Detailed information for compound 1999678

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.565 | Formula: C24H25N7O3S
  • H donors: 2 H acceptors: 7 LogP: 3.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cn1)Nc1ncc(cc1c1nc(C)nc(n1)N)C(c1ccc(cc1)S(=O)(=O)C)C
  • InChi: 1S/C24H25N7O3S/c1-14(16-5-8-19(9-6-16)35(4,32)33)17-11-20(23-28-15(2)29-24(25)31-23)22(27-12-17)30-18-7-10-21(34-3)26-13-18/h5-14H,1-4H3,(H,27,30)(H2,25,28,29,31)
  • InChiKey: JGMAWYHYNAVLJS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0474 0.5545 0.9536
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0244 0.0317
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0453 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0378 0.435 0.7466
Loa Loa (eye worm) hypothetical protein 0.0181 0.1923 0.2589
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0264 0.0237
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0929 0.1414
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0263 0.0235
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.033
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.03 0.3397 0.8322
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0244 0.0244
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0132 0.1315 0.3062
Mycobacterium ulcerans 6-phosphofructokinase 0.0132 0.1315 0.157
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0686 0.8156 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0036 0.013 0.131
Brugia malayi phosphofructokinase 0.0132 0.1315 0.2031
Echinococcus multilocularis bloom syndrome protein 0.005 0.0307 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0496 0.5813 1
Toxoplasma gondii phosphofructokinase PFKII 0.0036 0.013 0.0743
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0257 0.0371
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0028 0.0043 0.0003
Plasmodium falciparum thioredoxin reductase 0.0046 0.0257 0.3162
Plasmodium vivax glutathione reductase, putative 0.0046 0.0257 0.3162
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1639
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Toxoplasma gondii thioredoxin reductase 0.0046 0.0257 0.1794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Brugia malayi PHD-finger family protein 0.003 0.0064 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Trypanosoma brucei trypanothione reductase 0.0046 0.0257 0.0518
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.0195 0.0369
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Loa Loa (eye worm) hypothetical protein 0.0536 0.6308 0.8491
Mycobacterium ulcerans hypothetical protein 0.0193 0.2068 0.2498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0453 0.071
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0072 0.0586 0.1309
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0686 0.8156 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.033
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0366 0.4203 0.7211
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0326 0.0491
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0326 0.0685
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.017
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0244 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0058 0.0025
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0686 0.8156 1
Brugia malayi jmjC domain containing protein 0.0071 0.057 0.0842
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0036 0.013 1
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0307 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0453 0.099
Brugia malayi jmjC domain containing protein 0.0074 0.0599 0.0887
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0058
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.11
Brugia malayi MAP kinase sur-1 0.0062 0.0453 0.0654
Echinococcus granulosus L aminoadipate semialdehyde 0.0101 0.0934 0.0908
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0036 0.013 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.0229 0.0201
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0244 0.0349
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0058 0.0251
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0281
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0307 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Leishmania major ATP-dependent phosphofructokinase 0.0132 0.1315 0.3062
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0678 0.153
Onchocerca volvulus 0.0114 0.1099 0.0308
Schistosoma mansoni lozenge 0.0067 0.0522 0.0522
Echinococcus multilocularis microtubule associated protein 2 0.0835 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0161 0.1677 0.2832
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0678 0.0678
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0232 0.1586
Schistosoma mansoni apoptosis regulator bax 0.01 0.0929 0.0929
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0084 0.0723 0.0697
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0257 0.0346
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1125 0.1335
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.024
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0496 0.5813 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.057 0.0543
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0072 0.0586 0.0944
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0232 0.0204
Echinococcus granulosus bloom syndrome protein 0.005 0.0307 0.0279
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0072 0.0586 0.0867
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.1677 0.2832
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.3931
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.017
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0036 0.013 0.0155
Plasmodium vivax 6-phosphofructokinase, putative 0.0036 0.013 0.131
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Treponema pallidum fructose-bisphosphate aldolase 0.0354 0.4058 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0232 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0453 0.0847
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0453 0.099
Schistosoma mansoni jumonji domain containing protein 0.0071 0.057 0.057
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0929 0.125
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0453 0.0426
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.1244 0.1482
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0678 0.1013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0599 0.0599
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1125 0.1335
