TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 463.527 | Formula: C20H21N3O6S2
H donors: 2 H acceptors: 5 LogP: 1.14 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N[C@H](C(=O)N[C@@H]1C(=O)N2[C@H]1S(=O)(=O)CC2)Cc1cccs1)OCc1ccccc1
InChi: 1S/C20H21N3O6S2/c24-17(22-16-18(25)23-8-10-31(27,28)19(16)23)15(11-14-7-4-9-30-14)21-20(26)29-12-13-5-2-1-3-6-13/h1-7,9,15-16,19H,8,10-12H2,(H,21,26)(H,22,24)/t15-,16+,19-/m0/s1
InChiKey: YAGNDONYTVCOFN-FCEWJHQRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Rattus norvegicus	Cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin L	334 aa	329 aa	39.5 %
Brugia malayi	cathepsin B-like cysteine proteinase	Cathepsin L	334 aa	303 aa	23.4 %
Onchocerca volvulus		Cathepsin L	334 aa	321 aa	36.4 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin L	334 aa	294 aa	23.8 %
Babesia bovis	papain family cysteine protease containing protein	Cathepsin L	334 aa	321 aa	32.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Cathepsin L	334 aa	359 aa	29.8 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	270 aa	25.6 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin L	334 aa	304 aa	33.2 %
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Cathepsin L	334 aa	290 aa	27.6 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Cathepsin L	334 aa	277 aa	24.5 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	282 aa	26.2 %
Onchocerca volvulus		Cathepsin L	334 aa	321 aa	38.0 %
Plasmodium yoelii	cysteine proteinase precursor	Cathepsin L	334 aa	360 aa	29.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	346 aa	26.9 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin L	334 aa	298 aa	28.9 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin L	334 aa	278 aa	26.6 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	27.9 %
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Cathepsin L	334 aa	273 aa	26.0 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	279 aa	28.3 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	275 aa	29.1 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	276 aa	26.8 %
Dictyostelium discoideum	hypothetical protein	Cathepsin L	334 aa	324 aa	34.6 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	317 aa	33.8 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	341 aa	26.7 %
Onchocerca volvulus		Cathepsin L	334 aa	311 aa	40.8 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	270 aa	25.6 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin L	334 aa	309 aa	26.5 %
Echinococcus granulosus	cathepsin L	Cathepsin L	334 aa	325 aa	29.5 %
Echinococcus multilocularis	cathepsin L	Cathepsin L	334 aa	274 aa	48.2 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	28.6 %
Theileria parva	cysteine proteinase, putative	Cathepsin L	334 aa	347 aa	28.8 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin L	334 aa	273 aa	27.8 %
Theileria parva	cysteine proteinase, putative	Cathepsin L	334 aa	337 aa	26.1 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	279 aa	25.8 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	274 aa	24.8 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	295 aa	25.4 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Cathepsin L	334 aa	304 aa	28.3 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin L	334 aa	322 aa	41.6 %
Onchocerca volvulus		Cathepsin L	334 aa	300 aa	24.3 %
Theileria parva	cysteine proteinase, putative	Cathepsin L	334 aa	333 aa	28.8 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Cathepsin L	334 aa	311 aa	36.0 %
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	Cathepsin L	334 aa	316 aa	30.1 %
Brugia malayi	Papain family cysteine protease containing protein	Cathepsin L	334 aa	296 aa	31.8 %
Plasmodium vivax	vivapain-1	Cathepsin L	334 aa	366 aa	28.4 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	346 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Echinococcus granulosus	cysteine protease	Cathepsin L	334 aa	323 aa	44.3 %
Echinococcus multilocularis	cathepsin L	Cathepsin L	334 aa	309 aa	30.4 %
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Cathepsin L	334 aa	277 aa	26.0 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	346 aa	23.4 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin L	334 aa	273 aa	25.3 %
Plasmodium vivax	unspecified product	Cathepsin L	334 aa	366 aa	28.4 %
Schistosoma mansoni	cathepsin S (C01 family)	Cathepsin L	334 aa	311 aa	35.0 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin L	334 aa	271 aa	27.7 %
Dictyostelium discoideum	hypothetical protein	Cathepsin L	334 aa	325 aa	38.1 %
Echinococcus granulosus	cathepsin L	Cathepsin L	334 aa	274 aa	48.5 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin L	334 aa	329 aa	39.5 %
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Cathepsin L	334 aa	288 aa	26.7 %
Plasmodium berghei	berghepain-1	Cathepsin L	334 aa	353 aa	29.7 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin L	334 aa	295 aa	28.1 %
Trypanosoma cruzi	cysteine protease, putative	Cathepsin L	334 aa	323 aa	30.3 %
Echinococcus granulosus	cathepsin L cysteine protease	Cathepsin L	334 aa	323 aa	46.1 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin L	334 aa	312 aa	42.0 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Onchocerca volvulus		Cathepsin L	334 aa	325 aa	47.4 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	347 aa	26.5 %
Onchocerca volvulus	Protein MCM10 homolog	Cathepsin L	334 aa	300 aa	41.0 %
Neospora caninum	hypothetical protein	Cathepsin L	334 aa	299 aa	28.4 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	27.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	372 aa	23.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	319 aa	25.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	336 aa	25.9 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Cathepsin L	334 aa	345 aa	35.4 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	271 aa	26.9 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	277 aa	26.0 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	303 aa	26.1 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	27.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	332 aa	23.5 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Cathepsin L	334 aa	318 aa	48.4 %
