0403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Mycobacterium tuberculosis Conserved protein 0.0038 0.014 0.1045
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0019 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.014 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0028 0.1938
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0027 0.0077 0.0222
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0019 0.0029 0.2003
Trypanosoma brucei subtilisin peptidase 0.0019 0.0029 0.2003
Plasmodium vivax subtilisin-like serine protease, putative 0.0019 0.0029 0.008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0077 0.0542
Schistosoma mansoni hypothetical protein 0.0179 0.0959 0.276
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0128 0.0367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.02 0.02
Schistosoma mansoni hypothetical protein 0.0036 0.0128 0.0367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.02 0.0575
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0027 0.0077 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.014 0.1045
Brugia malayi endoprotease bli-4 precursor 0.0019 0.0029 0.0084
Mycobacterium leprae Possible secreted protease 0.0019 0.0029 0.2003
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0028 0.0081
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0229 0.125 0.125
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0027 0.0077 0.4911
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0019 0.0029 0.1572
Onchocerca volvulus 0.0019 0.0029 0.0312
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0019 0.0029 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.014 0.014
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0028 0.5
Leishmania major cytochrome p450-like protein 0.0023 0.0052 0.2866
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.133 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0001 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0077 0.5453
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0028 0.1521
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0019 0.0029 0.1572
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0047 0.0047
Brugia malayi latrophilin 2 splice variant baaae 0.0025 0.0065 0.0186
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0077 0.0222
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.0178 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0077 0.5453
Echinococcus multilocularis Furin 1 0.0019 0.0029 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.0178 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0028 0.0203
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0052 0.015
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0229 0.125 0.125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0084
Plasmodium vivax SET domain protein, putative 0.0022 0.0047 0.1645
Brugia malayi hypothetical protein 0.0036 0.0128 0.0367
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Entamoeba histolytica hypothetical protein 0.0036 0.0128 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.014 0.0403
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0081
Brugia malayi celfurPC protein 0.0019 0.0029 0.0084
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0028 0.5
Brugia malayi beta-lactamase family protein 0.0038 0.014 0.0403
Toxoplasma gondii exonuclease III APE 0.0019 0.0028 0.1521
Toxoplasma gondii subtilisin SUB5 0.0019 0.0029 0.1572
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0047 0.0134
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0403
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0019 0.0029 0.2003
Loa Loa (eye worm) endoprotease bli-4 0.0019 0.0029 0.0084
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0028 0.0081
Schistosoma mansoni cytochrome P450 0.0014 0.0001 0.0004
Echinococcus multilocularis membrane bound transcription factor site 1 0.0019 0.0029 0.0029
Toxoplasma gondii subtilisin SUB1 0.0019 0.0029 0.1572
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Mycobacterium tuberculosis Conserved protein 0.0038 0.014 0.1045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0077 0.0222
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0403
Onchocerca volvulus 0.0038 0.014 0.1508
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0027 0.0077 0.428
Echinococcus granulosus membrane bound transcription factor site 1 0.0019 0.0029 0.0029
Echinococcus multilocularis neuroendocrine convertase 2 0.0019 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.02 0.02
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0077 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.014 0.7849
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Toxoplasma gondii subtilisin SUB8 0.0019 0.0029 0.1572
Schistosoma mansoni aldehyde dehydrogenase 0.0045 0.0178 0.0513
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0128 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.02 0.0575
Leishmania major subtilisin-like serine peptidase 0.0019 0.0029 0.1572
Schistosoma mansoni site-1 peptidase (S08 family) 0.0019 0.0029 0.0084
Entamoeba histolytica hypothetical protein 0.0036 0.0128 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0019 0.0029 0.0209
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0019 0.0029 0.2003
Plasmodium vivax hypothetical protein, conserved 0.0038 0.014 1
Onchocerca volvulus 0.0174 0.093 1
Plasmodium falciparum subtilisin-like protease 1 0.0019 0.0029 1
Plasmodium vivax subtilisin-like protease 2, putative 0.0019 0.0029 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.014 0.1243
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0045 0.0178 0.0178
Trichomonas vaginalis esterase, putative 0.0038 0.014 0.1243
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0153 0.0807 0.2323
Schistosoma mansoni aldehyde dehydrogenase 0.0045 0.0178 0.0513
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0047 0.0134
Toxoplasma gondii subtilisin SUB4 0.0019 0.0029 0.1572
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.014 0.1045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Onchocerca volvulus 0.0022 0.0047 0.0501
