TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 283.347 | Formula: C20H15N2+
H donors: 0 H acceptors: 0 LogP: 5.48 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: C[n+]1cc2c3ccc4c(n3cc2c2c1cccc2)cccc4
InChi: 1S/C20H15N2/c1-21-12-17-16(15-7-3-5-9-19(15)21)13-22-18-8-4-2-6-14(18)10-11-20(17)22/h2-13H,1H3/q+1
InChiKey: PELFHBDSKZVABF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	DIX domain containing protein	0.001	0.0005	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0054
Entamoeba histolytica	sodium/calcium exchanger protein, putative	0.0157	0.0242	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.0142	0.0142
Loa Loa (eye worm)	solute carrier family 8	0.6225	1	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0007	0.0001	0.0001
Echinococcus multilocularis	sodium:potassium:calcium exchanger	0.0157	0.0242	0.0241
Brugia malayi	Sodium/calcium exchanger protein	0.249	0.3994	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0054	0.5
Brugia malayi	steroid hormone receptor	0.0007	0.0001	0.0001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0142	0.0142
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0004	0.0004
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0062	0.0089	0.0088
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0007	0.0001	0.0001
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0035	0.0045	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0007	0.0001	0.0001
Schistosoma mansoni	dep domain containing protein	0.001	0.0005	0.0005
Schistosoma mansoni	caspase-7 (C14 family)	0.0035	0.0045	0.0045
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0039	0.0039
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0005	0.0012
Schistosoma mansoni	hypothetical protein	0.0028	0.0034	0.0034
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0001	0.0001
Onchocerca volvulus		0.0035	0.0045	0.1168
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0039	0.0038
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0054	0.0054
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0001	0.0001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0142	0.0142
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0007	0.0001	0.0001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0142	0.0142
Brugia malayi	Nuclear hormone receptor-like 1	0.0007	0.0001	0.0001
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0007	0.0001	0.0001
Echinococcus granulosus	ecdysone induced protein 78C	0.0007	0.0001	0.0001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0142	0.0142
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0007	0.0001	0.0001
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0004	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0242	0.1375
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0007	0.0001	0.0001
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0007	0.0001	0.0001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0054	0.0306
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0001	0.0001
Trichomonas vaginalis	esterase, putative	0.0041	0.0054	0.0306
Plasmodium falciparum	cation/H+ antiporter	0.0157	0.0242	0.5
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0005	0.0005
Onchocerca volvulus	Sodium\/potassium\/calcium exchanger	0.0157	0.0242	0.628
Brugia malayi	MH2 domain containing protein	0.0009	0.0004	0.0008
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0004	0.0004
Onchocerca volvulus	Protein ultraspiracle homolog	0.0007	0.0001	0.0014
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0007	0.0001	0.0001
Treponema pallidum	hypothetical protein	0.0157	0.0242	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0007	0.0001	0.0001
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0054	0.0054
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0001	0.0001
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0007	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0242	0.0241
Brugia malayi	MH1 domain containing protein	0.0009	0.0004	0.0008
Onchocerca volvulus		0.0246	0.0385	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Echinococcus granulosus	smad	0.0009	0.0004	0.0003
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0005	0.0005
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0007	0.0001	0.0001
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0215	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Brugia malayi	Pre-SET motif family protein	0.0031	0.0039	0.0096
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0007	0.0001	0.0001
Onchocerca volvulus	Cell death protein 3 homolog	0.0035	0.0045	0.1168
Brugia malayi	beta-lactamase	0.0041	0.0054	0.0134
Schistosoma mansoni	dishevelled	0.001	0.0005	0.0005
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0054	0.0054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0007	0.0001	0.0001
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0004	0.0003
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0001	0.0001
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.0142	0.0355
Echinococcus multilocularis	Smad4	0.0009	0.0004	0.0003
Loa Loa (eye worm)	Na/Ca eXchangers family member	0.0157	0.0242	0.0241
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0007	0.0001	0.0001
Echinococcus granulosus	caspase 2	0.0035	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0039	0.0038
Brugia malayi	hypothetical protein	0.001	0.0005	0.0012
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0054	0.0306
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0077	0.0077
