Detailed information for compound 206855

Basic information

Technical information
  • TDR Targets ID: 206855
  • Name: Paullone Analogue 74
  • MW: 279.316 | Formula: C15H9N3OS
  • H donors: 2 H acceptors: 2 LogP: 1.99 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc2c(c1)c1CC(=O)Nc3c(c1[nH]2)scc3
  • InChi: 1S/C15H9N3OS/c16-7-8-1-2-11-9(5-8)10-6-13(19)17-12-3-4-20-15(12)14(10)18-11/h1-5,18H,6H2,(H,17,19)
  • InChiKey: OJYCCGFKNFUHFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin B1 References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.045 0.1052 1
Echinococcus granulosus sodium and chloride dependent glycine 0.045 0.1052 0.1664
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.001
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0225 0.8207
Echinococcus multilocularis thymidine phosphorylase 0.1352 0.3209 0.5077
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0459 0.6379
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.045 0.1052 1
Loa Loa (eye worm) hypothetical protein 0.2653 0.6321 0.6321
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.045 0.1052 0.1052
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0116 0.4012
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.0006 0.0009
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.0006 0.0006
Brugia malayi Receptor family ligand binding region containing protein 0.0099 0.0211 0.0211
Echinococcus multilocularis cpg binding protein 0.0036 0.0062 0.0097
Onchocerca volvulus 0.045 0.1052 0.1657
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0225 0.3045
Schistosoma mansoni nAChR subunit 0.0013 0.0006 0.0001
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0116 0.1003
Schistosoma mansoni cyclin G 0.0016 0.0012 0.001
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0099 0.0211 0.0211
Entamoeba histolytica hypothetical protein 0.0099 0.0211 0.7648
Onchocerca volvulus 0.045 0.1052 0.1657
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0129 0.1664
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0105 0.0225 0.0214
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.0006 0.0001
Schistosoma mansoni metabotropic glutamate receptor 0.0099 0.0211 0.0325
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Schistosoma mansoni glutamate receptor NMDA 0.0193 0.0435 0.0681
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0073 0.0876
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.045 0.1052 0.1664
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0103 0.0222 0.0221
Loa Loa (eye worm) CYL-1 protein 0.0016 0.0012 0.0012
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0105 0.0225 0.0214
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0105 0.0225 0.0225
Echinococcus multilocularis serotonin transporter 0.2653 0.6321 1
Schistosoma mansoni nAChR subunit 0.0013 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0006 0.0009
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0686 0.1616 0.2555
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.045 0.1052 0.1657
Echinococcus granulosus neuropeptide receptor A26 0.0553 0.1297 0.2051
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.008 0.0127
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0203
Schistosoma mansoni cyclin d 0.0016 0.0012 0.001
Loa Loa (eye worm) glutamate receptor 0.0099 0.0211 0.0211
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0021 0.0026 0.0014
Echinococcus granulosus cyclin dependent kinase 0.0105 0.0225 0.0356
Onchocerca volvulus 0.2653 0.6321 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0309 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Entamoeba histolytica cyclin family protein 0.0064 0.0129 0.4486
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.0006 0.0006
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0006 0.0006
Onchocerca volvulus Glucosylceramidase homolog 0.0202 0.0459 0.0718
Schistosoma mansoni nAChR subunit 0.0013 0.0006 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.0713 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0116 0.1003
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.008 0.008
Echinococcus granulosus cyclin A3 4 0.0016 0.0012 0.0019
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.009 0.0134
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0006 0.0001
Loa Loa (eye worm) LGC-31 protein 0.0013 0.0006 0.0006
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0006 0.0009
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.045 0.1052 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0006 0.0009
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0066 0.0066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.2653 0.6321 0.6321
Loa Loa (eye worm) hypothetical protein 0.0148 0.0329 0.0328
Brugia malayi Serine protease Z688.6 precursor 0.0021 0.0026 0.0026
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0493 0.1155 1
Trichomonas vaginalis cyclin D, putative 0.0064 0.0129 0.1664
Echinococcus granulosus thymidine phosphorylase 0.1352 0.3209 0.5077
Loa Loa (eye worm) solute carrier family 6 member 4 0.2653 0.6321 0.6321
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0382 0.0888 0.5
Loa Loa (eye worm) hypothetical protein 0.045 0.1052 0.1052
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0006 0.0009
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0021 0.0026 0.013
