Detailed information for compound 1942918

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 620.857 | Formula: C36H60O8
  • H donors: 6 H acceptors: 6 LogP: 5.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](O[C@H]2CC[C@]3([C@H](C2(C)C)[C@@H](O)C[C@@]2([C@@H]3C[C@@H](O)[C@H]3[C@@]2(C)CC[C@@H]3/C(=C/CC=C(C)C)/C)C)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C36H60O8/c1-19(2)10-9-11-20(3)21-12-15-35(7)27(21)22(38)16-25-34(6)14-13-26(33(4,5)31(34)23(39)17-36(25,35)8)44-32-30(42)29(41)28(40)24(18-37)43-32/h10-11,21-32,37-42H,9,12-18H2,1-8H3/b20-11+/t21-,22-,23+,24-,25-,26+,27+,28-,29+,30-,31+,32+,34-,35-,36-/m1/s1
  • InChiKey: STGSRVGAMRCRDT-QWPWDPHFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis RUN 0.0019 0.0085 0.0155
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0417 0.0804
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0144 0.0352
Schistosoma mansoni glucose transport protein 0.011 0.2116 0.5181
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.2231 0.4098
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Leishmania major glucose transporter, lmgt1 0.0034 0.0417 0.1658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0351 0.0577
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0351 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0835 0.1534
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0569 0.0569
Loa Loa (eye worm) hypothetical protein 0.0031 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 1
Schistosoma mansoni hypothetical protein 0.0053 0.0835 0.2044
Leishmania major glucose transporter, lmgt3 0.0034 0.0417 0.1658
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0288 0.2172
Trypanosoma brucei glucosidase, putative 0.0041 0.0569 0.4297
Schistosoma mansoni biogenic amine receptor 0.0022 0.0144 0.0352
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0243 0.1836
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi hypothetical protein 0.0017 0.0034 0.0063
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0162 0.5
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0162 0.0396
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.0637 0.0684
Brugia malayi ORL1-like opioid receptor 0.0022 0.0144 0.0264
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0022 0.0144 0.0277
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0144 0.0144
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0288 0.1142
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0144 0.0352
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 0.526
Loa Loa (eye worm) hypothetical protein 0.0058 0.0957 0.0957
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0032 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.1325 0.2433
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0144 0.0264
Schistosoma mansoni alpha-glucosidase 0.0159 0.3204 0.7846
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0417 0.0804
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0144 0.0264
Brugia malayi Inositol-1 0.0075 0.1325 0.2433
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0044 0.0637 0.1124
Onchocerca volvulus Huntingtin homolog 0.0135 0.2654 0.5111
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0569 0.4297
Brugia malayi Melatonin receptor type 1A 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0351 0.0577
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0066 0.0066
Echinococcus granulosus endoplasmin 0.0028 0.0288 0.0528
Onchocerca volvulus 0.0022 0.0144 0.0277
Loa Loa (eye worm) endoplasmin 0.0036 0.045 0.045
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0099 0.0191
Echinococcus granulosus survival motor neuron protein 1 0.026 0.5445 1
Echinococcus multilocularis serotonin receptor 0.0022 0.0144 0.0264
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0351 0.0377
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Loa Loa (eye worm) hypothetical protein 0.0031 0.0337 0.0337
Plasmodium vivax endoplasmin, putative 0.0036 0.045 0.0483
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0288 0.1902
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.115 1
Schistosoma mansoni opsin-like receptor 0.0022 0.0144 0.0352
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.1325 0.2551
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0595 0.1146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0144 0.0264
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0071 0.0538
Echinococcus multilocularis musashi 0.0032 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.0135 0.2654 0.2654
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0545 0.1001
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0308 0.0565
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0144 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0085 0.0091
Brugia malayi hypothetical protein 0.004 0.0535 0.0982
Brugia malayi Endoplasmin precursor 0.0036 0.045 0.0826
Trichomonas vaginalis set domain proteins, putative 0.0248 0.5193 1
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0144 0.0264
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0351 0.0377
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0144 0.0352
Brugia malayi Cytochrome P450 family protein 0.0018 0.0049 0.0091
Brugia malayi Carboxylesterase family protein 0.0066 0.1123 0.2062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0066 0.0122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0307 0.0307
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0144 0.0352
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0044 0.0637 0.4811
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0352 0.0861
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0337 0.1503
Onchocerca volvulus 0.0022 0.0144 0.0277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.2518 1
Brugia malayi exodeoxyribonuclease III family protein 0.0044 0.0637 0.117
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0417 0.0804
Echinococcus multilocularis serotonin receptor 0.0022 0.0144 0.0264
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Onchocerca volvulus 0.0022 0.0144 0.0277
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0049 0.0049
Brugia malayi neuropeptide F receptor 0.0022 0.0144 0.0264
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0308 0.0565