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0054	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0007	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0005
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0005	0.0005
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0007	0.0001	0.0001
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0005	0.0005
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0055	0.0077	0.1983
Loa Loa (eye worm)	mbt repeat family protein	0.0055	0.0077	0.0076
Schistosoma mansoni	coup transcription factor	0.0007	0.0001	0.0001
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0001	0.0001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0001	0.0001
Onchocerca volvulus		0.0031	0.0039	0.0998
Brugia malayi	K+-dependent Na+/Ca+ exchanger related-protein	0.0157	0.0242	0.0604
Schistosoma mansoni	retinoic acid receptor RXR	0.0007	0.0001	0.0001
Brugia malayi	Pre-SET motif family protein	0.0216	0.0337	0.0842
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0007	0.0001	0.0001
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0004	0.0003
Brugia malayi	mbt repeat family protein	0.0055	0.0077	0.0191
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0062	0.0089	0.0089
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0001	0.0001
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0007	0.0001	0.0001
Mycobacterium ulcerans	lipase LipD	0.0041	0.0054	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Echinococcus granulosus	SAM and MBT domain containing protein	0.0055	0.0077	0.0076
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.0337	0.0336
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0055	0.0077	0.0076
Brugia malayi	Na/Ca eXchangers family member (ncx-4)	0.0157	0.0242	0.0604
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0007	0.0001	0.0001
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0054	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0242	0.0241
Mycobacterium tuberculosis	Probable ionic transporter integral membrane protein ChaA	0.0157	0.0242	0.5337
Brugia malayi	MH2 domain containing protein	0.0009	0.0004	0.0008
Brugia malayi	ecdysteroid receptor	0.0007	0.0001	0.0001
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0005	0.0012
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0005	0.0005
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0004	0.0003
Loa Loa (eye worm)	hypothetical protein	0.249	0.3994	0.3993
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0055	0.0077	0.0077
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0005	0.0005
Echinococcus multilocularis	FTZ F1 alpha	0.0007	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Brugia malayi	nuclear receptor NHR-88	0.0007	0.0001	0.0001
Onchocerca volvulus		0.0055	0.0077	0.1983
Schistosoma mansoni	potassium-dependent sodium-calcium exchanger 3 4	0.0157	0.0242	0.0242
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0005	0.0005
Echinococcus multilocularis	smad	0.0009	0.0004	0.0003
Echinococcus multilocularis	sodium calcium exchanger	0.6225	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0001	0.0001
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0037	0.0036
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0001	0.0001
Echinococcus granulosus	sodium:potassium:calcium exchanger	0.0157	0.0242	0.0241
Schistosoma mansoni	dishevelled	0.001	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0007	0.0001	0.0001
Brugia malayi	N-terminal motif family protein	0.0204	0.0318	0.0794
Mycobacterium leprae	Probable ionic transporter integral membrane protein ChaA	0.0157	0.0242	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0089	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0054
Echinococcus granulosus	histone acetyltransferase MYST2	0.0062	0.0089	0.0088
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0054	0.0306
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0054	0.0134
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0039	0.1424
Brugia malayi	hypothetical protein	0.001	0.0005	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0242	0.0241
Brugia malayi	nuclear hormone receptor	0.0007	0.0001	0.0001
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0005	0.0005
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0331	0.0522	0.0522
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0004	0.0003
Schistosoma mansoni	sodium/calcium exchanger	0.6225	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0142	0.0142
Onchocerca volvulus		0.001	0.0005	0.0121
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0054	0.0756
Loa Loa (eye worm)	transcription factor SMAD2	0.0135	0.0206	0.0206
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0007	0.0001	0.0001
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0005	0.0005
Brugia malayi	Smad1	0.0009	0.0004	0.0008
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0005	0.0005
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0001	0.0001
Brugia malayi	Steroid receptor seven-up type 2	0.0007	0.0001	0.0001
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0007	0.0001	0.0001
Echinococcus granulosus	apoptotic protease activating factor 1	0.0035	0.0045	0.0045
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.1098	0.1755	1
Leishmania major	hypothetical protein, conserved	0.0041	0.0054	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0054	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0054	0.0054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0007	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0039	0.0039