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0423 0.2378 0.6844
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.014 0.0403
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.014 0.1243
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.014 0.1045
Schistosoma mansoni hypothetical protein 0.0025 0.0065 0.0186
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Schistosoma mansoni furin-1 (S08 family) 0.0019 0.0029 0.0084
Toxoplasma gondii subtilisin SUB9 0.0019 0.0029 0.1572
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Echinococcus multilocularis 0.0019 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.0542
Loa Loa (eye worm) hypothetical protein 0.0025 0.0065 0.0186
Plasmodium vivax subtilisin-like protease 1 0.0019 0.0029 0.008
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.014 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.014 1
Plasmodium falciparum subtilisin-like protease 3 0.0019 0.0029 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0019 0.0029 0.0209
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.02 0.0575
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Onchocerca volvulus 0.0038 0.014 0.1508
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0045 0.0178 0.0178
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0612 0.3474 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.014 1
Loa Loa (eye worm) subtilase 0.0612 0.3474 1
Toxoplasma gondii aldehyde dehydrogenase 0.0045 0.0178 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.02 0.0575
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.014 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.02 0.02
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0019 0.0029 0.0084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0423 0.2378 0.2378
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.4614 0.4614
Echinococcus multilocularis 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0403
Brugia malayi Subtilase family protein 0.0612 0.3474 1
Schistosoma mansoni hypothetical protein 0.0179 0.0959 0.276
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0019 0.0029 0.0209
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0052 0.3652
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0128 0.0128
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0423 0.2378 0.6844
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0052 0.015
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0019 0.0029 0.0084
Brugia malayi beta-lactamase family protein 0.0038 0.014 0.0403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.014 0.1045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0037 0.0132 0.038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0028 0.1521
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0047 0.2562
Echinococcus granulosus furin 0.0019 0.0029 0.0029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0042 0.0042
Onchocerca volvulus 0.0038 0.014 0.1508
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0077 0.5453
Echinococcus multilocularis ubiquitin specific protease 41 0.0027 0.0077 0.0077
Brugia malayi proprotein convertase 2 0.0019 0.0029 0.0084
Mycobacterium ulcerans beta-lactamase 0.0038 0.014 0.7849
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.014 0.1045
Toxoplasma gondii subtilisin SUB11 0.0019 0.0029 0.1572
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.02 0.02
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.014 0.0403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Brugia malayi Pre-SET motif family protein 0.0022 0.0047 0.0134
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.014 0.1045
Entamoeba histolytica hypothetical protein 0.0036 0.0128 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0019 0.0029 0.0084
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0019 0.0029 0.2003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.014 0.7849
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0081
Echinococcus multilocularis geminin 0.0179 0.0959 0.0959
Echinococcus granulosus neuroendocrine convertase 2 0.0019 0.0029 0.0029
Toxoplasma gondii subtilisin SUB10 0.0019 0.0029 0.1572
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0423 0.2378 0.2378
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0403
Mycobacterium ulcerans hypothetical protein 0.0038 0.014 0.7849
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0045 0.0178 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.001
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0001 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0022 0.0047 0.0047
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0077 0.0077
Brugia malayi cytochrome P450 0.0014 0.0001 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0045 0.0178 0.1332
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0077 0.0077
Leishmania major hypothetical protein, conserved 0.0038 0.014 0.7849
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0037 0.0132 0.038
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0019 0.0029 0.2003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0132 0.038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0019 0.0029 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0047 0.0134
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.1938
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0403
Brugia malayi Cytochrome P450 family protein 0.0023 0.0052 0.015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0047 0.0134
Plasmodium falciparum subtilisin-like protease 2 0.0019 0.0029 1
Echinococcus granulosus geminin 0.0179 0.0959 0.0959
Brugia malayi Cytochrome P450 family protein 0.0023 0.0052 0.015

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 230 umol/Kg Antiarrhythmic activity in po dosed Swiss-Webster mouse assessed as protection against chloroform-induced ventricular fibrillation administered in 4% acacia ChEMBL. 874956

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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