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.115 0.2028
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0144 0.0352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi Pre-SET motif family protein 0.0031 0.0352 0.0646
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.2518 0.4625
Schistosoma mansoni inositol monophosphatase 0.0075 0.1325 0.3243
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.3779 0.694
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0595 0.1146
Entamoeba histolytica protein kinase, putative 0.0031 0.0351 0.1625
Onchocerca volvulus 0.0022 0.0144 0.0277
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0142 0.0274
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0144 0.0144
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Brugia malayi AKH receptor 0.0022 0.0144 0.0264
Brugia malayi Dopamine receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0144 0.0264
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.2518 0.4625
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0144 0.0264
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0144 0.0352
Schistosoma mansoni rab6-interacting 0.0019 0.0085 0.0207
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0569 0.1096
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0162 0.0297
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.045 0.3395
Echinococcus granulosus orexin receptor type 2 0.0022 0.0144 0.0264
Plasmodium falciparum protein kinase 7 0.0288 0.6085 0.6533
Echinococcus granulosus g protein coupled receptor 0.0022 0.0144 0.0264
Schistosoma mansoni hypothetical protein 0.0019 0.0085 0.0207
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0085
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0144 0.0264
Echinococcus granulosus lamin 0.0032 0.0359 0.0659
Echinococcus granulosus neuropeptide receptor 0.0022 0.0144 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0352 0.0861
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0595 0.1093
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.045 0.3395
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0049 0.0049
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0144 0.0277
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0044 0.0637 0.2531
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0162 0.1222
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Schistosoma mansoni rab6-interacting 0.0019 0.0085 0.0207
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0049 0.0372
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.3779 0.694
Toxoplasma gondii ABC1 family protein 0.0042 0.0595 0.0978
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0352 0.0861
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi hypothetical protein 0.0135 0.2654 0.4874
Onchocerca volvulus 0.0107 0.204 0.3928
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Schistosoma mansoni alpha-glucosidase 0.0159 0.3204 0.7846
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0359 0.0359
Brugia malayi beta-lactamase 0.0042 0.0595 0.1093
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0144 0.0264
Schistosoma mansoni myosin xvIII 0.0022 0.0144 0.0352
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0595 0.105
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Onchocerca volvulus 0.0022 0.0144 0.0277
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0022 0.0144 0.0277
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Echinococcus granulosus acetylcholinesterase 0.0066 0.1123 0.2062
Echinococcus multilocularis lamin 0.0032 0.0359 0.0659
Onchocerca volvulus 0.0042 0.0595 0.1146
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Brugia malayi Sugar transporter family protein 0.011 0.2116 0.3886
Mycobacterium ulcerans lipase LipD 0.0042 0.0595 0.2364
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.1325 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis geminin 0.0199 0.4084 0.7501
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0144 0.0264
Brugia malayi putative neuropeptide receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0288 0.2172
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0144 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0569 0.4297
Mycobacterium tuberculosis Conserved protein 0.0042 0.0595 0.105
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0144 0.0264
Leishmania major glucose transporter, lmgt2 0.0034 0.0417 0.1658
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.1123 0.1123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0144 0.0264
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0142 0.0274
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0243 0.1836
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma brucei glucose transporter 2A 0.0034 0.0417 0.3151
Loa Loa (eye worm) hypothetical protein 0.0023 0.0162 0.0162
Brugia malayi GnHR receptor homolog 0.0022 0.0144 0.0264
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0359 0.0359
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Loa Loa (eye worm) heat shock protein 90 0.0036 0.045 0.045
Brugia malayi hypothetical protein 0.0019 0.0085 0.0155
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0144 0.0352
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0351 0.0577
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0144 0.0264
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0595 0.2364
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Echinococcus granulosus sex peptide receptor 0.0022 0.0144 0.0264
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.045 0.1786
Schistosoma mansoni lipoxygenase 0.0116 0.2231 0.5463
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0595 0.105
Loa Loa (eye worm) sugar transporter 0.011 0.2116 0.2116
Echinococcus multilocularis heat shock protein 0.0036 0.045 0.0826
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0144 0.0144
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.045 0.3396
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0352 0.0578
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3332 0.3577
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.2231 0.4098
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.1325 0.2551