Loa Loa (eye worm)	steroid hormone receptor	0.0007	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0062	0.0089	0.0088
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0005	0.0121
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0007	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0039	0.0039
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0007	0.0001	0.0001
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0007	0.0001	0.0001
Onchocerca volvulus		0.0041	0.0054	0.1397
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0242	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0215	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0005
Loa Loa (eye worm)	MH2 domain-containing protein	0.0135	0.0206	0.0206
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0001	0.0001
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0077	0.0077
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0054	0.0306
Toxoplasma gondii	manganese resistance 1 protein, putative	0.0157	0.0242	1
Plasmodium vivax	cation/H+ antiporter, putative	0.0157	0.0242	1
Loa Loa (eye worm)	MBCTL1	0.0062	0.0089	0.0088
Brugia malayi	mbt repeat family protein	0.0055	0.0077	0.0191
Toxoplasma gondii	ABC1 family protein	0.0041	0.0054	0.2073
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0259	0.0406	1
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0005	0.0012
Brugia malayi	Cell death protein 3 precursor	0.0035	0.0045	0.0112
Brugia malayi	small heat shock protein	0.0571	0.0907	0.227
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0004	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0062	0.0089	0.0088
Brugia malayi	beta-lactamase family protein	0.0041	0.0054	0.0134
Brugia malayi	hypothetical protein	0.0035	0.0045	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0077	0.0076
Schistosoma mansoni	na/ca exchanger	0.0157	0.0242	0.0242
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0001	0.0001
Schistosoma mansoni	ras GTP exchange factor	0.0007	0.0001	0.0001
Brugia malayi	MH2 domain containing protein	0.0135	0.0206	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0571	0.0907	0.0906
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0039	0.0039
Echinococcus granulosus	Smad4	0.0009	0.0004	0.0003
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0005	0.0005
Onchocerca volvulus		0.0041	0.0054	0.1397
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0054	0.5
Echinococcus granulosus	polycomb protein SCMH1	0.0055	0.0077	0.0076
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0054	0.0306
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0039	0.0038
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0007	0.0001	0.0001
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.1098	0.1755	1
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0004	0.0004
Brugia malayi	beta-lactamase family protein	0.0041	0.0054	0.0134
Echinococcus granulosus	sodium:potassium:calcium exchanger 6	0.0157	0.0242	0.0241
Echinococcus granulosus	FTZ F1 alpha	0.0007	0.0001	0.0001
Echinococcus multilocularis	polycomb protein SCMH1	0.0055	0.0077	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0318	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0054
Schistosoma mansoni	Smad4	0.0009	0.0004	0.0004
Onchocerca volvulus		0.0007	0.0001	0.0014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0142	0.0142
Echinococcus multilocularis	ecdysone induced protein 78C	0.0007	0.0001	0.0001
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0062	0.0089	0.0221
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0054	0.0054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0142	0.0142
Brugia malayi	photoreceptor-specific nuclear receptor	0.0007	0.0001	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0242	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0054
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.0385	0.2189
Schistosoma mansoni	hypothetical protein	0.0035	0.0045	0.0045
Brugia malayi	MH1 domain containing protein	0.0009	0.0004	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0007	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0007	0.0001	0.0001
Echinococcus multilocularis	sodium:potassium:calcium exchanger 6	0.0157	0.0242	0.0241
Schistosoma mansoni	hypothetical protein	0.0157	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0054
Onchocerca volvulus		0.0041	0.0054	0.1397
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0007	0.0001	0.0001
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0007	0.0001	0.0014
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0005	0.0005
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0054	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0007	0.0001	0.0001
Schistosoma mansoni	smad	0.0009	0.0004	0.0004
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0039	0.0038
Onchocerca volvulus	Bile acid receptor homolog	0.0007	0.0001	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0007	0.0001	0.0001
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0005	0.0005
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0204	0.0318	0.8253
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0005
Echinococcus multilocularis	caspase 2	0.0035	0.0045	0.0045
Schistosoma mansoni	potassium-dependent sodium-calcium exchanger 3 4	0.0157	0.0242	0.0242
Loa Loa (eye worm)	Smad1	0.0009	0.0004	0.0003
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0054	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0001	0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3558690

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1939213