Plasmodium knowlesi	knowpain-1	Cathepsin L	334 aa	373 aa	27.6 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin L	334 aa	304 aa	33.9 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	276 aa	25.4 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin L	334 aa	292 aa	22.6 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	347 aa	26.5 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	274 aa	25.9 %
Plasmodium vivax	vivapain-3	Cathepsin L	334 aa	345 aa	30.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1197	0.2924
Echinococcus multilocularis	cysteine protease	0.0086	0.1197	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0346	0.0346
Plasmodium falciparum	transporter, putative	0.0081	0.1076	0.8646
Schistosoma mansoni	sodium/chloride dependent transporter	0.0081	0.1076	0.1076
Echinococcus multilocularis	transient receptor potential gamma protein	0.0094	0.1383	0.1344
Brugia malayi	hypothetical protein	0.0081	0.1076	0.1076
Schistosoma mansoni	transient receptor potential channel	0.0062	0.0661	0.0661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Schistosoma mansoni	transient receptor potential channel	0.0062	0.0661	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1076	0.1076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Onchocerca volvulus		0.0086	0.1197	0.0644
Echinococcus granulosus	cathepsin b	0.0181	0.3347	0.3317
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.1197	1
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0081	0.1076	0.1037
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0081	0.1076	0.1037
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.0591	0.3182
Plasmodium vivax	amine transporter, putative	0.0081	0.1076	0.8646
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0081	0.1076	0.5
Echinococcus granulosus	serotonin transporter	0.0474	1	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0081	0.1076	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0474	1	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3347	0.3347
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.1197	0.1157
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.6723
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.6723
Toxoplasma gondii	hypothetical protein	0.0081	0.1076	0.6723
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Schistosoma mansoni	transient receptor potential channel 4	0.0094	0.1383	0.1383
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1076	0.1076
Plasmodium vivax	vivapain-2	0.0086	0.1197	1
Echinococcus granulosus	short transient receptor potential channel 6	0.0062	0.0661	0.062
Onchocerca volvulus		0.0086	0.1197	0.0644
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0044	0.0044
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.083	0.5868
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.3347	0.3347
Echinococcus granulosus	transient receptor potential gamma protein	0.0094	0.1383	0.1344
Echinococcus granulosus	cathepsin L	0.0047	0.0308	0.0265
Treponema pallidum	sodium- and chloride- dependent transporter	0.0474	1	0.5
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1197	0.1197
Toxoplasma gondii	hypothetical protein	0.0081	0.1076	0.6723
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0591	0.0591
Echinococcus multilocularis	serotonin transporter	0.0474	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.1197	0.1197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.1197	0.1197
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.3347	0.3347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0062	0.0661	0.062
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0081	0.1076	0.1037
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0081	0.1076	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0059	0.059	0.059
Loa Loa (eye worm)	cathepsin B	0.007	0.083	0.083
Entamoeba histolytica	cysteine protease, putative	0.0086	0.1197	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1197	0.1197
Echinococcus multilocularis	cysteine protease	0.0086	0.1197	0.1157
Onchocerca volvulus		0.0086	0.1197	0.0644
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0591	0.093
Echinococcus multilocularis	cathepsin b	0.0181	0.3347	0.3317
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0591	0.3182
Echinococcus granulosus	cathepsin l1	0.0059	0.0591	0.0549
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.1076
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0081	0.1076	0.1076
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.6723
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0081	0.1076	0.1076
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.1197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.1197	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0346	0.0346
Echinococcus granulosus	cysteine protease	0.0047	0.0308	0.0265
Onchocerca volvulus		0.0081	0.1076	0.0516
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1197	0.1197
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0591	0.0591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.1197	0.1197
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0591	0.0591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Onchocerca volvulus		0.0081	0.1076	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1383	0.1383
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0346	0.0346
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.083	0.1716
Echinococcus multilocularis	transient receptor potential ion channel A	0.0091	0.1312	0.1273
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.1197	0.0644
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1197	0.1197
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.1197	0.1197
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1197	0.2924
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0308	0.0308
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Echinococcus granulosus	transient receptor potential ion channel A	0.0091	0.1312	0.1273
Plasmodium vivax	hypothetical protein, conserved	0.0081	0.1076	0.8646
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0591	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0474	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.1197	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1197	0.1197