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0043 0.0016
Brugia malayi Bromodomain containing protein 0.0046 0.0264 0.0352
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.0141 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Loa Loa (eye worm) glutathione reductase 0.0046 0.0257 0.0346
Mycobacterium ulcerans hypothetical protein 0.0126 0.1244 0.1482
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0084 0.0723 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0326 0.0491
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0244 0.0244
Schistosoma mansoni DNA helicase recq1 0.0035 0.0119 0.0119
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0119 0.0091
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0307 0.0421
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1125 0.1335
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0244 0.0216
Loa Loa (eye worm) hypothetical protein 0.0045 0.0244 0.0329
Echinococcus multilocularis L aminoadipate semialdehyde 0.0101 0.0934 0.0908
Loa Loa (eye worm) phosphofructokinase 0.0132 0.1315 0.1771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0092
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0244 0.0216
Schistosoma mansoni DNA helicase recq5 0.0035 0.0119 0.0119
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0354 0.4058 0.6959
Echinococcus multilocularis Zinc finger, PHD finger 0.0084 0.0723 0.0697
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0158 0.0199
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0043 0.0005
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0028 0.0043 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0028 0.0043 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0678 0.0651
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0119 0.0091
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0141 0.024
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0232 0.0327
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0584 0.0557
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0366 0.4203 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2125 0.2103
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.2186 0.3716
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0084 0.0723 0.0697
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0063 0.0465 0.0731
Loa Loa (eye worm) hypothetical protein 0.0052 0.0329 0.0443
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0141 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Loa Loa (eye worm) phosphatidylinositol 3 0.0627 0.7429 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0981 0.1158
Loa Loa (eye worm) runx1 0.0067 0.0522 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0723 0.5673
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0313 0.0467
Schistosoma mansoni alpha-glucosidase 0.017 0.1787 0.1787
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0084 0.0723 0.0723
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0453 0.099
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0084 0.0723 0.0697
Loa Loa (eye worm) 6-phosphofructokinase 0.0132 0.1315 0.1771
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0072 0.0586 0.0559
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1827 0.3092
Giardia lamblia GTOR 0.0072 0.0586 0.1185
Onchocerca volvulus 0.0536 0.6308 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.057 0.0543
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0929 0.0903
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0686 0.8156 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0326 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0141 0.024
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0099 0.0913 0.2016
Brugia malayi 6-phosphofructokinase 0.0132 0.1315 0.2031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0354 0.4058 0.6959
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0453 0.0426
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0232 0.0301
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0981 0.1158
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0496 0.5813 1
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.1677 0.2835
Leishmania major phosphatidylinositol 3-kinase, putative 0.0084 0.0723 0.1639
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0084 0.0723 0.1179
Leishmania major trypanothione reductase 0.0046 0.0257 0.0518
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2125 0.3324
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0119 0.0091
Giardia lamblia Fructose-bisphosphate aldolase 0.0354 0.4058 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0279 0.3139 0.4942
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0453 0.0453
Schistosoma mansoni fkbp-rapamycin associated protein 0.0028 0.0043 0.0043
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0084 0.0723 1
Echinococcus multilocularis muscleblind protein 0.0181 0.1923 0.19
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0043 0.0043
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0132 0.1315 0.157
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0488
Schistosoma mansoni microtubule-associated protein tau 0.0835 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Mycobacterium tuberculosis Probable reductase 0.0104 0.0981 0.1158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Loa Loa (eye worm) hypothetical protein 0.0536 0.6308 0.8491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0488 0.0771
Loa Loa (eye worm) RecQ helicase 0.005 0.0307 0.0413
Echinococcus granulosus 6 phosphofructokinase 0.0132 0.1315 0.1291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0029 0.0029
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0119 0.0091
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0036 0.013 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.0141 0.024
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.0141 0.0113
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0496 0.5813 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0496 0.5813 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0453 0.071
Loa Loa (eye worm) hypothetical protein 0.0046 0.0265 0.0357
Loa Loa (eye worm) hypothetical protein 0.01 0.0929 0.125
Schistosoma mansoni bromodomain containing protein 0.0077 0.0637 0.0637
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0132 0.1315 0.157
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0072 0.0586 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0366 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Brugia malayi Bromodomain containing protein 0.0091 0.0812 0.1227