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0595 0.1146
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0595 0.1146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0351 0.0351
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Toxoplasma gondii exonuclease III APE 0.0044 0.0637 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2116 0.4075
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.2518 0.6165
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0569 0.226
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0351 0.0351
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.045 0.3396
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.045 0.3395
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.2518 0.4138
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0144 0.0264
Schistosoma mansoni ap endonuclease 0.0044 0.0637 0.156
Echinococcus granulosus intermediate filament protein 0.0032 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus RUN 0.0019 0.0085 0.0155
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.0637 0.1227
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0351 0.2648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Loa Loa (eye worm) hypothetical protein 0.0135 0.2654 0.2654
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0144 0.0264
Schistosoma mansoni hypothetical protein 0.0051 0.0784 0.192
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Echinococcus multilocularis somatostatin receptor 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0032 0.0359 0.0691
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0351 0.0675
Loa Loa (eye worm) hypothetical protein 0.0066 0.1123 0.1123
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0144 0.0264
Echinococcus granulosus g protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1123 0.2062
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0144 0.0352
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0144 0.0264
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0359 0.0659
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.2116 0.3886
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3332 0.3577
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0351 0.0644
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0144 0.0264
Schistosoma mansoni inositol monophosphatase 0.0075 0.1325 0.3243
Onchocerca volvulus Huntingtin homolog 0.0135 0.2654 0.5111
Schistosoma mansoni heat shock protein 0.0036 0.045 0.1101
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0595 0.0639
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0352 0.0646
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0162 0.0643
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.045 0.3395
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0595 0.105
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis lamin dm0 0.0032 0.0359 0.0659
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni intermediate filament proteins 0.0032 0.0359 0.0879
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0595 0.4493
Loa Loa (eye worm) hypothetical protein 0.0118 0.2284 0.2284
Treponema pallidum exodeoxyribonuclease (exoA) 0.0044 0.0637 1
Onchocerca volvulus 0.0032 0.0359 0.0691
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0144 0.0144
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0337 0.0618
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Echinococcus granulosus g protein coupled receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.026 0.5445 0.5445
Echinococcus granulosus hypothetical protein 0.0022 0.0144 0.0264
Echinococcus multilocularis transcription factor eb 0.0119 0.2297 0.4219
Schistosoma mansoni loxhd1 0.0019 0.0085 0.0207
Onchocerca volvulus 0.0022 0.0144 0.0277
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.004 0.0545 0.1334
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0144 0.0264
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.1325 0.2433
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0144 0.0264
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0144 0.0264
Trichomonas vaginalis esterase, putative 0.0042 0.0595 0.1146
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Echinococcus multilocularis General substrate transporter 0.0095 0.177 0.3251
Schistosoma mansoni adenoreceptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0026 0.0243 0.0243
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0144 0.0264
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0162 0.0174
Onchocerca volvulus 0.0042 0.0595 0.1146
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0162 0.0297
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0144 0.0144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0044 0.0637 0.117
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.045 0.2476
Plasmodium vivax hexose transporter 0.011 0.2116 0.2272
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0569 0.1096
Schistosoma mansoni lamin 0.0032 0.0359 0.0879
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Mycobacterium leprae Probable lipase LipE 0.0042 0.0595 0.4791
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus fmrfamide receptor 0.0022 0.0144 0.0264
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0957 0.1758
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0144 0.0264
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0352 0.0646
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0569 0.1045
Schistosoma mansoni glucose transport protein 0.011 0.2116 0.5181
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus granulosus transcription factor eb 0.0119 0.2297 0.4219
Brugia malayi hypothetical protein 0.026 0.5445 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0085 0.015
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 0.9314 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2311 0.2311
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0085 0.0155
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0351 0.0351
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.2518 1
Brugia malayi Cytochrome P450 family protein 0.0018 0.0049 0.0091
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Schistosoma mansoni alpha glucosidase 0.0041 0.0569 0.1393
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0337 0.5282