Echinococcus multilocularis cyclin y 0.0016 0.0012 0.0019
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0272 0.0272
Echinococcus granulosus cyclins 0.0064 0.0129 0.0203
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0116 0.1488
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.0006 0.0006
Echinococcus multilocularis cyclin B 0.0124 0.0272 0.043
Echinococcus multilocularis glutamate receptor 2 0.0291 0.0671 0.1062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0005 0.0008
Brugia malayi hypothetical protein 0.0016 0.0012 0.0012
Schistosoma mansoni sodium/chloride dependent transporter 0.2653 0.6321 1
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0225 0.0348
Loa Loa (eye worm) glutamate receptor 2 0.0193 0.0435 0.0435
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0013 0.0006 0.0009
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0116 0.0116
Echinococcus granulosus glutamate NMDA receptor subunit 0.0193 0.0435 0.0688
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0012 0.0012
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0006 0.0009
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0099 0.0211 0.0333
Loa Loa (eye worm) serotonin transporter b 0.2653 0.6321 0.6321
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0006 0.0006
Trypanosoma brucei mitotic cyclin 6 0.0124 0.0272 0.026
Echinococcus granulosus cyclin dependent kinase 1 0.0105 0.0225 0.0356
Echinococcus multilocularis cyclin dependent kinase 0.0105 0.0225 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0459 0.6379
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0225 0.0348
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0097 0.0207 0.0319
Brugia malayi cell division control protein 2 homolog 0.0105 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) norepinephrine transporter 0.2653 0.6321 0.6321
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.0714 0.1129
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0012 0.0012
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0016 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0099 0.0211 0.0211
Chlamydia trachomatis glutamine binding protein 0.0493 0.1155 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.045 0.1052 0.1052
Brugia malayi CXXC zinc finger family protein 0.0034 0.0057 0.0057
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0006 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0006 0.0006
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0021 0.0026 0.004
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0021 0.0026 0.0014
Schistosoma mansoni cpg binding protein 0.0034 0.0057 0.0082
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.045 0.1052 0.1664
Echinococcus granulosus uncharacterized sodium dependent transporter 0.045 0.1052 0.1664
Schistosoma mansoni nAChR subunit 0.0013 0.0006 0.0001
Echinococcus granulosus nmda type glutamate receptor 0.0686 0.1616 0.2555
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus multilocularis cyclin b3 0.0064 0.0129 0.0203
Trichomonas vaginalis cyclin B, putative 0.0124 0.0272 0.371
Loa Loa (eye worm) hypothetical protein 0.045 0.1052 0.1052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.0006 0.0006
Echinococcus granulosus serotonin transporter 0.2653 0.6321 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0291 0.0671 0.1062
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Trypanosoma cruzi cyclin 6, putative 0.0124 0.0272 0.026
Echinococcus multilocularis cyclin t1 0.0016 0.0012 0.0019
Mycobacterium ulcerans thymidine phosphorylase 0.1352 0.3209 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.045 0.1052 0.1657
Trypanosoma cruzi cdc2-related kinase 3 0.0105 0.0225 0.0214
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Echinococcus multilocularis cyclin G2 0.0016 0.0012 0.0019
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.0272 0.026
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0193 0.0435 0.0688
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0116 0.4012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0012 0.0012
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0006 0.0009
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0105 0.0225 0.0356
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.001
Brugia malayi Metabotropic glutamate receptor precursor. 0.0099 0.0211 0.0211
Plasmodium falciparum protein kinase 5 0.0105 0.0225 0.2052
Echinococcus granulosus nmda type glutamate receptor 0.0099 0.0211 0.0333
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.0272 0.026
Echinococcus multilocularis cyclin G2 0.0016 0.0012 0.0019
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Echinococcus multilocularis Cyclin L1 0.0016 0.0012 0.0019
Toxoplasma gondii hypothetical protein 0.045 0.1052 1
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0459 0.6379
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0026 0.0193
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.045 0.045
Schistosoma mansoni glutamate receptor AMPA 0.0193 0.0435 0.0681
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Echinococcus multilocularis neuropeptide s receptor 0.0553 0.1297 0.2051
Giardia lamblia Hypothetical protein 0.0064 0.0129 0.4486
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0025
Brugia malayi Cyclin C 0.0016 0.0012 0.0012
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.0006 0.0001