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0036 0.013 0.0222
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0036 0.013 0.0028
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.11
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0122
Schistosoma mansoni hypothetical protein 0.01 0.0929 0.0929
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Mycobacterium tuberculosis Conserved hypothetical protein 0.0193 0.2068 0.2498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0277 0.0406
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0084 0.0723 0.1182
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0232 0.0327
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0072 0.0586 0.0941
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0101 0.0934 0.0934
Entamoeba histolytica protein kinase rad3, putative 0.0028 0.0043 0.0003
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0929 0.0903
Brugia malayi Muscleblind-like protein 0.0181 0.1923 0.3001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0084 0.0723 0.5673
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0072 0.0586 0.0944
Loa Loa (eye worm) 6-phosphofructokinase 0.0132 0.1315 0.1771
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2125 0.2861
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.057 0.0543
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0981 0.1158
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0132 0.1315 0.3173
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0208 0.2262 0.3542
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0313 0.0467
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0232 0.0327
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0161 0.1677 0.2832
Brugia malayi glutathione reductase 0.0046 0.0257 0.0341
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0263 0.0235
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.0229 0.0201
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0084 0.0723 0.1086
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0122
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0257 0.3162
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0233 0.0461
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0244 0.0216
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0141 0.0156
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.013
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1125 0.1335
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.005 0.0073
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0173 0.1825 0.2198
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0232 0.0458
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1639
Plasmodium falciparum glutathione reductase 0.0046 0.0257 0.3162
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0279 0.3139 0.312
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0101 0.0934 0.1422
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0366 0.4203 0.7211
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0058 0.0137
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0132 0.1315 0.2205
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0043 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0072 0.0586 0.0586
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0704 0.8383 0.8378
Schistosoma mansoni memapsin-2 (A01 family) 0.0377 0.434 0.434
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0036 0.013 0.0151
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0084 0.0723 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0232 0.0327
Toxoplasma gondii hypothetical protein 0.0059 0.0419 0.3146
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0244 0.0349
Entamoeba histolytica hypothetical protein 0.0419 0.4859 0.8348
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0072 0.0586 0.0941
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0651
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1179
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0119 0.0651
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Brugia malayi hypothetical protein 0.0536 0.6308 1
Schistosoma mansoni 6-phosphofructokinase 0.0132 0.1315 0.1315
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0981 0.1158
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0232 0.0327
Echinococcus granulosus muscleblind protein 0.0181 0.1923 0.19
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0072 0.0586 0.1309
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Trypanosoma brucei glucosidase, putative 0.0044 0.0232 0.0458
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0072 0.0586 0.1309
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0678 0.0912
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0119 0.1148
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0072 0.0586 0.0559
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0161 0.1677 0.1677
Loa Loa (eye worm) phosphatidylinositol 3 0.0072 0.0586 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Toxoplasma gondii 6-phosphofructokinase 0.0036 0.013 0.0743
Echinococcus multilocularis Protein lozenge 0.0067 0.0522 0.0495
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0929 0.0903
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0496 0.5813 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0278 0.0407
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0981 0.1158
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0599 0.0599
Brugia malayi 6-phosphofructokinase 0.0132 0.1315 0.2031
Loa Loa (eye worm) hypothetical protein 0.0217 0.2365 0.3183
Treponema pallidum licC protein (licC) 0.0126 0.1244 0.2994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 0.0474
Loa Loa (eye worm) hypothetical protein 0.0181 0.1923 0.2589
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0232 0.0204
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0061 0.045 0.0981
Loa Loa (eye worm) hypothetical protein 0.0101 0.0934 0.1257
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0232 0.0327
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0173 0.1825 0.2198
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0084 0.0723 0.1179
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.1677 0.2608
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0244 0.0349
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0453 0.3424
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0453 0.0426
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0199
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0929 0.0929