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0595 0.1093
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0569 0.1096
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0595 0.2364
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0144 0.0264
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2311 0.2311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0595 0.1457
Echinococcus multilocularis endoplasmin 0.0028 0.0288 0.0528
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0144 0.0264
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0085 0.0091
Echinococcus granulosus heat shock protein 0.0036 0.045 0.0826
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0066 0.0122
Schistosoma mansoni lamin 0.0032 0.0359 0.0879
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0144 0.0264
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.045 0.7057
Mycobacterium ulcerans beta-lactamase 0.0042 0.0595 0.2364
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0085 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0066 0.0122
Echinococcus granulosus carboxylesterase 5A 0.0066 0.1123 0.2062
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Onchocerca volvulus 0.0019 0.0085 0.0163
Onchocerca volvulus 0.0042 0.0595 0.1146
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0144 0.0352
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0417 0.0804
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0144 0.0264
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0337 0.0824
Schistosoma mansoni hypothetical protein 0.004 0.0535 0.131
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0144 0.0264
Brugia malayi heat shock protein 90 0.0036 0.045 0.0826
Mycobacterium ulcerans hypothetical protein 0.0042 0.0595 0.2364
Brugia malayi Dopamine receptor protein 1 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0162 0.2539
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0312
Brugia malayi sulfakinin receptor protein 0.0022 0.0144 0.0264
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0162 0.0297
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0162 0.0643
Brugia malayi intermediate filament protein 0.0032 0.0359 0.0659
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0595 0.105
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Schistosoma mansoni endoplasmin 0.0036 0.045 0.1101
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0595 0.1457
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0144 0.0264
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0066 0.0122
Plasmodium falciparum proline--tRNA ligase 0.0036 0.045 0.0483
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0066 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0066 0.0122
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.1325 0.2551
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0022 0.0144 0.0277
Schistosoma mansoni heat shock protein 0.0036 0.045 0.1101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Schistosoma mansoni hypothetical protein 0.0199 0.4084 1
Echinococcus granulosus lamin dm0 0.0032 0.0359 0.0659
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0595 0.105
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0595 0.105
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0144 0.0144
Plasmodium falciparum protein kinase 6 0.0433 0.9314 1
Giardia lamblia Grp94/Hsp90 0.0028 0.0288 0.4514
Trichomonas vaginalis heat shock protein, putative 0.0036 0.045 0.0866
Leishmania major hypothetical protein, conserved 0.0026 0.0243 0.0966
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.452 0.452
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0417 0.1658
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0569 0.3503
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0144 0.0264
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3332 0.5476
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.045 0.0483
Echinococcus granulosus somatostatin receptor 0.0022 0.0144 0.0264
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0351 0.0859
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0144 0.0144
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.045 0.0739
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0044 0.0637 0.0637
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0144 0.0264
Brugia malayi G-protein coupled receptor 0.0022 0.0144 0.0264
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.0637 0.1227
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0643
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0144 0.0264
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.2518 1
Brugia malayi hypothetical protein 0.0019 0.0085 0.0155
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0351 0.0377
Mycobacterium tuberculosis Conserved protein 0.0042 0.0595 0.105
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0162 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0595 0.4493
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0144 0.0264
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0337 0.0824
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.2518 0.6165
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.045 0.3395
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0144 0.0264
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0595 0.1093
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0032 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0352 0.0646
Echinococcus granulosus General substrate transporter 0.0095 0.177 0.3251
Toxoplasma gondii protein kinase, putative 0.0288 0.6085 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0118 0.2284 0.2284
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0144 0.0352
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0535 0.131
Echinococcus granulosus neuropeptide receptor 0.0022 0.0144 0.0264
Brugia malayi Serotonin receptor 0.0022 0.0144 0.0264
Schistosoma mansoni protein kinase 0.0031 0.0351 0.0859
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0085
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Onchocerca volvulus 0.0022 0.0144 0.0277
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0417 0.3151
Onchocerca volvulus 0.0022 0.0144 0.0277