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.0272 1
Schistosoma mansoni glutamate receptor kainate 0.0193 0.0435 0.0681
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0116 0.4012
Entamoeba histolytica cyclin, putative 0.0124 0.0272 1
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0021 0.0026 0.0014
Trypanosoma brucei cdc2-related kinase 1 0.0105 0.0225 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0026 0.0193
Onchocerca volvulus Cyclin L homolog 0.0016 0.0012 0.001
Plasmodium falciparum amino acid transporter, putative 0.045 0.1052 1
Brugia malayi hypothetical protein 0.045 0.1052 0.1052
Brugia malayi intracellular kinase 0.0059 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0193 0.0435 0.0688
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.0006 0.0006
Trichomonas vaginalis cyclins, putative 0.0075 0.0155 0.2046
Loa Loa (eye worm) RGC/RGC protein kinase 0.0099 0.0211 0.0211
Schistosoma mansoni hypothetical protein 0.0489 0.1144 0.1803
Brugia malayi Sodium:neurotransmitter symporter family protein 0.2653 0.6321 0.6321
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0116 0.0116
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.008 0.0127
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.045 0.1052 0.1664
Plasmodium vivax amine transporter, putative 0.045 0.1052 1
Echinococcus granulosus cyclins 0.0064 0.0129 0.0203
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.009 0.0134
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0012 0.0012
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0193 0.0435 0.0688
Schistosoma mansoni metabotropic glutamate receptor 0.0099 0.0211 0.0325
Echinococcus granulosus cyclin y 0.0016 0.0012 0.0019
Echinococcus granulosus cyclin G2 0.0016 0.0012 0.0019
Trypanosoma cruzi cdc2-related kinase 1 0.0105 0.0225 0.0214
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0291 0.0671 0.1062
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.0006 0.0009
Brugia malayi Protein kinase domain containing protein 0.0105 0.0225 0.0225
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.045 0.1052 0.1664
Brugia malayi Sodium:neurotransmitter symporter family protein 0.045 0.1052 0.1052
Onchocerca volvulus 0.0099 0.0211 0.0325
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0493 0.1155 0.1151
Trichomonas vaginalis cyclins, putative 0.0124 0.0272 0.371
Loa Loa (eye worm) hypothetical protein 0.045 0.1052 0.1052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0006 0.0006
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0021 0.0026 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus multilocularis dnaJ subfamily B 0.0489 0.1144 0.1809
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0013 0.0006 0.0006
Giardia lamblia Cyclin A 0.0064 0.0129 0.4486
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0006 0.0009
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0026 0.052
Echinococcus multilocularis glutamate receptor 2 0.0099 0.0211 0.0333
Trichomonas vaginalis cyclin A, putative 0.0124 0.0272 0.371
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0006 0.0006
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.0006 0.0006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.045 0.1052 0.1657
Schistosoma mansoni cyclin l 0.0016 0.0012 0.001
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0225 0.8207
Trypanosoma cruzi extracellular receptor, putative 0.0099 0.0211 0.0199
Echinococcus granulosus cyclin dependent kinase 5 0.0105 0.0225 0.0356
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0006 0.0001
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0291 0.0671 0.1062
Trichomonas vaginalis cyclin B, putative 0.0124 0.0272 0.371
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0116 0.1003
Trypanosoma cruzi cdc2-related kinase 3 0.0105 0.0225 0.0214
Echinococcus granulosus cyclin G2 0.0016 0.0012 0.0019
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0006 0.0006
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.045 0.1052 0.1657
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0021 0.0026 0.0193
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Brugia malayi Cation transporter family protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0097 0.0207 0.0207
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Giardia lamblia Serine peptidase, putative 0.0021 0.0026 0.052
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0225 0.0225
Echinococcus granulosus Cyclin L1 0.0016 0.0012 0.0019
Brugia malayi Cation transporter family protein 0.0013 0.0006 0.0006
Trichomonas vaginalis cyclins, putative 0.0064 0.0129 0.1664
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus granulosus cyclin k 0.0016 0.0012 0.0019
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4192 1 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0099 0.0211 0.0333
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0073 0.0876
Trichomonas vaginalis cyclin B, putative 0.0124 0.0272 0.371
Entamoeba histolytica cyclin family protein 0.0064 0.0129 0.4486
Echinococcus multilocularis cyclin 0.0016 0.0012 0.0019
Brugia malayi Receptor family ligand binding region containing protein 0.0099 0.0211 0.0211
Brugia malayi Sodium:neurotransmitter symporter family protein 0.045 0.1052 0.1052
Brugia malayi cyclin fold protein 1 variant b 0.0016 0.0012 0.0012
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0013 0.0006 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0006 0.0006