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0346	0.0346
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0308	0.0308
Echinococcus granulosus	cathepsin b	0.0181	0.3347	0.3317
Loa Loa (eye worm)	cysteine protease	0.0086	0.1197	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1076	0.1076
Echinococcus multilocularis	short transient receptor potential channel 6	0.0062	0.0661	0.062
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.0591	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1076	0.1076
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.1197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.1197	0.1157
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.1197	0.1157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0591	0.0591
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0081	0.1076	0.1076
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.1197	0.2924
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0081	0.1076	0.1076
Loa Loa (eye worm)	norepinephrine transporter	0.0474	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.1197	0.0644
Onchocerca volvulus		0.0081	0.1076	0.0516
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0474	1	1
Loa Loa (eye worm)	serotonin transporter b	0.0474	1	1
Giardia lamblia	Cathepsin B precursor	0.007	0.083	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0591	0.0591
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0081	0.1076	0.1037
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1197	0.1197
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0081	0.1076	0.1076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.0081	0.1076	0.1037
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.3347	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.1197	0.1197
Onchocerca volvulus		0.0086	0.1197	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0474	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.083	0.5868
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1076	0.1076
Echinococcus granulosus	cathepsin l1	0.0086	0.1197	0.1157
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0081	0.1076	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1076	0.1076
Schistosoma mansoni	sodium/chloride dependent transporter	0.0474	1	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0081	0.1076	0.1076
Loa Loa (eye worm)	ctsf protein	0.0086	0.1197	0.1197
Loa Loa (eye worm)	fibroinase	0.0086	0.1197	0.1197
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0308	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0308	0.0308
Onchocerca volvulus		0.0086	0.1197	0.0644
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.1197	0.0644
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0081	0.1076	0.1037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.1197	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0081	0.1076	0.1076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1197	1
Toxoplasma gondii	cathepsin CPL	0.0086	0.1197	1
Onchocerca volvulus		0.0086	0.1197	0.0644
Onchocerca volvulus		0.0474	1	1
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0081	0.1076	0.1037
Schistosoma mansoni	transient receptor potential channel	0.0094	0.1383	0.1383
Plasmodium vivax	vivapain-2	0.0086	0.1197	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0081	0.1076	0.1076
Echinococcus multilocularis	cathepsin L	0.0047	0.0308	0.0265
Brugia malayi	Transient-receptor-potential like protein	0.0035	0.0044	0.0044
Echinococcus multilocularis	cathepsin b	0.0181	0.3347	0.3317
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0081	0.1076	0.1076
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.3347	0.3347
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.1197	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1076	0.1076
Giardia lamblia	Cathepsin B precursor	0.007	0.083	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.1197	0.1157
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.083	0.083
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1197	0.2924
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.1197	0.1157
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0308	0.0265
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0081	0.1076	0.1037
Leishmania major	cathepsin L-like protease	0.0086	0.1197	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.1076
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1197	0.1197
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.1076
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.3347	0.3347
Onchocerca volvulus		0.0086	0.1197	0.0644
Plasmodium falciparum	amino acid transporter, putative	0.0081	0.1076	0.8646
Giardia lamblia	Cathepsin B precursor	0.007	0.083	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0081	0.1076	0.1076
Echinococcus granulosus	sodium and chloride dependent glycine	0.0081	0.1076	0.1037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1197	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0308	0.0308
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1197	0.2924
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.3347	0.3347
Brugia malayi	cathepsin L-like precursor	0.0059	0.0591	0.0591
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.0591	0.0591
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0081	0.1076	0.1076
Echinococcus granulosus	short transient receptor potential channel 6	0.0062	0.0661	0.062
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0474	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1197	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.0018 uM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 0.0018 uM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 0.003 uM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 0.003 uM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 0.0046 uM	In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC	ChEMBL.	12419374
IC50 (binding)	= 0.0046 uM	In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC	ChEMBL.	12419374
IC50 (binding)	= 0.43 uM	Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 0.43 uM	Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine protease	ChEMBL.	12419374

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL113706

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 200789