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.045 0.3395
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.1325 0.2177
Schistosoma mansoni opsin-like receptor 0.0022 0.0144 0.0352
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0144 0.0264
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0144 0.0264
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0144 0.0352
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0595 0.1146
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0144 0.0277
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0351 0.0377
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0144 0.0264
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.1325 0.526
Loa Loa (eye worm) hypothetical protein 0.0031 0.0352 0.0352
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0144 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi RE15519p 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0019 0.0085 0.0163
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0144 0.0264
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0144 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi Cam kinase protein 1 0.0031 0.0351 0.0644
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0144 0.0264
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0144 0.0264
Schistosoma mansoni lipoxygenase 0.0081 0.1456 0.3564
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0352 0.0861
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0044 0.0637 0.4811
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0535 0.0982
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0288 0.0507
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0337 0.0618
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0569 0.1045
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0337 0.0648
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0144 0.0264
Leishmania major protein kinase, putative 0.0031 0.0351 0.1393
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0288 0.0528
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni biogenic amine receptor 0.0022 0.0144 0.0352
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1123 0.2749
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.5668 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0417 0.3151
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0049 0.0372
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0144 0.0264
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0049 0.0049
Leishmania major hypothetical protein, conserved 0.0042 0.0595 0.2364
Onchocerca volvulus 0.0248 0.5193 1
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Brugia malayi neuropeptide F receptor 0.0022 0.0144 0.0264
Brugia malayi Cytochrome P450 family protein 0.0029 0.0307 0.0564
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Onchocerca volvulus 0.0022 0.0144 0.0277
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0162 0.1222
Echinococcus granulosus allatostatin A receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0243 0.0261
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0337 0.0618
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0243 0.0261
Brugia malayi MH2 domain containing protein 0.0119 0.2311 0.4245
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.1325 1
Schistosoma mansoni endoplasmin 0.0036 0.045 0.1101
Echinococcus multilocularis sex peptide receptor 0.0022 0.0144 0.0264
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0085 0.015
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0049 0.0196
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0144 0.0352
Schistosoma mansoni opsin-like receptor 0.0022 0.0144 0.0352
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0049 0.0372
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0417 0.0804
Echinococcus granulosus acetylcholinesterase 0.0066 0.1123 0.2062
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0595 0.4791
Echinococcus granulosus heat shock protein 90 0.0036 0.045 0.0826
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0595 0.4493
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0569 0.1096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0209
Echinococcus multilocularis heat shock protein 90 0.0028 0.0288 0.0528
Brugia malayi Serotonin receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0066 0.1123 0.1123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0326 0.0599
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0595 0.105
Onchocerca volvulus 0.0053 0.0835 0.1608
Brugia malayi Doublecortin family protein 0.0019 0.0085 0.0155
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0044 0.0637 0.4811
Echinococcus multilocularis GPCR, family 2 0.0018 0.0066 0.0122
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.1123 0.2062
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0144 0.0352
Entamoeba histolytica protein kinase, putative 0.0031 0.0351 0.1625
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0162 0.0174
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0288 0.0554
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0044 0.0637 0.117
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0044 0.0637 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0162 0.072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.045 0.3395
Schistosoma mansoni ap endonuclease 0.0044 0.0637 0.156
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi G-protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi larval opioid receptor 0.0022 0.0144 0.0264
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0417 0.3151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0535 0.0982
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0243 0.04
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0144 0.0352
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0119 0.2297 0.4219
Schistosoma mansoni survival motor neuron protein 0.0053 0.0835 0.2044
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Leishmania major cytochrome p450-like protein 0.0018 0.0049 0.0196
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.2116 0.3478
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Loa Loa (eye worm) hypothetical protein 0.004 0.0545 0.0545
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0044 0.0637 0.2531