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0097 0.0207 0.0327
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0459 0.6379
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0193 0.0435 0.0688
Onchocerca volvulus 0.0059 0.0116 0.0175
Onchocerca volvulus 0.0021 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Echinococcus granulosus cyclins 0.0064 0.0129 0.0203
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Onchocerca volvulus 0.0099 0.0211 0.0325
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0012 0.0012
Schistosoma mansoni glutamate receptor kainate 0.0193 0.0435 0.0681
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0057 0.0057
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.045 0.0711
Schistosoma mansoni nAChR subunit 0.0013 0.0006 0.0001
Treponema pallidum sodium- and chloride- dependent transporter 0.2653 0.6321 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Echinococcus granulosus metabotropic glutamate receptor 2 0.0099 0.0211 0.0333
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2653 0.6321 1
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0203
Echinococcus multilocularis cyclin k 0.0016 0.0012 0.0019
Schistosoma mansoni tyrosine kinase 0.0099 0.0211 0.0325
Schistosoma mansoni ATP-binding cassette transporter 0.0193 0.0435 0.0681
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.0713 1
Echinococcus multilocularis cyclin B3 1 0.0064 0.0129 0.0203
Trichomonas vaginalis cyclins, putative 0.0124 0.0272 0.371
Brugia malayi metabotropic glutamate receptor type 2 0.0099 0.0211 0.0211
Schistosoma mansoni sodium-dependent amino acid transporter 0.045 0.1052 0.1657
Giardia lamblia Thymus-specific serine protease precursor 0.0021 0.0026 0.052
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0026 0.052
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0225 0.3045
Echinococcus multilocularis nmda type glutamate receptor 0.0099 0.0211 0.0333
Schistosoma mansoni sodium/chloride dependent transporter 0.0452 0.1056 0.1664
Trichomonas vaginalis cyclins, putative 0.0124 0.0272 0.371
Plasmodium vivax protein kinase Crk2 0.0105 0.0225 0.2052
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0016 0.0012 0.0012
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0099 0.0211 0.0333
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0021 0.0026 0.0193
Echinococcus multilocularis nmda type glutamate receptor 0.0686 0.1616 0.2555
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0116 0.1488
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1352 0.3209 1
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0193 0.0435 0.0688
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0099 0.0211 0.0333
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0012
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0021 0.0026 0.0193
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0012 0.0012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0012 0.0012
Onchocerca volvulus 0.0034 0.0057 0.0081
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0116 0.4012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0291 0.0671 0.1062
Echinococcus multilocularis cyclin A3 4 0.0016 0.0012 0.0019
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0309 0.0713 0.0713
Schistosoma mansoni g1/s-specific cyclin C 0.0016 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.006 0.0118 0.0118
Echinococcus multilocularis cyclin dependent kinase 5 0.0105 0.0225 0.0356
Trypanosoma cruzi cyclin, putative 0.0124 0.0272 0.026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Onchocerca volvulus Cyclin L homolog 0.0016 0.0012 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0459 0.6379
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.045 0.0711
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0012 0.0012
Schistosoma mansoni glutamate receptor AMPA 0.0193 0.0435 0.0681
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0485 0.6751
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.0006 0.0009
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0291 0.0671 0.1062
Brugia malayi Guanylyl cyclase protein 23 0.0099 0.0211 0.0211
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0225 0.3045
Schistosoma mansoni cyclins 0.0064 0.0129 0.0195
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Echinococcus multilocularis G1:S specific cyclin D1 0.0016 0.0012 0.0019
Schistosoma mansoni cyclin k 0.0016 0.0012 0.001
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.0006 0.0009
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.0006 0.0001
Trypanosoma brucei protein kinase, putative 0.0059 0.0116 0.0104
Schistosoma mansoni cpg binding protein 0.0036 0.0062 0.0089
Trichomonas vaginalis cyclin B3, putative 0.0064 0.0129 0.1664
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0005 0.0008
Trypanosoma cruzi cdc2-related kinase 1 0.0105 0.0225 0.0214
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0021 0.0026 0.004
Loa Loa (eye worm) RGC/RGC protein kinase 0.0099 0.0211 0.0211
Brugia malayi hypothetical protein 0.0099 0.0211 0.0211
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0099 0.0211 0.0211
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.045 0.1052 0.1052
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0116 0.0176
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0493 0.1155 0.1151