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0496 0.5813 0.9209
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1827 0.4291
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0678 0.153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0586 0.0941
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0126 0.1244 0.1482
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1827 0.4291
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0244 0.0216
Schistosoma mansoni 6-phosphofructokinase 0.0132 0.1315 0.1315
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0244 0.0352
Loa Loa (eye worm) hypothetical protein 0.0279 0.3139 0.4226
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.1244 0.1482
Loa Loa (eye worm) hypothetical protein 0.0086 0.0748 0.1007
Toxoplasma gondii target of rapamycin (TOR), putative 0.0059 0.0414 0.3104
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0126 0.1244 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0678 0.0651
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.1409 0.1897
Mycobacterium ulcerans hypothetical protein 0.0126 0.1244 0.1482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.017
Brugia malayi Thioredoxin reductase 0.0046 0.0257 0.0341
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0084 0.0723 0.0974
Leishmania major mitochondrial DNA polymerase beta 0.0366 0.4203 1
Echinococcus multilocularis 6 phosphofructokinase 0.0132 0.1315 0.1291
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0119 0.0161
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0084 0.0723 0.1182
Echinococcus multilocularis muscleblind protein 1 0.0181 0.1923 0.19
Trypanosoma cruzi target of rapamycin kinase 3 0.0061 0.045 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0232 0.0327
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0061 0.045 0.0981
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0704 0.8383 0.8383
Loa Loa (eye worm) hypothetical protein 0.0035 0.0119 0.0161
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0678 0.1103
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0139 0.1409 0.2368
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0981 0.1158
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0453 0.071
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0158 0.0203
Plasmodium vivax 6-phosphofructokinase, putative 0.0036 0.013 0.131
Entamoeba histolytica hypothetical protein 0.0028 0.0043 0.0003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0036 0.013 0.131
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0449 0.0704
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0929 0.0903
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0244 0.0349
Trichomonas vaginalis phosphofructokinase, putative 0.0036 0.013 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0414 0.0644
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0453 0.0426
Entamoeba histolytica phosphofructokinase, putative 0.0132 0.1315 0.2208
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0264 0.0237
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0244 0.0488
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0268 0.3324
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0257 0.0266
Schistosoma mansoni alpha-glucosidase 0.017 0.1787 0.1787
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.0141 0.0113
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0158 0.0281
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0084 0.0723 0.0723
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0161 0.1677 0.2832
Schistosoma mansoni alpha glucosidase 0.0044 0.0232 0.0232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0354 0.4058 0.6958
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0419 0.4859 0.8348
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0089 0.0089
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0378 0.435 0.7466
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0599 0.0806
Trichomonas vaginalis phosphofructokinase, putative 0.0132 0.1315 0.2205
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0173 0.1825 0.2198
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0043 0.0015
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0704 0.8383 0.8378
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0351 0.0534
Trypanosoma brucei protein kinase, putative 0.0062 0.0453 0.099
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0599 0.0572
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0453 0.071
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0244 0.0321
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0584 0.0557
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0244 0.0216
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0084 0.0723 0.1179
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0453 0.071
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0279 0.3139 0.312

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM BindingDB_Patents: In Vitro Inhibition Assay. The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vitro setting. Active mTOR phosphorylates eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) on residue threonine 46. This phosphorylation event can be detected with a phospho-specific terbium (Tb) labeled Ab, in turn bringing the Tb label in close proximity to the GFP tagged 4E-BP1 and allowing for time-resolved fluorescence resonance energy transfer (TR-FRET), which correlates 4E-BP1 phosphorylation levels with mTOR kinase activity. ChEMBL. No reference
Ki (binding) = 5 nM BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein. ChEMBL. No reference
Ki (binding) = 5 nM BindingDB_Patents: Alphascreen Assay. The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta. Each of these enzymes phosphorylates the 3'-hydroxyl group on phosphatidylinositiol (4,5)-bisphosphate (PIP2) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This phosphorylation activity is measured using a GST-tagged PIP3 binding protein (Echelon Biosciences, Salt Lake City, Utah), an anti-GST-tagged Acceptor bead, and streptavidin-Donor bead. The interaction of biotinylated-PIP3 analog (IP4) and the PIP3 binding protein brings both Acceptor and Donor beads together producing, upon excitation of the Donor beads at 680 nm, a singlet oxygen species leading to the luminescent AlphaScreen signal. When PIP3 is produced via phosphorylation of PIP2 by a PI3K, PIP3 competes with biotinylated-PIP3 analog (IP4) for binding to the PIP3 binding protein. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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