Brugia malayi beta-lactamase family protein 0.0042 0.0595 0.1093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0569 0.0935
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0044 0.0637 0.4811
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0569 0.1045
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0144 0.0352
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0288 0.4514
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0144 0.0264
Plasmodium falciparum endoplasmin, putative 0.0022 0.0142 0.0153
Echinococcus granulosus serotonin receptor 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0022 0.0144 0.0277
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.045 0.3395
Schistosoma mansoni histamine h1 receptor 0.0022 0.0144 0.0352
Onchocerca volvulus 0.0022 0.0144 0.0277
Echinococcus multilocularis heat shock protein 90 0.0036 0.045 0.0826
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.045 0.1786
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0337 0.2362
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.045 0.3396
Onchocerca volvulus 0.0022 0.0144 0.0277
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 1
Brugia malayi Carboxylesterase family protein 0.0066 0.1123 0.2062
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0957 0.0957
Brugia malayi G protein-coupled receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus heat shock protein 90 0.0028 0.0288 0.0528
Brugia malayi Dopamine receptor protein 2 0.0022 0.0144 0.0264
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0351 0.0644
Loa Loa (eye worm) inositol-1 0.0075 0.1325 0.1325
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0243 0.0261
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0351 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0417 0.0804
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0351 0.0377
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Onchocerca volvulus 0.0022 0.0144 0.0277
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.0637 0.0684
Schistosoma mansoni polycystin 1-related 0.0019 0.0085 0.0207
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0144 0.0352
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0957 0.1758
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0144 0.0264
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0351 0.0377
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0337 0.0618
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Trypanosoma brucei glucose transporter 1E 0.0034 0.0417 0.3151
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.3779 0.3779
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0144 0.0264
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.3779 0.694
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) carboxylesterase 0.0066 0.1123 0.1123
Toxoplasma gondii heat shock protein HSP90 0.0036 0.045 0.0739
Mycobacterium tuberculosis Conserved protein 0.0042 0.0595 0.105
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0243 0.1836
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0144 0.0352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0595 0.0595
Brugia malayi hypothetical protein 0.0026 0.0243 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0417 0.0804
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0144 0.0264
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0044 0.0637 0.4089
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.045 0.2476
Echinococcus granulosus geminin 0.0199 0.4084 0.7501
Schistosoma mansoni hypothetical protein 0.011 0.2116 0.5181
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0144 0.0264
Schistosoma mansoni protein kinase 0.0031 0.0351 0.0859
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1123 0.2062
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0144 0.0264
Plasmodium falciparum hexose transporter 0.011 0.2116 0.2272
Plasmodium vivax SET domain protein, putative 0.0031 0.0352 0.0378
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0288 0.0554
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0288 0.1142
Brugia malayi beta-lactamase family protein 0.0042 0.0595 0.1093
Schistosoma mansoni hypothetical protein 0.0199 0.4084 1
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0288 0.0554
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.045 0.0739
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0022 0.0144 0.0277
Loa Loa (eye worm) beta-lactamase 0.0042 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0124 0.0933
Plasmodium falciparum heat shock protein 90 0.0036 0.045 0.0483
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0144 0.0264
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.2518 1
Schistosoma mansoni protein kinase 0.0031 0.0351 0.0859
Plasmodium vivax heat shock protein 86, putative 0.0036 0.045 0.0483
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0288 0.2172
Brugia malayi Pre-SET motif family protein 0.0218 0.452 0.8302
Echinococcus granulosus GPCR family 2 0.0018 0.0066 0.0122
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0351 0.0377
Schistosoma mansoni biogenic amine receptor 0.0022 0.0144 0.0352
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0569 0.3503
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0162 0.0266
Onchocerca volvulus 0.0031 0.0352 0.0678
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0144 0.0144
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Loa Loa (eye worm) hypothetical protein 0.0032 0.0359 0.0359
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0144 0.0264
Trypanosoma cruzi hexose transporter 0.0034 0.0417 0.3151
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.2518 0.4443
Schistosoma mansoni glucose transport protein 0.011 0.2116 0.5181
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.3779 0.694
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.5445 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Activation of SIRT1 (unknown origin) after 45 mins by NAD/NADH enzyme-based fluorometric assay ChEMBL. 26420067
IC50 (functional) = 50.22 uM Cytotoxicity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 26420067

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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