Loa Loa (eye worm) hypothetical protein 0.045 0.1052 0.1052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0006 0.0006
Trichomonas vaginalis cyclin B, putative 0.0124 0.0272 0.371
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0016 0.0012 0.0019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.045 0.1052 0.1657
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0016 0.0012 0.0019
Trypanosoma brucei C-8 sterol isomerase, putative 0.4192 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.0713 1
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.0713 1
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0485 0.6751
Brugia malayi hypothetical protein 0.0148 0.0329 0.0329
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0149 0.0227
Echinococcus granulosus receptor type guanylyl cyclase 0.0099 0.0211 0.0333
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.0714 0.1129
Echinococcus granulosus protein kinase shaggy 0.0059 0.0116 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0459 0.6379
Loa Loa (eye worm) cyclin C 0.0016 0.0012 0.0012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.045 0.1052 0.1657
Toxoplasma gondii hypothetical protein 0.045 0.1052 1
Schistosoma mansoni cpg binding protein 0.0036 0.0062 0.0089
Loa Loa (eye worm) hypothetical protein 0.045 0.1052 0.1052
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.045 0.1052 0.1664
Schistosoma mansoni sodium/chloride dependent transporter 0.045 0.1052 0.1657
Brugia malayi Serine protease Z688.6 precursor 0.0021 0.0026 0.0026
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.0006 0.0006
Echinococcus granulosus tyrosine kinase 0.0099 0.0211 0.0333
Echinococcus multilocularis glutamate receptor 2 0.0193 0.0435 0.0688
Schistosoma mansoni nAChR subunit 0.0013 0.0006 0.0001
Entamoeba histolytica cyclin, putative 0.0064 0.0129 0.4486
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.0006 0.0009
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0459 0.6379
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.013 0.1138
Schistosoma mansoni tyrosine kinase 0.0099 0.0211 0.0325
Echinococcus granulosus cpg binding protein 0.0036 0.0062 0.0097
Echinococcus multilocularis neuropeptide receptor A26 0.0553 0.1297 0.2051
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.0006 0.0006
Onchocerca volvulus 0.0016 0.0012 0.001
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0006 0.0009
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0309 0.0714 0.0714
Plasmodium falciparum cyclin 0.0064 0.0129 0.1122
Echinococcus multilocularis tyrosine kinase 0.0099 0.0211 0.0333
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0225 0.8207
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0116 0.0184
Loa Loa (eye worm) RGC/RGC protein kinase 0.0099 0.0211 0.0211
Echinococcus granulosus neuropeptide s receptor 0.0553 0.1297 0.2051
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.0006 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0006 0.0009
Trypanosoma brucei cdc2-related kinase 3 0.0105 0.0225 0.0214
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0006 0.0009
Plasmodium vivax hypothetical protein, conserved 0.045 0.1052 1
Brugia malayi Serine carboxypeptidase S28 family protein 0.0097 0.0207 0.0207
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0203
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0124 0.0272 0.0272
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0099 0.0211 0.0211
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0203
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0193 0.0435 0.0688
Echinococcus granulosus glutamate receptor 2 0.0291 0.0671 0.1062
Brugia malayi Cation transporter family protein 0.0013 0.0006 0.0006
Echinococcus granulosus G1:S specific cyclin D1 0.0016 0.0012 0.0019
Echinococcus granulosus glutamate receptor 2 0.0099 0.0211 0.0333
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.045 0.1052 0.1052
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0005 0.0008
Echinococcus granulosus cyclin t1 0.0016 0.0012 0.0019
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0225 0.0356
Loa Loa (eye worm) hypothetical protein 0.2142 0.5099 0.5099
Onchocerca volvulus 0.045 0.1052 0.1657
Echinococcus granulosus cyclins 0.0064 0.0129 0.0203
Schistosoma mansoni hypothetical protein 0.0193 0.0435 0.0681
Echinococcus multilocularis sodium and chloride dependent glycine 0.045 0.1052 0.1664
Echinococcus granulosus cyclins 0.0016 0.0012 0.0019
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.0006 0.0006
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Echinococcus granulosus cyclin 0.0016 0.0012 0.0019
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.0006 0.0009
Toxoplasma gondii hypothetical protein 0.0049 0.0092 0.0765
Schistosoma mansoni nAChR subunit 0.0013 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0203
Loa Loa (eye worm) hypothetical protein 0.0097 0.0207 0.0207
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0005 0.0008
Echinococcus multilocularis receptor type guanylyl cyclase 0.0099 0.0211 0.0333
Echinococcus granulosus cyclin y 0.0016 0.0012 0.0019
Trichomonas vaginalis cyclins, putative 0.0124 0.0272 0.371
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0105 0.0225 0.2052
Echinococcus granulosus sodium and chloride dependent glycine 0.045 0.1052 0.1664
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.0713 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0291 0.0671 0.1062
Loa Loa (eye worm) glutamate receptor 1 0.0193 0.0435 0.0435
Trichomonas vaginalis glucosylceramidase, putative 0.0309 0.0713 1
Schistosoma mansoni cyclin G2 0.0016 0.0012 0.001
Schistosoma mansoni glutamate receptor kainate 0.0193 0.0435 0.0681
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0012 0.0012
Brugia malayi hypothetical protein 0.0016 0.0012 0.0012
Echinococcus granulosus glutamate receptor subunit protein glur 0.0193 0.0435 0.0688
Echinococcus granulosus nAChR subunit 0.0013 0.0006 0.0009
Schistosoma mansoni protein kinase 0.0099 0.0211 0.0325
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0116 0.0184
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.0714 0.1122
Trichomonas vaginalis cyclin B, putative 0.0064 0.0129 0.1664
Echinococcus granulosus cyclins 0.0064 0.0129 0.0203
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0005 0.0005
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0012 0.0012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.045 0.045
Brugia malayi Glutamate receptor 2 precursor 0.0193 0.0435 0.0435
Echinococcus granulosus cyclin B3 1 0.0064 0.0129 0.0203
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.008 0.008
Echinococcus multilocularis nAChR subunit 0.0013 0.0006 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0124 0.0272 0.0272
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0097 0.0207 0.0327
Loa Loa (eye worm) hypothetical protein 0.0097 0.0207 0.0207
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0006 0.0009
Echinococcus multilocularis sodium and chloride dependent glycine 0.045 0.1052 0.1664
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0291 0.0671 0.1062
Echinococcus granulosus cyclin B 0.0124 0.0272 0.043
Brugia malayi Glutamate receptor 1 precursor 0.0193 0.0435 0.0435
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0116 0.0104
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0225 0.0356
Loa Loa (eye worm) hypothetical protein 0.045 0.1052 0.1052
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0006 0.0001
Echinococcus multilocularis NMDA receptor 0.0193 0.0435 0.0688
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.045 0.1052 0.1657
Onchocerca volvulus Protein CNPPD1 homolog 0.0016 0.0012 0.001
Schistosoma mansoni Cyclin fold protein 0.0016 0.0012 0.001
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0026 0.052
Onchocerca volvulus 0.0124 0.0272 0.0421
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0016 0.0012 0.0019
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0099 0.0211 0.0325
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0148 0.0329 0.0328
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0272 0.0272
Leishmania major C-8 sterol isomerase-like protein 0.4192 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0291 0.0671 0.1062
Plasmodium falciparum transporter, putative 0.045 0.1052 1
Leishmania major extracellular receptor, putative 0.0099 0.0211 0.0199
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0026 0.0193
Loa Loa (eye worm) hypothetical protein 0.4192 1 1
Echinococcus granulosus dnaJ subfamily B 0.0489 0.1144 0.1809
Echinococcus granulosus atrial natriuretic peptide receptor 0.0099 0.0211 0.0333
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0006 0.0006
Echinococcus granulosus cyclin b3 0.0064 0.0129 0.0203
Echinococcus granulosus uncharacterized sodium dependent transporter 0.045 0.1052 0.1664
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.045 0.1052 0.1657
Entamoeba histolytica protein kinase, putative 0.0059 0.0116 0.4012
Schistosoma mansoni glutamate receptor NMDA 0.0291 0.0671 0.1054
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0012 0.0012
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.045 0.1052 0.1052
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0016 0.0012 0.001
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.0006 0.0006
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0116 0.0104
Trichomonas vaginalis cyclin D, putative 0.0064 0.0129 0.1664
Loa Loa (eye worm) hypothetical protein 0.2653 0.6321 0.6321
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0225 0.8207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Leishmania major cyclin 0.0124 0.0272 0.026
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0193 0.0435 0.0688
Schistosoma mansoni cyclin B3 0.0199 0.045 0.0704
Trypanosoma cruzi cyclin, putative 0.0124 0.0272 0.026
Schistosoma mansoni cyclin B 0.0124 0.0272 0.0422
Echinococcus multilocularis cyclin y 0.0016 0.0012 0.0019
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0012 0.0012
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0116 0.0184
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.0211

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.481 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817
IC50 (binding) = 6.495 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
IC50 (binding) = 7.125 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817
Log IC50 (binding) = 6.481 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817
Log IC50 (binding) = 6.495 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
Log IC50 (binding) = 7.12499999999999 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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